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Neuroscience Bulletin 2015年第5期31卷 601-610页

作者： Sebastien H.Bauquier Alan lai jonathan l.jiang Yi Sui Mark J.Cook Faculty of Veterinary and Agricultural Sciences The University of Melbourne Department of Electrical and Electronic Engineering The University of Melbourne Department of Clinical Neurosciences St Vincent's Hospital Faculty of Medicine The University of Melbourne Department of Neurology Shenyang First People's Hospital

The aim of this prospective blinded study was to evaluate an automated algorithm for spike-andwave discharge（SWD） detection applied to EEGs from genetic absence epilepsy rats from Strasbourg（GAERS）.Five GAERS underwent four sessions of 20-min EEG *** EEG was manually analyzed for SWDs longer than one second by two investigators and automatically using an algorithm developed in MATlAB（？）.The sensitivity,specificity,positive predictive value（PPV）,and negative predictive value（NPV） were calculated for the manual（reference） versus the automatic（test） *** results showed that the algorithm had specificity,sensitivity,PPV and NPV 〉94%,comparable to published methods that are based on analyzing EEG changes in the frequency *** provides a good alternative as a method designed to mimic human manual marking in the time domain.

关键词： GAERS seizure detection epilepsy

The 2^(nd)Asian Conference on Porphyrins,Phthalocyanines and Related Materials

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Chinese Chemical letters 2024年第7期35卷 1-3页

作者： Gaojie Zhu Zhen Yang Shijun li Weihua Zhu Rui Cao Junlong Zhang Jianzhang Zhao jonathan l.Sessler Xunjin Zhu Jianxin Song Yongshu Xie Jianzhuang jiang Key laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China Key laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710119China Beijing National laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Department of Chemistry The University of TexasAustinTexas 78712-1224United States Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist UniversityHong Kong 999077China Key laboratory of Chemical Biology and Traditional Chinese Medicine(Ministry of Educational of China) Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline MaterialsDepartment of Chemistry and Chemical EngineeringSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China

In the past decades,porphyrins,phthalocyanines and related materials have attracted significant attention due to their diverse and brilliant structures[1,2],as well as their unique electronic structures and photophysi... 详细信息

关键词： cyanine phthalocyanine Porphyrin

Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

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CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao li Zhong-Yu Yu Jiamin Wang Zhaoyang liu Chao jiang Zhen-Feng Chen Xiaoyu Wu Ming-Xing li Hong Yang Zhao-Xi Wang jonathan l.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCl),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCl is green and absorbs light e... 详细信息

stable neutral Fe(IV)complex(Fe-HDCl),readily accessible on the g scale,was found to possess high water solubility and good stability(l is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCl also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCl to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCl is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCl also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCl allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCl has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

COVID-19 and atherosclerosis: looking beyond the acute crisis

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Emergency and Critical Care Medicine 2022年第1期2卷 1-4页

作者： Zhang Shi Yuanliang jiang jonathan Weir-McCall Ximing Wang Zhongzhao Teng Department of Radiology Zhongshan HospitalFudan UniversityShanghaiChina Department of Radiology University of CambridgeCambridgeUK Department of Radiology General Hospital of Central Theater of the PLAWuhanChina Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina Nanjing Jingsan Medical Science and Technology Ltd.NanjingChina

The novel coronavirus disease 2019(COVID-19)was firstly reported in Wuhan,China,and eventually identified on December 31,2019 and remains as an ongoing worldwide *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)invades human alveolar epithelial cells in the nose and throat mainly through angiotensin-converting enzyme 2(ACE2),[1]inducing innate inflammation in the lungs largely mediated by pro-inflammatory macrophages and granulocytes.

关键词： acute inflammation respiratory

Variant selection in stationary shoulder friction stir welded Ti-6Al-4V alloy

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Journal of Materials Science & Technology 2018年第1期34卷 198-208页

作者： Xiaoqing jiang Bradley P.Wynne jonathan Martin Engineering Research Center of Advanced Manufacturing Technology for Automotive Structural Parts Ministry of Education College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Department of Materials Science and Engineering The University of Sheffield The Welding Institute Granta Park

Stationary shoulder friction stir welding of Ti-6Al-4V of 7 mm thickness was conducted with varying welding speeds and rotation speeds. Variant selection analysis was carried out based on the inherited α phase texture and the reconstructed 13 phase texture. The weld surfaces became significantly smoother with increasing welding speed and decreasing rotation speed. Heat input decreased greatly with increased welding speed and it decreased slightly with decreased rotation speed. The orientation relationship between the prior 13 grains was measured based on the reconstructed electron backscattered diffraction （EBSD） data. Weak Variant selection has occurred in all the welds because most of the prior 13 grains did not share { 110} poles. Strong links between crystal orientation of the prior 13 grains and hardness have been found.

关键词： Stationary shoulder friction stir welding Texture Variant selection Hardness

Calculation of Ecological Footprint Based on Modified Method and Quantitative Analysis of Its Impact Factors——A Case Study of Shanghai

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Chinese Geographical Science 2006年第4期16卷 306-313页

作者： GAO Chengkang jiang Dahe WANG Dan YAN jonathan College of Environmental Science and Engineering Tongji University Shanghai 200092 China Department of Geography Shanghai Normal University Shanghai 200234 China Department of Pacific and International Affairs University of California San Diego USA

Ecological footprint(EF) has attracted much attention internationally as a potential indicator for sustainable *** China,EF has also gained recognition in related fields and ***,some scholars in these fields have proposed alternative methods to calculate EF and have made some *** paper,therefore,begins with the introduction and development of EF in ***,the established methods of EF calculation hold some limitations,such as indicator variance and result *** order to resolve those problems,the authors make a further modification considering the demand of EF as a comprehensive indicator:1) More accurate analysis has been done to divide EF into several parts:imported EF,exported EF,and producible EF,which is the solution to the problem of abnormality in original EF results and can explain abnormal phenomena reasonably.2) Considering the actual situa-tion of Shanghai,amended equivalence factor is brought forward and a matrix is formed with equivalence *** measure can reduce the deviation between the fact and the results.3) The calculation compares local yield with global average yield to analyze the effects of *** based on local yields in different years,the results are more ***,the calculation method is applied to calculating EF of Shanghai from 1980 to 2003,and the subsequent detailed analysis is *** data and results suggest a statistically significant correlation coefficient between EF and GDP,population density and urbanization *** analyzing the process of calculating EF and its results,it can be seen that EF,as a macro-indicator,can not exactly indicate whether development within a region can meet the re-quests of sustainable development,which can be explained by the fact that the result of EF is impacted greatly by sub-jective factors including national policy,available technology,population,***,EF can demonstrate,at least to some degree,the

关键词：上海生态足迹法计算方法定量分析冲击因子可持续发展

Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy

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Bioactive Materials 2022年第3期7卷 541-553页

作者： Yuhan Zhou Ting Ye Chengzhi Ye Chao Wan Siyue Yuan Yushuai liu Tianyu li Fagang jiang jonathan F.lovell Honglin Jin Jing Chen Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan430060PR China Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Department of Biomedical Engineering University at BuffaloState University of New York.BuffaloNew York14260USA College of Biomedicine and Health and College of life Science and Technology Huazhong Agricultural UniversityWuhan430070China

Autologous tumor cells and cell-derived secretions(CDS)can induce antitumor immune *** conditions in which cells are cultured and treated impact CDS,and cellular insults alter their composition and *** this study,we generated CDS from tumor cells exposed to normal culture conditions,hypoxia,cisplatin,radiotherapy,photodynamic therapy,or hypochlorous acid(HOCl).In vitro HOCl-CDS showed the strongest stimulatory effects on dendritic cells and macrophages compared to CDS generated by hypoxia,cisplatin,radiotherapy or photodynamic *** improve HOCl-CDS activity at the tumor site,we loaded HOCl-CDS into a melittin-encapsulated hydrogel *** injected intratumorally,the HOCl-CDS hydrogel promoted tumor cell death,cytotoxic T lymphocyte infiltration,and tumor-associated macrophage reprogramming towards an M1 *** hydrogel inhibited tumor growth and prolonged the survival of mice bearing B16-F10 ***,hydrogel-delivered HOCl-CDS augmented the antitumor effects of immune checkpoint *** results underscore the importance of the CDS generation method and delivery approach for improving cancer immunotherapy.

关键词： Cancer immunotherapy Hydrogel Melittin Anti-PD-1 Cell-derived secretions

Understanding urban structures and crowd dynamics leveraging large-scale vehicle mobility data

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Frontiers of Computer Science 2020年第5期14卷 77-88页

作者： Zhihan jiang Yan liu Xiaoliang Fan Cheng Wang jonathan li longbiao Chen Fujian Key laboratory of Sensing and Computing for Smart Cities School of Information Science and EngineeringXiamen UniversityXiamen361005China

A comprehensive understanding of city structures and urban dynamics can greatly improve the efficiency and quality of urban planning and management,while the traditional approaches of which,such as manual surveys,usually incur substantial labor and *** this paper,we propose a data-driven framework to sense urban structures and dynamics from large-scale vehicle mobility ***,we divide the city into fine-grained grids,and cluster the grids with similar mobility features into structured urban areas with a proposed distance-constrained clustering algorithm(DCCA).Second,we detect irregular mobility traffic patterns in each area leveraging an ARIMA-based anomaly detection algorithm(ADAM),and correlate them to the urban social and emergency ***,we build a visualization system to demonstrate the urban structures and crowd *** evaluate our framework using real-world datasets collected from Xiamen city,China,and the results show that the proposed framework can sense urban structures and crowd comprehensively and effectively.

关键词： vehicle mobility big data spatial clustering event detection urban computing ubiquitous computing

Imaging atomic-scale chemistry from fused multi-modal electron microscopy

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npj Computational Materials 2022年第1期8卷 164-171页

作者： jonathan Schwartz Zichao Wendy Di Yi jiang Alyssa J.Fielitz Don-Hyung Ha Sanjaya D.Perera Ismail El Baggari Richard D.Robinson Jeffrey A.Fessler Colin Ophus Steve Rozeveld Robert Hovden Department of Materials Science and Engineering University of MichiganAnn ArborMIUSA Mathematics and Computer Science Division Argonne National LaboratoryLemontILUSA Advanced Photon Source Facility Argonne National LaboratoryLemontILUSA Dow Chemical Co. MidlandMIUSA Department of Material Science and Engineering Cornell UniversityIthacaNew YorkUSA School of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea Department of Physics Cornell UniversityIthacaNYUSA The Rowland Institute at Harvard CambridgeMAUSA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMIUSA National Center for Electron Microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied Physics Program University of MIchiganAnn ArborMIUnited States

Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAADF))and inelastic spectroscopic signals(electron energy loss(EElS)or energy-dispersive x-ray(EDX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high SNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.

关键词： materials chemistry fused

Aerosol Microphysical and Radiative Effects on Continental Cloud Ensembles

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Advances in Atmospheric Sciences 2018年第2期35卷 234-247页

作者： Yuan WANG jonathan M. VOGEl Yun lIN Bowen PAN Jiaxi HU Yangang lIU Xiquan DONG jonathan H. jiang Yuk l. YUNG Renyi ZHANG Division of Geological and Planetary Sciences California Institute of Technology Pasadena CA 91106 USA Department of Atmospheric Sciences Texas A&M University College Station TX 77840 USA Environmental & Climate Sciences Department Brookhaven National Laboratory Upton NY 11973 USA Department of Hydrology and Atmospheric Sciences University of Arizona Tucson AZ 85721 USA Jet Propulsion laboratory California Institute of Technology Pasadena CA 91109 USA Department of Atmo wheric and Oceanic Sciences McGill University Montreal Quebec QC H3A OG4 Canada

Aerosol-cloud-radiation interactions represent one of the largest uncertainties in the current climate assessment. Much of the complexity arises from the non-monotonic responses of clouds, precipitation and radiative fluxes to aerosol perturbations under various meteorological conditions. In this study, an aerosol-aware WRF model is used to investigate the microphysical and radiative effects of aerosols in three weather systems during the March 2000 Cloud Intensive Observational Period campaign at the US Southern Great Plains. Three simulated cloud ensembles include a low-pressure deep convective cloud system, a collection of less-precipitating stratus and shallow cumulus, and a cold frontal passage. The WRF simulations are evaluated by several ground-based measurements. The microphysical properties of cloud hydrometeors, such as their mass and number concentrations, generally show monotonic trends as a function of cloud condensation nuclei concentrations. Aerosol radiative effects do not influence the trends of cloud microphysics, except for the stratus and shallow cumulus cases where aerosol semi-direct effects are identified. The precipitation changes by aerosols vary with the cloud types and their evolving stages, with a prominent aerosol invigoration effect and associated enhanced precipitation from the convective sources. The simulated aerosol direct effect suppresses precipitation in all three cases but does not overturn the aerosol indirect effect. Cloud fraction exhibits much smaller sensitivity （typically less than 2%） to aerosol perturbations, and the responses vary with aerosol concentrations and cloud regimes. The surface shortwave radiation shows a monotonic decrease by increasing aerosols, while the magnitude of the decrease depends on the cloud type.

关键词： aerosol-cloud-radiation interactions cloud-resolving model cloud microphysics and macrophysics precipita-tion