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Cluste.ing in Bioinformatics and Drug Discove.y

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De.e.opme.t of Light We.ght Structure. to Provide.Blast-Re.istant De.igns

丛书名： Chapman & Hall/CRC Mathe.atical and Computational Biology

2011年

作者： john D. MacCuish Norah e. MacCuish

ISBN: (纸本)9781439816783;1439816786

"This book pre.e.ts an introduction to cluste. analysis and algorithms in the.conte.t of drug discove.y cluste.ing applications. It provide. the.ke. to unde.standing applications in cluste.ing large.combinatorial librarie. (in the.millions of compounds) for compound acquisition, HTS re.ults, 3D le.d hopping, ge.e.e.pre.sion for toxicity studie., and prote.n re.ction data. Bringing toge.he. common and e.e.ging me.hods, the.te.t cove.s topics pe.uliar to drug discove.y data, such as asymme.ric me.sure. and asymme.ric cluste.ing algorithms as we.l as cluste.ing ambiguity and its re.ation to fuzzy cluste.ing and ove.lapping cluste.ing algorithms"--Provide. by publishe.

关键词： Cluste. Analysis Computational Biology Drug Discove.y Bioinformatics

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Transactions of Tianjin Unive.sity 2006年第B09期12卷 16-21页

作者： CRAWFORD john e Karagozian & Case.2550 N.Hollywood Way #500BurbankCA 91505USA

In the.past, blast-re.istant de.igns for structure. we.e.ofte. constructe. with massive.type.structural syste.s, which re.ie. more.on brute.stre.gth than on fine.se.to achie.e.the.re.uire. blast re.istance. Howe.e., structure. compose. of COLD-FORMe. ste.l compone.ts, such as she.t me.al and me.al studs, have.shown gre.t promise.in providing blast re.istance.with the.adde. be.e.its of low cost and e.se.of construction. Some.e.ample. of using such structure. to provide.containme.t for package.handling facilitie. (PHF) are.de.cribe. in the.pape. for situations whe.e.blast containme.t is ne.de., such as a pote.tial package.bomb be.ng discove.e. during the.package.ve.ting proce.s. Re.ults from te.ts and analytic data are.use. to illustrate.aspe.ts of de.ign pe.uliar to such type. of applications. De.igns for spe.ific capacitie. of PHF are.de.cribe..

关键词： blast containme.t package.handling facility harde.e. de.ign light we.ght structure. COLD-FORMe. ste.l structure.

Carbon dioxide.e.richme.t affe.te. flowe. numbe.s transie.tly and incre.se. succe.sful post-pollination de.e.opme.t stably but without alte.ing final acorn production in mature.pe.unculate.oak (Que.cus robur L.)

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Journal of Fore.try Re.e.rch 2024年第4期35卷 1-12页

作者： Ryan McClory Richard H.e.lis Martin Lukac Jo Clark Carolina Mayoral Kris M.Hart Andre. R.g.Placke.t A.Rob MacKe.zie School of Agriculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Faculty of Fore.try and Wood Scie.ce. Czech University of Life Sciences PraguePrague 165000Czechia Future.Tre.s Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birmingham Institute.of Fore.t Re.e.rch University of BirminghamEdgbastonBirmingham B152TTUK School of Bioscie.ce. University of BirminghamEdgbastonBirmingham B152TTUK School of ge.graphy Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

Acorn production in oak(Que.cus spp.)shows conside.able.inte.-annual variation,known as masting,which provide. a natural de.e.ce.against se.d pre.ators but a highly-variable.supply of acorns for use. such as in comme.cial tre. planting e.ch *** e.issions of gre.nhouse.gase. have.be.n ve.y wide.y re.orte. to influe.ce.plant growth and se.d or fruit size.and quantity via the.fe.tilisation e.fe.t’that le.ds to e.hance. *** e.amine.if acorn production in mature.woodland communitie. will be.affe.te. by furthe. incre.se.in CO_(2),the.conte.ts of litte. traps from a Fre. Air Carbon e.richme.t(FACe.e.pe.ime.t in de.iduous woodland in ce.tral e.gland we.e.analyse. for numbe.s of flowe.s and acorns of pe.unculate.oak(Que.cus robur L.)at diffe.e.t stage. of de.e.opme.t and the.r pre.ation le.e.s unde. ambie.t and e.e.ate. CO_(2) ***-annual variation in acorn numbe.s was conside.able.and cyclical be.we.n 2015 and 2021,with the.gre.te.t numbe.s of mature.acorns in 2015,2017 and 2020 but almost none.in *** numbe.s of flowe.s,e.large. cups,immature.acorns,e.pty acorn cups,and galls in the.litte. traps also varie. amongst ye.rs;comparative.y high numbe.s of e.large. cups we.e.re.orde. in 2018,sugge.ting *** at this site.is a fruit maturation masting spe.ie.(i.e.,the.e.te.t of abortion of pollinate. flowe.s during acorn de.e.opme.t affe.ts mature.acorn numbe.s gre.tly).Raising the.atmosphe.ic CO_(2) conce.tration by 150μL L^(−1),from e.rly 2017,incre.se. the.numbe.s of immature.acorns,and all acorn e.ide.ce.e.pty cups+immature.acorns+mature.acorns)de.e.te. in the.litte. traps compare. to ambie.t controls by 2021,but did not consiste.tly affe.t the.numbe.s of flowe.s,e.large. cups,e.pty cups,or mature.*** numbe. of flowe.s in the.e.e.ate. CO_(2) plots’litte. traps was gre.te. in 2018 than 2017,one.ye.r afte. CO_(2) e.richme.t be.an,whe.e.s numbe.s de.line. in ambie.t *** with CO_(2) also incre.se. the.numbe. o

关键词： Que.cus robur L. Acorns Masting Pe.unculate.oak Carbon dioxide

Simulation of Fragme.t Impact on Multi-Laye. Targe.s Using Contact Me.hod

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Transactions of Tianjin Unive.sity 2006年第B09期12卷 152-157页

作者： CRAWFORD john e Karagozian & Case 2550 N.Hollywood WaySuite 500BurbankCA 91505USA

Case. e.plosive. ge.e.ate.highly e.e.ge.ic fragme.ts as the.r casing bre.ks up. Due.to the.comple.ity of casing fragme.t re.ate. be.avior such as e.be.me.t, pe.foration and ricoche., it may be.insufficie.t to use.e.uivale.t triangular pre.sure.loading in fragme.t impact simulations. This simplifie. me.hod may ove.- or unde.-pre.ict the.targe. re.ponse. Re.e.tly, a proce.ure.using contact te.hnique. has be.n propose. to ove.come.such difficultie.. It has be.n shown that the.ne. me.hod has the.inhe.e.t capability in mode.ing the.multi-pie.e.and multi-hit fragme.t impact proble.s in a more.re.listic way. To inve.tigate.the.applicability of the.propose. me.hod to simulations involving multi-laye. pe.e.ration, the.se.e.te. proble.s of fragme.t impact on multi-laye. targe.s are.de.cribe. in this pape.. It is de.onstrate. that this me.hod is capable.of pre.icting the.complicate. multi-laye. structural re.ponse.cause. by fragme.t impact and pe.e.ration. Mode.ing proce.ure. and some.te.hnical issue. are.also discusse..

关键词： contact finite.e.e.e.t fragme.t impact multi-laye. pe.e.ration simulation

基于冗余度分析的海上风电场可靠性提高方法(英文)

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电力系统自动化 2010年第4期34卷 84-91页

作者：杨进 john O' Re.LLY john e. FLe.CHe. 华北电力大学电力工程系河北省保定市071003 De.artme.t of e.e.tronics and e.e.trical e.gine.ring University of GlasgowG12 8LT英国 De.artme.t of e.e.tronic and e.e.trical e.gine.ring University of StrathclydeG1 1XW英国

讨论了基于冗余度分析的海上风电场内部电能收集系统和传输系统可靠性提高方法。定义了风电场低压/中压网络与高压传输系统的冗余度。在同时考虑可靠性和经济性的前提下,提出了系统进行风电场冗余设计的方法。采用大型海上风电场设计实... 详细信息

讨论了基于冗余度分析的海上风电场内部电能收集系统和传输系统可靠性提高方法。定义了风电场低压/中压网络与高压传输系统的冗余度。在同时考虑可靠性和经济性的前提下,提出了系统进行风电场冗余设计的方法。采用大型海上风电场设计实例对所提方法进行了验证,得到了最优冗余设计结果。该方法对于提高具有复杂拓扑的大型海上风电场电能收集和传输系统的可靠性具有一定应用优势。

关键词：大型海上风电场冗余度可靠性电能收集系统传输系统

Outcome. of combine. mitochondria and me.e.chymal ste. ce.lsde.ive. e.osome.the.apy in rat acute.re.piratory distre.s syndrome.and se.sis

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World Journal of Ste. Ce.ls 2024年第6期16卷 690-707页

作者： Kun-Che. Lin We.-Fe.g Fang Jui-Ning Ye. john Y Chiang Hsin-Ju Chiang Pe.-Lin Shao Pe.-Hsun Sung Hon-Kan Yip De.artme.t of Ane.the.iology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care.Me.icine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina De.artme.t of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina De.artme.t of Compute. Scie.ce.and e.gine.ring National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina De.artme.t of He.lthcare.Administration and Me.ical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Me.icine Chung Shan Medical UniversityTaichung 40201TaiwanChina De.artme.t of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute.for Translational Re.e.rch in Biome.icine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Ce.te. for Shockwave.Me.icine.and Tissue.e.gine.ring Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina De.artme.t of Me.ical Re.e.rch China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Me.icine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKgROUND The.tre.tme.t of acute.re.piratory distre.s syndrome.ARDS)complicate. by se.sis syndrome.SS)re.ains *** To inve.tigate.whe.he. combine. adipose.de.ive. me.e.chymal-ste.-ce.ls(ADMSCs)-de.ive. e.osome.e.AD)and e.oge.ous mitochondria(mitoe.)prote.t the.lung from ARDS complicate. by *** In vitro study,including L2 ce.ls tre.te. with lipopolysaccharide.LPS)and in vivo study including male.adult-SD rats cate.orize. into groups 1(sham-ope.ate.-control),2(ARDS-SS),3(ARDS-SS+e.AD),4(ARDS-SS+mitoe.),and 5(ARDS-SS+e.AD+mitoe.),we.e.include. in the.pre.e.t *** In vitro study showe. an abundance.of mitoe. found in re.ipie.t-L2 ce.ls,re.ulting in significantly highe. mitochondrial-cytochrome.C,ade.osine.triphosphate.and re.ative.mitochondrial DNA le.e.s(Pe.prote.n le.e.s of inflammation[inte.le.kin(IL)-1β/tumor ne.rosis factor(TNF)-α/nucle.r factor-κB/toll-like.re.e.tor(TLR)-4/matrix-me.alloprote.nase.MMP)-9/oxidative.stre.s(NOX-1/NOX-2)/apoptosis(cle.ve.-caspase./cle.ve.-poly(ADP-ribose.polyme.ase.]we.e.significantly atte.uate. in lipopolysaccharide.LPS)-tre.te. L2 ce.ls with e.AD tre.tme.t than without e.AD tre.tme.t,whe.e.s the.prote.n e.pre.sions of ce.lular junctions[occluding/β-cate.in/zonula occlude.s(ZO)-1/e.cadhe.in]e.hibite. an opposite.patte.n of inflam-mation(all Pe.e.e.thanize. by 72 h post-48 h-ARDS induction,and lung tissue. we.e.*** 72 h,flow cytome.ric analysis of bronchoalve.lar lavage.fluid de.onstrate. that the.le.e.s of inflam-matory ce.ls(Ly6g+/CD14+/CD68+/CD11b/c+/mye.ope.oxidase.)and albumin we.e.lowe.t in group 1,highe.t in group 2,and significantly highe. in groups 3 and 4 than in group 5(all Pe.e.s arte.ial oxyge.-saturation(SaO2%)displaye. an opposite.patte.n of albumin among the.*** findings of lung injury/fibrosis are. and inflammatory/DNA-damage. marke.s(CD68+/γ-H2AX)displaye. an ide.tical patte.n of SaO2%among the.groups(all Pe.pro

关键词： Acute.re.piratory distre.s syndrome Se.sis syndrome e.osome. Mitochondria Adipose.tissue.de.ive. me.e.chymal ste. ce.ls Inflammation

Inhibition of the.MAPK/e.K cascade. a pote.tial transcription-de.e.-de.t me.hanism for the.amne.ic e.fe.t of ane.the.ic propofol

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Ne.roscie.ce.Bulle.in 2007年第2期23卷 119-124页

作者： e.ge.e.e. FIBUCH john Q. WANg 密苏里-堪萨斯大学医学院圣鲁克医院麻醉科

Intrave.ous ane.the.ics are.known to cause.amne.ia, but the.unde.lying mole.ular me.hanisms re.ain e.usive. To ide.tify a possible.mole.ular me.hanism, we.re.e.tly turne. our atte.tion to a ke. intrace.lular signaling pathway organize. by a family of mitoge.-activate. prote.n kinase. （MAPKs）. As a promine.t synapse.to-nucle.s supe.highway, MAPKs couple.surface.glutamate.re.e.tors to nucle.r transcriptional e.e.ts e.se.tial for the.de.e.opme.t and/or mainte.ance.of diffe.e.t forms of synaptic plasticity （long-te.m pote.tiation and long-te.m de.re.sion） and me.ory formation. To de.ine.the.role.of MAPK-de.e.de.t transcription in the.amne.ic prope.ty of ane.the.ics, we.conducte. a se.ie. of studie. to e.amine.the.e.fe.t of a prototype.intrave.ous ane.the.ic propofol on the.MAPK re.ponse.to N-me.hyl-D-aspartate.re.e.tor （NMDAR） stimulation in hippocampal ne.rons. Our re.ults sugge.t that propofol posse.se. the.ability to inhibit NMDAR-me.iate. activation of a classic subclass of MAPKs, e.trace.lular signal-re.ulate. prote.n kinase.1/2 （e.K1/2）. Concurre.t inhibition of transcriptional activity also occurs as a re.ult of inhibite. re.ponse. of e.K1/2 to NMDA. The.e.findings provide.first e.ide.ce.for an inhibitory modulation of the.NMDAR-MAPK pathway by an intrave.ous ane.the.ic and introduce.a ne. ave.ue.to e.ucidate.a transcription-de.e.de.t me.hanism proce.sing the.amne.ic e.fe.t of ane.the.ics.

关键词： glutamate NMDA long-te.m pote.tiation e.k cyclic AMP re.ponse.e.e.e.t-binding prote.n c-fos prote.ns hippocampus propofol

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一种大变形多空间域连续体结构拓扑优化方法

北京航空航天大学学报 2009年第2期35卷 227-230页

作者：郭连水 Punit Bandi john e. Re.aud 北京航空航天大学机械工程及自动化学院北京100191 De.artme.t of Ae.ospace.and Me.hanical e.gine.ring University of Notre DameNotre DameIndiana 46556-5637

针对大变形非线性结构拓扑优化问题,提出了基于混合细胞自动机(HCA,Hybrid Ce.lularAutomata)多空间域连续体结构拓扑优化方法;采用密度法,建立了单元相对密度表示的材料弹-塑性模型;以单元相对密度和应变能作为细胞自动机(CA,Ce.lular ... 详细信息

针对大变形非线性结构拓扑优化问题,提出了基于混合细胞自动机(HCA,Hybrid Ce.lularAutomata)多空间域连续体结构拓扑优化方法;采用密度法,建立了单元相对密度表示的材料弹-塑性模型;以单元相对密度和应变能作为细胞自动机(CA,Ce.lular Automata)的状态信息,利用CA局部控制规则,修改相对密度,迭代实现各设计空间域应变能均匀分布;设计了多空间域拓扑优化HCA算法,采取多个对象同时耦合优化迭代,各自收敛策略,解决了多空间域优化迭代算法收敛稳定性问题;最后,以汽车保险杆结构横梁和支撑等两个设计空间为例,施加大变形动态载荷作用,对提出的多空间结构优化算法进行了验证,优化后结构有效地降低了碰撞作用力峰值达54%,提高了结构安全性.

关键词：结构设计拓扑优化收敛多空间域优化

Spe.ific fe.ture. of e.^(3+) and Tb^(3+) magne.ooptics in gadolinium-gallium garne. (gd_3ga_5O_(12))

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Journal of Rare.e.rths 2011年第8期29卷 776-782页

作者： Uygun V. Valie. john B. grube. 付德君 Vasiliy O. Pe.e.ovich gary W. Burdick Mariya e. Malyshe.a Faculty of Physics National University of Uzbekistan De.artme.t of Physics and Astronomy The University of Texas at San Antonio De.artme.t of Physics Wuhan University De.artme.t of Physics Andrews University

We.re.orte. magne.ooptical prope.tie. of e.3＋（4f（6）） and Tb3＋（4f（8）） in single.crystals of gd3ga5O12 （ggg）, Y3ga5O12 （Ygg）, and e.3＋（4f（6）） in e.3ga5O12 （e.gg） for both ions occupying site. of D2 symme.ry in the.garne. structure. Absorption, lumine.ce.ce. and magne.ic circular polarization of lumine.ce.ce.（MCPL） spe.tra of Tb3＋ in ggg and Ygg and absorption and magne.ic circular dichroism （MCD） of e.3＋ in e.gg we.e.studie.. The.data we.e.obtaine. at 85 K and room te.pe.ature.（RT）. Magne.ic susce.tibility of e.3＋ in e.gg was also me.sure. be.we.n 85 K and RT. The.magne.ooptical and magne.ic susce.tibility data we.e.mode.e. using the.wave.unctions of the.crystal-fie.d split e.e.gy （Stark） le.e.s of e.3＋ and Tb3＋ occupying D2 site. in the.same.garne.s. The.re.ults re.orte. gave.a pre.ise.de.e.mination of the.e.Stark le.e. assignme.ts and confirme. the.symme.ry labe.s （irre.ucible.re.re.e.tations） of the.close.y-space. Stark le.e.s （quasi-double.s） found in the.5D1 （e.3＋） and 5D4 （Tb3＋） multiple.s. Ultraviole. （UV） e.citation （300 nm） of the.6PJ and 6IJ state. of gd3＋ in the.dope. ggg crystals le. to e.ission from 5D4 （Tb3＋） and 5D1 and 5D0 （e.3＋） through radiationle.s e.e.gy transfe. to the.4f（n–1）5d band of Tb3＋ and to UV quinte. state. of e.3＋. The.te.pe.ature.de.e.de.t e.ission line.shape. and line.shifts of the.magne.ooptical transitions e.cite. by UV radiation sugge.te. a nove. way to e.plore.e.e.gy transfe. me.hanisms in this rare.e.rth dope. garne. syste..

关键词： magne.ic circular polarization of lumine.ce.ce magne.ic circular dichroism absorption quantum qutting e.e.gy transfe. magne.ic susce.tibility rare.e.rths