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Renal drug transporters and their significance in drug–drug interactions

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Acta Pharmaceutica Sinica B 2016年第5期6卷 363-373,518页

作者： Jia Yin joanne wang Department of Pharmaceutics University of Washington

The kidney is a vital organ for the elimination of therapeutic drugs and their *** drug transporters,which are primarily located in the renal proximal tubules,play an important role in tubular secretion and reabsorption of drug molecules in the *** secretion is characterized by high clearance capacities,broad substrate specificities,and distinct charge selectivity for organic cations and *** the past two decades,substantial progress has been made in understanding the roles of transporters in drug disposition,efficacy,toxicity and drug–drug interactions(DDIs).In the kidney,several transporters are involved in renal handling of organic cation(OC) and organic anion(OA) *** transporters are increasingly recognized as the target for clinically significant *** review focuses on the functional characteristics of major human renal drug transporters and their involvement in clinically significant DDIs.

关键词： Renal drug transporters Drug–drug interactions Organic cations Organic anions Nephrotoxicity

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Cover story

Acta Pharmaceutica Sinica B 2020年第1期10卷 10-10页

作者： joanne wang Michael Schwarz 不详

Front Targeted delivery of imaging or therapeutic agents into cancer cells represents a major strategy in contemporary oncology drug discover and *** several different approaches can be used,one strategy to selectively and non-invasively deliver small molecule imaging or therapeutic agents into cancer cells is to take advantage of solute carrier(SLC)uptake transporters selectively expressed in cancer cells.

关键词： agent Cover story Front Targeted delivery

Health behavior outcomes in stroke survivors prescribed wearables for atrial fibrillation detection stratified by age

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Journal of Geriatric Cardiology 2024年第3期21卷 323-330页

作者： joanne Mathew Jordy Mehawej Ziyue wang Taylor Orwig Eric Ding Andreas Filippaios Syed Naeem Edith Mensah Otabil Alex Hamel Kamran Noorishirazi IrinaRadu Jane Saczynski David D.McManus Khanh-Van Tran Division of Cardiovascular Medicine Department of MedicineUniversity of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA Department of Internal Medicine Central Michigan UniversityMount PleasantUSA Department of Pharmacy and Health Systems Sciences School of PharmacyNortheastern UniversityBostonUSA Department of Population and Quantitative Health Sciences University of Massachusetts Chan Medical SchoolLake Avenue NorthWorcesterUSA

BACKGROUND Smartwatches have become readily accessible tools for detecting atrial fibrillation(AF).There remains limited data on how they affect psychosocial outcomes and engagement in older *** examine the health behavior outcomes of stroke survivors prescribed smartwatches for AF detection stratified by *** We analyzed data from the Pulsewatch study,a randomized controlled trial that enrolled patients(≥50 years)with a history of stroke or transient ischemic attack and CHA2DS2-VASc≥*** participants were equipped with a cardiac patch monitor and a smartwatch-app dyad,while control participants wore the cardiac patch monitor for up to 44 *** evaluated health behavior parameters using standardized tools,including the Consumer Health Activation Index,the Generalized Anxiety Disorder questionnaire,the 12-Item Short Form Health Survey,and wear time of participants categorized into three age groups:Group 1(ages 50-60),Group 2(ages 61-69),and Group 3(ages 70-87).We performed statistical analysis using a mixedeffects repeated measures linear regression model to examine differences amongst age *** Comparative analysis between Groups 1,2 and 3 revealed no significant differences in anxiety,patient activation,perception of physical health and wear *** use of smartwatch technology was associated with a decrease in perception of mental health for Group 2 compared to Group 1(β=-3.29,P=0.046).CONCLUSION Stroke survivors demonstrated a willingness to use smartwatches for AF ***,among these study participants,the majority did not experience negative health behavior outcomes or decreased engagement as age increased.

关键词： prescribed stratified wear

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伊格尔福特页岩的多地震属性综合研究

石油地质科技动态 2013年第1期 60-63页

作者： joanne wang 李文杰(译) 宋建平(校)

地震资料中含有地下地质和岩石性质的重要信息。经过正确处理、成像和分析后，这些地震资料便成为描述和评价页岩非均质性、原地应力以及脆性或塑性等特征的重要信息来源。刊用成熟的技术和最新研发的技术，我们可以对地质构造属性、取... 详细信息

地震资料中含有地下地质和岩石性质的重要信息。经过正确处理、成像和分析后，这些地震资料便成为描述和评价页岩非均质性、原地应力以及脆性或塑性等特征的重要信息来源。刊用成熟的技术和最新研发的技术，我们可以对地质构造属性、取决于频率的属性、应力属性和岩石物性属性等进行提取、可视化并成图。对于页岩目的层的认识、远景区的识别与排序以及地震资料在页岩油气藏勘探开发中的更好应用，这些属性的综合分析和解释是至关重要的。

关键词：地震属性页岩福特地震资料信息来源原地应力岩石性质非均质性

Characterization of tub_4^(P287L), a β-tubulin mutant,revealed new aspects of microtubule regulation in shade

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维普期刊数据库

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Journal of Integrative Plant Biology 2015年第9期57卷 757-769页

作者： Jie Yu Hong Qiu Xin Liu Meiling wang Yongli Gao joanne Chory Yi Tao School of Life Sciences Xiamen Plant Genetics Key Laboratory Xiamen University State Key Laboratory of Cellular Stress Biology Xiamen University Howard Hughes Medical Institute The Salk Institute for Biological Studies Plant Biology Laboratory The Salk Institute for Biological Studies

When sun plants, such as Arabidopsis thaliana, are under canopy shade, elongation of stems/petioles will be induced as one of the most prominent responses. Plant hormones mediate the elongation growth. However, how environmental and hormonal signals are translated into cell expansion activity that leads to the elongation growth remains elusive. Through forward genetic study, we identi-fied shade avoidance2 (sav2) mutant, which contains a P287L mutation in b-TUBULIN 4. Cortical microtubules (cMTs) play a key role in anisotropic cell growth. Hypocotyls of sav2 are wild type-like in white light, but are short and highly swollen in shade and dark. We showed that shade not only induces cMT rearrangement, but also affects cMT stability and dynamics of plus ends. Even though auxin and brassinosteroids are required for shade-induced hypocotyl elongation, they had little effect on shade-induced rearrangement of cMTs. Blocking auxin transport suppressed dark phenotypes of sav2, while overexpressing EB1b-GFP, a microtubule plus-end binding protein, rescued sav2 in both shade and dark, suggesting that tub4P287L represents a unique type of tubulin mutation that does not affect cMT function in supporting cell elongation, but may affect the ability of cMTs to respond properly to growth promoting stimuli.

关键词： Arabidopsis microtubules plant hormones shade

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疼痛对乳腺癌患者生活质量影响调查

中国循证医学杂志 2008年第4期8卷 233-236页

作者：王世平马玲 joanne Chung 四川大学华西护理学院成都610041 香港理工大学护理学院

目的了解乳腺癌患者的疼痛感受和生活质量状况,评估疼痛对生活质量的影响程度。方法采用中国人癌症疼痛评估工具(Chinese Cancer Pain Assessment Tool,CCPAT)和生活质量调查问卷(第3版)[EORTIC QLQ-C30(Version 3)]对200例乳腺癌患者... 详细信息

目的了解乳腺癌患者的疼痛感受和生活质量状况,评估疼痛对生活质量的影响程度。方法采用中国人癌症疼痛评估工具(Chinese Cancer Pain Assessment Tool,CCPAT)和生活质量调查问卷(第3版)[EORTIC QLQ-C30(Version 3)]对200例乳腺癌患者进行横断面设计的面对面问卷调查。结果200例乳腺癌患者中有疼痛者84例(42%),无疼痛者116例(58%)。疼痛组患者疼痛评分高于非疼痛组患者评分(P0.05);疼痛组患者的疼痛评分与整体生活质量评分呈显著负相关(r=–0.731,P<0.001)。结论疼痛对乳腺癌患者的躯体功能、角色功能和社会功能有一定的负面影响;患者受疼痛的冲击加重时,其整体生活质量降低。

关键词：乳腺癌疼痛生活质量横断面调查

依那西普预充液与复溶冻干粉注射液的生物等效性研究

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中国临床药理学杂志 2019年第13期35卷 1370-1373页

作者： HUIFEN FAYE wang ROBERT R LABADIE joanne SALAGEANU 辉瑞公司

目的确证依那西普预充液(PFS■)和复溶冻干粉注射液(LYO■)的生物等效性,并评估依那西普PFS在中国健康男性受试者中的安全性和耐受性。方法一项随机、开放、双向交叉设计的研究,共纳入50位健康受试者。在受试者腹部皮下单次注射50 mg的... 详细信息

目的确证依那西普预充液(PFS■)和复溶冻干粉注射液(LYO■)的生物等效性,并评估依那西普PFS在中国健康男性受试者中的安全性和耐受性。方法一项随机、开放、双向交叉设计的研究,共纳入50位健康受试者。在受试者腹部皮下单次注射50 mg的依那西普PFS■(受试组)或LYO■(参比组)后,评估2组间的生物等效性。连续收集受试者用药后2周内的血液样本,用酶联免疫吸附实验测定血清样本中依那西普的浓度,用标准非房室模型法计算药代动力学参数。主要研究终点为初始至终末采血时间点内的浓度-时间曲线下面积(AUClast)和血清峰浓度(Cmax)。结果 50名受试者中有48名完成研究。受试组与参比组AUClast和Cmax的校正几何平均数比例(90%的置信区间)分别为119.2%(114.1%~124.6%)和115.8%(109.6%~122.4%),完全位于已制定的80%~125%的生物等效性范围内。在本研究中,2种剂型的依那西普均是安全的,具有良好的耐受性。结论在中国健康受试者腹部皮下注射等量的依那西普时,PFS?和LYO?剂型间具有生物等效性。由此预测,等剂量的2种剂型具有同等的治疗效果,可以互换使用。

关键词：依那西普复溶冻干粉注射液预充注射液中国健康受试者生物等效性

Development and Implementation of an Advanced Planning & Scheduling (APS) System for Semiconductor Backend Assembly

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厦门大学学报（自然科学版） 2002年第S1期41卷 189-190页

作者： T J Chua T X Cai F Y wang William Liu X F Yin W J Yan J P Zhu joanne Lam Gintic Institute of Manufacturing Technology Gintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing TechnologyGintic Institute of Manufacturing Technology SingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingaporeSingapore

In this paper, the design, customization and implem en tation of an integrated Advanced Planning and Scheduling (APS) system for a Semi conductor Backend Assembly environment is described. The company is one of the w orldwide market leaders in semiconductor packaging technology. The project was d riven by the company’s quest to achieve a competitive edge as a manufacturing po werhouse by providing the shortest possible cycle time with a high degree of fle xibility through the application of Computer Integrated Manufacturing (CIM) tech nology. Gintic was responsible for the Planning & Scheduling functions through o ur APS tool kit, which is called Gintic Scheduling System (GSS). Our APS system is to be integrated with the other two key software systems, namely, the Enterpr ise Resource Planning (ERP) and Manufacturing Execution System (MES), with the C IM framework. The project was divided into four major execution phases. Phase One activities w ere focused on the gathering and analysis of the end users requirements in order to establish the ’As-Is’ situation and the wish list & the expectation of the ’To-Be’ system. Planning and Scheduling prototypes were built using GSS to iden tify the functionality gap between the existing GSS system and the ’To-Be’ mode l, in order to determine the customization effort needed. The project team perfo rmed detailed system analysis, design and development of the ’To-Be’ system dur ing Phase Two of the project. There are a total of four planning and scheduling modules, including Capacity Planning (CP), Daily Lot Release (DLR), Daily Produc tion Scheduling (DPS) and Dynamic Operation Scheduling (DOS). The detailed desig n specifications of each of the features and functionality were confirmed and ac cepted by the end users before the commencement of the development effort. The c ompleted and tested modules were delivered in stages for testing and acceptance by the end user during the Phase Three of the project. Pilot product line was

关键词： integrated planning scheduling semiconductor b ackend assembly

Small RNAs and Transgenerational Epigenetic Variation

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American Journal of Plant Sciences 2013年第3期4卷 641-646页

作者： joanne R. M. Lee Zane Duxbury Ming-Bo wang Commonwealth Scientific and Industrial Research Organization Plant Industry Canberra Australia

Small RNAs are found in eukaryotes and are responsible for regulation of chromatin structure, RNA processing and stability, translation and transcription. 24-nt small interfering RNA (siRNA) are known to mediate gene inactivation via the RNA-directed DNA methylation pathway (RdDM) and are important for natural heritable changes in plant species. DNA cytosine methylation can be maintained between generations and this may be important for accelerated adaption to stress conditions. Research is currently focused toward the epigenetic response to disease, the stability of DNA methylation over generations, the elucidation of newly discovered pathways for de novo DNA methylation, and the application of epigenetic variation to breeding programs. This review aims to give a brief but comprehensive examination on small RNAs and transgenerational epigenetic variation.

关键词： siRNA Epigenetics Arabidopsis Thaliana Transgenerational Epigenetic Variation RNA Directed DNA Methylation (RdDM)