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Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer

Chinese Journal of Cancer 2014年第3期33卷 133-139页

作者： john M.pawelek Department of Dermatology and the Yale Cancer Center Yale University School of Medicine

This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.

关键词： Bone marrow-derived cell-cancer cell hybrids metastasis cell fusion

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Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis

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World Journal of Clinical Oncology 2020年第3期11卷 121-135页

作者： Ivan Shabo Joar Svanvik Annelie Lindström Tanguy Lechertier Sara Trabulo James Hulit Tim Sparey john pawelek Endocrine and Sarcoma Surgery Unit Department of Molecular Medicine and SurgeryKarolinska InstituteStockholm SE 17177Sweden Patient Area of Breast Cancer Sarcoma and Endocrine TumoursTheme CancerKarolinska University HospitalStockholm SE 17176Sweden The Transplant Institute Sahlgrenska University HospitalGothenburg SE 41345Sweden Division of Surgery Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58183Sweden Division of Cell Biology Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesLinköping UniversityLinköping SE 58185Sweden Novintum Bioscience Ltd London Bioscience Innovation CentreLondon NW10NHUnited Kingdom Department of Dermatology and the Yale Cancer Center Yale University School of MedicineNew HavenCT 06520United States

Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation,repair and *** cell fusion somatic cells undergo rapid nuclear reprogramming and epigenetic modifications to form hybrid cells with new genetic and phenotypic properties at a rate exceeding that achievable by random *** that stimulate cell fusion are inflammation and *** of cancer cells with non-neoplastic cells facilitates several malignancy-related cell phenotypes,e.g.,reprogramming of somatic cell into induced pluripotent stem cells and epithelial to mesenchymal *** is now considerable in vitro,in vivo and clinical evidence that fusion of cancer cells with motile leucocytes such as macrophages plays a major role in cancer *** the many changes in cancer cells after hybridizing with leucocytes,it is notable that hybrids acquire resistance to chemo-and radiation *** phenomenon that has been largely overlooked yet plays a role in these processes is *** of the mechanism of polyploid cell formation,it happens in response to genotoxic stresses and enhances a cancer cell’s ability to *** we summarize the recent progress in research of cell fusion and with a focus on an important role for polyploid cells in cancer *** addition,we discuss the clinical evidence and the importance of cell fusion and polyploidization in solid tumors.

关键词： Cell fusion Hybrid formation Polyploidization Macrophage Cancer progression Oncologic treatment resistance

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