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皮肤镜影像引入整形外科PBL临床教学法的应用

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组织工程与重建外科杂志 2020年第4期16卷 343-344页

作者：刘蔡钺孙一丹徐露文韦坤辰高雅姗李海洲朱海男高博闻杨雅骊朱晓海张亮李青峰上海交通大学医学院附属第九人民医院整复外科上海市200011 上海交通大学医学院附属第九人民医院皮肤科上海市200011 海军军医大学附属第二医院整形外科上海市200003 中国科学院上海生命科学研究院营养与健康研究所上海市200031

皮肤镜检查是伴随皮肤影像技术发展起来的一种无创性皮肤辅助诊断方法,主要用于皮肤良、恶性肿瘤的早期预判和辅诊,在皮肤外科、整形外科和激光美容等领域应用较为广泛。我们在传统的PBL教学模式中,创新性地引入经典的皮肤镜影像素材,... 详细信息

皮肤镜检查是伴随皮肤影像技术发展起来的一种无创性皮肤辅助诊断方法,主要用于皮肤良、恶性肿瘤的早期预判和辅诊,在皮肤外科、整形外科和激光美容等领域应用较为广泛。我们在传统的PBL教学模式中,创新性地引入经典的皮肤镜影像素材,使标准化病例在具体的临床实践教学中更加形象生动,主要聚焦于快速有效提高医学生以临床能力为导向的皮肤无创诊疗水平。

关键词：皮肤影像皮肤镜整复外科皮肤病学教学设计

bowen Ratio Energy Balance measurement of Carbon Dioxide (CO<sub>2</sub>) Fluxes of No-Till and Conventional Tillage Agriculture in Lesotho

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Open Journal of Soil Science 2014年第3期4卷 87-97页

作者： Deb O’Dell Thomas J. Sauer Bruce B. Hicks Dayton m. Lambert David R. Smith Wendy Bruns August Basson makoala V. marake Forbes Walker michael D. Wilcox Jr. Neal Samuel Eash Department of Agricultural & Resource Economics University of Tennessee Knoxville USA Institute of Agriculture University of Tennessee Knoxville USA KEL Growing Nations Trust Mohaleshoek Lesotho metCorps Norris USA United States Department of Agriculture (USDA) Agriculture Research Service (ARS) Ames USA Purdue University West Lafayette USA

Global food demand requires that soils be used intensively for agriculture, but how these soils are managed greatly impacts soil fluxes of carbon dioxide (CO2). Soil management practices can cause carbon to be either sequestered or emitted, with corresponding uncertain influence on atmospheric CO2 concentrations. The situation is further complicated by the lack of CO2 flux measurements for African subsistence farms. For widespread application in remote areas, a simple experimental methodology is desired. As a first step, the present study investigated the use of bowen Ratio Energy Balance (BREB) instrumentation to measure the energy balance and CO2 fluxes of two contrasting crop management systems, till and no-till, in the lowlands within the mountains of Lesotho. Two BREB micrometeorological systems were established on 100-m by 100-m sites, both planted with maize (Zea mays) but under either conventional (plow, disk-disk) or no-till soil mangement systems. The results demonstrate that with careful maintenance of the instruments by appropriately trained local personnel, the BREB approach offers substantial benefits in measuring real time changes in agroecosystem CO2 flux. The periods where the two treatments could be compared indicated greater CO2 sequestration over the no-till treatments during both the growing and non-growing seasons.

关键词： CO2 Flux CO2 Emissions Soil Soil Carbon Tillage Till No-Till bowen Ratio micrometeorology Agriculture Climate Change Lesotho Africa

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中国南极昆仑站深冰芯科学钻探工程进展

钻探工程 2021年第9期48卷 1-9页

作者：范晓鹏张楠胡正毅安春雷史贵涛宫达李冰杨成李传金刘科于金海刘博文鲁思宇马天明孙友宏 Pavel Talalay 李院生吉林大学极地研究中心吉林长春130026 吉林大学地球探测科学与技术学院吉林长春130026 吉林大学建设工程学院吉林长春130026 中国极地研究中心上海200129 中国地质大学(北京)工程技术学院北京100083 中国科学院西北生态环境资源研究院冰冻圈科学国家重点实验室甘肃兰州730000 南京大学地理与海洋科学学院江苏南京200136

我国于2012年1月在南极Dome A区域正式开展实施了南极昆仑站深冰芯科学钻探工程,截至2021年,钻孔深度已达803.54 m。该工程是我国第一个深冰芯钻探工程,也是国际上第一个在Dome A地区开展的深冰芯钻探项目。本文介绍了昆仑站深冰芯科学... 详细信息

我国于2012年1月在南极Dome A区域正式开展实施了南极昆仑站深冰芯科学钻探工程,截至2021年,钻孔深度已达803.54 m。该工程是我国第一个深冰芯钻探工程,也是国际上第一个在Dome A地区开展的深冰芯钻探项目。本文介绍了昆仑站深冰芯科学钻探工程实施的整体情况,对过去近10年的钻探活动以及取得的成果和经验进行了总结,以期为后续的深冰芯钻探工作提供理论和经验指导。

关键词：南极昆仑站深冰芯取芯钻探 Dome A

基于量子精密测量的铁磁材料表面无损检测技术研究

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无损探伤 2024年第6期48卷 15-19页

作者：范华林史红兵赵博文谢赛南王仁涛毕挺肖久华安徽省特种设备检测院合肥230041 安徽省国盛量子科技有限公司合肥230031

量子科技在保障信息安全、提高运算速度、提升测量精度等方面突破了传统技术的瓶颈,成为信息、能源和材料等重大技术领域创新的源泉。本文中的量子精密测量技术基于国产研发的高精度扫描金刚石探针技术,能够实现高空间分辨率、高灵敏度... 详细信息

量子科技在保障信息安全、提高运算速度、提升测量精度等方面突破了传统技术的瓶颈,成为信息、能源和材料等重大技术领域创新的源泉。本文中的量子精密测量技术基于国产研发的高精度扫描金刚石探针技术,能够实现高空间分辨率、高灵敏度的磁性成像,可以对特种设备广泛使用的铁磁材料表面缺陷进行精密测量。通过基于金刚石中氮-空位(NV)色心制备的高灵敏度量子传感器,可以完成A1试片表面裂纹的检测实验,实现对铁磁材料表面15μm深度缺陷的识别和检测。该技术提升了表面无损检测技术的检测精度,同时具有可建立信号图像、可读取可定量分析等优势,该技术研究必将更好地保障我国特种设备的安全,促进我国社会和经济的发展。

关键词：量子精密测量铁磁材料表面无损检测

终冷温度对Q500耐候桥梁钢的低温冲击断裂行为影响

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工业建筑 2024年第12期54卷 10-17页

作者：李博文高彩茹李旺王琬淇王军彭存财吴红艳高秀华杜林秀东北大学轧制技术及连轧自动化国家重点实验室沈阳110819 南京钢铁股份有限公司南京210044

针对高原复杂环境桥梁建设工程,开发屈服强度500 mPa级别的高抗冲击、韧脆转变温度低的耐候桥梁钢。研究了轧制后终冷温度对试验钢的微观组织和力学性能的影响,深入分析了低温对试验钢冲击韧性的影响。结果表明:经控轧控冷(TmCP)处理后... 详细信息

针对高原复杂环境桥梁建设工程,开发屈服强度500 mPa级别的高抗冲击、韧脆转变温度低的耐候桥梁钢。研究了轧制后终冷温度对试验钢的微观组织和力学性能的影响,深入分析了低温对试验钢冲击韧性的影响。结果表明:经控轧控冷(TmCP)处理后试验钢满足Q500级桥梁钢的力学性能要求,且在-40~-80℃的低温环境下,两种不同终冷温度(500、550℃)的试验钢均表现出良好的冲击性能。但随终冷温度的升高,试验钢晶粒尺寸增加;马氏体/奥氏体(m/A)岛尺寸增加、形态改变;大角度晶界比例降低是造成两种试验钢冲击性能差异的主要原因。

关键词：耐候桥梁钢 TmCP 终冷温度力学性能低温冲击韧性

TLR7增效剂咪喹莫特增强Ⅰ型干扰素信号并募集表达趋化因子受体CXCR3的淋巴细胞到局部皮肤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 59-59页

作者： Wenzel J. Uerlich m. Haller O. 李政霄 Department of Dermatology University of Bonn Sigmund-Freud-Strasse2553105BonnGermany Dr.

Introduction: Imiquimod (Aldara.) is an immune response modifier approved for the topical treatment of external genital and perianal warts which can mediate regression of several cutaneous malignancies basal cell carcinoma (BCC), bowen’ s disease, actinic keratosis, and metastasis of malignant melanoma . Recently, it was discovered that imiquimod acts through the toll- like receptor (TLR) 7. We hypothesizethat TLR7- signaling strongly induces the production of interferon (IFN) α , which is able to enhance Th1- mediated cellular antiviral and antitumor immunity. Patients and methods: In the present study we analyzed the expression of mxA, a protein specifically induced by type I IFNs during topical imiquimod treatment in several patients suffering from different cutaneous malignancies (BCC, cutaneous metastasis of melanoma, and breast cancer), and characterized the inflammatory infiltrate, along with the expression of chemokine receptor CXCR3, by immunohistochemistry. Results: Treatment with the TLR7agonist imiquimod induced a significant lesional lymphocytic inflammation, associated with strong expression of mxA, indicating the induction of type I IFN signaling. The extent of lesional mxA staining closely correlated with the number of infiltrating T lymphocytes and the expression of the chemokine receptorCXCR3,characteristic for Th1- biased immuneresponses. Discussion: Our in vivo results suggest an important role for TLR7- induced production of type I IFN, which links innate and adaptive immunity and promotes specific Th1- biased cellular immune response capable of eliminating cutaneous malignancies. mxA appears to be a valuable parameter to demonstrate IFN- type I expression in imiquimod therapy.

关键词：咪喹莫特 CXCR3 TLR7 趋化因子受体 Ⅰ型干扰素增效剂恶性黑素瘤鲍温病基底细胞癌肛周疣

肛周鲍温病患者的预后、患其他恶性疾病的风险和正规映像检查的必要性

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 21-21页

作者： margenthaler J.A. Dietz D.W. mutch m.G. J.W. Fleshman 陈云茹 Department of Surgery Barnes Jewish Hospital Campus Box 8109 660 S. Euclid Street St. Louis MO 63110 United States Dr.

PURPOSE: Local excision is standard treatment for bowen’s disease, but controversy exists over the incidence of synchronous and metachronous cancers as well as the role of a preexcision mapping procedure. mETHODS: The medical records of 25 patients treated for perianal bowen’s disease between 1978 and 2001 were retrospectively reviewed. RESULTS: There were 11 men and 14 women with a mean age at diagnosis of 47.9 ±14.9 years. The majority of patients (72 percent) had symptom driven biopsies. Presentation included pruritus (56 percent), mass (28 percent), bleeding (24 percent), and anal pain (4 percent). The average duration of symptoms before diagnosis was 1.3 ±0.5 years. Two patients had microscopic disease discovered incidentally after hemorrhoidectomy and underwent no further treatment. Twenty three patients underwent wide local excision, of which 19 (83 percent) had a formal mapping procedure. On final pathology, 23 patients (92 percent) had clear margins. There were three recurrences (mean time to recur 2.0 ±1.0 years), including the two patients who had positive margins after wide excision (1 after mapping) and one patient who had clear margins after mapping. Five patients (20 percent) had other carcinomas (1 sigmoid, 4 vulvar). At follow up, 24 patients were alive with no evidence of bowen’s disease and 1 patient was dead secondary to sigmoid cancer with no evidence of bowen’s disease. CONCLUSIONS: Wide excision of perianal bowen’s disease results in excellent local control, although this is highly dependent on clear pathologic margins. A formal mapping procedure does not preclude recurrence. Initial screening and follow up regimens are not uniform because of the wide range of treatment options available.

关键词：鲍温病肛周肛门痛痔切除术局部切除术切缘阳性广泛切除术早期筛查复发时间异时发生

局部外用氨基酮戊酸光动力疗法治疗指甲下bowen病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 17-17页

作者： Usmani N. Stables G.I. Telfer N.R. Stringer m.R. 吴佳纹 Centre for Dermatology Leeds General Infirmary 27 Belle Vue Ave Leeds West Yorkshire LS8 2NN United Kingdom

A 66- year- old man presented with an 18- month history of progressive nail dystrophy involving his left index finger. A diagnostic biopsy specimen confirmed the clinical suggestion of subungual bowen’ s disease (carcinoma in situ). Various treatment options were considered, and the decision was made to treat with photodynamic therapy using topical 5- aminolevulunic acid administered as two treatments 4 weeks apart. The patient was reviewed 3 months after treatment and then regularly at 6- month intervals. Thirty months after treatment there remained no clinical evidence of recurrence of the condition with preservation of a normal nail unit. Although the successful treatment of cutaneous bowen’ s disease with photodynamic therapy is well documented, this is the first report of the successful treatment of subungual bowen’ s disease using topical aminolevulunic acid- photodynamic therapy.

关键词： bowen 光动力疗法氨基酮戊酸甲营养不良原位癌左手食指活检标本病已