检索结果-南通市图书馆

Current perspectives on the antidepressant-like effects of guanosine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第9期11卷 1411-1413页

作者： Luis E.B.Bettio joana Gil-Mohapel Ana Lucia S.Rodrigues Department of Biochemistry Center of Biological Sciences Federal University of Santa Catarina Florianopolis-SC Brazil Division of Medical Sciences and UBC Island Medical Program University of Victoria Victoria BC V8W 2Y2 Canada

Purines have a recognized importance as intercellular mes- sengers. These molecules play an important role in the de- velopment and maintenance of the central nervous system （CNS）, as well as in its response to pathological conditions. Both adenine and guanine-based purines can be released from astrocytes, where they play a relevant role as extracel- lular signaling molecules. Particularly, the nucleoside gua- nosine has been proposed as an extracellular molecule that regulates the response of CNS to damage. Following injury, this nucleoside attains high concentrations in the extracel- lular space, where it activates multiple signaling pathways.

关键词： Current perspectives on the antidepressant-like effects of guanosine

The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2011年第2期6卷 147-155页

作者： joana BARBOSA Ana Vanessa NASCIMENTO Juliana FARIA Patrícia SILVA Hassan BOUSBAA Centro de Investigação em Ciências da Saúde(CICS) Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal

Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAC),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAC activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAC and tumorigenesis,and the therapeutic strategy to target the SAC for cancer treatment.

关键词： spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy

Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn's disease patients with anastomotic strictures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第35期23卷 6482-6490页

作者： Susana Lopes Patrícia Andrade Eduardo Rodrigues-Pinto joana Afonso Guilherme Macedo Fernando Magro Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto

AIM To evaluate the accuracy and best cut-off value of fecal calprotectin(FC) and fecal lactoferrin(FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures. METHODS This was a longitudinal single tertiary center study based on prospectively collected data(recorded in a clinical database created for this purpose) performed between March 2010 and November 2014. Crohn's disease(CD) patients with anastomotic stricture who submitted to postoperative endoscopic evaluation were included. Stools were collected on the day before bowel cleaning for FC and FL. Endoscopic balloon dilation(EBD) was performed if the patient presented an anastomotic stricture not traversed by the colonoscope, regardless of patients' symptoms. Successful dilation was defined as passage of the colonoscope through the dilated stricture into the neotermimal *** recurrence was defined as a modified Rutgeerts score of ≥ i2 b. RESULTS In a total of 178 patients who underwent colonoscopy, 58 presented an anastomotic stricture, 86% were asymptomatic, and 48(54% male; median age of 46.5 years) were successfully dilated. Immediate success rate was 92% and no complications were recorded. FC and FL levels correlated significantly with endoscopic recurrence(P < 0.001) with an optimal cut-off value of 90.85 μg/g(sensitivity of 95.5%, specificity of 69.2%, positive predictive value(PPV) of 72.4%, negative predictive value(NPV) of 94.7% and accuracy of 81%] for FC and of 5.6 μg/g(sensitivity of 77.3%, specificity of 69.2%, PPV of 68%, NPV of 78.4% and accuracy of 72.9%) for *** Fecal markers are good predictors of CD endoscopic recurrence in patients with asymptomatic anastomotic stricture. FC and FL may guide the need for EBD in this context.

关键词： Crohn's disease Anastomotic strictures Endoscopic balloon dilation Fecal markers Po stoperative recurrence

Power and Architecture in Portuguese Fascism： Political and Artistic Control and Resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journalism and Mass Communication 2015年第7期5卷 360-371页

作者： joana Brites University ofCoimbra Coimbra Portugal

This paper analyses the system of artistic and ideological conditioning that architects were subject to during the Portuguese fascism, the so-called ＂New State＂, the longest western European dictatorship of the previous century, that lasted from 1933 to 1974, under the uninterrupted leadership of Ant6nio de Oliveira Salazar until 1968. After a concise exposition of the importance of a major public work campaign to the regime affirmation as well as the aesthetic discourse promoted in its architecture, the standard course of a building project evaluation will be described. Crossing varied legislation and taking into consideration the results of a thorough examination to more than one hundred processes of architectural plans approval, the interaction of the various decision-making bodies will illustrate the existence of an efficient apparatus which progressively depurate designs. Prevention and repression of artistic deviation will be demonstrated. Furthermore, the development and importance of self-censorship will be highlighted. Secondly, a characterization of the atmosphere of ideological surveillance and dissident＇s oppression will be provided. Architects＇ participation in opposition＇s initiatives and strategies will be portrayed. As a conclusion, New State practice of a negotiation and inclusion （both artistic and ideological） tactic in the architectural field will be underlined.

关键词： New State fascism architecture control opposition

Changes in feeding selectivity of freshwater invertebrates across a natural thermal gradient

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2018年第2期64卷 231-242页

作者： Timothy A. C. GORDON joana NETO-CEREJEIRA Paula C. FUREY Eoin J. O'GORMAN Imperial College London Silwood Park Campus Buckhurst Road Ascot Berkshire SL5 7PY UK Biosciences College of Life and Environmental Sciences University of Exeter Stocker Road Exeter EX4 4QD UK Department of Biology Saint Catherine University St Paul MN 55105 USA

Environmental warming places physiological constraints on organisms, which may be mitigated by their feeding behavior. Theory predicts that consumers should increase their feeding selectivity for more energetically valuable resources in warmer environments to offset the disproportionate increase in metabolic demand relative to ingestion rate. This may also result in a change in feeding strategy or a shift towards a more specialist diet. This study used a natural warming experiment to investigate temperature effects on the feeding selectivity of three freshwater invertebrate grazers： the snail Radix balthica, the blackfly larva Simulium aureum, and the midgefly larva Eukiefferiella minor. Chesson＇s Selectivity Index was used to compare the proportional abundance of diatom species in the guts of each invertebrate species with corresponding rock biofilms sampled from streams of different tem- perature. The snails became more selective in warmer streams, choosing high profile epilithic diatoms over other guilds and feeding on a lower diversity of diatom species. The blackfly larvae appeared to switch from active collector gathering of sessile high profile diatoms to more passive filter feeding of motile diatoms in warmer streams. No changes in selectivity were observed for the midgefly larvae, whose diet was representative of resource availability in the environment. These results suggest that key primary consumers in freshwater streams, which constitute a major portion of invertebrate biomass, can change their feeding behavior in warmer waters in a range of different ways. These patterns could potentially lead to fundamental changes in the flow of energy through freshwater food webs.

关键词： climate change global warming diet Lymnaea peregra Simuliidae Chironomidae

Primary malignant melanoma of the esophagus:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第42期17卷 4734-4738页

作者： joana Machado Paula Ministro Ricardo Araújo Eugénia Cancela António Castanheira Américo Silva Department of Gastroenterology S Teotónio Hospital

The authors present the clinical case of an 87-year-old Caucasian male admitted to the emergency room with hematemesis. He had a history of intermittent dys-phagia during the previous month. Endoscopic evaluation revealed an eccentric,soft esophageal lesionlocated 25-35 cm from the incisors,which appeared asa protrusion of the esophagus wall,with active bleeding. Biopsies were acquired. Tissue evaluation wascompatible with a melanoma. After excluding other sites of primary neoplasm,the definitive diagnosis of Primary Malignant Melanoma of the Esophagus(PMME) was made. The patient developed a hospital-acquired respiratory infection and died before tumor-directed treatment could begin. Primary malignant melanoma represents only 0.1% to 0.2% of all esophageal ma-lignant tumors. Risk factors for PMME are not defined.A higher incidence of PMME has been described in Japan. Dysphagia,predominantly for solids,is the most frequent symptom at presentation. Retrosternal orepigastric discom fort or pain,melena or hemate mesishave also been described. The characteristic endoscopic finding of PMME is as a polypoid lesion,with variablesize,usually pigmented. The neoplasm occurs in thelower two-thirds of the esophagus in 86% of *** metastasizes via hematogenic and lymphatic pathways. At diagnosis,50% of the patients present with distant metastases to the liver,the mediastinum,the lungs and the brain. When possible,surgery(curative or palliative) ,is the preferential method of treatment. There are some reports in the literature where chemotherapy,chemohormon otherapy,radiotherapy and immunotherapy,with or without surgery,wereused with variable efficacy. The prognosis is poor;themean survival after surgery is less than 15 mo.

关键词： Esophagus Melanoma Esophagoscopy Upper gastrointestinal tract Neoplasms

Development and characterization of 3CaO·P_(2)O_(5)-SiO_(2)-MgO glass-ceramics with different crystallization degree

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2013年第4期2卷 378-388页

作者： Juliana Kelmy M.F.DAGUANO Paulo A.SUZUKI Kurt STRECKER JoséMartinho Marques de OLIVEIRA Maria Helena.figueira Vaz FERNANDES Claudinei SANTOS Universidade de São Paulo-Escola de Engenharia de Lorena USP-EEL-Pólo Urbo-Industrials/nGleba AI-6Lorena-SPCEP 12600-000Brazil Universidade Federal de São João del-Rei -UFSJ-CENENCampus S^(to)Antônio-Praça Frei Orlando 170-CentroS.J.del-Rei-MG.CEP 36307-352Brazil Escola Superior Aveiro Norte Edifício Rainha3720-232 O.AzeméisPortugal Universidade de Aveiro Campus Universitário de Santiago 3810-193 AveiroPortugal Universidade do Estado do Rio de Janeiro-Faculdade de Tecnologia de Resende-UERJ-FAT-Rod.Presidente Dutra km298Resende-RJCEP 27537-000Brazil

The CaO-P_(2)O_(5)-SiO_(2)-MgO system presents several compounds used as biomaterials such as hydroxyapatite(HA),tricalcium phosphate(TCP)and TCP with magnesium substituting partial calcium(TCMP).Theβ-TCMP phase with whitlockite structure has interesting biological features and mechanical properties,meeting the requirements of a bioactive material for bone *** this work,the production of Mg-doped TCP,β-TCMP,has been investigated by crystallization from a glass composed of 52.75 wt%3CaO·P_(2)O_(5),30 wt%SiO_(2)and 17.25 wt%MgO(i.e.,31.7 mol%CaO,10.6 mol%P_(2)O_(5),26.6 mol%MgO and 31.1 mol%SiO_(2))using heat treatments between 775℃and 1100℃for up to 8 *** devitrification process of the glass has been accompanied by differential scanning calorimetry(DSC),high-resolution X-ray diffraction(HRXRD),relative density and bending strength *** characterization by HRXRD and DSC revealed the occurrence of whitlockite soon after the bulk glass preparation,a transient non-cataloged silicate between 800℃and 1100℃,and the formation of diopside in samples treated at 1100℃as crystalline *** overall crystalline fraction varied from 26%to 70%depending on the heat ***,contraction of the a-axis lattice parameter and expansion of the c-axis lattice parameter of the whitlockite structure have been observed during the heat treatments,which were attributed to theβ-TCMP formation with the partial substitution of Ca^(2+)by Mg^(2+).Relative densities near 99%and 97%for the glass and glass-ceramics respectively indicated a discrete reduction as a function of the devitrification *** strengths of 70 MPa and 120 MPa were determined for the glass and glass-ceramic material crystallized at 975℃for 4 h,respectively.

关键词： glass-ceramics heat treatment high-resolution X-ray diffraction(HRXRD) bending strength

On the Cauchy Problem Describing an Electron-Phonon Interaction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

数学年刊（A辑） 2011年第4期32卷 I0001-I0004页

作者： Dias, João-Paulo figueira, Mário Oliveira, Filipe Centro de Matemática e Aplicações Fundamentais and Faculdade de Ciências Universidade de Lisboa Lisboa Portugal Centro de Matemática e Aplicações Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa Monte da Caparica Portugal

In this paper, a model is derived to describe a quartic anharmonic interatomic interaction with an external potential involving a pair electron-phonon. The authors study the corresponding Cauchy Problem in the semilin... 详细信息

关键词：英文摘要内容介绍编辑工作期刊

Tailoring RGD local surface density at the nanoscale toward adult stem cell chondrogenic commitment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2017年第6期10卷 1959-1971页

作者： Anna Lagunas Iro Tsintzou Yolanda Vida Daniel Collado Ezequiel Perez-Inestrosa Cristina Rodriguez Pereira joana Magalhaes Jose A. Andrades Josep Samitier Networking Biomedical Research Center (CIBER) C/Monforte de Lemos 3-5 Pabellon 11 Planta 0 Madrid 28029 Spain Institute for Bioengineering of Catalonia (IBEC) Baldiri-Reixac 10-12 Barcelona 08028 Spain Instituto de Investigacion Biomedica de Malaga (IBIMA) Department of Organic Chemistry Universidad de Malaga (UMA) Malaga 29071 Spain Andalusian Centre for Nanomedicine and Biotechnology-BlONAND Parque Tecnoldgico de Andalucia Mdlaga 29590 Spain Unidad de Bioingenieria Tisulary Terapia Celular (GBTTC-CHUAC) Grupo de Reumatologia Instituto de Investigacion Biomedica de A Coru6a (INIBIC) Complexo Hospitalario Universitario de A Coruf~a (CHUAC) Sergas Universidade da Coruna (UDC) As Xubias 84 Coruna 15006 A Spain Cell Biology Genetics and Physiology Department University de Malaga (UMA) Campus Teatinos Malaga 29071 Spain Department of Engineering Electronics University of Barcelona (UB) Marti i Franques 1-11 Barcelona 08028 Spain

Arginine-glycine-aspartic acid （RGD） dendrimer-based nanopatterns on poly（L- lactic acid） were used as bioactive substrates to evaluate the impact of the RGD local surface density on the chondrogenic induction of adult human mesenchymal stem cells. During chondrogenic commitment, active extracellular matrix （ECM） remodeling takes place, playing an instructive role in the differentiation process. Although three-dimensional environments such as pellet or micromass cultures are commonly used for in vitro chondrogenic differentiation, these cultures are rather limited with respect to their ability to interrogate cells in celI-ECM interactions. In the present study, the nanopatterns of the tunable RGD surface density were obtained as a function of the initial dendrimer concentration. The local RGD surface density was quantified through probability contour plots for the minimum interparticle distance, constructed from the corresponding atomic force microscopy images, and correlated with the cell adhesion and differentiation response. The results revealed that the local RGD surface density at the nanoscale acts as a regulator of chondrogenic commitment, and that intermediate adhesiveness of cells to the substrates favors mesenchymal cell condensation and early chondrogenic differentiation.

关键词： dendrimer arginine-glycine-asparticacid (RGD) nanopattem human mesenchymalstem cells (hMSCs) chondrogenesis