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中国有色金属学会会刊：英文版 2009年第4期19卷 956-960页

作者： Seok-Hern JANG Jun-hyung LIM Chang-Min LEE Eui-Cheol PARK Soo-Min HWANG Jun-Hyuk CHOI Jong-hyun SHIM Jin-hyun PARK Won KIM Jinho joo School of Advanced Materials Science and Engineering Sungkyunkwan University

YBa2Cu3O7-x(YBCO) films were fabricated on an LAO substrate using the trifluoroacetic acid-metal organic deposition(TFA-MOD) method and the effects of the humidity and heat treatment temperatures on the microstructure,degree of texture and critical properties of the films were *** order to understand the combined effects of the humidity and the calcining and firing temperatures on critical properties,heat-treatment was performed at various temperatures with the other processing variables *** films were calcined at 400-430 ℃ and fired at 750-800 ℃ in a 0-12.1% humidified Ar-O2 *** texture was determined by pole-figure *** amount of the BaF2 phase was effectively reduced and a sharp and strong biaxial texture was formed under a humidified atmosphere,which led to increased critical *** addition,the microstructure varied significantly with firing temperature but changed little with calcining *** highest IC of 40 A/cm-width,which corresponds to JC value of 1.8 MA/cm2,was obtained for the films fired at 775 ℃(in 12.1% humidity) after calcining at 400-430 ℃.It is likely that the highest IC value is due to the formation of a more pure YBCO phase,c-axis grains,and a denser microstructure.

关键词： YBa2Cu3O7 热处理温度三氟乙酸沉积过程湿度涂层导体有机金属微观结构变化

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim Sung hyun Tag Eunjoo nam Suji Ham Sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee Young-Su Yang Seung Eun Lee Yong Sik Kim Il-joo Cho Kwang Pyo Kim Su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Pravastatin activates the expression of farnesoid X receptor and liver X receptor alpha in Hep3B cells

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 65-73页

作者： hyun Woo Byun Eun Mi Hong Soo Hee Park Dong Hee Koh Min Ho Choi hyun joo Jang Sea Hyub Kae Jin Lee Division of Gastroenterology Department of Internal Medicine Hallym University College of Medicine Dongtan Sacred Heart Hospital

BACKGROUND: Statins are suggested to preserve gallbladder function by suppressing pro-inflammatory cytokines and preventing cholesterol accumulation in gallbladder epithelial cells. They also affect cross-talk among the nuclear hormone receptors that regulate cholesterol-bile acid metabolism in the nuclei of hepatocytes. However, there is controversy over whether or how statins change the expression of peroxisome proliferator-activated receptor(PPAR)α, PPARγ, liver X receptor α(LXRα), farnesoid X receptor(FXR), ABCG5, ABCG8, and 7α-hydroxylase(CYP7A1) which are directly involved in the cholesterol saturation index in bile. METHODS: Human Hep3B cells were cultured on dishes. MTT assays were performed to determine the appropriate concentrations of reagents to be used. The protein expression of PPARα and PPARγ was measured by Western blotting analysis, and the mRNA expression of LXRα, FXR, ABCG5, ABCG8 and CYP7A1 was estimated by RT-PCR. RESULTS: In cultured Hep3B cells, pravastatin activated PPARα and PPARγ protein expression, induced stronger expression of PPARγ than that of PPARα, increased LXRα mRNA expression, activated ABCG5 and ABCG8 mRNA expression mediated by FXR as well as LXRα, enhanced FXR mRNA expression, and increased CYP7A1 mRNA expression mediated by the PPARγ and LXRα pathways, together or independently. CONCLUSION: Our data suggested that pravastatin prevents cholesterol gallstone diseases via the increase of FXR, LXRαand CYP7A1 in human hepatocytes.

关键词： pravastatin PPARγ liver X receptor α farnesoid X receptor gallstone disease

Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria

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World Journal of Gastroenterology 2013年第1期19卷 97-102页

作者： Goh Eun Chung nam Ju Heo Min Jung Park Su Jin Chung Hae Yeon Kang Seung joo Kang Department of Internal Medicine Healthcare Research InstituteSeoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM:To investigate the relationship between Helicobacter pylori(***) seropositivity and the presence of ***:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for *** immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were *** study subjects completed a structured questionnaire,anthropometric measurements and laboratory *** immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the *** presence of microalbuminuria was defined as a UACR from 30 to 300 μg/*** presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic *** logistic regression analysis was performed to identify the risk *** dependent variable was microalbuminuria,and the independent variables were the other study ***:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were *** them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with *** with microalbuminuria had a significantly higher *** seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that *** seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL < glucose < 126 mg/dL,and ≥ 126 mg/dL or history of DM),*** seropositivity was found to be significantly associated with microalbuminuria in diabetic subjects after adjust

关键词： Helicobacter pylori Seropositivity Microalbuminuria Atherosclerosis Diabetes

Ethanol extract of Kalopanax septemlobus leaf inhibits HepG2 human hepatocellular carcinoma cell proliferation via inducing cell cycle arrest at G_1 phase

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 336-342页

作者： Cheol Park Ji-Suk Jeong Jin-Woo Jeong Sung Ok Kim Yong-joo Kim Gi-Young Kim Su-hyun Hong Yung hyun Choi Department of Molecular Biology College of Natural Sciences and Human EcologyDongeui University Department of Research and Development of Resources Gurye-gun Agricultural Center Wild Flower Institute.Gurye-gun Anti-Aging Research Center.Dongeui University Department of Food Science & Biotechnology College of EngineeringKyungsung University Republic of Korea Laboratory of Immunobiology.Department of Marine Life.Sciences.Jeju National University Department of Biochemistry.Dongeui University

Objective:To investigate the effects of an ethanol extract of Kalopanax septemlobus(Thunb.)***(EEKS) on cell proliferation in human hepatocellular carcinoma cells and its mechanisms of ***:Cells were treated with EEKS and subsequently analyzed for cell proliferation and flow cytometry *** of cell cycle regulators were determined by reverse transcriptase polymerase chain reaction analysis and Western blotting,and activation of eyclin-associaled kinases studied using kinase ***:The EEKS suppressed cell proliferation in both HepG2 and Hep3 B cells,but showed a more sensitive anli-proliferative activity in HepG2 *** cytometry analysis revealed an association between the growth inhibitory effect of EEKS and with G_1 phase cell cycle arrest in HepG2 cells,along with the dephosphorylation of retinoblastoma protein(pRB) and enhanced binding of pRB with the E2 F transcription factor family *** with EEKS also increased the expression of cyclin-dependent kinase(CDK) inhibitors,such as p21WAF1/CIP1 and *** any noticeable changes in G_1 cyclins and CDKs(except for a slight decrease in CDK4).Treatment of HepG2 cells with EEKS also increased the binding of p21 and p27 with CDK4 and *** was paralleled by a marked decrease in the cyclin D- and cyclin E-associated kinase ***:Overall,our findings suggest that EEKS may be an effective treatment for liver cancer through suppression of cancer cell proliferation via G_1,cell cycle arrest Further studies arc required to identify the active compounds in EEKS.

关键词： Kalopanax septemlobus Hepatocellular carcinoma G1 cell cycle arrest CDK inhibitor pRB

Spin Self-Assembled Clay Nanocomposite Passivation Layers Made from a Photocrosslinkable Poly（vinyl alcohol） and Na^-Montmorillonite Enhance the Environmental Stability of Organic Thin-Film Transistors

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Chinese Journal of Chemistry 2016年第11期34卷 1103-1108页

作者： Hayoung Jeon Seonuk Park Sooji nam Kwonwoo Shin Sung-Ryong Kim Se hyun Kim Jaeyoung Jang Tae Kyu An POSTECH Organic Electronics Laboratory Polymer Research Institute Department of Chemical Engineering Pohang University of Science and Technology Pohang 790-784 Republic of Korea Smart I/O Control Device Research Section Electronics and Telecommunications Research Institute Daejeon 305- 700 Republic of Korea Nano Materials & Components Research Center Korea Electronics Technology Institute (KET1) Seongsam-si Gyeonggi-do 13509 Republic of Korea Department of Polymer Science & Engineering Korea National University of Transportation 50 Daekak-Ro Chungju 27469 Republic of Korea School of Chemical Engineering Yeungnam University 280 Daehak-Ro Gyeongsan Gyeongbuk 38541 Republic of Korea Department of Energy Engineering Hanyang University Seoul 133-791 Republic of Korea

We investigated the effects of the multilayer polymer-clay nanohybrid passivation films on the stability of pentacene organic thin-film transistors （OTFTs） exposed to air and UV irradiation. Well-ordered multilayer films were deposited by the spin-assisted layer-by-layer assembly method using photocrosslinkable poly（vinyl alcohol） with the N-methyl-4（4＇-formylstyryl）pyridinium methosulfate acetal group （SbQ-PVA） and Na＋-montmorillonite in a water-based solution process. When photocrosslinked, these SbQ-PVA/clay multilayers were found to serve as excellent barriers to 02 and UV-light. Moreover, when used as passivation layers, they enhanced the stability of pen- tacene OTFT devices exposed to air and UV radiation.

关键词： polymer-clay passivation layer-by-layer montmorillonite long-term stability

Severe mediastinitis and pericarditis after endobronchial ultrasoundguided transbronchial needle aspiration:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10723-10727页

作者： Jeong Suk Koh Yoon joo Kim Da hyun Kang Jeong Eun Lee Song-I Lee Department of Pulmonary and Critical Care Medicine Chungnam National University HospitalDaejeon 35015South Korea

BACKGROUND Endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)is a safe and minimally invasive diagnostic tool for mediastinal and hilum ***,infectious complications may occur after *** these,mediastinitis and pericarditis are *** SUMMARY A 67-year-old woman was referred to our hospital due to paratracheal lymph node enlargement on chest computed tomography(CT).EBUS-TBNA was performed on the lymph node lesions,and prophylactic oral antibiotics were *** days after EBUS-TBNA,the patient visited the emergency room with a high fever and chest *** test results revealed leukocytosis with a left shift and elevated C-reactive protein level(25.7 mg/dL).Chest CT revealed the formation of a mediastinal abscess in the right paratracheal lymph node and pericardial and bilateral pleural *** patient received intravenous antibiotic treatment,cardiac drainage through pericardiocentesis,and surgical *** patient recovered favorably and was discharged 31 d after the *** Mediastinitis and pericarditis after EBUS-TBNA are rare but should be considered even after the use of prophylactic antibiotics.

关键词： Endoscopic ultrasound-guided fine needle aspiration Complication Mediastinitis Pericarditis Antibiotics Case report

Proteome analysis of alfalfa roots in response to water deficit stress

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Journal of Integrative Agriculture 2016年第6期15卷 1275-1285页

作者： Rahman Md Atikur Kim Yong-Goo Alam Iftekhar LIU Gong-she Lee Hyoshin Lee Jeung joo Lee Byung-hyun Division of Applied Life Sciences (BK21Plus) Institute of Agriculture & Life Sciences (IALS) Gyeongsang National University Jinju 660-701 Republic of Korea Institute of Botany Chinese Academy of Sciences Beijing 100093 P.R.China National Institute of Biotechnology Dhaka-1349 Bangladesh Division of Forest Biotechnology Korea Forest Research Institute Suwon 441-847 Republic of Korea Department of Applied Biology Institute of Agriculture & Life Sciences (IALS) Gyeongsang National University Jinju 660-701 Republic of Korea

To evaluate the response of alfalfa to water deficit （WD） stress, WD-induced candidates were investigated through a proteomic approach. Alfalfa seedlings were exposed to WD stress for 12 and 15 days respectively, followed by 3 days re-watering. Water deficit increased H202 content, lipid peroxidation, DPPH （1,1-diphenyl-2-picrylhydrazyl）-radical scavenging activity, and the free proline level in alfalfa roots. Root proteins were extracted and separated by two-dimentional polyacrylamide gel electrophoresis （2-DE）. A total of 49 WD-responsive proteins were identified in alfalfa roots; 25 proteins were reproducibly found to be up-regulated and 24 were down-regulated. Two proteins, namely cytosolic ascorbate peroxidase （APx2） and putative F-box protein were newly detected on 2-DE maps of WD-treated plants. We identified several proteins including agamous-like 65, albumin b-32, inward rectifying potassium channel, and auxin-independent growth promoter. The identified proteins are involved in a variety of cellular functions including calcium signaling, abacisic acid （ABA） biosynthesis, reactive oxygen species （ROS） regulation, transcription/translation, antioxidant/detoxification/stress defense, energy metabolism, signal transduction, and storage. These results indicate the potential candidates were responsible for adaptive response in alfalfa roots.

关键词： alfalfa proteome root water deficit stress

Effect of Isothermal Annealing on Nano Ti-Carbides Precipitation

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Journal of Iron and Steel Research International 2011年第S1期18卷 287-289页

作者： Cheol-ho Park Woo-jin Kim nam-hyun Kang hyung-hyup Do Kyung-Mox Cho Department of Materials Science and Engineering Pusan National UniversityBusan 609-735Korea Technical Research Laboratories Hyundai steelsDangjinChungnam 343-711Korea

Transmission electron microscopy was used to investigate the effect of isothermal holding temperature and time on the nano Ti-precipitates.A holding temperature was varied systematically from 400℃ to 1200℃.The isothermal holding was continued for 30s,300s and 900s,*** carbides of (Ti,Nb)C were precipitated significantly at 900℃.The size of carbides was approximately 10nm at 30s holding and increased to 20～30nm at 900s *** holding at 1000℃ showed the increased amount of carbides larger than *** 800℃,nano (Ti,Nb)C was not observed at 30s and it was examined at *** size of nano (Ti,Nb)C was smaller than that of 900℃.As the isothermal temperature decreased to 700 ℃,the nano (Ti,Nb)C was only seen at 900s holding and the size of carbides was smaller than *** (Ti,Nb)C was disappeared at isothermal holding below 600℃.The kinetics of nano (Ti,Nb)C precipitation were studied as a function of isothermal holding temperature and time,respectively,using the precipitate growth equations.

关键词： Ti carbide hot rolled steel hole expansion ratio isothermal holding nano precipitates