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Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy

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World Journal of Experimental Medicine 2017年第3期7卷 58-77页

作者： pedro Xavier-Elsas Renato nunes Ferreira Maria Ignez C Gaspar-Elsas Department of Immunology Instituto de Microbiologia Paulo de GóesUniver-sidade Federal do Rio de Janeiro Department of Pediatrics Instituto Nacional de Saúde da Mulherda Crian?a e do Adolescente Fer-nandes FigueiraFIOCRUZ

Bone marrow, the vital organ which maintains lifelong hemopoiesis, currently receives considerable attention, as a source of multiple cell types which may play important roles in repair at distant sites. This emerging function, distinct from, but closely related to, bone marrow roles in innate immunity and inflammation, has been characterized through a number of strategies. However, the use of surgical models in this endeavour has hitherto been limited. Surgical strategies allow the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors(such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations. This endows surgical models overall with great potential for exploring bone marrow responses to injury, inflammation and infection, and its roles in repair and regeneration. We review three different murine surgical models, which variously combine trauma with infection, antigenic stimulation, or immune reconstitution, thereby illuminating different aspects of the bone marrow response to systemic injury in sepsis, trauma and allergy. They are:(1) cecal ligation and puncture, a versatile model of polymicrobial sepsis;(2) egg white implant, an intriguing model of eosinophilia induced by a combination of trauma and sensitization to insoluble allergen; and(3) ectopic lung tissue transplantation, which allows us to dissect afferent and efferent mechanisms leading to accumulation of hemopoietic cells in the lungs. These models highlight the gain in analytical power provided by the association of surgical and immunological strategies.

关键词： Bone-marrow Trauma Repair Transplantation Surgery

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Towards the Recovery of By-Product Metals from Mine Wastes:An X-Ray Absorption Spectroscopy Study on the Binding State of Rhenium in Debris from a Centennial Iberian Pyrite Belt Mine

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Journal of Minerals and Materials Characterization and Engineering 2014年第2期2卷 135-143页

作者： Maria-Ondina Figueiredo Teresa Pereira da Silva joao pedro Veiga Daniel de Oliveira Maria joao Batista CENIMAT/I3N Faculty of Sciences and TechnologyNew University of LisbonCampus da CaparicaLisbonPortugal Unit of Mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal

Rhenium is a very scarce element, occurring in the Earth's crust mainly carried by molybdenite (MoS2). Due to a very low availability comparative to actual industrial demand, rhenium is nowadays one of the most expensive mineral commodities and an increased interest is focused on ex- ploring residues resulting from a long-term mining, particularly of sulphide ore deposits. It is therefore noteworthy to assign the presence of rhenium (in a concentration up to 3 ppm) in the waste materials from the old sulphur factory at the abandoned mine of Sao Domingos (Iberian Pyrite Belt, Southeast Portugal), exploited since the Roman occupation of Iberia. Aiming at a potential sustainable recovery of rhenium as a by-product, X-ray near-edge absorption spectroscopy (XANES) was applied to clarify the Re-binding and mode of occurrence by comparing Re L3-edge XANES spectra obtained from mine waste samples (previously fully characterized by X-ray laboratory techniques) with similar spectra collected from Re-rich molybdenites (Mo1-xRexS2) and from Re-O model compounds configuring various valences and coordination environments of rhenium ions. Obtained results are commented, ruling out a possible Re-S binding and rather conforming with the binding of rhenium to oxygen in the analysed mine waste materials.

关键词： Mine Waste Materials By-Products Iberian Pyrite Belt Rhenium XANES Re L_(3)-Edge

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Methodological Guidelines for the Use of Geoprocessing Tools:Spatial Analysis Operations—Kernel,Buffer and the Remote Sensing Image Classification

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Agricultural Sciences 2015年第7期6卷 707-716页

作者： Christian nunes da Silva joao Marcio Palheta da Silva Carlos Jorge Nogueira Castro Federal University of Pará (UFPA)BelémBrazil

The so-called geotechnology has been used in recent years in the planning, supervision and monitoring of various human activities, both locally and regionally, nationally and internationally, either it in the rural environment, as in urban áreas. This study, based on references and activities in the Geographic Information Analysis Laboratory of the Federal University of Pará (LAIG/UFPA), selects and presents the application of three tools for spatial analysis available in the Terraview [1] and Arcgis softwares, with the main objective being to demonstrate how they can be applied in geographical studies, starting with the spatial information gathered by remote or Field sensors, assisting the activities of researchers who stick to working with the planning and management of natural and human resources. Geotechnologies are important tools in the analysis of geographic space and its use tends to be increased with the advancement of new software and hardware collection, manipulation and generation of new specialized information. So we will do in this manuscript a brief discussion of three spatial analysis tools that can be used in rural areas with agricultural potential.

关键词： Geotechnology Geoprocessing Spatial Analysis

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阿尔托德·圣卡塔琳娜城市复兴

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景观设计 2016年第6期 104-109页

作者： joao Ferreira nunes

该项目的设计符合人们对冥想空间的理解和期望，在城市空间中打造一处迷人而独特的区域，同时满足了里斯本市民的特殊需求。偶然经过这里的游客和里斯本的市民都会来到这个“冥想空间”，他们帮助设计师重新发现项目的场地特点。

关键词：城市复兴阿尔托城市空间里斯本设计师塔市民

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Agave sisalana extract induces cell death in Aedes aegypti hemocytes increasing nitric oxide production

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 396-399页

作者： Louise Helena Guimaraes de Oliveira Patricia Alexandria Paiva Silva de Sousa Fabrine Felipe Hilario Gabriel Joventino Nascimento joao Paulo Saraiva Morais Everaldo Paulo de Medeiros Manoel Francisco de Sousa Fabiola da Cruz nunes Biotechnology Center Federal University of Paraiba Embrapa Algodao Brazilian Agricultural Research Corporation

Objective: To investigate the effects of Agave sisalana(A. sisalana) extract on Aedes aegypti(Ae. aegypti) primary cell ***: Cells of Ae. aegypti were exposed to different concentrations of A. sisalana crude extract(0.18–6.00 mg/m L) for 24 h. Then, the cells were labeled with propidium iodide and subjected to fluorescence microscopy to verify cell viability. In addition, nitric oxide production was ***: Results showed that cells exposed to 6 mg/m L of the crude extract presented a greater percentage of death when compared to control(73.8% ± 9.6% vs. 34.6% ± 9.6%).Furthermore, there was an increase in the nitric oxide production in cells exposed to 6 mg/m L of A. sisalana crude extract [(0.81 ± 0.08) mmol/L] compared to control group[(0.41 ± 0.18) mmol/L].Conclusions: The results show that A. sisalana is cytotoxic to Ae. aegypti and may be used as raw material for new eco-friendly and inexpensive insecticides, since sisal industry discards the liquid waste for the extraction of plant fiber.

关键词： Sisal Cell culture Mosquito Insecticide

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Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts

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Infectious Diseases of Poverty 2020年第6期9卷 5-15页

作者： pedro Henrique Ferreira Marçal Rafael Silva Gama Lorena Bruna Pereira de Oliveira Olindo Assis Martins-Filho Roberta Olmo Pinheiro Euzenir nunes Sarno Milton Ozório Moraes Lucia Alves de Oliveira Fraga Universidade Vale do Rio Doce–Univale Governador ValadaresMGBrazil Grupo Integrado de Pesquisas em Biomarcadores Institute Rene RachouFIOCRUZ-MinasBelo HorizonteMGBrazil Laboratorio de Hanseniase Instituto Oswaldo CruzFundagao Oswaldo Cruz-FIOCRUZ-RJRio de JaneiroRJBrazil Nucleo de Pesquisa em Hansenologia Universidade Federal de Juiz de ForaInstituto de Ciencias da VidaCam pus Governador ValadaresRua Sao Paulo582-CentroGovernador ValadaresMG 30190-002Brazil

Background: Leprosy is a chronic infectious disease classified into two subgroups for therapeutic purposes:paucibacillary(PB)and multibacillary(MB),closely related to the host immune *** this context it is noteworthy looking for immunological biomarkers applicable as complementary diagnostic tools as well as a laboratorial strategy to follow-up leprosy household ***:: The cross-sectional study enrolled 49 participants,including 19 patients and 30 healthy *** blood mononuclear cells(PBMC)were isolated and incubated in the presence of Mycobacterium leprae *** cells were prepared for surface(CD4+and CD8+)and intracytoplasmic cytokine staining(IFN-γ,IL-4 and IL-10).Multiple comparisons amongst groups were carried out by ANOVA,Kruskal–Wallis,Student T or Mann–Whitney *** analysis of categorical variables was performed by *** biomarker signature analysis was conducted using the global median values for each biomarker index as the cut-off edge to identify the proportion of subjects with high biomarker ***: The cytokine signature analysis demonstrated that leprosy patients presented a polyfunctional profile of T-cells subsets,with increased frequency of IFN-γ+T-cell subsets along with IL-10+and IL-4+from CD4+T-cells,as compared to health Controls(Venn diagram report).Moreover,statistical analysis was carried out using parametric or non-parametric variance analysis followed by pairwise multiple comparisons,according to the data normality distribution.L(PB)displayed a polyfunctional profile characterized by enhanced percentage of IFN-γ+,IL-10+and IL-4+produced by most T-cell subsets,as compared to L(MB)that presented a more restricted cytokine functional profile mediated by IL-10+and IL-4+T-cells with minor contribution of IFN-γproduced by CD4+*** was that HHC(MB)exhibited enhanced frequency of IFN-γ+T-cells,contrasting with HHC(PB)that presented a cytokine profile limited t

关键词： Leprosy Mycobacterium leprae Cytokines Household contacts

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Measuring External Debt in a Context of Macroeconomic Imbalances

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Journal of Mathematics and System Science 2014年第3期4卷 202-207页

作者： joao Cadete de Matos Ana Margarida de Almeida Ligia Maria nunes Daniela Black Miranda Director Banco de Portugal Statistics Department Lisboa Portugal Deputy-Director Banco de Portugal Statistics Department Lisboa Portugal Banco de Portugal Statistics Department Lisboa Portugal

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Almond cold-pressed oil by-product as ingredient for cookies with potential health benefits:Chemical and sensory evaluation

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Food Science and Human Wellness 2019年第3期8卷 292-298页

作者： joao C.M.Barreira M.Antonia nunes Beatriz Vieira da Silva Filipa B.Pimentel Anabela S.G.Costa M.Alvarez-Ortic J.E.Pardo M.Beatriz P.P.Oliveira REQUIMTE/LAQV Faculdade de Farmácia da Universidade do PortoR.Jorge Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacade Montanha(CIMO) Instituto Politécnico de BragancaCampus de Santa Apolónia5300-253PortoPortugal Escuela Técnica Superior de Ingenieros Agrónomos y de Montes Universidad de Castilla-La ManchaCampus Universitario02071AlbaceteSpain

Nowadays,food security is a global concern and a great scientific ***-industrial by-products can be used as potential ingredients of innovative food products,contributing to solve this societal ***-products of high specialty oils processing,for instance,have remarkable nutritional and organoleptic ***,the partially delipidified almond flour(PDAF)remaining from almond oil extraction,was used as an alternative ingredient in a highly appreciated almond-based cookie(“almendrados”).For comparison purposes,four different“almendrados”formulations(one industrial,two with PDAF,and one with whole almond flour),were compared regarding nutritional composition,vitamin E and fatty acids *** assess the cookie sensory properties,seventy-four consumers evaluated“appearance”,“taste”,“sweetness”,“crunchiness”,“hardness”,“overall quality”using adequate hedonic *** and protein levels showed significant differences among industrial and the other three *** with PDAF presented similar tocopherols and fatty acids to the traditional(more expensive)formulation,besides reaching the highest scores on“appearance”,“sweetness”,“hardness”,“overall quality”and“buying predisposition”***,the incorporation of PDAF might represent an effective way of adding value to an industrial by-product,while providing a pleasant novel cookie formulation.

关键词： By-products Almond Food security Cookie formulation Principal component analysis

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Acrylic Customized X-Ray Positioning Stent for Prospective Bone Level Analysis in Long-Term Clinical Implant Studies

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Open Journal of Radiology 2013年第3期3卷 136-142页

作者： Ana Messias joao Paulo Tondela Salomao Rocha Rita Reis pedro Nicolau Fernando Guerra Department of Dentistry Faculty of MedicineUniversity of CoimbraCoimbraPortugal

Objectives: This paper describes a technique to produce individualized X-ray positioning devices for intraoral digital imaging of dental implants with long-term stability. Materials and Methods: An X-ray positioning device was built for Gendex? Visualix? eHD sensor, using the Dentsply rinn XCP-DS? system individualized by the incorporation of the bite piece within an acrylic stent to perform successive standardized radiographs to 16 patients. X-ray tube stabilization was achieved with polivinylsiloxane. Series of 3 radiographs were taken to each patient in different moments. Specific linear measurements as the implant diameter (mesio-distal width) and the height between consecutive threads (thread pitch) were made to all radiographs to determine the reproducibility and accuracy of the procedure. Results: The intraclass correlation coefficient for the mesio-distal width was 0.964 [(0.920 - 0.986) 95% CI] (p 0.00156 mm for the test value of 3.3 (p = 0.9), -0.00026 mm for 0.8 (p = 0.96) and 0.0124 for 4.125 (p = 0.72), respectively, after the application of a magnification correction factor. Conclusion: The device produced reproducible images in different moments and was suitable for comparative clinical examinations of marginal bone as it was convenient to perform reliable linear measurements.

关键词： Dental Radiovisiography Radiograph Dental Implant Outcome Measurement Errors Reproducibility of Results

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Tree structure and diversity of lowland Atlantic forest fragments：comparison of disturbed and undisturbed remnants

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Journal of Forestry Research 2016年第3期27卷 605-609页

作者： Fabricio Alvim Carvalho joao Marcelo Alvarenga Braga Marcelo Trindade Nascimento Departamento de Botanica Universidade Federal de Juiz de Fora. Campus Universitario s/n Sao PedroJuiz de Fora-MG 36036-900 Brazil Instituto de Pesquisas do Jardim Botanico do Rio de Janeiro. Rio de Janeiro-RJ Brazil Laboratorio de Ciencias Ambientais CBB Universidade Estadual do Norte Fluminense Campos dos Goytacazes-RJ 28013-602 Brazil

This study describes the tree community structure of three moist lowland Atlantic Forest fragments in Rio de Janeiro State, southeastern Brazil. Two fragments were disturbed and an undisturbed one was used as reference. Our hypothesis was that disturbed fragments show distinct structural patterns in comparison with undisturbed stands due to past disturbance practices and forest fragmentation. Four 100 ×5 m sampling plots were demarcated in each fragment and all live and dead trees with DBH C 5 cm were located, measured and identified. The results supported our hypothesis, due to the high values found for standing dead trees, an increase of dominance of a few pioneer species, lower values of large trees and species richness in disturbed fragments in comparison with the undisturbed one. The advanced fragmentation process in the Southern Brazilian lowland areas and the high species richness in undisturbed areas highlight these forest fragments as priority areas for conservation and management.

关键词： Phytosociology Tree community Forestfragmentation . Hotspot Brazil

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