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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning Yeh john Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Ply(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Plysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all P<0.0001),whereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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Gas-phase synthesis of Ti_(2)CCl_(2) enables an efficient catalyst for lithiumsulfur batteries

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The Innovation 2024年第1期5卷 33-40页

作者： Maoqiao Xiang Zihan Shen Jie Zheng Miao Song Qiya He Yafeng Yang Jiuyi Zhu Yuqi Geng Fen Yue Qinghua Dong Yu Ge Rui Wang Jiake Wei Weiliang Wang Haiming Huang Huigang Zhang Qingshan Zhu Chuanfang john Zhang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of the Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China China Nuclear Power Engineering Co. Ltd.117 West Third Ring RoadNorth SectionBeijing 100840China College of Materials Science&Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Physics Guangdong Province Key Laboratory of Display Material and TechnologyCenter for Neutron Science and TechnologySun Yat-sen UniversityGuangzhou 510275China Solid State Physics&Material Research Laboratory School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China

MXenes have aroused intensive enthusiasm because of their exotic properties and promising ***,to date,they are usually synthesized by etching *** synthetic technologies provides more opportunities for innovation and may extend unexplored ***,we report a bottom-up gas-phase synthesis of Cl-terminated MXene(Ti_(2)CCl_(2)).The gas-phase synthesis endows Ti_(2)CCl_(2) with unique surface chemistry,high phase purity,and excellent metallic conductivity,which can be used to accelerate polysulfide conversion kinetics and dramatically prolong the cyclability of Li-S ***-depth mechanistic analysis deciphers the origin of the formation of Ti_(2)CCl_(2) and offers a paradigm for tuning MXene chemical vapor *** brief,the gas-phase synthesis transforms the synthesis of MXenes and unlocks the hardly achieved potentials of MXenes.

关键词： synthesis phase lithium

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皮肤色度学:一种客观可靠的肤色测量技术

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中华皮肤科杂志 2022年第2期55卷 185-186页

作者： ly BCK Dyer EB Feig JL Department of Dermatology John Hopkins University School of Medicine Baltimore Maryland L’Oréal Research and Innovation Aulnay-sous-Bois France

皮肤科需要具有良好的一致性和可重复性的肤色评价方法。研究人员和医生在评价药物干预、环境暴露和生理变化时经常需要描述皮肤的颜色,肤色参数(如色素沉着)与罹患皮肤癌的风险有关。此外,紫外线暴露引起的最小红斑量常被用于制定光疗... 详细信息

皮肤科需要具有良好的一致性和可重复性的肤色评价方法。研究人员和医生在评价药物干预、环境暴露和生理变化时经常需要描述皮肤的颜色,肤色参数(如色素沉着)与罹患皮肤癌的风险有关。此外,紫外线暴露引起的最小红斑量常被用于制定光疗计划。迄今为止,Fitzpatrick皮肤类型(FST)量表被广泛用于皮肤分型,肤色是其中重要的考量因素。

关键词：最小红斑量色素沉着环境暴露皮肤的颜色皮肤类型光疗色度学可重复性

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Dual color optogenetic control of neural populations using low-noise,multishank optoelectrodes

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Microsystems & Nanoengineering 2018年第1期4卷 309-324页

作者： Komal Kampasi Daniel F.English john Seymour Eran Stark Sam McKenzie Mihály Vöröslakos György Buzsáki Kensall D.Wise Euisik Yoon Department of Biomedical Engineering University of MichiganAnn ArborMI 48105USA Center for Micro and Nanotechnology Lawrence Livermore National LaboratoryLivermoreCA 94550USA NYU Neuroscience Institute School of MedicineEast River Science ParkAlexandria Center450 East 29th St9th FloorNew YorkNY 10016USA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMI 48105USA Department of Physiology and Pharmacology Sackler Faculty of MedicineTel Aviv University69978 Tel AvivIsrael Sagol School of Neuroscience Tel Aviv University69978 Tel AvivIsrael

Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological ***-identified classes of neurons are optically manipulated,though the versatility of optogenetics would be increased if independent control of distinct neural populations could be achieved on a sufficient spatial and temporal *** report a scalable multisite optoelectrode design that allows simultaneous optogenetic control of two spatially intermingled neuronal populations in *** describe the design,fabrication,and assembly of low-noise,multisite/multicolor *** shank of the four-shank assembly is monolithically integrated with 8 recording sites and a dualcolor waveguide mixer with a 7×30μm cross-section,coupled to 405 nm and 635 nm injection laser diodes(ILDs)via gradient-index(GRIN)lenses to meet optical and thermal design *** better understand noise on the recording channels generated during diode-based activation,we developed a lumped-circuit modeling approach for EMI coupling mechanisms and used it to limit artifacts to amplitudes under 100μV upto an optical output power of 450μ*** implanted the packaged devices into the CA1 pyramidal layer of awake mice,expressing Channelrhodopsin-2 in pyramidal cells and ChrimsonR in paravalbumin-expressing interneurons,and achieved optical excitation of each cell type using sub-mW *** highlight the potential use of this technology for functional dissection of neural circuits.

关键词： waveguide mixer neural

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Efficacy and safety of modified tetracycline dosing in a quadruple therapy for Helicobacter pylori:A retrospective single center study

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World Journal of Gastroenterology 2023年第22期29卷 3508-3518页

作者： Ying-Chao Sun Meng-Jia Zhu Xue-Qin Chen Lei Yue Yi-Ru Zhao Xin-Jie Wang john J Kim Qin Du Wei-Ling Hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Division of Gastroenterology Loma Linda University HealthLoma LindaCA 92354United States Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhou 310009Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Although highly effective as a component of Helicobacter pylori(***)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse *** dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication *** To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with *** *** Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for *** infection at Sir Run Run Shaw Hospital were *** patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue *** tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times *** Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for *** infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose *** In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.

关键词： Helicobacter pylori Tetracycline Furazolidone Eradication Penicillin allergy Bismuth quadruple therapy

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Different Performances of H_2O_2 to Oxidise Aldicarb and Hexazinone in the Advanced Oxidation Process of Ozone/Hydrogen Peroxide

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Journal of Donghua University(English Edition) 2014年第3期31卷 348-353页

作者：冉治霖孙楚李绍峰 CRAIG Denver Williams TREVOR john Hocking School of Transportation and Environment Shenzhen Institute of Information Technology College of Resources and Environment Northeast Agricultural University Shenzhen Key Lab of Industrial Water Saving&Municipal Sewage Reclamation Technology Shenzhen Polytechnic Institute School of Applied Science University of WolverhamptonWolverhampton WV1 1LYUK

The degradations of hexazinone and aldicarb by direct ozonation combined an advanced oxidation process( AOP) of O3/H2O2 were investigated in this study focusing on the oxidation mechanism by identifying the hydrogen peroxide consumption during the oxidation process of the two chemicals. The results showed that H2O2 could enhance the removal rate of the triazine herbicide hexazinone,and it was consumed along with the variation of removal rate in the light of different pH levels. The addition of H2O2 contributed little to the removal of the thiocarbamate herbicide aldicarb and H2O2 content kept constantly throughout the degradation process. Tert-butyl alcohol( TBA) effectively scavenged the ·OH radical for hexazinone,but had no effect on the removal rate of aldicarb. Aldicarb removal was mainly attributed to direct ozonation molecule in both O3( 97.00%) and O3/H2O2( 96.76%)systems. Moreover,sole O3 could hardly oxidize hexazinone whereas·OH radicals contribute respective 74.70% and 97.50% of removal in O3 system and O3/H2O2 AOP. All of these findings suggest that the mechanism of ·OH radical generation and the chain reaction in O3/H2O2 AOP should be further discussed.

关键词： hexazinone aldicarb O3/H2O2 direct and indirect oxidation H2O2consumption

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Perception of artificial conspecifics by bearded dragons(Pogona vitticeps)

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Integrative Zoology 2019年第2期14卷 214-222页

作者： Anna FROHNWIESER Thomas W.PIKE john C.MURRAY Anna WILKINSON School of Life Sciences University of LincolnLincolnUK School of Computer Science University of LincolnLincolnUK Wildlife Research Center Kyoto UniversityKyotoJapan

Artificial animals are increasingly used as conspecific stimuli in animal behavior ***,researchers often have an incomplete understanding of how the species under study perceives conspecifics,and,hence,which features are needed for a stimulus to be perceived *** investigate the features that bearded dragons(Pogona vitticeps)attend to,we measured their lateralized eye use when assessing a successive range of *** ranged through several stages of realism in artificial conspecifics,to see how features such as color,the presence of eyes,body shape and motion influence *** found differences in lateralized eye use depending on the sex of the observing bearded dragon and the artificial conspecific,as well as the artificial conspecific’s ***,this approach can inform the design of robotic animals that elicit biologically-meaningful responses in live animals.

关键词： bearded dragons conspecifics lateralized eye use perception

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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

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Frontiers of Medicine 2021年第3期15卷 416-437页

作者： Xu Yu Jin Mario Petrou Jiang Ting Hu Ed D Nicol john R Pepper Surgical Echo-Cardiology Services Oxford Heart CentreJohn Radcliffe HospitalOxford University Hospitals NHS Foundation TrustOxford OX39DUUK Cardiac Surgical Physiology and Genomics Group Nuffield Division of Clinical Laboratory SciencesRadcliffe Department of MedicineUniversity of OxfordOxford OX39DUUK Department of Cardiac Surgery Royal Brompton HospitalLondon SW36NPUK National Heart and Lung Institute Imperial College LondonLondon SW36LYUK NIHR Imperial Biomedical Research Centre London W21NYUK Department of Cardiology Royal Brompton HospitalLondon SW36NPUK

Over the last half century,surgical aortic valve replacement(SAVR)has evolved to offer a durable and efficient valve haemodynamically,with low procedural complications that allows favourable remodelling of left ventricular(LV)structure and *** latter has become more challenging among elderly patients,particularly following trans-catheter aortic valve implantation(TAVI).Precise understanding of myocardial adaptation to pressure and volume overloading and its responses to valve surgery requires comprehensive assessments from aortic valve energy loss,valvular-vascular impedance to myocardial activation,force-velocity relationship,and myocardial *** hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this *** intervention in asymptomatic aortic stenosis or regurgitation along with individualised management of hypertension and atrial fibrillation is likely to improve patient *** pacing via the His-Purkinje system for conduction abnormalities,further reduction in para-valvular aortic regurgitation along with therapy of angiotensin receptor blockade will improve patient outcome by facilitating hypertrophy regression,LV coordinate contraction,and global vascular *** leaflet thromboses require anticoagulation while impaired access to coronary ostia risks future TAVI-in-TAVI or coronary *** comparable long-term durability and the resolution of TAVI related complications become available,SAVR remains the first choice for lower risk younger patients.

关键词： surgical aortic valve replacement trans-catheter aortic valve implantation left ventricular hypertrophy and fibrosis myocardial force-velocity relationship His-Purkinje pacing renin-angiotensin system inhibitors coronary access impairment

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Strategies supporting the prevention and control of neglected tropical diseases during and beyond the COVID-19 pandemic

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Infectious Diseases of Poverty 2020年第4期9卷 135-141页

作者： john P.Ehrenberg Xiao-Nong Zhou Gilberto Fontes Eliana M.M.Rocha Marcel Tanner Jürg Utzinger Avenida Cedro 9 #303CholulMeridaYucatanMexico Formerly World Health Organization Regional Office for the Western PacificManilaThe Philippines National Institute of Parasitic Diseases at the Chinese Center for Disease Control and Prevention&Chinese Center for Tropical Diseases Research ShanghaiPeople's Republic of China School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Laboratory of Parasitology Central-West CampusFederal University of S(a)o Jo(a)o del ReiDivinopolisMinas GeraisBrazil Swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland

Emerging and re-emerging zoonotic diseases represent a public health challenge of international *** include a large group of neglected tropical diseases(NTDs),many of which are of zoonotic *** disease 201g(COVID-19),another emerging zoonotic disease,has just increased the stakes *** NTDs are subject to the impact of some of the very same human-related activities triggering other emerging and re-emerging diseases,including COVID-19,severe acute respiratory syndrome(SARS),bird flu and swine *** is conceivable that COVID-19 will exacerbate the NTDs,as it will divert much needed financial and human *** is considerable concern that recent progress achieved with control and elimination efforts will be *** potential strategies will need to reconsider the determinants of health in NTDs in order to galvanize efforts and come up with a comprehensive,well defined programme that will set the stage for an effective multi-sectorial *** this Commentary,we propose areas of potential synergies between the COVID-19 pandemic control efforts other health and non-health sector initiatives and NTD control and elimination programmes.

关键词： COVID-19 Emerging and re-emerging diseases Multi-sectorial approaches Neglected tropical diseases Zoonotic diseases

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一种流水车间批量调度的高效计算三阶段优化方法（英文）

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Frontiers of Information Technology & Electronic Engineering 2019年第7期20卷 1002-1021页

作者： Hai-yan WANG Fu ZHAO Hui-min GAO john WSUTHERLAND College of Mechanical and Electrical Engineering Jiaxing UniversityJiaxing314000China Environmental and Ecological Engineering Purdue UniversityWest LafayetteIN47907USA School of Mechanical Engineering Purdue UniversityWest LafayetteIN47907USA

在工件含批量生产任务情况下如何进行最佳生产调度是一个重要的生产计划问题。通常将批量工件划分为子批处理(称为分批优化)。若子批数较大,则会大大增加工件完成时间的计算复杂性。现有研究未能考虑此类计算时间问题。本文考虑可变子... 详细信息

在工件含批量生产任务情况下如何进行最佳生产调度是一个重要的生产计划问题。通常将批量工件划分为子批处理(称为分批优化)。若子批数较大,则会大大增加工件完成时间的计算复杂性。现有研究未能考虑此类计算时间问题。本文考虑可变子批、准备时间以及子批批量约束(传输子批批量受传输设备容量限制),提出一种求解n个工件、m台机器流水车间分批优化调度方法。所提方法包含3个阶段:初始批量划分、基于生产周期/总流程时间指标快速评价法的工件排序优化、分批传输方案调整。为验证3阶段优化方法的有效性,采用5个标准数据集进行测试。实验结果表明,所提方法能节省大量计算时间,尤其对大规模问题能提供更优解。

关键词：批量流流水车间调度传输子批可变批量批量约束差分进化

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