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Microscopic Magnetism of Nickel-Based Infinite-Layer Superconducting Parent Compounds RNiO_(2)(R=La,Nd):AμSR Study

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Chinese Physics Letters 2024年第9期41卷 133-139页

作者： qiong Wu Ying Fu Le wang Xuefeng Zhou Shanmin wang Zihao Zhu Kaiwen Chen Chengyu Jiang Toni Shiroka Adrian D.Hillier Jia-Wei Mei Lei Shu State Key Laboratory of Surface Physics Department of PhysicsFudan UniversityShanghai 200438China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Shenzhen Institute for Quantum Science and Engineering and Department of PhysicsSouthern University of Science and TechnologyShenzhen 518055China Laboratory for Muon-Spin Spectroscopy Paul Scherrer InstituteCH-5232 Villigen PSISwitzerland Laboratorium fur Festkorperphysik ETH ZurichCH-8093 ZurichSwitzerland ISIS Facility STFC Rutherford Appleton LaboratoryChiltonDidcotOxfordshireOX110QXUnited Kingdom Shanghai Research Center for Quantum Sciences Shanghai 201315China

By using muon spin relaxation(μSR)measurements,we perform a comparative study of the microscopic magnetism in the parent compounds of infinite-layer nickelate superconductors RNiO_(2)(R=La,Nd).In either compound,the zero-fieldμSR spectra down to the lowest measured temperature reveal no long-range magnetic *** LaNiO_(2),short-range spin correlations appear below T=150 K,and spins fully freeze below T∼10 ***_(2)exhibits a more complex spin dynamics driven by the Nd 4𝑓and Ni3d electron spin ***,it shows features suggesting the proximity to a spin-glass state occurring below T=5 *** both compounds,the spin behavior with temperature is further confirmed by longitudinal-fieldμSR *** results provide new insight into the magnetism of the parent compounds of the superconducting nickelates,crucial to understanding the microscopic origin of their superconductivity.

关键词： order. nickel relaxation

Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying wang Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

Recent progress in functional metal-organic frameworks for bio-medical application

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Regenerative Biomaterials 2024年第2期3卷 37-54页

作者： Wenwen Chai Xiaochen Chen Jing Liu Liyan Zhang Chunyu Liu Li Li john Robert Honiball Haobo Pan Xu Cui Deping wang School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Orthopaedics&Traumatology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)have a high specific surface area,adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly,which has intrigued wide interest in a broad range of *** the arena of biomedical engineering,the functionalized modification of MOFs has produced drug carriers with excellent dispersion and functionalities such as target delivery and response release,with promising applications in bio-detection,disease therapy,tissue healing,and other *** review summa-rizes the present state of research on the functionalization of MOFs by physical binding or chemical cross-linking of small *** *** hvdrogels and evaluates the role and approach of MOFs functionalization in boosting the reactivity of *** this basis,research on the application of functionalized MOFs composites in biomedical engineering fields such as drug delivery,tissue repair,disease treatment,bio-detection and imaging is surveyed,and the development trend and application prospects of functionalized MOFs as an important new class of biomedical materials in the biomedical field are anticipated,which may provide some inspiration and reference for further development of MOF for bio-medical applications.

关键词： metal-organic frameworks porous functionalization tissue repair disease treatment

Pain and immune function in patients undergoing gastric cancer surgery following stellate ganglion block with total intravenous anesthesia

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2961-2967页

作者： Zhen Wu Hong-Qin Cai Chun-Feng wang Xiang-Yuan Yu Jie-qiong wang Department of Anesthesiology The Kunshan Second People’s HospitalKunshan 215300Jiangsu ProvinceChina

BACKGROUND Stellate ganglion block is a commonly used sympathetic nerve block technique that restores the balance of the sympathetic and vagal nervous systems of the body and inhibits sympathetic nerve *** To analyze the effect of a stellate ganglion block combined with total diploma intravenous anesthesia on postoperative pain and immune function in patients undergoing laparoscopic radical gastric cancer(GC)surgery to provide a refe-rence basis for the formulation of anesthesia protocols for radical GC *** This study included 112 patients who underwent laparoscopic radical surgery for GC between January 2022 and March *** was no restriction on *** patient grouping method used was a digital random table method,and the num-ber of cases in each group was *** control group was administered total intravenous anesthesia,and the observation group compounded the stellate gan-glion block according to the total intravenous anesthesia *** hemodynamics,pain levels,and immune indices were compared between the *** The heart rate and mean arterial pressure in the observation group after in-tubation were lower than those in the control group(P0.05).The number of CD3+,CD4+,and CD4+/CD8+cells at the end of surgery was higher in the observation group than in the control group,and the number of CD8+cells was lower in the observation group than in the control group(P0.05).CONCLUSION The application of a stellate ganglion block combined with total intravenous anesthesia had no significant effect on postoperative pain levels in patients undergoing laparoscopic radical GC ***,it can safely reduce the effect of surgery on the immune function

关键词： Stellate ganglion block Total intravenous anesthesia Laparoscopy Radical gastric cancer surgery Immune

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审思与建构:大学图书馆治理现代化

大学图书馆学报 2024年第4期42卷 35-41页

作者：王琼于静北京师范大学图书馆北京100875 北京师范大学政府管理学院北京100875

中国共产党二十届三中全会进一步明确了全面深化改革的目标和要求。大学图书馆应立足新发展阶段、贯彻新发展理念,主动融入国家和高等教育现代化进程,促进大学图书馆高质量发展。文章阐述了大学图书馆治理现代化面临的机遇与挑战、目标... 详细信息

中国共产党二十届三中全会进一步明确了全面深化改革的目标和要求。大学图书馆应立足新发展阶段、贯彻新发展理念,主动融入国家和高等教育现代化进程,促进大学图书馆高质量发展。文章阐述了大学图书馆治理现代化面临的机遇与挑战、目标与内容,从六个方面构建了多维度大学治理现代化建设的基本框架:统筹兼顾:党建与业务齐头并进;软硬兼施:“硬制度”与“软环境”提升并重;标本兼治:资源与服务和谐共生;倍道兼行:技术应用与数据治理相辅相成;内外兼修:馆员与用户合作共赢;神形兼俱:打造未来学习新生态,推动大学图书馆治理现代化的进程。

关键词：大学图书馆治理现代化高质量发展

Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy

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Food Science and Human Wellness 2024年

作者： Hong-Yu Pan Na wang Qian-wang Zheng Yuan Zou Jing-Ru Zhong Guo-Zhao Luo Ming-Zhen Tu Li-qiong Guo Jun-Fang Lin College of Food Science， South China Agricultural University.Guangzhou Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province Faculty of Food Science and Engineering， Kunming University of Science and Technology Guangzhou Alchemy Biotechnology Co.， Ltd

Ergothioneine is a natural amino acid with powerful antioxidant activity. Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans， and enhance telomerase activity. In present study， the metagenomics sequencing and qRT-PCR analysis were employed to characterize the composition and diversity of gut microbiome in aging flies. And the alterations in the gut barrier， gut morphology， and other gut physiological indicators of aging flies were evaluated. Here， the results showed that EGT induced little variations in gut microbiota composition in flies at mid-life， and significant alterations in the gut microbiota populations were only observed in flies at late-life. And ergothioneine attenuated age-related gut injuries， including decreasing reactive oxygen species levels in intestinal enterocytes， reduction of intestinal cells death， and preservation of gut integrity in aging flies. Ergothioneine also improved the gut morphology by preserving the structure and shape of cell organelles and inducing the intestinal autophagy. And activation of intestinal autophagy also contributed to the longevity effect mediated by ergothioneine in an unidentified mechanism.

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-Min wang Min-Yue Xie Yi-Qing Sun Xiao-Huan Zhao Yu-Hong Chen Jie-qiong Chen Si-Yang Han Min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

三元空间视角下的村镇公共空间叙事分析与解读——以山西荫城镇为例

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城市发展研究 2024年第1期31卷 30-34页

作者：王琼秦时玥西安建筑科技大学艺术学院

列斐伏尔的三元空间论是分析村镇公共空间演变的重要理论依据，从三元空间论的认知视角出发，通过分析社会生产与空间演变的关系，可将荫城镇的发展历程概括为村落集聚、镇域衰落、新镇再造三个阶段。通过引入叙事分析的逻辑，利用叙事... 详细信息

列斐伏尔的三元空间论是分析村镇公共空间演变的重要理论依据，从三元空间论的认知视角出发，通过分析社会生产与空间演变的关系，可将荫城镇的发展历程概括为村落集聚、镇域衰落、新镇再造三个阶段。通过引入叙事分析的逻辑，利用叙事线索中故事层与讲述层的关系，将故事发生的背景、事件和人物与表述过程中的叙事结构、情境和语言逐一对应，从三元空间论中感知的空间、构想的空间、生活的空间三个层面出发，来分析比较荫城古镇与新镇之间不同的叙事方式，并对当地乡村城镇化过程中新老空间发展的平衡提出相应策略。三元空间与叙事理论的结合，有助于人们从新角度审视当前的村镇空间，分析其中不断变化的物、事、人，以及由村民所叙述的空间故事。

关键词：三元空间空间叙事村镇公共空间荫城镇

儿童原发性十二指肠胃反流与幽门螺杆菌感染对胃炎和抗生素耐药性的影响

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中国当代儿科杂志 2024年第5期26卷 493-498页

作者：王旭阳林琼南京医科大学附属无锡人民医院儿童消化内科江苏无锡214000 无锡市儿童医院消化科江苏无锡214000

目的探讨儿童原发性十二指肠胃反流(duodenogastric reflux,DGR)伴幽门螺杆菌(Helicobacter pylori,HP)感染发生的危险因素及对胃炎和抗生素耐药性的影响。方法回顾性分析2019年1月—2022年2月在无锡市儿童医院接受上消化道内镜检查的... 详细信息

目的探讨儿童原发性十二指肠胃反流(duodenogastric reflux,DGR)伴幽门螺杆菌(Helicobacter pylori,HP)感染发生的危险因素及对胃炎和抗生素耐药性的影响。方法回顾性分析2019年1月—2022年2月在无锡市儿童医院接受上消化道内镜检查的患儿的临床资料,308例经内镜诊断为原发性DGR,根据是否伴HP感染,分为原发性DGR伴HP感染组(53例)和不伴HP感染组(255例),分析影响原发性DGR伴HP感染发生的危险因素及其对胃炎发病率和严重程度的影响。331例HP感染患儿根据是否伴原发性DGR,分为HP感染伴原发性DGR组(29例)和不伴原发性DGR组(302例),分析原发性DGR伴HP感染对抗生素耐药性的影响。结果原发性DGR伴HP感染组患儿年龄高于不伴HP感染组(P0.05)。多因素logistic回归分析显示,年龄大是原发性DGR伴HP感染发生的危险因素(P0.05)。结论年龄大与原发性DGR伴HP感染密切相关。原发性DGR伴HP感染对儿童胃炎和抗生素耐药性无显著影响。

关键词：原发性十二指肠胃反流胃炎幽门螺杆菌耐药性儿童