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Breast adenoid cystic carcinoma arising in microglandular adenosis:A case report and review of literature

World Journal of Clinical Cases 2021年第25期9卷 7579-7587页

作者： Jin Kyung An Jeong joo Woo Eun Kyung Kim Hee yong Kwak Department of Radiology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Surgery Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea

BACKGROUND Breast adenoid cystic carcinoma(AdCC)is a rare invasive carcinoma composed of epithelial and myoepithelial *** adenosis(MGA)is a rare benign proliferative lesion consisting of small,uniform,and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell *** may progress to atypical MGA and carcinoma arising in *** various invasive carcinomas from MGA,AdCC has been rarely ***,we report a case of AdCC arising in *** SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine *** density was similar to or slightly lower than that of the breast *** showed an irregular mass with a slightly higher echo than that of *** resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast *** lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing ***,the tumor was composed of invasive AdCC,in situ AdCC,and *** is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets,or haphazardly scattered small cribriform or tubular *** showed small glands with a single epithelial lining and retained lumen.S-100 staining was strongly positive in MGA *** patient underwent breast-conserving surgery with sentinel lymph node *** Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

关键词： Breast neoplasms Fibrocystic breast disease Carcinoma Adenoid cystic Case report

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Roughness coefficient and its uncertainty in gravel-bed river

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Water Science and Engineering 2010年第2期3卷 217-232页

作者： Ji-Sung KIM Chan-joo LEE Won KIM yong-Jeon KIM River and Coastal Research Division Korea Institute of Construction Technology

Manning＇s roughness coefficient was estimated for a gravel-bed river reach using field measurements of water level and discharge, and the applicability of various methods used for estimation of the roughness coefficient was evaluated. Results show that the roughness coefficient tends to decrease with increasing discharge and water depth, and over a certain range it appears to remain constant. Comparison of roughness coefficients calculated by field measurement data with those estimated by other methods shows that, although the field-measured values provide approximate roughness coefficients for relatively large discharge, there seems to be rather high uncertainty due to the difference in resultant values. For this reason, uncertainty related to the roughness coefficient was analyzed in terms of change in computed variables. On average, a 20% increase of the roughness coefficient causes a 7% increase in the water depth and an 8% decrease in velocity, but there may be about a 15% increase in the water depth and an equivalent decrease in velocity for certain cross-sections in the study reach. Finally, the validity of estimated roughness coefficient based on field measurements was examined. A 10% error in discharge measurement may lead to more than 10% uncertainty in roughness coefficient estimation, but corresponding uncertainty in computed water depth and velocity is reduced to approximately 5%. Conversely, the necessity for roughness coefficient estimation by field measurement is confirmed.

关键词： roughness coefficient estimation field measurement gravel-bed river uncertainty

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Electroacupuncture for abdominal pain relief in patients with acute pancreatitis:A three-arm randomized controlled trial

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Journal of Integrative Medicine 2023年第6期21卷 537-542页

作者： Dong Kee Jang Jun Kyu Lee Chan Yung Jung Kyung Ho Kim Ha Ra Kang Yeon Sun Lee Jong Hwa Yoon Kwang Ro joo Min Kyu Chae yong Hyeon Baek Byung-Kwan Seo Sang Hyub Lee Chiyeon Lim Department of Internal Medicine Seoul Metropolitan Government Boramae Medical CenterSeoul National University College of MedicineSeoul 07061Republic of Korea Department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion Dongguk University Ilsan Oriental HospitalCollege of Korean MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38067Republic of Korea Department of Gastroenterology Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Department of Acupuncture and Moxibustion Kyung Hee University Korean Medicine Hospital at GangdongSeoul 05278Republic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Republic of Korea Department of Biostatistics College of MedicineDongguk UniversityGoyang 10326Republic of Korea

Background: Electroacupuncture(EA) may reduce the severity of acute pancreatitis(AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well ***: This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with ***, setting, participants and interventions: This study was conducted using a randomized, controlled,three-arm, parallel-group and multi-center design. Patients diagnosed with AP were randomly and equally assigned to EA1, EA2 or control groups. All participants received conventional standard-of-care therapy for AP. Local EA alone was administered in EA1, and local plus distal EA was given in *** EA included two abdominal acupoints, while distal EA included twelve peripheral acupoints. EA groups underwent one session of EA daily for 4 days(days 1–4), or until pain was resolved or *** outcome measures: The primary outcome measure was the change in the visual analogue scale(VAS;0–100) pain score between baseline and day ***: Eighty-nine participants were randomized into EA1, EA2 and control groups, and 88(EA1, 30;EA2, 29;control, 29) were included in the full-analysis set. VAS score change(median [interquartile range]) on day 5 was(12.3 ± 22.5) in the EA1 group,(10.3 ± 21.5) in the EA2 group, and(8.9 ± 15.2) in the control group. There were not significant differences in the change in VAS score among treatments(P = 0.983). However, time to food intake was significantly shorter in the EA group(EA1 + EA2) than in the control group(median 2.0 days vs 3.0 days), with a hazard ratio of 0.581(P = 0.022;95% CI,0.366–0.924). No significant adverse events ***: EA treatment did not significantly reduce pain after 4 days of treatment in patients with AP-associated abdominal pain but significantly reduced time to first food intake.

关键词： Acute pancreatitis Electroacupuncture Pain management Abdominal pain Randomized controlled trial

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Understanding the physical metallurgy of the CoCrFeMnNi high-entropy alloy:an atomistic simulation study

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npj Computational Materials 2018年第1期4卷 662-670页

作者： Won-Mi Choi yong Hee Jo Seok Su Sohn Sunghak Lee Byeong-joo Lee Department of Material Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Although high-entropy alloys(HEAs)are attracting interest,the physical metallurgical mechanisms related to their properties have mostly not been clarified,and this limits wider industrial applications,in addition to the high alloy *** clarify the physical metallurgical reasons for the materials phenomena(sluggish diffusion and micro-twining at cryogenic temperatures)and investigate the effect of individual elements on solid solution hardening for the equiatomic CoCrFeMnNi HEA based on atomistic simulations(Monte Carlo,molecular dynamics and molecular statics).A significant number of stable vacant lattice sites with high migration energy barriers exists and is thought to cause the sluggish *** predict that the hexagonal close-packed(hcp)structure is more stable than the face-centered cubic(fcc)structure at 0 K,which we propose as the fundamental reason for the micro-twinning at cryogenic *** alloying effect on the critical resolved shear stress(CRSS)is well predicted by the atomistic simulation,used for a design of non-equiatomic fcc HEAs with improved strength,and is experimentally *** study demonstrates the applicability of the proposed atomistic approach combined with a thermodynamic calculation technique to a computational design of advanced HEAs.

关键词： alloy alloying entropy

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SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim Sung Hyun Tag Eunjoo Nam Suji Ham Sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee Young-Su Yang Seung Eun Lee yong Sik Kim Il-joo Cho Kwang Pyo Kim Su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

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分子印迹固相萃取-同位素稀释气相色谱质谱法测定肉制品中16种欧盟优控多环芳烃

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环境化学 2024年第8期43卷 2864-2868页

作者：鞠香陈克云李海霞陈倩倩王艳丽梁秀清刘艳明汪勇山东省食品药品检验研究院国家市场监管重点实验室（肉及肉制品监管技术）产业技术基础公共服务平台济南250101 岛津企业管理（中国）有限公司上海210005

结合分子印迹固相萃取对多环芳烃的特异性净化，建立了同位素稀释气相色谱质谱法测定肉制品中16种欧盟优控多环芳烃的分析方法. 样品加入7种氘代同位素内标，经正己烷+二氯甲烷(7 : 3，V/V)混合溶液提取，分子印迹固相萃取柱净化，选择... 详细信息

结合分子印迹固相萃取对多环芳烃的特异性净化，建立了同位素稀释气相色谱质谱法测定肉制品中16种欧盟优控多环芳烃的分析方法. 样品加入7种氘代同位素内标，经正己烷+二氯甲烷(7 : 3，V/V)混合溶液提取，分子印迹固相萃取柱净化，选择离子监测模式(sim)下采集. 在1.0—200 ng·mL−1范围内，16种欧盟优控多环芳烃线性相关系数(r)均大于0.9990，不同加标浓度下，回收率为87.1%— 114.8%，相对标准偏差(RSDs) (n=6)在1.0%—5.5%范围内，方法的检出限为0.2—0.3 μg·kg−1，定量限为0.6—0.9 μg·kg−1. 方法前处理简单高效，灵敏度高，适用大批量肉制品中多环芳烃的快速测定.

关键词：欧盟优控多环芳烃气相色谱质谱法同位素稀释分子印迹柱肉制品

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Role of transcription factor acetylation n the regulation of metabolic homeostasis

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Protein & Cell 2015年第11期6卷 804-813页

作者： joo-Man Park Seong-Ho Jo Mi-Young Kim Tae-Hyun Kim yong-Ho Ahn Department of Biochemistry and Molecular Biology Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea Brain Korea 21 PLUS Project for Medical Sciences Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea

Post-translational modifications （PTMs） of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphory- lation, methylation, acetylation, ubiqulUnation, SUMOy- lation, and O-GIcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhis- tone proteins including transcription factors. Acetyla- tion of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetyla- tion of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.

关键词： metabolic homeostasis transcriptionfactor post-translational modification type 2 diabetesmellitus

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Enhanced biometric encryption algorithm for private key protection in BioPKI system

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Journal of Central South University 2014年第11期21卷 4286-4290页

作者： Cheol-joo Chae Kwang-Nam Choi Kiseok Choi Jae-Soo Kim yong Ju Shin Korea Institute of Science and Technology Information 245 DaehangnoYuseong-gu Daejeon Korea

Protection of private key is the most critical part in public key infrastructure(PKI) system since it depends on the confidentiality of private key. Thread of password detection has been known as the vulnerability in this PKI system. Recently, studies have been conducted on Bio PKI system that uses the biometric information of users in order to replace the password type of private key protection in PKI system. However, Bio PKI system also has vulnerability in that biometric information used for protection of private key cannot be reused once it is stolen or lost. So, we propose the method to protect the private key using FIDSEQi which binds sequence to biometric information. The proposed method enhances reusability of biometric information and presents higher attack complexity than the method of authentication by cross matching single biometric information.

关键词：生物特征信息 PKI系统密钥保护私钥加密算法 Bio 公共密钥基础设施 PKI体系

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基于无人机技术的露天矿山越界开采监测与评估方法

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中国矿业 2024年第1期33卷 105-113页

作者：刘一马灿璇湛龙范卓伟宋世明曾勇中国地质调查局南京地质调查中心江苏南京210016

高效快速评估露天矿山越界开采对开展矿产卫片执法检查和推进严格保护矿产资源策略、推动区域高质量发展具有重要意义。基于无人机飞行技术、传感器技术、通信技术和影像处理技术,结合卫星遥感、地理信息系统应用,采集无人机航测数据与... 详细信息

高效快速评估露天矿山越界开采对开展矿产卫片执法检查和推进严格保护矿产资源策略、推动区域高质量发展具有重要意义。基于无人机飞行技术、传感器技术、通信技术和影像处理技术,结合卫星遥感、地理信息系统应用,采集无人机航测数据与飞控系统数据,快速获取了疑似违法矿山二维场景图像(sim),动态飞行展示矿区全貌和精细地物;进一步建立了矿山三维数字高程模型(DEM),定性研判违法类型与性质;针对需求建立了矿山的三维数字表面模型(DSM),定量估算违法采矿资源量;利用四维数字表面模型(DSM),查明矿山历史时期的违法过程,测算违法开采的资源量。无人机航测技术实现区域矿产资源开发秩序的快速监测和精细评估,为矿产资源的卫片执法检查工作提供理论支撑和决策依据。在江南某地进行试验的实例表明,基于无人机技术的露天矿山越界开采监测与评估方法技术具有时效性强、操作便捷、精细高效等优势,在支撑服务自然资源领域的卫片执法检查工作方面可以更加广泛地应用。

关键词：露天矿山无人机越界开采监测评估三维模型

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Compatible taper and stem volume equations for Larix kaempferi(Japanese larch) species of South Korea

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Journal of Mountain Science 2017年第7期14卷 1341-1349页

作者： Nova D.DOYOG Young Jin LEE Sun joo LEE Jin Taek KANG Sung yong KIM Department of Forest Resources College of Industrial Science Kongju National University National Institute of Forest Science

In this study, compatible taper and stem volume equations were developed for Larix kaempferi species of South Korea. The dataset was split into two groups: 80% of the data were used in model fitting and the remaining 20% were used for validation. The compatible MB76 equations were used to predict the diameter outside bark to a specific height, the height to a specific diameter and the stem volume of the species. The result of the stem volume analysis was compared with the existing stem volume model of Larix kaempferi species of South Korea which was developed by the Korea Forest Research Institute and with a simple volume model that was developed with fitting dataset in this study. The compatible model provided accurate prediction of the total stem volume when compared to the existing stem volume model and with a simple volume model. It is concluded that the compatible taper and stem volume equations are more convenient to use and therefore it is recommended to be applied in the Larix kaempferi species of South Korea.

关键词：日本落叶松材积方程韩国兼容锥度体积模型品种模型拟合

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