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Chinese Medicine and Cul.ure 2024年第1期7卷 51-62页

作者： john l.McDonal. Judy B James School.of Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Austral.a Brisbane 4120Australia

In 2012, traditional.Chinese medicine(TCM) practitioners in Austral.a became national.y-registered al.ied heal.h professional. in three categories: acupuncturist, Chinese herbal.medicine practitioner, and Chinese herbal.medicine dispenser. Austral.a was the first Western country to introduce national.registration for Chinese medicine, fol.owed by Portugal.and, recentl., New Zeal.nd. The practice of TCM in Austral.a can be traced back to the beginning of Chinese immigration to Austral.a during the Victorian Gol. Rush which began in the 1850s. The process which l.d to national.registration commenced in the earl. 1970s with the establ.shment of the first acupuncture courses. Decades of gradual.devel.pment of courses from unaccredited part-time dipl.mas to accredited bachel.r degrees, and the devel.pment, by the profession, of national.consensus on educational.standards were essential.el.ments in the process which l.d to registration. Professional.associations, such as the Austral.an Acupuncture and Chinese Medicine Association l.d.(AACMA), al.o devel.ped a framework of professional.sel.regul.tion, incl.ding Codes of Ethics, Codes of Conduct, ongoing professional.devel.pment requirements and Infection Control.Guidel.nes, and provided l.adership in the devel.pment of the profession. After decades of tribal.sm and division within the TCM profession, the National.Academic Standards Committee brought al.ost al. stakehol.ers together to reach a consensus on the Austral.an Guidel.nes for Traditional.Chinese Medicine Education which were publ.shed by AACMA in 2001. Professional.associations al.o col.aborated on joint submissions to the government in support of registration, which was introduced first in the state of Victoria in 2000, and subsequentl. became national.in 2012. Despite national.registration, some barriers stil. remain, and professional.associations continue to l.bby the federal.government for incl.sion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regul.tion Education Standards Austral.a TCM

Robust Machine l.arning Mapping of sEMG Signal. to Future Actuator Commands in Biomechatronic Devices

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Journal.of Bionic Engineering 2024年第1期21卷 270-287页

作者： Al. Nasr Sydney Bel. Rachel.l.Whittaker Cl.rk R.Dickerson john McPhee Systems Design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiol.gy and Heal.h Sciences University of WaterlooWaterloo N2L3G3Canada

A machine l.arning model.for regression of interrupted Surface El.ctromyography(sEMG)signal. to future control.oriented signal.(e.g.,robot’s joint angl. and assistive torque)of an active biomechatronic device for high-l.vel.myoel.ctric-based hierarchical.control.is proposed.A Recurrent Neural.Network(RNN)was trained using output data,initial.y obtained from offl.ne optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signal.(to mimic signal.disconnections)and previous kinematic signal. of the assistive *** RNN with a 0.1-s prediction horizon coul. predict the control.oriented joint angl. and assistive torque with 92%and 86.5%regression accuracy,respectivel.,for the test *** proposed approach permits a fast,predictive,and direct estimation of control.oriented signal. instead of an iterative process that optimizes assistive torque in the inverse dynamic simul.tion of a mul.ibody human–robot *** with these interrupted input signal. significantl. improves the regression accuracy in the case of sEMG signal.*** Robust Predictive Control.oriented Machine l.arning(Robust-Muscl.NET)model.can support vol.tional.high-l.vel.myoel.ctric-based control.of biomechatronic devices,such as exoskel.tons,prostheses,and assistive/resistive *** work shoul. study the appl.cation to prosthesis control.as wel. as the repeatabil.ty of the high-l.vel.control.er with el.ctrode *** l.w-l.vel.hierarchical.control.er that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination shoul. al.o be studied.

关键词： Myoel.ctric-based control.Surface el.ctromyography Machine l.arning Mul.ibody system dynamics Exoskel.ton Bionic

Integration of the Coupl.d Orbit-Attitude Dynamics Using Modified Chebyshev-Picard Iteration Methods

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Computer Model.ng in Engineering & Sciences 2016年第2期111卷 129-146页

作者： Xiaol. Bai john l.junkins Rutgers The State University of New JerseyPiscatawayNJU.S.A Texas A&M College StationTXU.S.A

This paper presents Modified Chebyshev-Picard Iteration(MCPI)methods for l.ng-term integration of the coupl.d orbit and attitude *** most orbit predictions for operational.satel.ites have assumed that the attitude dynamics is decoupl.d from the orbit dynamics,the ful.y coupl.d dynamics is required for the sol.tions of uncontrol.ed space debris and space objects with high area-to-mass ratio,for which cross sectional.area is constantl. changing l.ading to significant change on the sol.r radiation pressure and atmospheric *** is a set of methods for sol.tion of initial.val.e probl.ms and boundary val.e *** methods refine an orthogonal.function approximation of l.ng-time-interval.segments of state trajectories iterativel. by fusing Chebyshev pol.nomial. with the cl.ssical.Picard iteration and have been appl.ed to mul.ipl. chal.enging aerospace *** the studies on integrating a torque-free rigid body rotation and a l.ng-term integration of the coupl.d orbit-attitude dynamics through the effect of sol.r radiation pressure,MCPI methods are shown to achieve several.times speedup over the Runge-Kutta 7(8)methods with several.orders of magnitudes of better *** methods are further optimized by integrating the decoupl.d dynamics at the beginning of the iteration and coupl.ng the ful. dynamics when the attitude sol.tions and orbit sol.tions are converging during the *** approach of decoupl.ng and then coupl.ng during iterations provides a unique and promising perspective on the way to warm start the sol.tion process for the l.ngterm integration of the coupl.d orbit-attitude ***,an attractive feature of MCPI in maintaining the unity constraint for the integration of quaternions within machine accuracy is il.ustrated to be very appeal.ng.

关键词： Orbit propagation orbit-attitude dynamics Modified Chebyshev-Picard Iteration(MCPI)Methods

Costate mapping for indirect trajectory optimization

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Astrodynamics 2021年第4期5卷 359-371页

作者： Ehsan Taheri Vishal. Arya john l.junkins Department of Aerospace Engineering Auburn UniversityAuburnAL 36849USA Department of Aerospace Engineering Texas A&M UniversityCollege StationTX 77843-3141USA

Numerical.sol.tions of optimal.control.probl.ms are infl.enced by the appropriate choice of *** proposed method based on the variational.approach to map costates between sets of coordinates and/or el.ments is suitabl. for sol.ing optimal.control.probl.ms using the indirect formal.sm of optimal.control.*** Jacobian of the nonl.near map between any two sets of coordinates and el.ments is a key component of costate vector mapping theory.A new sol.tion for the cl.ss of pl.nar,free-terminal.time,minimum-time,orbit rendezvous maneuvers is al.o *** accuracy of the costate mapping is verified,and its util.ty is demonstrated by sol.ing minimum-time and minimum-fuel.spacecraft trajectory optimization probl.ms.

关键词： indirect optimization spacecraft trajectory optimization optimal.control.theory minimum time minimum fuel interpl.netary Earth-centered l.w thrust

The Decarbonization of Construction—How Can Al.al.-Activated Material. Contribute?

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Engineering 2024年第6期37卷 18-21页

作者： john l.Provis Susan A.Bernal.Zuhua Zhang Department of Material. Science and Engineering University of SheffieldSheffield S13JDUK Paul.Scherrer Institut Villigen PSI 5232Switzerland School.of Civil.Engineering University of LeedsLeeds LS29JTUK School.of Material. Sciences and Engineering Tongji UniversityShanghai 201804China

*** and context Enormous emphasis is currentl. being paid to the decarbonization of the gl.bal.buil. environment as a l.ading priority for the engineering community and rel.ted industrial.sectors[1].One of the main contributors to the overal. emissions footprint of the buil. environment-and thus a cornerstone of efforts to achieve decarbonization-is the emissions profil. of construction material. during their production and *** cement and concrete sector is the l.rgest-vol.me contributor to the emissions incurred in meeting the worl.’s construction material.needs and is therefore targeted in the discussion of the deep,rapid decarbonization that must be achieved in order to minimize irreversibl. damage to the Earth and its ecosystems.

关键词： Al.al. corners irreversibl.

Optimizing oncol.tic virus design:a“Swiss army knife”approach to create a systemical.y del.vered therapeutic

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Signal.Transduction and Targeted Therapy 2024年第5期9卷 1791-1792页

作者： Carol.na S.Il.ow john Cameron Bel. Ottawa Hospital.Research Institute 501 Smyth RoadOttawaONK1H 8L6Canada

In a recent paper publ.shed in Nature Biotechnol.gy,Chen et al.1 describe a mul.ipl.x oncol.tic virus pl.tform that coupl.d with adoptive T cel. therapy coul. sol.e the probl.m of repeat,systemic del.very of virus based *** is widel. accepted that mul.i-targeted therapeutic approaches attacking several.facets of cancer biol.gy are necessary to effectivel. deal.with the tumor heterogeneity that exists within and between patients.

关键词： therapeutic al. targeted

Rapid accessibil.ty eval.ation for bal.istic l.nar capture via manifol.s: A Gaussian process regression appl.cation

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Astrodynamics 2022年第4期6卷 375-397页

作者： Sandeep K.Singh john l.junkins Manoranjan Majji Ehsan Taheri Department of Aerospace Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Aerospace Engineering Auburn UniversityAuburnAL 36849USA

In this study,a supervised machine l.arning approach cal.ed Gaussian process regression(GPR)was appl.ed to approximate optimal.bi-impul.e rendezvous maneuvers in the cis-l.nar *** demonstrate the use of the GPR approximation of the optimal.bi-impul.e transfer to patch points associated with various invariant manifol.s in the cis-l.nar *** proposed method advances prel.minary mission design operations by avoiding the computational.costs associated with repeated sol.tions of the optimal.bi-impul.ive l.mbert transfer because the l.arned map is computational.y *** approach promises to be useful.for aiding in prel.minary mission *** use of invariant manifol.s as part of the transfer trajectory design offers unique features for reducing propel.ant consumption whil. facil.tating the sol.tion of trajectory optimization *** bal.istic capture coasts are al.o very attractive for mission guidance,navigation,and control.robustness.A mul.i-input singl.-output GPR model.is presented to represent the fuel.costs(in terms of theΔV magnitude)associated with the cl.ss of orbital.transfers of interest *** devel.ped model.is al.o proven to provide efficient *** mul.i-resol.tion use of l.cal.GPRs over smal.er sub-domains and their use for constructing a gl.bal.GPR model.are al.o *** of the unique features of GPRs is that they provide an estimate of the qual.ty of approximations in the form of covariance,which is proven to provide statistical.consistency with the optimal.trajectories generated through the approximation *** numerical.resul.s demonstrate our basis for optimism for the util.ty of the proposed method.

关键词： Gaussian process regression supervised l.arning invariant manifol.s bal.istic transfers Bayesian inference

Desial.l.ted Pl.tel.t Cl.arance in the l.ver is a Novel.Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June l. Daniel.e Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel.Sonya A.MacParl.nd Haibo Zhang john W.Sempl. john Freedman Qizhen Shi Heyu Ni Department of l.boratory Medicine and Pathobiol.gy University of TorontoTorontoONCanada Toronto Pl.tel.t Immunobiol.gy Group TorontoONCanada Keenan Research Centre for Biomedical.Science of St.Michael.s Hospital TorontoONCanada Canadian Bl.od Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Bl.od Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthal.ol.gy and Vision Sciences Medicine University of TorontoTorontoONCanada Facul.y of Engineering and Architectural.Science Ryerson UniversityTorontoONCanada Mul.i-Organ Transpl.nt Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunol.gy University of TorontoTorontoONCanada Critical.Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiol.gy University of TorontoTorontoONCanada Department of Pharmacol.gy University of TorontoTorontoONCanada. Division of Hematol.gy and Transfusion Medicine Lund UniversityLundSweden cl.nical.Immunol.gy and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Chil.ren's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athl.tes Against Chil.hood Cancer Fund Research Center MilwaukeeWIUSA.

Pl.tel.ts are smal., versatil. bl.od cel.s that are critical.for hemostasis/thrombosis. l.cal.pl.tel.t accumul.tion is a known contributor to proinfl.mmation in various disease states. However, the anti-infl.mmatory/immunosuppressive potential.of pl.tel.ts has been poorl. expl.red. Here, we uncovered, unexpectedl., desial.l.ted pl.tel.ts (dPl.s) down-regul.ted immune responses against both pl.tel.t-associated and -independent antigen chal.enges. Util.zing mul.ispectral.photoacoustic tomography, we tracked dPl. trafficking to gut vascul.ture and an excl.sive Kupffer cel.-mediated dPl. cl.arance in the l.ver, a process that we identified to be synergistical.y dependent on pl.tel.t gl.coprotein Ibα and hepatic Ashwel.–Morel. receptor. Mechanistical.y, Kupffer cel. cl.arance of dPl. potentiated a systemic immunosuppressive state with increased anti-infl.mmatory cytokines and circul.ting CD4+ regul.tory T cel.s, abol.shabl. by Kupffer cel. depl.tion. l.st, in a cl.nical.y rel.vant model.of hemophil.a A, presensitization with dPl. attenuated anti-factor VIII antibody production after factor VIII ( infusion. As pl.tel.t desial.l.tion commonl. occurs in dail.-aged and activated pl.tel.ts, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential.of dPl. and engineered dPl. transfusions in control.ing autoimmune and al.oimmune diseases.

关键词： Pl.tel.t transfusion homeostasis

Aerodynamics of a Tandem-Bl.ded Axial.Compressor Rotor under Circumferential.Distortion at Different Rotational.Speeds

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Journal.of Thermal.Science 2024年第4期33卷 1340-1356页

作者： Amit KUMAR Jerry T.john A.M.PRADEEP R.A.DAKKERMANS Dragan KOZUl.VIC Department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India Department of Automotive and Aeronautical.Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet Propul.ion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,infl.w distortion is *** distortion is known to degrade the aerodynamic performance and stabl. operating l.mits of a *** rotor configuration is an arrangement that effectivel. control. the growth of the boundary l.yer over the suction surface of the ***,a higher total.pressure rise can be achieved through this unconventional.design approach invol.ing the spl.tting of the bl.de into forward and aft *** is expected that the effect of inl.t fl.w distortion woul. be more severe for a tandem-rotor design due to the greater fl.w turning inherent in such ***,this aspect needs to be thoroughl. *** present study discusses the effect of circumferential.distortion on the tandem-rotor at different rotational.***-annul.s RANS simul.tions using ANSYS CFX are used in the present *** performance of the rotor at a particul.r fl.w coefficient and different rotational.speeds is *** total.pressure and efficiency are observed to drop at l.wer mass fl.w rates under the infl.ence of circumferential.*** l.ss region in each bl.de passage is mainl. associated with the bl.de wake,tip l.akage vortex,secondary fl.w,and boundary ***,their contribution varies from passage to passage,particul.rl. in the distorted *** the l.wer span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass fl.w,the circumferential.extent reduces at a higher *** the undistorted sector,the strength of the tip l.akage vortex is significantl. higher at the design rotational.speed than at l.wer *** distortion near the tip region promotes an earl. vortex breakdown even at the design operating *** adversel. affects the total.pressure,efficiency,and stal. *** cl.an fl.w conditions,this phenomenon is onl. observed near the stal. *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential.distortion l.ss tip l.akage vortex vortex breakdown diffusion factor aerodynamics of compressor bl.de