Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy
作者机构：Cancer CenterUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Department of PediatricsRenmin Hospital of Wuhan UniversityWuhan430060PR China Department of OphthalmologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Department of Biomedical EngineeringUniversity at BuffaloState University of New York.BuffaloNew York14260USA College of Biomedicine and Health and College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan430070China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第3期
页 面：541-553页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.81773285,81874233 and 82022040) Health Commission of Hubei Province scientific research project(WJ2021Z004) Scientific Research Project of Hubei Provincial Health and Family Planning Commission,China(WJ2015MB017 to J.C.)
主 题：Cancer immunotherapy Hydrogel Melittin Anti-PD-1 Cell-derived secretions
摘 要：Autologous tumor cells and cell-derived secretions(CDS)can induce antitumor immune *** conditions in which cells are cultured and treated impact CDS,and cellular insults alter their composition and *** this study,we generated CDS from tumor cells exposed to normal culture conditions,hypoxia,cisplatin,radiotherapy,photodynamic therapy,or hypochlorous acid(HOCl).In vitro HOCl-CDS showed the strongest stimulatory effects on dendritic cells and macrophages compared to CDS generated by hypoxia,cisplatin,radiotherapy or photodynamic *** improve HOCl-CDS activity at the tumor site,we loaded HOCl-CDS into a melittin-encapsulated hydrogel *** injected intratumorally,the HOCl-CDS hydrogel promoted tumor cell death,cytotoxic T lymphocyte infiltration,and tumor-associated macrophage reprogramming towards an M1 *** hydrogel inhibited tumor growth and prolonged the survival of mice bearing B16-F10 ***,hydrogel-delivered HOCl-CDS augmented the antitumor effects of immune checkpoint *** results underscore the importance of the CDS generation method and delivery approach for improving cancer immunotherapy.
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