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Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research

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World Journal of Gastroenterology 2020年第4期26卷 375-382页

作者： jordan m Cloyd Allan Tsung John Hays Celia E Wills John FP Bridges Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Internal medicine The Ohio State UniversityColumbusOH 43210United States College of Nursing The Ohio State UniversityColumbusOH 43210United States Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210United States

Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical *** adjuvant chemotherapy improves survival,a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance *** administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival *** therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however,patient-centered research on its use is *** this review,we highlight opportunities to focus research efforts in the domains of patient preferences,patient-reported outcomes,patient experience,and *** research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization,improve shareddecision making for patients and providers,and optimize the experience of those undergoing neoadjuvant therapy.

关键词： Preoperative therapy Pancreatic ductal adenocarcinoma Quality of life Shared decision making Patient preferences

Neoadjuvant treatment strategies for intrahepatic cholangiocarcinoma

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World Journal of Hepatology 2020年第10期12卷 693-708页

作者： Clifford Akateh Aslam m Ejaz Timothy michael Pawlik jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgery The Ohio State UniversityColumbusOH 43210United States

Intrahepatic cholangiocarcinoma(ICC)is the second most common primary liver malignancy and is increasing in ***-term outcomes are optimized when patients undergo margin-negative resection followed by adjuvant ***,a significant proportion of patients present with locally advanced,unresectable ***,recurrence rates are high even among patients who undergo surgical *** delivery of systemic and/or liver-directed therapies prior to surgery may increase the proportion of patients who are eligible for surgery and reduce recurrence rates by prioritizing early systemic therapy for this aggressive ***,the available evidence for neoadjuvant therapy in ICC is currently limited yet recent advances in liver directed therapies,chemotherapy regimens,and targeted therapies have generated increasing interest its *** this article,we review the rationale for,current evidence for,and ongoing research efforts in the use of neoadjuvant therapy for ICC.

关键词： Biliary tract cancer Preoperative therapy Conversion therapy Down-staging Hepatectomy Liver resection

Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： muteb H.Alshammari Ahmed Onayzan Alshammari mohamed Tharwat Elabbasy Rafat Zreiq Faris mohammed Albati m.A.El-morsy A.A.menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEm). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

Contemporary indications for and outcomes of hepatic resection for neuroendocrine liver metastases

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World Journal of Gastrointestinal Surgery 2020年第4期12卷 159-170页

作者： Steven D Scoville Dimitrios Xourafas Aslam m Ejaz Allan Tsung Timothy Pawlik jordan m Cloyd Department of Surgery Division of Surgical Oncology at The Ohio State UniversityJames Cancer CenterColumbusOH 43210United States The Arthur G James Comprehensive Cancer Center and Solove Research Institute The Ohio State UniversityColumbusOH 43210United States Department of Surgery Harvard Medical SchoolDepartment of SurgeryBrigham and Women's HospitalHarvard Medical SchoolBostonMA 02215United States Department of Surgery The Ohio State UniversityColumbusOH 43210United States Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Although surgical resection is associated with the best long-term outcomes for neuroendocrine liver metastases(NELm),the current indications for and outcomes of surgery for NELm from a population perspective are not well *** To determine the current indications for and outcomes of liver resection(LR)for NELm using a population-based *** A retrospective review of the 2014-2017 American College of Surgeons National Surgical Quality Improvement Program and targeted hepatectomy databases was performed to identify patients who underwent LR for *** characteristics and 30-d morbidity and mortality were *** Among 669 patients who underwent LR for NELm,the median age was 60(interquartile range:51-67)and 51%were *** the number of metastases resected ranged from 1 to 9,the most common(45%)number of tumors resected was *** majority(68%)of patients had a largest tumor size ofmy(71%)while fewer underwent a right or left hepatectomy or *** majority of operations were open(82%)versus laparoscopic(17%)or robotic(1%).In addition,30%of patients underwent intraoperative ablation while 45%had another concomitant operation including cholecystectomy(28.8%),bowel resection(20.2%),or partial pancreatectomy(3.4%).Overall 30-d morbidity and mortality was 29%and 1.3%,*** multivariate analysis,American Society of Anesthesiologists class≥3[odds ratios(OR),OR=2.089,95%confidence intervals(CI):1.197-3.645],open approach(OR=1.867,95%CI:1.148-3.036),right hepatectomy(OR=1.618,95%CI:1.014-2.582),and prolonged operative time of>230 min(OR=1.731,95%CI:1.168-2.565)were associated with higher 30-d morbidity while intraoperative ablation and concomitant procedures were *** LR for NELm was performed with relatively low postoperative morbidity and *** procedures performed at the time of LR did not increase morbidity.

关键词： Carcinoid Neuroendocrine tumor Primary tumor resection Intraoperative ablation Cholecystectomy Small bowel resection

First report of small cell lung cancer with PTHrP-induced hypercalcemic pancreatitis causing disconnected duct syndrome

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World Journal of Clinical Oncology 2017年第5期8卷 420-424页

作者： Eric m montminy Stephen W Landreneau jordan J Karlitz Division of Gastroenterology Tulane University Medical Center Division of Gastroenterology LSU Health Sciences Center

Here we report a patient diagnosed with small cell lung cancer after first presenting with parathyroid hormonerelated peptide-induced hypercalcemic pancreatitis and developed walled-off necrosis that resulted in disruption of the main pancreatic *** duct syndrome (DDS) is a rare syndrome that occurs when the main pancreatic duct exocrine flow is disrupted resulting in leakage of pancreatic enzymes and further inflammatory *** date,no prior reports have described DDS occurring with paraneoplastic *** imaging techniques and therapeutic interventions are reviewed to provide insight into current approaches to DDS.

关键词： Disconnected duct syndrome Parathyroid hormone-related peptide Hypercalcemic pancreatitis

Composite Fractional Trapezoidal Rule with Romberg Integration

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Computer modeling in Engineering & Sciences 2024年第9期140卷 2729-2745页

作者： Iqbal m.Batiha Rania Saadeh Iqbal H.Jebril Ahmad Qazza Abeer A.Al-Nana Shaher momani Department of mathematics Al Zaytoonah University of JordanAmman11733Jordan Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman 346United Arab Emirates Department of mathematics Faculty of ScienceZarqa UniversityZarqa13110Jordan Department of mathematics Prince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of mathematics The University of JordanAmman11942Jordan

The aim of this research is to demonstrate a novel scheme for approximating the Riemann-Liouville fractional integral *** would be achieved by first establishing a fractional-order version of the 2-point Trapezoidal rule and then by proposing another fractional-order version of the(n+1)-composite Trapezoidal *** particular,the so-called divided-difference formula is typically employed to derive the 2-point Trapezoidal rule,which has accordingly been used to derive a more accurate fractional-order formula called the(n+1)-composite Trapezoidal ***,in order to increase the accuracy of the proposed approximations by reducing the true errors,we incorporate the so-called Romberg integration,which is an extrapolation formula of the Trapezoidal rule for integration,into our proposed *** numerical examples are provided and compared with a modern definition of the Riemann-Liouville fractional integral operator to illustrate the efficacy of our scheme.

关键词： Composite fractional Trapezoidal rule Romberg integration

Neuroendocrine liver metastases: a contemporary review of treatment strategies

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 440-451页

作者： jordan m.Cloyd Aslam Ejaz Bhavana Konda mina S.makary Timothy m.Pawlik Departments of Surgery The Ohio State UniversityWexner Medical CenterColumbusOHUSA Departments of Internal medicine The Ohio State UniversityWexner Medical CenterColumbusOHUSA Departments of Radiology The Ohio State UniversityWexner Medical CenterColumbusOHUSA

Well-differentiated neuroendocrine tumors(NETs)are globally increasing in prevalence and the liver is the most common site of *** liver metastases(NELm)are heterogeneous in clinical presentation and ***,recent advances in diagnostic techniques and therapeutic strategies have improved the multidisciplinary management of this challenging *** feasible,surgical resection of NELm offers the best long-term *** indications for hepatic resection include performance status acceptable for major liver surgery,grade 1 or 2 tumors,absence of extrahepatic disease,adequate size and function of future liver remnant,and feasibility of resecting>90%of *** therapies including concomitant liver ablation are generally safe when used appropriately and may expand the number of patients eligible for *** patients with synchronous resectable NELm,resection of the primary either in a staged or combined fashion is *** patients who are not surgical candidates,liver-directed therapies such as transarterial embolization,chemoembolization,and radioembolization can provide locoregional control and improve symptoms of carcinoid *** systemic therapy options also exist for patients with advanced or progressive *** research efforts are needed to identify novel biomarkers that will define the optimal indications for and sequencing of treatments to be delivered in a personalized fashion.

关键词： Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) liver-directed therapies carcinoid hepatic resection targeted therapy

A machine learning approach for regional geochemical data:Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province

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Geoscience Frontiers 2021年第3期12卷 42-59页

作者： jordan J.Lindsay Hannah S.R.Hughes Christopher m.Yeomans Jens C.Ø.Andersen Iain mcDonald Camborne School of mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom School of Earth and Ocean Sciences Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation,by considering entire regional data sets on an objective basis using machine learning algorithms(mLAs),we can highlight new facets within the broader data structure and significantly enhance previous geochemical *** platinum-group element(PGE)budget of lavas in the North Atlantic Igneous Province(NAIP)has been shown to vary systematically according to age,geographic location and geodynamic *** the large multi-element geochemical data set available for the region,mLAs were employed to explore the magmatic controls on these shifting *** key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Principal Component Analysis(PCA)and t-Distributed Stochastic Neighbour Embedding(t-SNE)techniques to increase separability in the data alongside clustering using the k-means *** new multi-element classification is compared to the original geographic classification to assess the performance of both *** workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the *** techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input *** end-members are seen to fluctuate in prominence throughout the NAIP,which we propose reflects the changing geodynamic environment and melting ***,the variability of Pt and Pd are not reflected in mLA-based clustering trends,suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure(i.e.,other proxies for magmatic differe

关键词： Platinum-group elements machine learning Plume Geochemistry metallogenesis mantle

A comparison of lower limb stiffness and mechanical muscle function in ACL-reconstructed,elite,and adolescent alpine ski racers/ski cross athletes

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Journal of Sport and Health Science 2018年第4期7卷 416-424页

作者： matthew J.jordan Per Aagaard Walter Herzog Canadian Sport Institute Calgary Calgary AB T2N IN4Canada Department of Sports Science and Clinical Biomechanics SDU Muscle Research ClusterUniversity of Southern DenmarkOdense DK-5230Denmark Human Performance Laboratory University of CalgaryCalgaryAB T2N IN4Canada Corresponding author.E-mail address： mjordan@ucalgary.ca

Purpose： The aim of this study was to compare mechanical muscle function in the eccentric/concentric phases of vertical bilateral jumping in anterior cruciate ligament-reconstructed （ACLR）, elite （ELITE）, and adolescent （ADOL） alpine ski racers and ski cross athletes. methods： Alpine ski racers/ski crossers （ACLR： n = 12, age = 26.7 ± 3.8 years; ELITE： n = 12, age = 23.9 ± 3.0 years; ADOL： n = 12, age = 17.8 ± 0.7 years; females： n = 6 per group, males： n = 6 per group） performed 5 maximal countermovement jumps （CmJs） and 5 squat jumps. The ground reaction forces for each limb were analyzed using dual force plate recording to obtain body center of mass （BCm） velocity, displacement, and power. The eccentric deceleration （ECC） and concentric phases were determined from BCm velocity. CmJ net concentric and ECC impulses were calculated （body mass normalized） along with the peak and mean BCm power and maximal vertical jump height. CmJ lower limb stiffness （LLS） was determined by the slope of the ground reaction forces vs. the BCm displacement curve over the ECC phase. Concentric and ECC asymmetry indices were calculated for each leg, and the left vs. right LLS was compared. Outcome measures （reported as mean ± SD） calculated as a 5-jump mean were normalized to body mass and compared using an analysis of variance. Results： No between-group differences were found for peak and mean power or jump heights. There were no group differences for LLS or net concentric phase impulse, but the net ECC impulse was lower in the ADOL group compared with ELITE skiers （ADOL： 1.33 ± 0.32 Ns/kg; ELITE： 1.59 ± 0.16 Ns/kg; p 〈 0.05）. Although no group differences were found for ECC asymmetry indices, a group × limb interaction was found for LLS （p 〈 0.01）, which was systematically higher in the right vs. the left limb of ADOL skiers （right： 54.1 ± 17.9 N/m/kg; left： 48.7 ± 15.7 N/m/kg;p 〈 0.01）. Conclusion： ADOL skiers demonstrated decreased ECC impulse and systematic right limb dominance in

关键词： Between-limb asymmetry Injury prevention Knee injuries muscle power Vertical jump