Prevalence and Risk Factors Associated with <i>Campylobacter</i>Infection in Diarrheal Patients in Busia County, Kenya

作     者：Tom T. Ouko Andrew K. Nyerere John M. Njeru Eric M. Fèvre Samuel Kariuki Tom T. Ouko;Andrew K. Nyerere;John M. Njeru;Eric M. Fèvre;Samuel Kariuki

作者机构：Centre for Microbiology Research Kenya Medical Research Institute Nairobi Kenya Department of Medical Microbiology Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Institute of Infection Veterinary and Ecological Sciences University of Liverpool Liverpool United Kingdom International Livestock Research Institute Nairobi Kenya 

出 版 物：《Advances in Microbiology》 (微生物学（英文）)

年 卷 期：2021年第11卷第11期

页      面：657-680页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Risk Factors Prevalence Diarrhea Campylobacter 

摘      要：Introduction: Campylobacter are zoonotic bacteria that cause gastroenteritis worldwide with the species, Campylobacter jejuni and Campylobacter coli commonly associated with human diarrhea. Transmission is mainly through direct contact with farm animals, consumption of chicken and contaminated water. There is paucity of data on the epidemiology of Campylobacter in developing countries despite its global widespread and expansion of poultry farming;hence there is the need to explore and build on the available data. This study aimed at determining prevalence and homestead risk practices associated with Campylobacter infection in diarrheal patients in Busia County. Methods: A cross-sectional study was conducted from February, 2017 to April, 2019. Stool samples were collected from patients of all ages attending Busia County referral Hospital and structured questionnaires on homestead associated risk practices administered. Isolation and identification of Campylobacter species was performed using standard culture method on Modified Charcoal Cefoperazone Deoxycholate medium and confirmed by mPCR. Factors associated with Campylobacter infection were evaluated using logistic regression analysis. Results: A total of 132 (11.6%) Campylobacter comprising 89.2% C. jejuni and 10.8% C. coli were isolated from 1200 diarrhoegenic patients sampled. Isolation rate was higher in children aged 5 years (9.4%). Multilevel logistic models showed that homestead poultry farming was a significant risk associated with Campylobacter infection in 5 years (OR 10.05;95% CI: 2.60 - 24.29, P 0.001). Other homestead risk practices linked to children 2 years were drinking of pond water (OR 7.43, 95% CI: 1.70 - 16.33, P