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microbial symphony orchestrated by mucosal IgA

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Cellular & molecular Immunology 2022年第4期19卷 456-457页

作者： Alejandra Reyes-Ruiz jordan D.Dimitrov Centre de Recherche des Cordeliers INSERMCNRSSorbonne UniversitéUniversitéde Paris75006ParisFrance

The ability of an organism to handle the beauty and cruelty of existence is largely due to a complex network of molecular and cellular interactions and processes named the immune *** components of this network are antibodies(Abs)that have key roles in immune defense and *** biological functions of Abs include neutralizing pathogens by blocking functionally important molecules and/or to eliciting lethal effector functions by bridging the recognition of pathogens with binding to different innate immune receptors.

关键词： bridging neutral network

Fuzzy Difference Equations in Diagnoses of Glaucoma from Retinal Images Using Deep Learning

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Computer modeling in Engineering & Sciences 2024年第4期139卷 801-816页

作者： D.Dorathy Prema Kavitha L.Francis Raj Sandeep Kautish Abdulaziz S.Almazyad Karam m.Sallam Ali Wagdy mohamed Department of mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Colleges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of Science and Technology School of IT and SystemsUniversity of CanberraCanberraAustralia Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy set has found important application in decision-making and machine *** enrich and utilize the intuitive fuzzy set,this study designed and developed a deep neural network-based glaucoma eye detection using fuzzy difference equations in the domain where the retinal images *** image detections are categorized as normal eye recognition,suspected glaucomatous eye recognition,and glaucomatous eye *** degrees associated with weighted values are calculated to determine the level of concentration between the fuzzy partition and the retinal *** proposed model was used to diagnose glaucoma using retinal images and involved utilizing the Convolutional Neural Network(CNN)and deep learning to identify the fuzzy weighted regularization between *** methodology was used to clarify the input images and make them adequate for the process of glaucoma *** objective of this study was to propose a novel approach to the early diagnosis of glaucoma using the Fuzzy Expert System(FES)and Fuzzy differential equation(FDE).The intensities of the different regions in the images and their respective peak levels were *** the peak regions were identified,the recurrence relationships among those peaks were then *** partitioning was done due to varying degrees of similar and dissimilar concentrations in the *** and dissimilar concentration levels and spatial frequency generated a threshold image from the combined fuzzy matrix and *** distinguished between a normal and abnormal eye condition,thus detecting patients with glaucomatous eyes.

关键词： Convolutional Neural Network(CNN) glaucomatous eyes fuzzy difference equation intuitive fuzzy sets image segmentation retinal images

Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena Stevens Zachary J Brown Ryan Zeh Christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam m Ejaz Timothy michael Pawlik jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadjuvant therapy(NT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing NT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during NT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of NT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving NT to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during NT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing NT was the doctor’s recommendation,while most reported not being familiar with the concept of NT(n=11)and that NT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

Association between tourniquet use and intraoperative blood loss during below-knee amputation

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World Journal of Orthopedics 2022年第7期13卷 644-651页

作者： Alden E Wyland Erik Woelber Liam H Wong jordan Arakawa Zachary m Working James meeker School of medicine Oregon Health and Sciences UniversityPortlandOR 97239United States Department of Orthopaedics and Rehabilitation Oregon Health and Sciences UniversityPortlandOR 97239United States

BACKGROUND Despite over 150000 amputations of lower limbs annually,there remains a wide variation in tourniquet practice patterns and no consensus on their necessity,especially among orthopedic patient *** purpose of this study was to determine whether tourniquet use in orthopedic patients undergoing below knee amputation(BKA) was associated with a difference in calculated blood loss relative to no tourniquet *** To determine if tourniquet use in orthopedic patients undergoing BKA was associated with a difference in calculated blood loss relative to no tourniquet *** We performed a retrospective review of consecutive patients undergoing BKA by orthopedic surgeons at a tertiary care hospital from 2008 through *** loss was calculated using a combination of the Nadler equation for preoperative blood volume and a novel formula utilizing preoperative and postoperative hemoglobin levels and *** and forwards step-wise multivariate linear regressions were performed to determine the association between tourniquet use and blood loss.A Wilcoxon was used to determine the univariate relationship between tourniquet use and blood loss for in the restricted subgroups of patients who underwent BKA for trauma,tumor,and *** Of 97 eligible patients identified,67 underwent surgery with a tourniquet and 30 did *** multivariate regression,tourniquet use was associated with a 488 mL decrease in calculated blood loss(CI 119-857,P = 0.01).In subgroup analysis,no individual group showed a statistically significant decrease in blood loss with tourniquet *** was no significant association between tourniquet use and either postoperative transfusions or reoperation at one *** We found that tourniquet use during BKA is associated with decreased calculated intraoperative blood *** recommend that surgeons performing this procedure use a tourniquet to minimize blood loss.

关键词： Amputation Tourniquet Blood loss Hemostasis

Shifts in hydropower operation to balance wind and solar will modify effects on aquatic biota

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Water Biology and Security 2022年第3期1卷 88-98页

作者： Henriette I.Jager Thushara De Silva Rocio Uria-martinez Brenda m.Pracheil jordan macknick Oak Ridge National Laboratory Oak RidgeTN37831-6038USA National Renewable Energy Laboratory GoldenCOUSA

To avoid negative consequences to freshwater biota from climate change,society must complete the transition from fossil to renewable electricity ***,temporal patterns in hydropower generation(and flow releases that affect aquatic biota)may change with increased wind and solar *** used power cost modeling to characterize current and future within-day and seasonal patterns in hydropower generation across the Eastern Interconnection in a wet and a dry *** to the baseline,future hydropower generation across the grid decreased during the day and increased before dawn and after *** a project level,such a pattern would suggest‘double peaking’operation(up-and down-ramping before dawn and after dusk,with lower releases midday).Variation in generation was higher in wet years than dry years,foreshadowing possible flow constraints on hydropower *** the grid scale,projected ramping rates were higher in all seasons.A review of the ecological literature suggests that these changes would shift the timing of invertebrate drift and elevate the risk of nest scouring during up-ramping and the risk of stranding or dewatering during down *** conditions may be moderated by increased *** for adapting to future shifts in the renewable portfolio range from re-regulation in reservoir cascades to providing flow refuge(structures and vegetation)below individual *** basin-scale operation can distribute peaking operation to maintain grid support while restricting local ramping at critical ecological *** addition,research to design hybrid renewable systems that add battery storage is needed to understand how we can mitigate future risks to aquatic communities while promoting the use of renewable *** study,which is among the first to examine ecological side-effects of the shift to renewable energy in freshwater ecosystems,lays out a path toward understanding and navigating changes to flow regime

关键词： Wind Solar Hydropower Hydropeaking Temporal niche Double peaking Ramping Stranding Dewatering PLEXOS

Polar comonomer incorporation using cationic Ni α-diimine olefin polymerization catalysts

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Science China Chemistry 2019年第2期62卷 153-154页

作者： jordan m.Kaiser Brian K.Long Department of Chemistry University of Tennessee

Polyolefins are an indispensable class of materials that have become the most widely produced and utilized polymers *** are readily synthesized from cheap and abundant monomer feedstocks,such as ethylene and propylene,and are capable of achieving a vast array of thermal and mechanical properties based upon their composition and ***,despite their numerous advantages, polyolefins are typically devoid of functional groups which can limit their applicability to many product families,such as coatings,adhesives,and cross-linked polyolefins.

关键词： Ni α-diimine olefin polymerization catalysts

Immature and mature antibodies as defenders against cancer

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Cellular & molecular Immunology 2023年第1期20卷 3-5页

作者： Robin V.Lacombe Sophie Sibéril jordan D.Dimitrov Centre de Recherche des Cordeliers INSERMCNRSSorbonne UniversitéUniversitéParis CitéParisFrance

Antibodies(Abs)are glycoprotein molecules that represent an essential component of the adaptative immune *** are secreted in body fluids and act as a critical part of immune *** recognition of self-antigens by Abs is normally selected against during B-cell development,autoreactive Abs can be generated as a result of pathological immune responses,as observed in autoimmune *** can also be produced in cancer patients,where they may have beneficial roles[1].Indeed,the presence of intratumoral antibody-secreting cells(ASCs)and B-cell-rich tertiary lymphoid structures(TLSs)has been observed in many cancer types and generally correlates with a favorable clinical prognosis[2,3,4,5,6].The existence of specific antitumor antibody responses suggests that tumor cells express molecules that are recognized as nonself antigens by the immune system or that tolerance of self-antigens expressed on cancer cells is lost[1,4].The study of the origin of tumor-reactive Abs and their specificity and functions is of paramount importance for understanding the development of adaptive antitumor immune responses and for revealing novel therapeutic avenues.A recent publication in Cell by mazor et al.[7]has provided an important advance in our understanding of antibody responses in *** particular,this work paves the way for the distinction between antibody-reactive tumors and antibody-nonreactive tumors,which is reminiscent of the dichotomy of the noninfiltrated“cold”tumor microenvironment(TmE)in contrast with the highly infiltrated with immune cells“hot”TmE[8].moreover,an important finding of the study was the demonstration that tumor-directed autoreactivity may be either preexisting or induced by somatic hypermutations,a mechanism related to the chronicity of cancer.

关键词： cancer antibodies specificity

The emerging applications of pillararene architectures in supramolecular catalysis

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Chinese Chemical Letters 2022年第1期33卷 89-96页

作者： Kaiya Wang Xueqi Tian Jacobs H.jordan Krishnasamy Velmurugan Leyong Wang Xiao-Yu Hu College of materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China The Southern Regional Research Center Agricultural Research ServiceUSDANew OrleansLA 70124United States Key Laboratory of mesoscopic Chemistry of mOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Over the last decade,numerous research efforts have been devoted to pillar[n]arenes since their *** popularity of pillararenes is a reflection of current research trend in supramolecular and macrocyclic chemistry in *** the vast applications(such as chemosensors,drug delivery,transmembrance channels,and separation)of pillararenes,their utilization in catalysis is a relatively less explored ***,soaring attention has been paid by researchers in recent years and this field has seen gradual increasing ***,in this review we will discuss progress in the emerging applications of pillararene architectures in catalysis based on various reaction genre including reduction,oxidation,coupling,decomposition and ***,this review not only focuses on the pillararenes based current progress in catalysis,but also provides the signs for future development in this research field.

关键词： Supramolecular catalysis Host–guest chemistry macrocycles Pillararene Self-assembly

Robust Facial Biometric Authentication System Using Pupillary Light Reflex for Liveness Detection of Facial Images

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Computer modeling in Engineering & Sciences 2024年第4期139卷 725-739页

作者： Puja S.Prasad Adepu Sree Lakshmi Sandeep Kautish Simar Preet Singh Rajesh Kumar Shrivastava Abdulaziz S.Almazyad Hossam m.Zawbaa Ali Wagdy mohamed CSE Department Geethanjali College of EngineeringHyderabadTelangana501301India Department of Computer Science LBEF CampusKathmandu44600Nepal School of Computer Science Engineering and Technology(SCSET) Bennett UniversityGreater Noida201310India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia CeADAR Ireland’s Centre for AI Technological University DublinDublinD07 EWV4Ireland Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11937Jordan

Pupil dynamics are the important characteristics of face spoofing *** face recognition system is one of the most used biometrics for authenticating individual *** main threats to the facial recognition system are different types of presentation attacks like print attacks,3D mask attacks,replay attacks,*** proposed model uses pupil characteristics for liveness detection during the authentication *** pupillary light reflex is an involuntary reaction controlling the pupil’s diameter at different light *** proposed framework consists of two-phase *** the first phase,the pupil’s diameter is calculated by applying stimulus(light)in one eye of the subject and calculating the constriction of the pupil size on both eyes in different video *** above measurement is converted into feature space using Kohn and Clynes model-defined *** Support Vector machine is used to classify legitimate subjects when the diameter change is normal(or when the eye is alive)or illegitimate subjects when there is no change or abnormal oscillations of pupil behavior due to the presence of printed photograph,video,or 3D mask of the subject in front of the *** the second phase,we perform the facial recognition ***-invariant feature transform(SIFT)is used to find the features from the facial images,with each feature having a size of a 128-dimensional *** features are scale,rotation,and orientation invariant and are used for recognizing facial *** brute force matching algorithm is used for matching features of two different *** threshold value we considered is 0.08 for good *** analyze the performance of the framework,we tested our model in two Face antispoofing datasets named Replay attack datasets and CASIA-SURF datasets,which were used because they contain the videos of the subjects in each sample having three modalities(RGB,IR,Depth).The CASIA-SURF datasets showed an 89.9%Equal Err

关键词： SIFT pupil CASIA-SURF pupillary light reflex replay attack dataset brute force