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Inflammat.on-relat.d gene expression profiles of salivary ext.acellular vesicles in pat.ent. wit. head t.auma

Neural Regenerat.on Research 2020年第4期15卷 676-681页

作者： Yan Cheng Mandy Pereira Neha P.Raukar john L.Reagan Mat.ew Quesenberry Laura Goldberg t.eodor Borgovan W Curt.LaFrance jr.Mark Dooner Maria Deregibus Giovanni Camussi Bharat.Ramrat.am Pet.r Quesenberry Depart.ent.of Medicine Division of Hematology/OncologyRhode Island HospitalProvidenceRIUSA Depart.ent.of Emergency Medicine Mayo ClinicRochesterMNUSA Depart.ent.of Psychiat.y and Neurology Rhode Island HospitalProvidenceRIUSA Depart.ent.of Medicine Division of Infectious DiseasesRhode Island HospitalProvidenceRIUSA Depart.ent.of Medical Sciences University of TurinTorino TOItaly

At.present.t.ere is no reliable biomarker for t.e diagnosis of t.aumat.c brain injury(t.I).St.dies have shown t.at.ext.acellular vesicles released by damaged cells int. biological fluids can be used as pot.nt.al biomarkers for diagnosis of t.I and evaluat.on of t.I *** hypot.esize t.at.t.e genet.c profile of salivary ext.acellular vesicles in pat.ent. wit. head t.auma differs from t.at.in uninjured *** from t.is hypot.esis would help invest.gat. t.e severit. of *** st.dy included 19 subject.,consist.ng of seven healt.y cont.ols who denied hist.ry of head t.auma,six pat.ent. diagnosed wit. concussion injury from an out.at.ent.concussion clinic,and six pat.ent. wit. t.I who received t.eat.ent.in t.e emergency depart.ent.wit.in 24 hours aft.r ***-t.me PCR analysis of salivary ext.acellular vesicles in part.cipant. was performed using t.qMan Human Inflammat.on *** expression analysis revealed nine upregulat.d genes in emergency depart.ent.pat.ent.(LOX5,ANXA3,CASP1,IL2RG,It.AM,It.B2,Lt.4H,MAPK14,and t.FRSF1A)and 13 upregulat.d genes in concussion clinic pat.ent. compared wit. healt.y part.cipant.(ADRB1,ADRB2,BDKRB1,HRH1,HRH2,Lt.4R2,Lt.4R,Pt.FR,CYSLt.1,CES1,KLK1,MC2R,and Pt.ER3).Each pat.ent.group had a unique *** bet.een groups showed t.at.15 inflammat.on-relat.d genes had significant.expression *** result. indicat. t.at.inflammat.on biomarkers can be used for diagnosis of t.I and evaluat.on of disease *** st.dy was approved by t.e Inst.t.t.onal Review Board on December 18,2015(approval No.0078-12)and on June 9,2016(approval No.4093-16).

关键词： chronic t.aumat.c encephalopat.y emergency depart.ent ext.acellular vesicles inflammat.on out.at.ent concussion clinic real-t.me PCR analysis saliva t.aumat.c brain injury

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直销在变化中保持不变

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知识经济．中国直销 2017年第5期 102-103页

作者： john t. Fleming 程小琴不详《知识经济.中国直销》编辑部

这篇文章的标题虽然听起来很矛盾，但它几乎是每个直销公司的真实写照。

关键词：直销公司直销行业发展现状市场竞争

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Gene Discovery and Funct.onal Analyses in t.e Model Plant.Arabidopsis

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Journal of Int.grat.ve Plant.Biology 2006年第1期48卷 5-14页

作者： Cai-Ping Feng john Mundy Inst.t.t. of Loess Plat.au Shanxi University Taiyuan 030006 China Inst.t.t. of Molecular Biology Copenhagen University （~ster Farimagsgade 2A DK-1353 Copenhagen K Denmark

t.e present.mini-review describes newer met.ods and st.at.gies, including t.ansposon and t.DNA insert.ons, t.LLING, Delet.agene, and RNA int.rference, t. funct.onally analyze genes of int.rest.in t.e model plant.Arabi... 详细信息

关键词： Arabidopsis funct.onal genomics mut.genesis reverse genet.cs.

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Prevalence and Risk Fact.rs Associat.d wit. &lt.i&gt.Campylobact.r&lt./i&gt.Infect.on in Diarrheal Pat.ent. in Busia Count., Kenya

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Advances in Microbiology 2021年第11期11卷 657-680页

作者： t.m t. Ouko Andrew K. Nyerere john M. Njeru Eric M. Fèvre Samuel Kariuki Cent.e for Microbiology Research Kenya Medical Research Institute Nairobi Kenya Depart.ent.of Medical Microbiology Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Inst.t.t. of Infect.on Veterinary and Ecological Sciences University of Liverpool Liverpool United Kingdom Int.rnat.onal Livest.ck Research Inst.t.t. Nairobi Kenya

Int.oduct.on: Campylobact.r are zoonot.c bact.ria t.at.cause gast.oent.rit.s worldwide wit. t.e species, Campylobact.r jejuni and Campylobact.r coli commonly associat.d wit. human diarrhea. t.ansmission is mainly t.rough direct.cont.ct.wit. farm animals, consumpt.on of chicken and cont.minat.d wat.r. t.ere is paucit. of dat. on t.e epidemiology of Campylobact.r in developing count.ies despit. it. global widespread and expansion of poult.y farming;hence t.ere is t.e need t. explore and build on t.e available dat.. t.is st.dy aimed at.det.rmining prevalence and homest.ad risk pract.ces associat.d wit. Campylobact.r infect.on in diarrheal pat.ent. in Busia Count.. Met.ods: A cross-sect.onal st.dy was conduct.d from February, 2017 t. April, 2019. St.ol samples were collect.d from pat.ent. of all ages at.ending Busia Count. referral Hospit.l and st.uct.red quest.onnaires on homest.ad associat.d risk pract.ces administ.red. Isolat.on and ident.ficat.on of Campylobact.r species was performed using st.ndard cult.re met.od on Modified Charcoal Cefoperazone Deoxycholat. medium and confirmed by mPCR. Fact.rs associat.d wit. Campylobact.r infect.on were evaluat.d using logist.c regression analysis. Result.: A t.t.l of 132 (11.6%) Campylobact.r comprising 89.2% C. jejuni and 10.8% C. coli were isolat.d from 1200 diarrhoegenic pat.ent. sampled. Isolat.on rat. was higher in children aged t. 2 - 5 years (10.2%) and >5 years (9.4%). Mult.level logist.c models showed t.at.homest.ad poult.y farming was a significant.risk associat.d wit. Campylobact.r infect.on in t.o (OR) 9.02;95% CI: 3.19 - 25.47, P 5 years (OR 10.05;95% CI: 2.60 - 24.29, P t.er homest.ad risk pract.ces linked t. children t.r (OR 7.43, 95% CI: 1.70 - 16.33, P <

关键词： Risk Fact.rs Prevalence Diarrhea Campylobact.r

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Devolut.on of St.. Ana Davao Port. t.en and Now

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Int.rnat.onal Relat.ons and Diplomacy 2014年第10期2卷 691-696页

作者： Saidamin P. Bagolong Neil john t. Audan Angelica Faye G. Cameguing Sunshine B. Cordero t.e Universit. of Mindanao Davao City Philippines

Bet.er seaport.operat.on is one of t.e indicat.rs t.at.a cit. is achieving it. goals t.wards progress and development. t.e St.. Ana Davao Port.for example is one of t.e many seaport. in Region XI t.at.cat.rs t. t.ousands of passengers going from one t.rminal t. anot.er and from one island t. anot.er. In t.is st.dy, it.will revisit.t.e st.t.s of St.. Davao Port.from t.e t.me when it.was devolved from t.e nat.onal goverrmaent.under Philippine Port. Aut.orit. （PPA） t. local government.of Davao Cit.. t.e devolut.on was in accordance wit. t.e Memorandum of Agreement.by t.o part.es, which clearly st.pulat.s t.e full-cont.ol of operat.on of t.e local government.of Davao Cit. wit. an end view of bringing more invest.rs, t.urist.hubs and ot.er business relat.d concerns. t.is st.dy ut.lized descript.ve-evaluat.ve met.od using int.rview guide quest.on as a qualit.t.ve approach in gat.ering dat.. t.e part.cipant. were t.e former employees of t.e PPA and t.e current.management.of St.. Ana Davao Port.under t.e local government. Dat. gat.ered were analyzed using Nvivo soft.are for qualit.t.ve research and cont.nt.analysis t. obt.in fact.al informat.on direct.from t.e part.cipant.. It.was found out.t.at.most.of t.e employees agreed t.at.t.e office needs improvement.in t.rms of physical, financial and human aspect.. For several years, t.e passengers of bot. local and foreign shipping lines were complaining on it. limit.d bert.ing capacit.es, sat.rat.d cont.iner yards and even worse t.e collapse of t.e bert.ing area which result.d t. t.e delay of t.ansact.ons in t.e operat.on of t.e vessels. In spit. of employees claimed t.at.prior t. devolut.on of St.. Ana Davao Port.t. t.e local government.of Davao Cit., t.e operat.on was well-managed and maint.ined, t.ereby result.d t. passengers＇ sat.sfact.on. t.us, t.e researchers aimed t. provide an act.on plan as basis by t.e management.of t.e St.. Davao Port.t. achieve it. vision, missions and goals.

关键词： port.operat.on St.. Ana Davao Port devolut.on public administ.at.on local government Davao Philippines

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New Relat.onships Bet.een St.enrod Operat.ons for Cert.in Spaces

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Act. Mat.emat.ca Sinica,English Series 1992年第1期8卷 99-111页

作者： john Klippenst.in Depart.ent.of Mat.emat.cs University of British Columbia VancouverB.C.Canada V6T 1Y4

In t.is paper,we show t.at.under a cert.in t.chnical condit.on,if a space has no2-t.rsion,t.en eit.er Sq~2~nx≠0 or t.ere exist. some y wit. Sq~2~ny=Sq~(2)x,if for somen≥3 Sq~(2)x≠*** proof uses relat.ons bet.een St...

关键词： Connect.ve K-t.eory t.rsion free spaces Adams operat.ons St.enrod operat.ons Adams spect.al sequence

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＂Bodyheart.inding＂（Xin ,心）： Reconceiving t.e Inner Self and t.e Out.r World in t.e Language of Holographic Focus and Field

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Front.ers of Philosophy in China 2015年第2期10卷 167-180页

作者： Roger t. Ames Depart.ent.of Philosophy University of Hawai'i Honolulu HI 96822 USA

In t.is essay, inspired by t.e somat.c t.rn in philosophy init.at.d by Richard Shust.rman, I want.t. invoke t.e language of classical Confucian philosophy t. t.ink t.rough t.e best.effort. of William James and john Dewey t. escape t.e mind-body and nat.re-nurt.re dualisms--t.at.is, t. offer an alt.rnat.ve vocabulary t.at.might.lend furt.er clarit. t. t.e revolut.onary insight. of James and Dewey by appealing t. t.e processual cat.gories of Chinese cosmology. What.I will t.y t. do first.is t. refocus t.e pragmat.st.s explanat.on of t.e relat.onship bet.een mind and body t.rough t.e lens of a process Confucian cosmology. And t.en, t. make t.e case for James and Dewey, I will ret.rn t. t.e radical, imagist.c language t.ey invoke t. t.y and make t.e argument.t.at.t.is processual, holist.c underst.nding of ＂vit.l bodyminding＂ is in fact.what.t.ey were t.ying t. say all along.

关键词： Richard Shust.rman john Dewey William James dualism,"bodyheat.inding," cosmology Chinese medicine holography focus-field,int.mal relat.ons aspect.al language pragmat.sm somaest.et.cs

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Suit.bilit. of Soil Wat.r Ret.nt.on Charact.rist.c Models (SWRC) in Regions and Soil Dept.

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Journal of Wat.r Resource and Prot.ct.on 2019年第6期11卷 740-747页

作者： Vit.lis K. t.o Christ.an t. Omut. Elijah K. Biamah john P. O. Obiero Depart.ent.of Environment.l and Biosyst.ms Engineering University of Nairobi Nairobi Kenya

Soil Wat.r Ret.nt.on Charact.rist.cs (SWRC) models have been widely used in many applicat.ons. Present.y, t.ere are many models in t.e lit.rat.re and many more st.ll being developed so much so t.at.it.is confusing which model t. prefer. t.e current.choice of t.e appropriat. model t. use has not.been well guided by any incisive research on t.e predict.ve performance of t.ese models. Consequent.y, SWRC model applicat.ons have been largely moved by convenience. t.is st.dy used a global dat.set.t. evaluat. 12 commonly used SWRC models. t.e measured dat. ont. which t.e models were evaluat.d was grouped int. different.soil dept.s and different.regions of t.e world. t.e evaluat.on used correlat.on, Nash-Sut.liffe efficiency, and residual st.ndard error st.t.st.cs t. choose t.e best.overall performing model and models for each cat.gory. It.gives an indicat.on of t.e t.pe of SWRC models t. use in different.regions of t.e world and dept.s of sampling. t.e suit.bilit. of t.e models t. regions showed t.at.t.e Fredlund and Xing model had t.e best.performance in subsoils in Africa;Omut. in Sout.ern Asia;and van Genucht.n in subsoils of t.e ot.er regions. It.is recommended t.at.many more models be t.st.d using t.e procedures in t.is st.dy so t.at.benchmarks can be est.blished on SWRC model select.on suit.ble for various regions.

关键词： Soil Wat.r Ret.nt.on Charact.rist.c Soil Propert.es Ret.nt.on Models

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Modulat.on of Oxidat.ve St.ess Responses by Vit.min E, or Vit.min A plus Vit.min C t.eat.ent.in Human Ret.nal Pigment.Epit.elial Cells

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Nat.ral Science 2015年第12期7卷 558-570页

作者： Jinggang Yin Christ.na S. Winborn Fridt.of t.omas Quynh t. t.an john C. Lang Edward Chaum From t.e Depart.ent. of Opht.almology University of Tennessee Health Science Center Memphis USA Prevent.ve Medicine University of Tennessee Health Science Center Memphis USA Depart.ent.of Chemist.y and Biochemist.y University of Texas at Arlington Arlington USA Anat.my and Neurobiology University of Tennessee Health Science Center Memphis USA

t.e purpose of t.is st.dy was t. charact.rize t.e pot.nt.al of vit.mins t. prot.ct.t.e ret.nal pig-ment.epit.elium (RPE) from oxidat.ve st.ess (OS). We have previously shown t.at.OS induces t.e expression of AP1 t.anscript.on fact.rs (FOSB, CFOS and At.3), but.is modulat.d by pret.eat.ent.wit. vit.min C (200 μM). We propose t.at.OS-induced AP1 expression can be used as a biomarker of OS t. t.st.t.e efficacy of vit.mins t. limit.t.e impact.of OS in t.e RPE. Here we examined t.e efficacy of vit.min E or combined vit.min A plus vit.min C t. modulat. OS-induced AP1 expression in t.e RPE. We pret.eat.d human ARPE-19 cells wit. vit.min E (0 - 7.5 μM) or wit. combined vit.min A (10 or 15 μM) plus vit.min C (50 or 100 μM) for 3 days prior t. exposure t. 500 μM H2O2 OS for 1 - 4 h. AP1 expression was assessed using qRt.PCR. Pret.eat.ent.wit. ≥2.5 μM vit.min E significant.y decreased OS-induced AP1 expression at.1 - 4 h OS, compared t. cont.ols. Lower doses of vit.min E were ineffect.ve at.modulat.ng OS responses. Pret.eat.ent.wit. 100 μM vit.min C combined wit. 15 μM vit.min A prot.ct.d RPE cells from OS-induced AP1 expression. t.ere is an addit.ve and pot.nt.ally prot.ct.ve effect.of 100 μM vit.min C and 15 μM vit.min A on FOSB expression at.4 h, and a pot.nt.ally prot.ct.ve effect.of 100 μM vit.min C and 15 μM vit.min A on CFOS expression at.1 h OS. A prot.ct.ve effect.was also seen wit. 15 μM vit.min A pret.eat.ent.alone on At.3 expression. t.us, “sub-t.erapeut.c” levels of mult.ple vit.mins may prot.ct.RPE cells bet.er t.an higher doses of a single vit.min. t.is OS-induced AP1 expression biomarker assay may be useful t. ident.fy complex ant.oxidant.formulat.ons as t.erapeut.cs for degenerat.ve diseases t.at.are t.ought.t. be caused by OS, like age-relat.d macular degenerat.on.

关键词： Vit.min Supplement.t.on AP1 t.anscript.on Fact.rs Oxidat.ve St.ess Ret.nal Pigment Epit.elium Age-Relat.d Macular Degenerat.on

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t.e Microenvironment.wit.in and Pollen t.ansmission t.rough Polyet.ylene Sorghum Pollinat.on Bags

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American Journal of Plant.Sciences 2015年第2期6卷 265-274页

作者： Dennis C. Git. Jeffrey t. Baker Zhanguo Xin john J. Burke Robert.J. Lascano Unit.d St.t.s Depart.ent.of Agricult.re-Agricult.ral Research Service# Wind Erosion and Water Conservation Unit Lubbock Texas USA Unit.d St.t.s Depart.ent.of Agricult.re-Agricult.ral Research Service Wind Erosion and Water Conservation Unit Big Spring Texas USA Unit.d St.t.s Depart.ent.of Agricult.re-Agricult.ral Research Service Plant Stress and Germplasm Development Unit Lubbock Texas USA

Bird damage is a problem in sorghum breeding and germplasm maint.nance operat.ons. Paper pollinat.on bags are damaged by rain and provide minimal det.rrent.t. birds. Earlier we report.d upon bird resist.nce of spun polyet.ylene pollinat.on bags. Herein, we report.t.e pot.nt.al for pollen t.ansmission t.rough, and t.e microenvironment.wit.in, hard form (Hft. and soft.form (Sft. spun polyet.ylene pollinat.on bags as compared t. t.adit.onal Paper pollinat.on bags. Wit.in Paper pollinat.on bags morning t.mperat.res were 10°C - 15°C above ambient.and high t.mperat.re excursions as high as 45°C were measured. Heat.ng in Sft.and Hft.was 25% and 50% t.at.of Paper, respect.vely. t.mperat.re differences bet.een bags were at.ribut.d t. differences in albedo and air permeabilit. of t.e bag mat.rials. No difference in pollen t.ansmission t.rough Paper and Hft.was found. Alt.ough Sft.allowed 35% - 40% wind borne pollen t.rough t.e pores as compared t. cont.ols, male st.rile plant. covered wit. Sft.produced only 30 seeds/panicle, about.1% of a self-pollinat.ng fert.le plant. Our result. suggest.d t.at.Sft.could adequat.ly reduce or eliminat. cross-pollinat.on in self-pollinat.ng plant. while maint.ining near ambient.environment.l condit.ons.

关键词： Sorghum Breeding Pollinat.on Bags Bird Damage

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