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Predictive factors for interferon and ribavirin combination therapy in patients with chronic hepatitis C

World Journal of Gastroenterology 2007年第46期13卷 6236-6242页

作者： joonho Yoon Jong In Lee Soon Koo Baik Kwang Ho Lee joon Hyung Sohn Hyean-woo Lee Jun Namkung Sei Jin Chang Jong-Whan Choi Hyun-Won Kim Byung-Il Yeh Department of Biochemistry and Institute of Basic Medical Sciences Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Internal Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Internal Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Anesthesiology Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Biochemistry and Institute of Basic Medical Sciences Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Department of Preventive Medicine and Institute of Occupational Medicine Wonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea Institute of Lifelong HealthWonju College of MedicineYonsei UniversityWonju 220-701Republic of Korea

瞄准：为干扰素(IFN ) 证实预兆的因素为有丙肝的长期的肝炎病人的 -alpha 和 ribavirin 联合治疗病毒(HCV ) 遗传型 1b。方法：从感染 HCV 遗传型 1b 的 50 个病人的 HCV RNA 被决定区域(ISDR ) 的干扰素敏感克隆并且定序学习， PKR-eI... 详细信息

瞄准：为干扰素(IFN ) 证实预兆的因素为有丙肝的长期的肝炎病人的 -alpha 和 ribavirin 联合治疗病毒(HCV ) 遗传型 1b。方法：从感染 HCV 遗传型 1b 的 50 个病人的 HCV RNA 被决定区域(ISDR ) 的干扰素敏感克隆并且定序学习， PKR-eIF2alpha 磷酸化相同领域(PePHD ) 。病人们为 6 瞬间与 IFN-alpha 和 ribavirin 被对待并且由治疗的有效性组织了。许多因素被分析。结果：我们的数据证明年龄， HCV RNA 效价，和 ISDR 类型能为联合 IFN-alpha 和 ribavirin 功效被用作预兆的因素。表示特性地，仅仅当联合治疗是有效的时，在 PePHD 的变化出现了。另外的因素，例如性别和丙氨酸， aminotransferase (中高音) 铺平，不与它的功效有关。好久调整并且 HCV RNA titer 显示 ISDR 类型是最有势力预兆的因素。结论：HCV RNA ISDR 类型是为在朝鲜病人预言 IFN-alpha 和 ribavirin 联合治疗的功效的一个重要因素。

关键词：丙肝病毒干扰素病毒唑磷酸化

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The Phytophthora nucleolar effector pi23226 targets host ribosome biogenesis to induce necrotrophic cell death

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Plant Communications 2023年第5期4卷 263-276页

作者： Soeui Lee Jaehwan Kim Myung-Shin Kim Cheol woo Min Sun Tae Kim Sang-Bong Choi Joo Hyun Lee Doil Choi Plant Immunity Research Center Seoul National UniversitySeoul 08826Republic of Korea Plant Genomics and Breeding Institute Department of AgricultureForestry and BioresourcesCollege of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Programs in Agricultural Genomics College of Agriculture and Life ScienceSeoul National UniversitySeoul 08826Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Division of Bioscience and Bioinformatics Myongji UniversityYongin 449-728Republic of Korea

Pathogen effectors target diverse subcellular organelles to manipulate the plant immune *** the nucleolus has emerged as a stress marker and several effectors are localized in the nucleolus,the roles of nucleolar-targeted effectors remain *** this study,we showed that Phytophthora infestans infection of Nicotiana benthamiana results in nucleolar inflation during the transition from the biotrophic to the necrotrophic *** *** effectors were localized in the nucleolus:pi23226 induced cell death in *** and nucleolar inflation similar to that observed in the necrotrophic stage of infection,whereas its homolog pi23015 and a deletion mutant(pi23226DC)did not induce cell death or affect nucleolar *** immunoprecipitation and individual-nucleotide-resolution UV crosslinking and immunoprecipitation sequencing analysis indicated that pi23226 bound to the 30 end of 25S rRNA precursors,resulting in accumulation of unprocessed 27S *** nucleolar stress marker NAC082 was strongly upregulated under pi23226-expressing ***23226 subsequently inhibited global protein translation in host cells by interacting with ***23226 enhanced *** pathogenicity,indicating that pi23226-induced ribosome malfunction and cell death were beneficial for pathogenesis in the *** results provide evidence for the molecular mechanism underlying RNA-binding effector activity in host ribosome biogenesis and lead to new insights into the nucleolar action of effectors in pathogenesis.

关键词： Phytophthora infestans hemibiotroph nucleolar effector cell death ribosome biogenesis translation inhibition

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Impacts of low level aflatoxin in feed and the use of modified yeast cell wall extract on growth and health of nursery pigs

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Animal Nutrition 2015年第3期1卷 177-183页

作者： Yawang Sun Inkyung Park Jiyao Guo Alexandra C.Weaver Sung woo Kim Department of Animal Science North Carolina State University

This study was to investigate the effect of corn naturally contaminated with aflatoxins(AF)under the regulatory level on the growth performance and health of nursery pigs,and the efficiency of yeast cell wall based feed additive(YC)mainly composed ofβ-glucans and mannan oligosaccharide(MOS)(Integral A+,Alltech,Lexington,KY)in prevention of ***(60 barrows and 60 gilts at 6.02 ± 0.83kg BW)were randomly allotted to 4 treatments in a randomized complete block design based on a 2×2 factorial arrangement with 10 pens(5 barrow and 5 gilt pens)per treatment and 3 pigs per *** were fed experimental diets for 5 *** factor was AF(0 or 20 mg/kg in feed)and the second factor was YC(0 or 2 g/kg in feed).Feed intake and body weight were measured weekly,and blood samples were used to measure blood cell counts,immunoglobulin G(Ig G),tumor necrosis factor-a(TNF-a),oxidative damage status,and serological evaluation related to liver *** decreased(Ppigs whereas G:F was not affected,and it also tended to increase(P=0.055)albumin level(3.46 to 3.63 g/d L).Interactions(P pigs were eating AF contaminated ***(P pi

关键词： Aflatoxin β-glucans Health MOS Nursery pigs modified yeast cell wall extract

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High morbidity in myocardial infarction and heart failure patients after gastric cancer surgery

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World Journal of Gastroenterology 2015年第21期21卷 6631-6638页

作者： Sang-Ho Jeong Young-woo Kim Wansik Yu Sang Ho Lee Young Kyu Park Seong-Heum Park In Ho Jeong Sang Eok Lee Yongwhi Park Young-joon Lee Department of Surgery Gyengsang National University Department of Surgery Gastric Cancer BranchNational Cancer Center Department of Surgery Kyungpook National University Hospital Deparment of Surgery Kosin University College of Medicine Department of Surgery Chonnam National University Hwasun Hospital Department of Surgery South Korea University College of Medicine South Korea University Ansan hospital Department of Surgery Cheju National University Department of Surgery Konyang University Hospital Department of Cardilolgy Gyengsang National University

AIM:To evaluate to morbidity and mortality differences between 4 underlying heart diseases,myocardial infarction(MI),angina pectoris(Angina),heart failure(HF),and atrial fibrillation(AF),after radical surgery for gastric ***:We retrospectively collected data from 221 patients of a total of 15167 patients who underwent radical gastrectomy and were preoperatively diagnosed with a history of Angina,MI,HF,or AF in 8 ***:We find that the total morbidity rate is significantly higher in the MI group(44%) than the Angina(15.7%),AF(18.8%),and HF(23.1%) groups(P < 0.01).Moreover,we note that the risk for postoperative cardiac problems is higher in patients with a history of HF(23.1%) than patients with a historyof Angina(2.2%),AF(4.3%),or MI(6%; P = 0.01).The HF and MI groups each have 1 case of cardiogenic ***:We conclude that MI patients have a higher risk of morbidity,and HF patients have a higher risk of postoperative cardiac problems than Angina or AF.

关键词： Stomach neoplasm Comorbidity Morbidity Heart disease Heart failure

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Simplified fistula dilation technique and modified stent deployment maneuver for EUS-guided hepaticogastrostomy

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World Journal of Gastroenterology 2014年第17期20卷 5051-5059页

作者： woo Hyun Paik Do Hyun Park Jun-Ho Choi joon Hyuk Choi Sang Soo Lee Dong Wan Seo Sung Koo Lee Myung-Hwan Kim Jung Bok Lee Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea Department of Internal Medicine Inje University Ilsan Paik HospitalKoyang 411-706South Korea Department of Clinical Epidemiology and Biostatics University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

AIM:To evaluate the success rates,procedural time and adverse event rates of the modified methods in endoscopic ultrasonography-guided hepaticogastrostomy(EUS-HGS).METHODS:Twenty-eight patients in a prospective case series who underwent EUS-HGS(phaseⅠ).Fortysix patients in a matched case-control study(phaseⅡ).The simplified technique for fistula dilation was the primary use of a 4 mm balloon catheter with a stainless steel *** stent deployment was modified by deploying the metal stent inside a bile duct(half of the stent)under EUS and fluoroscopic guidance and gently pulling the echoendoscope after full deployment of the stent inside the echoendoscope channel(remaining portion of the stent)under fluoroscopic *** cohort was compared with a matched historical ***:In phaseⅠ,the technical and clinical success with the modified method was 96%(27/28)and89%(24/27 as per-protocol analysis).The overall adverse event rate was 7%.In phaseⅡ,there was no difference in technical and clinical success,stent patency and overall adverse events in each ***,the procedural time(15.3±5.2 min vs 22.3±6.0 min,P<0.001)and early adverse events(0%vs 26%,P=0.02)were statistically improved in case cohort compared with control ***:Compared with the conventional EUSHGS technique,the procedural time was shorter and early adverse events were less frequent with our simplified and modified technique.

关键词： Endoscopic ultrasonography Biliary drainage Hepati

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C<sub>16</sub>Saturated Fatty Acid Induced Autophagy in A549 Cells through Topoisomerase I Inhibition

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Food and Nutrition Sciences 2012年第9期3卷 1220-1227页

作者： Sandeep Karna Won Bong Lim Ji Sun Kim Sang woo Kim Hui Zheng Kum Hue Bae Min Sung Cho Hee Kyun Oh Ok Su Kim Hong Ran Choi Ok joon Kim Department of Oral & Maxillofacial Surgery Chonnam National University Dental Hospital Bug-Gu Gwangju Korea Department of Oral Pathology School of Dentistry Chonnam National University Bug-Gu Gwangju Korea Department of Periodontology School of Dentistry Chonnam National University Bug-Gu Gwangju Korea

C16 saturated fatty acid (Palmitic acid) is one of the most common dietary fatty acids which played an important role in the cellular biological functions. Palmitic acid (PA) was tested for potential inhibition of DNA topoisomerase I (topo I) and it exhibited inhibitory activity in the nanomolar range. Treatment of lung adenocarcinoma cell line A549 with PA resulted in a decrease in cell viability in a concentration-dependent manner, and PA showed cytotoxicity with an IC50 value of 150 μM. DNA fragmentation assay and caspase activity indicated that PA does not induce apoptotic cell death in A549 cells. Finally, we found that PA was able to cause an increase in autophagic flux in a time-dependent manner, evidenced by the accumulation of LC3 through monodansylcadaverine (MDC) staining. More importantly, inhibition of autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (pi-3K), by 3-Methyladenine (3-MA) was able to effectively suppress PA-induced autophagy. We showed that inhibition of autophagy sensitized the cells signal to PA-induced apoptosis, suggesting the pro-survival function of autophagy induced by PA. Taken together, results from this study reveal that PA as a topo I inhibitor induced autophagic cell death in A549 cells.

关键词： Palmitic Acid (PA) Topoisomerase I Monodansylcadaverine (MDC) 3-Methyladenine (3-MA) Autophagy

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Hematologic diseases: High risk of Clostridium difficile associated diarrhea

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World Journal of Gastroenterology 2014年第21期20卷 6602-6607页

作者： Tae-Geun Gweon Myung-Gyu Choi Myong Ki Baeg Chul-Hyun Lim Jae Myung Park In Seok Lee Sang woo Kim Dong-Gun Lee Yeon joon Park Jong wook Lee Division of Gastroenterology Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Division of Infectious Diseases Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Department of Laboratory Medicine Seoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea Division of Hematologic Diseases Department of Internal MedicineSeoul St Mary’s hospitalThe Catholic University of KoreaCollege of MedicineSeoul 137-701South Korea

AIM:To investigate the incidence and clinical outcome of Clostridium difficile(***)associated diarrhea(CDAD)in patients with hematologic ***:We retrospectively reviewed the medical records of patients who underwent *** testing in a tertiary hospital in *** incidence and risk factors for CDAD and its clinical course including recurrence and mortality were assessed in patients with hematologic disease and compared with those in patients with nonhematologic ***:About 320 patients were diagnosed with CDAD(144 patients with hematologic disease;176with nonhematologic disease).The incidence of CDAD in patients with hematologic disease was estimated to be 36.7 cases/10000 patient hospital days,which was higher than the 5.4 cases/10000 patient hospital days in patients with nonhematologic *** of CDAD was more frequent in patients with hematologic disease compared to those with nonhematologic disease(18.8%vs 8.5%,P<0.01),which was associated with higher re-use of causative antibiotics for *** due to CDAD did not differ between the two *** analysis showed that intravenous immunoglobulin was the only significant factor associated with a lower rate of recurrence of CDAD in patients with hematologic ***:The incidence and recurrence of CDAD was higher in patients with hematologic disease than in those with nonhematologic disease.

关键词： Clostridium difficile associated diarrhea Incidenc

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Clinical and endoscopic characteristics of drug-induced esophagitis

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World Journal of Gastroenterology 2014年第31期20卷 10994-10999页

作者： Su Hwan Kim Ji Bong Jeong Ji Won Kim Seong-joon Koh Byeong Gwan Kim Kook Lae Lee Mee Soo Chang Jong pil Im Hyoun woo Kang Cheol Min Shin Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Pathology Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Dongguk University Ilsan Hospital Goyang 410-773 Gyeonggi-do South Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam 463-707 Gyeonggido South Korea

AIM: To investigate clinical, endoscopic and pathological characteristics of drug-induced ***: Data for patients diagnosed with drug-induced esophagitis from April 2002 to May 2013 was reviewed. Patients diagnosed with malignancy, viral or fungal esophagitis were excluded. Clinical, endoscopic and pathological characteristics of patients diagnosed with drug-induced esophagitis were ***: Seventy-eight patients were diagnosed with drug-induced esophagitis. Their mean age was 43.9 ± 18.9 years and 35.9% were male. Common symptoms were chest pain(71.8%), odynophagia(38.5%) and dysphagia(29.5%). The endoscopic location was in the middle third of esophagus in 78.2%. Endoscopic findings were ulcer(82.1%), erosion(17.9%), ulcer with bleeding(24.4%), coating with drug material(5.1%), impacted pill fragments(3.8%) and stricture(2.6%). Kissing ulcers were observed in 43.6%. The main causative agents were antibiotics and non-steroidal antiinflammatory drugs. All the patients were treated with proton pump inhibitors(Ppis) or sucralfate, and the causative drugs were discontinued. Nineteen patients with drug-induced esophagitis were followed up with endoscopy and revealed normal findings, scars or healing ***: Drug-induced esophagitis mainly presents as chest pain, odynophagia and dysphagia, and may be successfully treated with Ppis and discontinuation of the causative drug. Kissing ulcers were observed in 43.6%.

关键词： Drug Esophagitis Endoscopy Pathology Symptoms Kiss

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Pathologic Analysis of Glioblastoma Via Stereotactic Biopsies Combined with Enhanced MR Images and ~11C-methionine PET

Pathologic Analysis of Glioblastoma Via Stereotactic Biopsie...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Tae-Young Jung Shin Jung In-Young Kim Kyung-Sub Moon woo-Youl Jang Seung-Jin Park Young-Hee Kim Hyung-Seok Kim Jung-joon Min Jahae Kim Departments of Neurosurgery Chonnam National University Research Institute of Medical Sciences Chonnam National University Hwasun Hospital & Medical School GwangjuSouth Korea Departments of Brain Tumor Research Laboratory Chonnam National University Research Institute of Medical Sciences Departments of Biomedical Engineering Chonnam National University Research Institute of Medical Sciences Departments of Pathology Chonnam National University Research Institute of Medical Sciences Departments of Nuclear Medicine Chonnam National University Research Institute of Medical Sciences

Objective:To obtain more representative biopsy specimens in glioblastoma,we combined MR stereotactic planning with 11C-methionine PET and analyzed the pathologic ***:From December 2009 to October 2010,we performed stereotactic biopsies in 12 patients with radiologically heterogeneous,ring-enhanced *** biopsied the MR enhanced lesions having higher 11C-methionine uptake and the MR non-enhanced lesions having lower uptake and analyzed differences in pathologic diagnoses between *** pathologic findings,including cell density,Ki-67 LI,microvessel density,and number of endothelial proliferations,were analyzed as correlating factors of the degree of 11C-methionine uptake（T/N ratio）.We performed immunohistochemical staining for L-amino acid transporter 1（LAT1） to demonstrate the correlation with T/N ratio and the pattern of ***:The final diagnosis of each specimen was *** T/N ratio correlated statistically with enhancement（p = 0.000）.The diagnostic failure rate was 33.3%（4/12 patients） when we selected only one MR enhanced,high 11C-methionine uptake lesion,and 40%（4/10 patients） when we selected one MR non-enhanced,low 11C-methionine uptake *** T/N ratio showed a statistical correlation with cell density depending on the degree of necrosis,LAT1 immunopositivity,microvessel density,number of endothelial proliferations,and Ki-67 LI（p = 0.002,0.032,0.057,0.24 and 0.741,respectively）.LAT1 was localized in the tumor cells,vascular endothelium,and the vicinity of endothelial ***:Multiple stereotactic biopsies combined with enhanced MR images and 11Cmethionine PET could provide the diagnostic yield in glioblastoma,which mostly differing cell densities depending on the degree of necrosis.

关键词： biopsy 11C-methionine PET enhanced MRI glioblastoma LAT1 stereotaxic

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Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 667-674页

作者： Min Jung Jo Ji Yeon Park joon Seon Song Myeong-Cherl Kook Keun Won Ryu Soo-Jeong Cho Jun Ho Lee Byung-Ho Nam Eun Kyung Hong Il Ju Choi Young-woo Kim Gastric Cancer Branch Research Institute and HospitalNational Cancer CenterGoyang-si 410-769South Korea Department of Pathology Research Institute and HospitalNational Cancer CenterGoyangsi 410-769South Korea Cancer Registration and Biostatistics Branch and Center for Clinical Trial National Cancer CenterGoyangsi 410-769South Korea

AIM: To evaluate the biopathologic features and clinical significance of nodal micrometastasis(MI) in early gastric cancer(EGC).METHODS: Among 1022 EGC patients who underwent gastrectomy with lymphadenectomy of D1 + β or more from March 2001 to December 2005 at the Korean National Cancer Center, available nodal metastasis was found in 90 p T1N1 patients. Nodal metastasis was confirmed by immunohistochemistry(IHC) with cytokeratin and patients were classified into MI and macrometastasis(MA) groups based on the main tumor burden according to the 6th International Union Against Cancer/American Joint Committee on Cancer staging system; the main tumor burden with a diameter of greater than 0.2 mm but no greater than 2 mm as MI, and greater than 2 mm as MA of the representative metastatic node. Proliferative and apoptotic activities of the primary tumor and the nodal metastasis were measured by IHC with Ki-67 and terminal deoxynucleotidyl transferase d UTP nick end labeling, respectively. Biopathologic and clinical features of the patients were analyzed and compared between MI and MA groups. Patients with recurrence were compared with those without recurrence to identify risk factors for ***: Thirty-seven patients showed MI and the other 53 patients revealed MA in the lymph node; the incidence of patients with MI and MA was 41.1% and 58.9%. The main tumor burden was 0.9 and 4.6 mm in the representative metastatic node, respectively. Japanese N2 stations were more frequently involved in MA group(20.9%) than in MI group(10.3%) butthe difference was not statistically different(P = 0.338). Proliferative and apoptotic activities of MI were decreased than those of MA(26.7% vs 40.5%, P = 0.004 and 1.0% vs 3.0%, P < 0.001, respectively). However, nodal MI in the current study showed a relatively high proliferative activity and an equivalent apoptotic activity compared to other cancers in the previously published studies. Recurrence was observed in 6 patients during

关键词： Early gastric cancer Sentinel node biopsy Lymphade

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