局部外用氨基酮戊酸光动力疗法治疗指甲下Bowen病
Subungual Bowen' s disease treated by topical aminolevulinic acid- Photodynamic therapy作者机构：Centre for Dermatology Leeds General Infirmary 27 Belle Vue Ave Leeds West Yorkshire LS8 2NN United Kingdom
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2006年第2卷第2期
页 面：17-17页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Bowen 光动力疗法 氨基酮戊酸 甲营养不良 原位癌 左手食指 活检标本 病已
摘 要：A 66- year- old man presented with an 18- month history of progressive nail dystrophy involving his left index finger. A diagnostic biopsy specimen confirmed the clinical suggestion of subungual Bowen’ s disease (carcinoma in situ). Various treatment options were considered, and the decision was made to treat with photodynamic therapy using topical 5- aminolevulunic acid administered as two treatments 4 weeks apart. The patient was reviewed 3 months after treatment and then regularly at 6- month intervals. Thirty months after treatment there remained no clinical evidence of recurrence of the condition with preservation of a normal nail unit. Although the successful treatment of cutaneous Bowen’ s disease with photodynamic therapy is well documented, this is the first report of the successful treatment of subungual Bowen’ s disease using topical aminolevulunic acid- photodynamic therapy.
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