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In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain

Bone Research 2014年第1期2卷 55-60页

作者： Subburaman Mohan Chetan Girijanand Bhat jon e wergedal Chandrasekhar Kesavan Musculoskeletal Disease Center VA Loma Linda Healthcare System Department of Medicine Loma Linda University Department of Biochemistry Loma Linda University Department of Physiology Loma Linda University

Although insulin-like growth factor-I （IGF-I） and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling pathways crosstalk with each other in producing a skeletal response to mechanical loading. To test this, at 5 weeks of age, partial ovariectomy （pOVX） or a sham operation was performed on heterozygous IGF-I conditional knockout （H IGF-I KO） and control mice generated using a Cre-loxP approach. At 10 weeks of age, a 10 N axial load was applied on the right tibia of these mice for a period of 2 weeks and the left tibia was used as an internal non-non-loaded control. At the cortical site, partial estrogen loss reduced total volumetric bone mineral density （BMD） by 5% in control pOVX mice （P=0.05, one-way ANOVA）, but not in the H IGF-I KO pOVX mice. At the trabecular site, bone volume/total volume （BV/TV） was reduced by 5%-6% in both control pOVX （P〈0.05） and H IGF-I KO pOVX （P=0.05） mice. Two weeks of mechanical loading caused a 7 %-8% and an 11%-13% （P〈0.05 vs. non-loaded bones） increase in cortical BMD and cortical thickness （***）, respectively, in the control sham, control pOVX and H IGF-I KO sham groups. By contrast, the magnitude of cortical BMD （4%, P=0.13） and *** （6%, P〈0.05） responses were reduced by 50% in the H IGF-I KO pOVX mice compared to the other three groups. The interaction between genotype and estrogen deficiency on the mechanical loading-induced cortical bone response was significant （P〈0.05） by two-way ANOVA. Two weeks of axial loading caused similar increases in trabecular BV/TV （13%-17%） and thickness （17%-23%） in all four groups of mice. In conclusion, partial loss of both estrogen and IGF-I significantly reduced cortical but not the trabecular bone response to mechanical loading, providing in vivo evidence of the above crosstalk in mediating the bone response to loading.

关键词： bone IGF estrogen crosstalk in mediating the cortical bone response to mechanical strain

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Batch Active Learning for Multispectral and Hyperspectral Image Segmentation Using Similarity Graphs

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1013-1033页

作者： Bohan Chen Kevin Miller Andrea L.Bertozzi jon Schwenk Department of Mathematics University of CaliforniaLos Angeles520 Portola PlazaLosAngeles90095CAUSA Oden Institute for Computational engineering and Sciences University of Texas at Austin201 E 24th StAustin 78712TXUSA Los Alamos National Laboratory Los AlamosNM 87545USA

Graph learning,when used as a semi-supervised learning(SSL)method,performs well for classification tasks with a low label *** provide a graph-based batch active learning pipeline for pixel/patch neighborhood multi-or hyperspectral image *** batch active learning approach selects a collection of unlabeled pixels that satisfy a graph local maximum constraint for the active learning acquisition function that determines the relative importance of each pixel to the *** work builds on recent advances in the design of novel active learning acquisition functions(e.g.,the Model Change approach in arXiv:2110.07739)while adding important further developments including patch-neighborhood image analysis and batch active learning methods to further increase the accuracy and greatly increase the computational efficiency of these *** addition to improvements in the accuracy,our approach can greatly reduce the number of labeled pixels needed to achieve the same level of the accuracy based on randomly selected labeled pixels.

关键词： Image segmentation Graph learning Batch active learning Hyperspectral image

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Implications for brainstem recovery from studies in primates after sensory loss from arm

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Neural Regeneration Research 2024年第3期19卷 479-480页

作者： Jamie L.Reed Hui-Xin Qi jon H.Kaas Department of Psychology Vanderbilt UniversityNashvilleTNUSA

For decades,researchers have known that when neurons lose their activating inputs,they can atrophy and even *** example,removing sensory nerve inputs from the arm to the spinal cord after amputation or cutting the spinal nerves can shrink the post-synaptic target zones(e.g.,Woods et al.,2000).From touch receptors for the hand and arm,primary nerve afferents enter the spinal cord,and axons travel in the dorsal columns to target the cuneate nucleus(Cu)of the brainstem on the same side of the body(Figure 1).When sensory loss is unilateral,the overwhelming result is for the associated primary target zone to shrink in total size(cross-sectional area),as compared to the size of the opposite side.

关键词： brainstem shrink removing

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The past,present,and future of the Siberian Grouse(Falcipennis falcipennis)under glacial oscillations and global warming

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Avian Research 2022年第1期13卷 57-63页

作者： Wendong Xie Kai Song Siegfried Klaus jon e.Swenson Yue-Hua Sun Key Laboratory of Animal ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China College of Life Science Hebei UniversityBaoding071002China Lindenhöhe 5 D-07749JenaGermany Faculty of environmental Sciences and Natural Resource Management Norwegian University of Life SciencesPO Box 5003NO-1432ÅsNorway

Global climate change has a significant effect on species,as environment conditions change,causing many species'distributions to *** the last three million years,the earth has experienced glacial oscillations,forcing some species to survive in ice-free refugia during glacial periods and then disperse *** this study,by assessing the potential distribution of Siberian Grouse(Falcipennis falcipennis),we used Global Circular Models and Representative Concentration Pathways to model their pattern of range changes during glacial oscillations and the potential impact of present global *** used 158 location records of Siberian Grouse to generate a full climate model using 19 bioclimate variables in *** discarded variables with a correlation coefficient larger than 0.8 and relatively lower modeling contributions between each pair of correlated *** the remaining variables,we created a normally uncorrelated simple climate model to predict the possible distribution of Siberian Grouse from the most recent Ice Age to present and to *** we added geographical data and the human interference index to construct a multiple factor full model to evaluate which were important in explaining the distribution of Siberian *** Total Suitability Zone(P≥0.33)of Siberian Grouse is about 243,000km^(2) and the Maximum Suitability Zone(P≥0.66)is 36,000km^(2) and is confined to the Russian Far *** habitat modeling suggested that annual precipitation,annual mean temperature,and the distance from lakes are the most explanatory variables for the current distribution of Siberian *** distribution center moved to the southeast during the Last Glacial Maximum and spread back to the northwest after the ice melted and temperatures *** total area range of Siberian Grouse experienced a dramatic loss during the Last Glacial *** warming is presently forcing the Siberian Grouse to migrate northward with a contraction of

关键词： Climate change Falcipennis falcipennis Ice age refugia Last glacial maximum

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Phenotypic plasticity of labile traits in the wild

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Current Zoology 2013年第4期59卷 485-505页

作者： jon e. BROMMeR Department of Biology University Hill 20014 University of Turku Finland ARONIA Research and Development Institute Novia Applied University and Abo Akademi University Raseborgsvaigen 9 10600 Ekenas Finland

Individual-based studies allow quantification of phenotypic plasticity in behavioural, life-history and other labile traits. The study of phenotypic plasticity in the wild can shed new light on the ultimate objectives (1) whether plasticity itself can evolve or is constrained by its genetic architecture, and (2) whether plasticity is associated to other traits, including fitness (selection). I describe the main statistical approach for how repeated records of individuals and a description of the environment (e) allow quantification of variation in plasticity across individuals (Ixe) and genotypes (Gxe) in wild populations. Based on a literature review of life-history and behavioural studies on plasticity in the wild, I discuss the present state of the two objectives listed above. Few studies have quantified Gxe of labile traits in wild populations, and it is likely that power to detect statistically significant Gxe is lacking. Apart from the issue of whether it is heritable, plasticity tends to correlate with average trait expression (not fully supported by the few genetic estimates available) and may thus be evolutionary constrained in this way. Individual-specific estimates of plasticity tend to be related to other traits of the individual (including fitness), but these analyses may be anti-conservative because they predominantly concern stats-on-stats. Despite the increased interest in plasticity in wild populations, the putative lack of power to detect Gxe in such populations hinders achieving general insights. I discuss possible steps to invigorate the field by moving away from simply testing for presence of Gxe to analyses that ‘scale up’ to population level processes and by the development of new behavioural theory to identify quantitative genetic parameters which can be estimated.

关键词：表型可塑性性状表达野生环境不稳定统计方法野生种群遗传结构遗传估计

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Reducing the loss of genetic diversity associated with assisted colonization-like introductions of animals

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Current Zoology 2015年第5期61卷 827-834页

作者： Jaana KeKKONeN jon e. BROMMeR Department of Biosciences University of Helsinki Helsinki Finland Department of Biology University of Turku Turku Finland

Translocations, especially assisted colonizations, of animals are increasingly used as a conservation management tool. In many cases, however, limited funding and other logistic challenges limit the number of individuals available for translocation. In conservation genetics, small populations are predicted to rapidly lose genetic diversity which can deteriorate population survival. Thus, how worried should we be about the loss of genetic diversity when introducing small, isolated populations? Historical species introductions provide a means to assess these issues. Here we review 13 studies of “assisted colonization-like” introductions of animals, where only a small known number of founders established an isolated population without secondary contact to the source population. We test which factors could be important in retaining genetic diversity in these cases. In many cases, loss in heterozygosity (-12.1%) was detected, and more seriously the loss in allelic richness (-27.8 %). Number of founders seemed to have an effect but it also indicated that high population growth rate could help to retain genetic diversity, i.e. future management actions could be effective even with a limited number of founders if population growth would be enhanced. On the contrary, translocated organisms with longer generation times did not seem to retain more genetic diversity. We advocate that, where possible, future studies on translocated animals should report the loss of genetic diversity (both heterozygosity and allelic richness), which is essential for meta-analyses like this one for deepening our understanding of the genetic consequences of assisted colonization, and justifying management decisions.

关键词：种群遗传多样性损失动物定植人口增长保护遗传学管理工具等位基因

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Tri-axial accelerometry shows differences in energy expenditure and parental effort throughout the breeding season in long-lived raptors

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Current Zoology 2022年第1期68卷 57-67页

作者： Pascual LOPeZ-LOPeZ Arturo MPeRONA Olga eGeA-CASAS jon MORANT Vicente URIOS Movement ecology Laboratory Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of Valencia.C/Catedratico JoseBeltran 2E-46980 PaternaValenciaSpain Department of Ornithology Aranzadi Sciences SocietyDonostia-S.SebastianGuipuzcoa 03690Spain Vertebrates Zoology Research Group University of AlicanteApdo.99Alicante E-03080Spain

Cutting-edge technologies are extremely useful to develop new workflows in studying ecological data,particularly to understand animal behavior and movement trajectories at the individual *** parental care is a well-studied phenomenon,most studies have been focused on direct observational or video recording data,as well as experimental ***,what happens out of our sight still remains *** high-frequency GPS/GSM dataloggers and tri-axial accelerometers we monitored 25 Bonelli’s eagles Aquila fasciata during the breeding season to understand parental activities from a broader *** used recursive data,measured as number of visits and residence time,to reveal nest attendance patterns of biparental care with role specialization between *** data interpreted as the overall dynamic body acceleration,a proxy of energy expenditure,showed strong differences in parental effort throughout the breeding season and between ***,males increased substantially their energetic requirements,due to the increased workload,while females spent most of the time on the ***,during critical phases of the breeding season,a low percentage of suitable hunting spots in eagles’territories led them to increase their ranging behavior in order to find food,with important consequences in energy consumption and mortality *** results highlight the crucial role of males in raptor species exhibiting biparental ***,we exemplify how biologging technologies are an adequate and objective method to study parental care in raptors as well as to get deeper insight into breeding ecology of birds in general.

关键词： biologging GPS movement ecology ODBA space use telemetry

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Conservation genomics of sibling grouse in boreal forests reveals introgression and adaptive population differentiation in genes controlling epigenetic variation

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Zoological Research 2022年第2期43卷 184-187页

作者： Kai Song Bin Gao Peter Halvarsson Yun Fang Siegfried Klaus Ying-Xin Jiang jon e.Swenson Zhi-Ming Han Yue-Hua Sun Jacob Hoglund Key Laboratory of Animal ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Animal ecology Department of Ecology and GeneticsUppsala UniversityUppsala 75236Sweden Unit of Parasitology Department of Biomedicine and Veterinary Public HealthSwedish University of Agricultural SciencesUppsala 75007Sweden Lindenhöhe 5 Jena D-07749Germany Faculty of environmental Sciences and Natural Resource Management Norwegian University of Life SciencesAs NO-1432Norway State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The Chinese Grouse(Tetrastes sewerzowi) and Hazel Grouse(T. bonasia) are sibling species that are well-adapted to harsh high-altitude and latitude habitats. In the current study, we sampled and sequenced 29 Chinese Grouse(n=16) and Hazel Grouse(n=13) from eight locations in China, Sweden,Germany, and northeast Poland to analyze population genetic diversity and structure, introgression, and local adaptation.

关键词： northeast adapted controlling

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Site survey and assessment for the planned seismogeodynamic monitoring network in the Republic of Armenia

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earthquake Science 2022年第6期35卷 510-518页

作者： jon Karapetyan Li Li eduard Geodakyan Songyong Yuan Roza Karapetyan Institute of Geophysics and engineering Seismology after A.Nazarov National Academy of Sciences of the Republic of ArmeniaGyumri 3115Armenia Institute of Geophysics China Earthquake AdministrationBeijing 100081China

We present results of a detailed analysis of data obtained from seismic geodynamic field studies conducted at proposed sites for the development of advanced seismic monitoring stations in the Republic of *** studies aim to determine the background seismic and geodynamic noise level around such ***,based on the received data and international standards,nine survey points were classified into respective classes according to their noise *** also calculated minimum significant earthquake magnitude detectable by the proposed seismic network in different regions of Armenia and mapped it based on recorded regional *** resulting map indicates that the proposed seismic monitoring network will provide homogenous initial data for the various seismically active regions of the territory of the Republic of Armenia.

关键词： seismic noise GNSS geodynamic spectral analysis seismic network

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Genes & Diseases 2022年第6期9卷 1506-1520页

作者： jon Christiansen Anne-Katrin Guttsches Ulrike Schara-Schmidt Matthias Vorgerd Christoph Heute Corinna Preusse Werner Stenzel Andreas Roos Department of Pediatric Neurology Centre for Neuromuscular DisordersCentre for Translational Neuro-and Behavioral SciencesUniversity Hospital EssenUniversity Duisburg-Essen45147 EssenGermany Department of Neurology Heimer Institute for Muscle ResearchUniversity Hospital BergmannsheilRuhr University Bochum44789 BochumGermany Department of Adult and Pediatric Diagnostic Interventional RadiologyNuclear MedicineBG University Hospital Bergmannsheil Bochum44789 BochumGermany Charite´e Universitatsmedizin Berlin Freie Universitat Berlin10117 BerlinGermany Humboldt-Universitat zu Berlin Department of Neuropathology10117 BerlinGermany Department of Neurology with Institute for Translational Neurology University Hospital MunsterAlbert-Schweitzer-Campus 148149 MunsterGermany Children’s Hospital of eastern Ontario Research Institute University of OttawaOttawaON K1H 8L1Canada

Anoctamin-5(ANO5)is a multi-pass membrane protein localized to the sarcolemma and the sarcoplasmic *** were linked to rare autosomal recessive muscle ***,we summarize the clinical spectrum,imaging data and molecular research findings as well as results of animal modeling,which significantly moved forward the understanding of mechanisms underlying ANO5-related muscle *** that precise histological information on inflammatory processes taking place in patient-derived muscle are still lacking,an(immuno)histological study on biopsies derived from six ANO5-patients was performed showing focal accumulation of necrotic fibers,mild fiber-size variances and *** addition,MRI data of four ANO5-patients(including a 10-year follow-up in one patient)are presented and discussed in the context of previously published ***,data presented in this article combining a review of the literature with own myopathological findings address scientific trends and open questions on ANO5-related muscle diseases,which would be of significant interest for a wide neuromuscular diseases *** conclude,a clear genotypeephenotype correlation does not exist,and ANO5-related muscle disorders might represent the next entity of a clinical continuum with varying degree of muscle cell *** addition,results of pre-clinical studies allowed the definition of suitable cell and animal models characterized by certain histological and functional pathologies resembling the human *** models might serve as suitable systems for testing of interventional concepts in future.

关键词： Anoctamin-5 LGMDR12 MMD3 Muscle inflammation Muscle MRI

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