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Plasma for cancer treatment: How can RONS penetrate through the cell membrane? Answers from computer modeling

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 253-263页

作者： Annemie Bogaerts Maksudbek Yusupov Jamoliddin Razzokov jonas Van der Paal Research group PlASMANT Department of ChemistryUniversity of AntwerpBE-2610 Antwerp-WilrijkBelgium

Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yet fully understood. Using computer simulations at the molecular level, we try to gain better insight in how plasma-generated reactive oxygen and nitrogen species (RONS) can penetrate through the cell membrane. Specifically, we compare the permeability of various (hydrophilic and hydrophobic) RONS across both oxidized and nonoxidized cell membranes. We also study pore formation, and how it is hampered by higher concentrations of cholesterol in the cell membrane, and we illustrate the much higher permeability of H2O2 through aquaporin channels. Both mechanisms may explain the selective cytotoxic effect of plasma towards cancer cells. Finally, we also discuss the synergistic effect of plasma-induced oxidation and electric fields towards pore formation.

关键词： plasma medicine cancer treatment computer modelling cell membrane reactive oxygen and nitrogen species

When a 17-Year-Old Girl Is Diagnosed with Myalgic Encephalomyelitis: A Case Study from the Swedish Health Care System—A Parent Perspective

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Case Reports in Clinical Medicine 2022年第8期11卷 280-296页

作者： Eva Bojner Horwitz jonas Axelsson Olli Polo leif Widebert T&ouml res Theorell Anabelle Paulino David Ullman jonas Bergquist Department of Music Pedagogy and Society Royal College of Music Stockholm Sweden Department of Clinical Neuroscience Karolinska Institutet Solna Sweden Center for Social Sustainability CSS Karolinska Institutet Solna Sweden Amelie Clinic and Karolinska Institutet Solna Sweden ME-Center Bragée Clinics Stockholm Sweden H&auml lsosj&auml len M&ouml lndal G&ouml teborg Sweden Stress Research Institute Stockholm University Stockholm Sweden Karolinska Institutet Solna Sweden Sophiahemmet Barnsjukhuset Martina Sweden Analytical Chemistry and Neurochemistry Department of Chemistry—BMC Uppsala University Uppsala Sweden The ME/CFS Collaborative Research Centre at Uppsala University Uppsala Sweden

This case study presents different strategies that were explored by the patient’s mother (who is a researcher in music and medicine) when her 17-year-old daughter was diagnosed with ME (Myalgic Encephalomyelitis), also known as Chronic Fatigue Syndrome (CFS). ME is not widely recognized in the Global as well as the Swedish population at large, and within healthcare, there are no standardized recommended treatments, partly due to the lack of published evidence-based studies. This case study aims to provide insights into how the Swedish healthcare system works, how different clinics and hospitals within it operate and interconnect;and how these contribute to health outcomes after 15 months of treatment.

关键词： Case Study Myalgic Encephalomyelitis Parent Perspective Swedish Health Care

Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases

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World Journal of Gastroenterology 2023年第18期29卷 2850-2863页

作者： Heinrich Steinhoff Miklos Acs Sebastian Blaj Magdolna Dank Magdolna Herold Zoltan Herold jonas Herzberg Patricia Sanchez-Velazquez Tim Strate Attila Marcell Szasz Pompiliu Piso Department of General and Visceral Surgery Hospital Barmherzige BrüderRegensburg 93049Germany Division of Oncology Department of Internal Medicine and OncologySemmelweis UniversityBudapest 1083Hungary Department of Internal Medicine and Hematology Semmelweis UniversityBudapest 1088Hungary Department of Surgery Krankenhaus Reinbek St.Adolf-StiftReinbek 21465Germany Department of General Surgery Hospital del MarBarcelona 08003Spain

BACKGROUND Advanced gastric cancer with synchronous peritoneal metastases(GC-PM)is associated with a poor *** cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC)is a promising approach,only a limited number of Western studies *** To investigate the clinicopathological outcomes of patients who underwent CRSHIPEC for *** A retrospective analysis of patients with GC-PM was *** patients were seen at the Department of General and Visceral Surgery,Hospital Barmherzige Brüder,Regensburg,Germany between January 2011 and July 2021 and underwent *** laboratory results,the use of neoadjuvant trastuzumab,and the details of CRS-HIPEC,including peritoneal carcinomatosis index,completeness of cytoreduction,and surgical procedures were ***-specific(DSS),and overall survival(OS)of patients were *** A total of 73 patients were included in the *** treated with neoadjuvant trastuzumab(n=5)showed longer DSS(P=0.0482).Higher white blood cell counts(DSS:P=0.0433)and carcinoembryonic antigen levels(OS and DSS:Plower hemoglobin(OS and DSS:Pl protein(OS:P=0.0368)levels were associated with shorter *** HIPEC duration was associated with more advantageous median survival times[60-min(n=59):12.86 mo;90-min(n=14):27.30 mo],but without statistical *** obtain additional data from this observation,further separation of the study population was ***,propensity score-matched patient pairs(n=14 in each group)were *** different DSS was found between patient pairs(hazard ratio=0.2843;95%confidence interval:0.1119-0.7222;P=0.0082).Second,those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity(median survival:12.68 mo vs 24.02 mo),or had to undergo the procedure before 2016(median survival:12.68 mo vs 27.30 mo;P=0.0493)were removed from the orig

关键词： Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal metastasis Stomach neoplasms Gastric cancer

Synthesis of Terminal Amino Substituted Cyclopentadienyl Titanium Complexes

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Chinese Chemical letters 1996年第12期7卷 1139-1142页

作者： Qian, Yl Guo, RW Huang, Jl jonas, K E CHINA UNIV SCI & TECHNOl ORGANOMET CHEM LABSHANGHAI 200237PEOPLES R CHINA MAX PlANCK INST KOHlENFORSCH D-45470 MULHEIMGERMANY

the synthesis of twelve new terminal amino substituted titanocene dichlorides is reported.

关键词： ORGANOTITANIUM CHEMISTRY CRYSTAl-STRUCTURE ZIRCONIUM COMPlEXES GROUP COORDINATION DERIVATIVES

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Railway wheel profile fine-tuning system for profile recommendation

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Railway Engineering Science 2021年第1期29卷 74-93页

作者： Yunguang Ye jonas Vuitton Yu Sun Markus Hecht Institute of land and Sea Transport Systems Technical University of Berlin10587 BerlinGermany College of Transportation Science and Engineering Nanjing Tech UniversityNanjing 210009China

This paper develops a wheel profile fine-tuning system(WPFTS)that comprehensively considers the influence of wheel profile on wheel damage,vehicle stability,vehicle safety,and passenger *** can recommend one or more optimized wheel profiles according to train operators’needs,e.g.,reducing wheel wear,mitigating the development of wheel out-of-roundness(OOR),improving the shape stability of the wheel ***,WPFTS includes four modules:(I)a wheel profile generation module based on the rotary-scaling finetuning(RSFT)method;(II)a multi-objective generation module consisting of a rigid multi-body dynamics simulation(MBS)model,an analytical model,and a rigid–flexible MBS model,for generating 11 objectives related to wheel damage,vehicle stability,vehicle safety,and passenger comfort;(III)a weight assignment module consisting of an adaptive weight assignment strategy and a manual weight assignment strategy;and(IV)an optimization module based on radial basis function(RBF)and particle swarm optimization(PSO).Finally,three cases are introduced to show how WPTFS recommends a wheel profile according to train operators’*** them,a wheel profile with high shape stability,a wheel profile for mitigating the development of wheel OOR,and a wheel profile considering hunting stability and derailment safety are developed,respectively.

关键词： Wheel profile fine-tuning system Optimization Recommendation Wear Contact concentration index Multi-body dynamics simulation(MBS) Railway wheel

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Inflammatory bowel disease registries for collection of patient iron parameters in Europe

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World Journal of Gastroenterology 2018年第10期24卷 1063-1071页

作者： jonas Halfvarson Fraser Cummings Olof Grip Guillaume Savoye Department of Gastroenterology Faculty of Medicine and HealthOebro UniversityObro SE 70182Sweden Department of Gastroenterology Southampton University Hospital NHS Foundation TrustSouthamptonHampshire SO16 6YDUnited Kingdom Department of Gastroenterology Skae University HospitalMalmo-20502Sweden Service d'heato-gastroenteologie CHU de Rouen-Hoital Charles NicolleRouen 76031France

Iron deficiency without anemia and iron deficiency anemia are common and frequently overlooked complications of inflammatory bowel disease. Despite the frequency and impact of iron deficiency in inflammatory bowel disease, there are gaps in our understanding about its incidence, prevalence and natural history and, consequently, patients may be undertreated. Medical registries have a key role in collecting data on the disease's natural history, the safety and effectiveness of drugs in routine clinical practice, and the quality of care delivered by healthcare services. Even though iron deficiency impacts inflammatory bowel disease patients and healthcare systems substantially, none of the established European inflammatory bowel disease registries systematically collects information on iron parameters and related outcomes. Collection of robust iron parameter data from patient registries is one way to heighten awareness about the importance of iron deficiency in this disease and to generate data to improve the quality of patient care, patient outcomes, and thus quality of life. This objective could be achieved through collection of specific laboratory, clinical, and patientreported measurements that could be incorporated into existing registries. This review describes the status of current European inflammatory bowel disease registries and the data they generate, in order to highlight their potential role in collecting iron data, to discuss how such information gathering could contribute to our understanding of iron deficiency anemia, and to provide practical information in regard to the incorporation of accumulated iron parameter data into registries.

关键词： Anemia Iron deficiency Registries Inflammatory bowel disease Patient care

Antioxidant, antibacterial and phytochemical properties of two medicinal plants against the wound infecting bacteria

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 817-825页

作者： Idowu jonas Sagbo Anthony Jide Afolayan Graeme Bradley Department of Botany University of Fort HarePrivate Bag X1314Alice 5700South Africa Department of Biochemistry and Microbiology University of Fort HarePrivate Bag X1314Alice 5700South Africa

Objective: To investigate the antioxidant, antibacterial and phytochemical properties of ethanol extracts of Brachylaena elliptica and Brachylaena ilicifolia against wound infecting bacteria normally found in diabetic ***: The in vitro antioxidant activity of the two plants extracts were investigated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl, nitric oxide, azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt, hydrogen peroxide(H_2O_2) and ferric reducing power. The antibacterial assay and minimum inhibitory concentration(MIC) was determined using the agar dilution method against five bacteria strains using amoxycillin and ciprofloxacin as positive control. The phytochemical analyses(tannins,total phenol, flavonoids, flavonols, proanthocyanidin, alkaloids and saponins) were assessed using standard ***: The ethanol extract of both plants exhibited strong antioxidant activities in some cases when compared to the standards(vitamin C and BHT). The antibacterial activity of both plants showed an appreciable broad spectrum activity against these wound pathogens with MIC value ranges between 0.3 mg/m l and 5 mg/m l. Tannins,phenols, flavanols, proanthocyanidins and alkaloids content of B. ilicifolia were significantly higher than those in B. elliptica. However, there were no significant differences in the flavanoid content of both plants ***: These results indicated that the ethanol leaf extracts of these plants have antioxidant and antibacterial activity against the tested bacteria possibly due to the presence of bioactive compounds and therefore could be used as alternative therapy against wound infection caused by these bacteria in diabetic patients.

关键词： Diabetes mellitus Antioxidant Phytochemical Brachylaena elliptica Brachylaena ilicifolia Wound

Mucosa-associated lymphoid tissue lymphoma simulating Crohn’s disease:A case report

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World Journal of Clinical Cases 2020年第8期8卷 1454-1462页

作者： Ieva Stundiene Vaidota Maksimaityte Valentina liakina jonas Valantinas Centre of Hepatology Gastroenterology and DieteticsFaculty of MedicineVilnius UniversityVilnius 03101Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania Clinic of Gastroenterology Nephrourology and SurgeryFaculty of MedicineVilnius UniversityVilnius 03101Lithuania

BACKGROUND Differential diagnosis between extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue and inflammatory bowel disease is mainly based on histopathologic evaluation of intestinal biopsies,although there is no single definitive diagnostic investigation and that circumstance can lead to misdiagnosis in particular *** we present a rare,ulcerative form of marginal zone lymphoma which mimics the Crohn’s disease(CD)of upper digestive *** SUMMARY A 50-year-old man was presented with recurrent episodes of malaise and melena also weight *** of the small bowel demonstrated an ulcer in the ***,biopsies showed lymphoplasmacytic *** of CD was *** treatment consisted of prednisone and azathioprine and was followed by azathioprine 100 mg per day with good clinical response in the following 2 years until *** this time the results of endoscopic biopsies derived from proximal wall of stomach revealed Helicobacter pylori-negative marginal zone lymphoma of the gastric *** confirmed atypical CD20-positive cell *** on these biopsies,marginal zone lymphoma of mucosa-associated lymphoid tissue was ***,the contact with the patient was lost until one year later he was hospitalized with nausea,vomiting and severe pain because of gastrointestinal *** months later after laparotomy,the patient was treated with a course of *** remission was observed following 6 cycles of *** This case report highlights the clinical relevance of knowledge and awareness of marginal zone lymphoma simulating CD.

关键词： Crohn disease Mucosa-associated lymphoid tissue lymphoma Rare diagnosis Gastrointestinal diseases Thiopurines Case report

Feature sensitive re-sampling of point set surfaces with Gaussian spheres

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Science China(Information Sciences) 2012年第9期55卷 2075-2089页

作者： BSCH jonas PAJAROlA Renato GOPI M. Department of Informatics University of ZürichZürich CH-8050Switzerland Department of Computer Science University of CaliforniaIrvine CA 92697-3425USA

Feature sensitive simplification and re-sampling of point set surfaces is an important and challenging issue for many computer graphics and geometric modeling *** on the regular sampling of the Gaussian sphere and the surface normals mapping onto the Gaussian sphere,an adaptive re-sampling framework for point set surfaces is presented in this paper,which includes a naive sampling step by index propagation and a novel cluster optimization step by normalized *** proposed re-sampling scheme can generate non-uniformly distributed discrete sample points for the underlying point sets in a feature sensitive *** intrinsic geometric features of the underlying point set surfaces can be preserved efficiently due to our adaptive re-sampling scheme.A novel splat rendering technique is adopted to illustrate the efficiency of our re-sampling ***,a numerical error statistics and surface reconstruction for simplified models are also given to demonstrate the effectiveness of our algorithm in term of the simplified quality of the point set surfaces.

关键词： point set surfaces feature sensitive re-sampling Gaussian sphere simplification surface reconstruction