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Metal alginates for polyphenol delivery systems: Studies on crosslinking ions and easy-to-use patches for release of protective flavonoids in skin

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Bioactive Materials 2020年第3期5卷 447-457页

作者： João Silva Pavlo Vanat Dorinda Marques-da-Silva joaquim rui rodrigues Ricardo Lagoa School of Technology and Management Polytechnic Institute of LeiriaPortugal Laboratório Associado LSRE-LCM School of Technology and ManagementPolytechnic Institute of LeiriaPortugal UCIBIO-Faculty of Science and Technology NOVA University of LisbonPortugal

Incorporation of bioactive natural compounds like polyphenols is an attractive approach for enhanced functionalities of *** particular flavonoids have important pharmacological activities,and controlled release systems may be instrumental to realize the full potential of these *** presents interesting attributes for dermal and other biomaterial applications,and studies were carried here to support the development of polyphenol-loaded alginate *** of capillary viscosity indicated that ionic medium is an effective strategy to modulate the polyelectrolyte effect and viscosity properties of *** gelation,considerable differences were observed between alginate gels produced with Ca^2+,Ba^2+,Cu^2+,Fe^2+,Fe^3+and Zn^2+as crosslinkers,especially concerning shrinkage and morphological *** assays with different polyphenols in the presence of alginate-gelling cations pointed to the choice of calcium,barium and zinc as safer ***-based films loaded with epicatechin were prepared and the kinetics of release of the flavonoid *** results with calcium,barium and zinc alginate matrices indicated that the release dynamics is dependent on film thicknesses,but also on the crosslinking metal *** these grounds,an alginate-based system of convenient use was devised,so that flavonoids can be easily loaded at simple point-of-care conditions before dermal *** epicatechin-loaded patch was tested on an ex-vivo skin model and demonstrated capacity to deliver therapeutically relevant concentrations on skin ***,the flavonoid released was not modified and retained full antioxidant *** alginate-based system proposed offers a multifunctional approach for flavonoid controllable delivery and protection of skin injured or under risk.

关键词： Topical drug delivery Intrinsic viscosity Biopolymer Epigallocatechin-gallate Antioxidant dressing

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Engineering nanoparticles for targeting rheumatoid arthritis： Past, present, and future trends

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Nano Research 2018年第9期11卷 4489-4506页

作者： Isabel Matos Oliveira Cristiana Goncalves rui Lufs Reis joaquim Miguel Oliveira B's Research Group - Biomatefials Biodegradables and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark 4805-017 Barco Guimaraes Portugal ICVS/3B's-PTGovernment Associate Laboratory University of Minho Campus de Gualtar 4710-057 Braga Portugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of Minho Avepark 4805-017 Barco Guimaraes Portugal

Rheumatoid arthritis （RA） is a chronic inflammatory disease characterized by synovial joint inflammation and cartilage and bone tissue destruction. Although there exist some treatment strategies for RA, they are not completely safe and effective. Therefore, it is important to develop and test new drugs for RA that specifically target inflamed/swollen joints and simultaneously attenuate other possible damages to healthy tissues. Nanotechnology can be a good alternative to consider when envisioning predse medication for treating RA. Through the use of nanopartides, it is possible to increase bioavailability and bioactivity of therapeutics and enable selective targeting to damaged joints. Herein, recent studies using nanoparticles for the treatment of RA, namely with liposomes, polymeric nanoparticles, dendrimers, and metallic nanoparticles, have been reviewed. These therapeutic strategies have shown great promise in improving the treatment over that by traditional drugs. The results of these studies confirm that feasibility of the use of nanopartides is mainly due to their biocompatibility, low toxicity, controlled release, and selective drug delivery to inflamed tissues in animal RA models. Therefore, it is possible to claim that nanotechnology will, in the near future, play a crucial role in advanced treatments and patient-specific therapies for human diseases such as RA.

关键词： nanoparticles liposomes dendrimers rheumatoid arthritis

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Surgical risk for patients with Chagasic achalasia and its correlation with the degree of esophageai dilation

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World Journal of Gastroenterology 2005年第37期11卷 5840-5844页

作者： José Garcia Neto Roberto de Cleva Bruno Zilberstein joaquim José Gama-rodrigues Surgery Division Hospital das Clínicas Federal University of Goiás Medical School Goiás Brazil Gastroenterology Department Digestive Tract Surgery Division Hospital das Clínicas University of Sao Paulo Medical School So Paulo Brazil

AIM： To analyze the risk of cardiovascular complications in patients with indication for surgical treatment of Chagasic esophageal achalasia and to correlate the surgical risks with the degree of esophageal dilation, thereby proposing a risk scale index. METHODS： One hundred and twenty-four patients with Chagasic esophageal achalasia, who received surgical treatment at the Hospital das Clinicas of the Federal University of Goiás, were included in this study. The patients were mostly related to the postoperative complications due to the cardiovascular system. All the patients were submitted to：（1） clinical history to define the cardiac functional class （New York Heart Association）; （2） conventional 12-lead electrocardiogram at rest; and （3） contrast imaging of the esophagus to determine esophageal dilatation according to Rezende＇s classification of Chagasic megaesophagus. RESULTS： An assessment of the functional classification （FC） of heart failure during the preoperative period determined that 67 patients （54.03%） were assigned functional class Ⅰ （FC Ⅰ）, 46 patients （37.09%） were assigned functional class Ⅱ （FC Ⅱ）, and 11 patients （8.87%） were assigned functional class Ⅲ （FC Ⅲ）. None of the patients were assigned to functional class Ⅳ （FC Ⅳ）. There was a positive correlation between the functional class and the postoperative complications （FC Ⅰ×FC Ⅱ： P〈0.001; FC Ⅰ×FC Ⅲ： P〈0.001）. The ECG was normal in 44 patients （35.48%） and presented abnormalities in 80 patients （64.52%）. There was a significant statistical correlation between abnormal ECG （arrhythmias and primary change in ventricular repolarization） and postoperative complications （P〈0.001）. With regard to the classification of the Chagasic esophageal achalasia, the following distribution was observed： group Ⅱ, 53 patients （42.74%）; group Ⅲ, 37 patients （29.83%）; and group Ⅳ, 34 patients （27.41%）. There was a positive correlation between the degree of esophageal dilation and the increase in postoperative compli

关键词： Postoperative Chagas' disease Surgical risk Chagasic achalasia Cardiovascular risk

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Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano Costa Joana Silva-Correia rui Luis Reis joaquim Miguel Oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词： Solid free-form Osteochondral Tissue engineering Scaffolds

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Properties of Collagen/Sodium Alginate Hydrogels for Bioprinting of Skin Models

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Journal of Bionic Engineering 2023年第1期20卷 105-118页

作者： Tian Jiao Qin Lian Weilong Lian Yonghui Wang Dichen Li rui L.Reis joaquim Miguel Oliveira State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an710049China Shaanxi Ketao-AM Technology Co. Ltd.Xi’an710100China B’s Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco4805-017GuimarãesPortugal ICVS/3B’s–PT Government Associate Laboratory Barco4805-017GuimarãesPortugal

3D printing technology has great potential for the reconstruction of human ***,the reconstructed skin has some differences from natural skin,largely because the hydrogel used does not have the appropriate biological and physical properties to allow healing and *** study examines the swelling,degradability,microstructure and biological properties of Collagen/Sodium Alginate(Col/SA)hydrogels of differing compositions for the purposes of skin *** the content of sodium alginate causes the hydrogel to exhibit stronger mechanical and swelling properties,a faster degradation ratio,smaller pore size,and less favorable biological *** optimal 1%collagen hydrogel was used to print bi-layer skin in which fibroblasts and keratinocytes showed improved spreading and proliferation as compared to other developed *** Col/SA hydrogels presented suitable tunability and properties to be used as a bioink for bioprinting of skin aiming at finding applications as 3D models for wound healing research.

关键词： Bioink Bioprinting-Collagen sodium alginate hydrogel-Skin Wound healing Bionic

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Importance of building maintenance at the time of architectural design of buildings rehabilitated with heritage value

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西安建筑科技大学学报（自然科学版） 2011年第6期43卷 768-776页

作者： rui Calejo rodrigues Patrícia Fernandes Rocha Faculty of Engineering University of Porto

During architectural conception phase,building maintenance problematic is mostly a result of the unintentional use of preconceived architectonical solutions rather than a consequence of a specific influence of maintenance *** the architect in the act of design understands the importance of these solutions in the service life span of a *** aware of this,is it possible for the architect to be supplied with a decision support system that allows him to consider the implications of building maintenance since the early design phases? Having awareness of this problem and its consequences in the early design phases a research project was started at the Faculty Engineering of the University of Oporto(FEUP),under which the implications of building maintenance in the act of architectural design is *** article presents the methodology developed to identify the needs of maintenance of buildings based on a DSS-decision support system that provides simple tools the architect can use in design *** methodology is based on decomposition of building parts-Elements Source of Maintenance ESM-,and subsequently,a set of functional requirements that determine the performance regarding building maintenance on account of architectural *** maintenance actions are defined: Inspection,Pro-action,Cleaning,Correction,Replacement,Legal enforcement,Limits of *** can thus set up a relationship between the act of design and its performance framework based on behavior,intervention and the ownership of the work of *** a Multicriteria Analysis(MCA) a qualitative evaluation of different options based on maintenance requirements *** on the importance of architectural conception concerning the building maintenance were clearly arrived at and the utility of the developed decision support tool was also highlighted.

关键词： architectural design building maintenance decision supporting system

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Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells

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Bioactive Materials 2021年第5期6卷 1375-1387页

作者： Zongrui Tong Lulu Jin joaquim Miguel Oliveira rui LReis Qi Zhong Zhengwei Mao Changyou Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017Barco GMRPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017BarcoGuimarãesPortugal Key Laboratory of Advanced Textile Materials&Manufacturing Technology Ministry of EducationNational Base for International Science and Technology Cooperation in Textiles and Consumer-Goods ChemistryZhejiang Sci-Tech University310018HangzhouChina

Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular *** materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and *** would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical *** developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular *** current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as ***,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent ***,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix ***,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative *** conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies.

关键词： Adaptable hydrogel Dynamic mechanical microenvironment Supramolecular chemistry Dynamic covalent chemistry Yes-associated protein

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Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering

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Bio-Design and Manufacturing 2019年第4期2卷 225-241页

作者： Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes rui LReis joaquim M.Oliveira B′s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 Barco GmrPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimaraesPortugal The Discoveries Centre for Regenerative and Precision Medicine Headquarters at University of MinhoAvepark4805-017 BarcoGuimar'sPortugal Ripoll y De Prado Sports Clinic:Murcia-Madrid FIFA Medical Centre of Excellence MurciaSpain Orthopedic Department Centro Hospitalar Póvoa de Varzim Vila do CondePortugal Clínica do Dragao Espregueira-Mendes Sports CentreFIFA Medical Centre of ExcellencePortoPortugal Dom Henrique Research Centre PortoPortugal Orthopedic Department University of MinhoBragaPortugal

The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patie

关键词： Patient-specific Indirect printing Hierarchical Silk fibroin Enzymatic-cross-linking Meniscus

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时变指向约束下姿态参数空间离散化路径规划方法

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宇航学报 2024年第3期45卷 352-365页

作者：朱哲徐瑞李朝玉朱圣英龙嘉腾朱雷北京理工大学深空探测技术研究所北京100081 深空自主导航与控制工信部重点实验室(北京理工大学) 北京100081 上海航天控制技术研究所上海201109

为满足深空探测器在复杂动态环境约束下的姿态机动任务需求,解决时变指向约束下姿态路径规划求解困难、路径优化性能差的问题,提出了一种基于修正罗德里格斯参数(MRP)和动态路径搜索的姿态参数空间离散化路径规划方法。通过MRP空间的笛... 详细信息

为满足深空探测器在复杂动态环境约束下的姿态机动任务需求,解决时变指向约束下姿态路径规划求解困难、路径优化性能差的问题,提出了一种基于修正罗德里格斯参数(MRP)和动态路径搜索的姿态参数空间离散化路径规划方法。通过MRP空间的笛卡尔网格划分和非奇异空间构建,实现航天器姿态的参数空间离散化和指向约束表征。考虑指向约束的时变动态特性,在三维动态空间中搜索初始到目标姿态的机动路径,并引入路径节点的时间特性,在约束冲突时对路径进行实时修正,设计非奇异空间时变约束路径搜索算法,生成执行路径节点序列。进一步,对生成的路径节点进行插值拟合,基于逆动力学方法计算角速度和控制力矩,完成姿态机动轨迹规划。仿真结果验证了该方法的有效性,可为深空探测器在时变指向约束下规划出姿态机动执行路径。

关键词：航天器姿态规划姿态参数离散化时变指向约束路径搜索算法

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Correlation of Disgust and Contempt Expressions with Conjugal Dissatisfaction

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Journal of Behavioral and Brain Science 2018年第10期8卷 562-573页

作者： rui Mateus joaquim Tariane Franciele Bastos Pereira Laiza de Oliveira Vilela Tayná Maiara Pilla rodrigues Angela Maria da Silva Muniz Brandino Sandro Caramaschi Faculty of Human Sciences Federal University of Grande Dourados-UFGD Dourados Mato Grosso do Sul Brazil Postgraduate Program in Developmental and Learning Psychology S&#227 o Paulo State University-UNESP/Bauru S&#227 o Paulo Brazil Faculdade Anhanguera Educacional de Bauru Bauru S&#227 o Paulo Brazil

Research has shown that dissatisfied couples in the relationship commonly exhibit facial expressions of contempt in interactions. At this point, based on the study of cognition and physiology, researchers were able to predict by longitudinal studies the probability of divorce in a marriage, with accuracy of up to 94%. Our objective was to investigate whether the occurrence of facial expressions of disgust and contempt in married women is associated with marital dissatisfaction. This is an experimental study that correlated, through filmed interviews, the frequency of facial expressions of disgust and disgust (Facial Action Coding System) to the Marital State’s Golombok Rust Inventory, in a sample composed of 20 women. Data analysis based on the Spearman Correlation Test showed a positive correlation between facial expressions of disgust and disdain and conjugal dissatisfaction (rs = 0.2198, p = 0.0280), corroborating the data in the literature.

关键词： Facial Expressions Disgust Contempt Nonverbal Communication Marital Dissatisfaction

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