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Qualitative and quantitative analysis of Arnebiae Radix and Dictamni Cortex and efficacy study of herbal extracts on allergic contact dermatitis using 3D human reconstructed epidermis

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Chinese Herbal Medicines 2021年第4期13卷 556-564页

作者： Huan Li Esther Lim Gladys Ang Zhi-qing Lim Martin Hui Cai jo-anne Loh Celine Ng Peijia Seetoh Edmund Tian Lay Beng Goh Centre of Innovation for Complementary Health Product School of Applied ScienceTemasek PolytechnicSingapore 529757Singapore Translational Research Project School of Applied ScienceTemasek PolytechnicSingapore 529757Singapore

Objective:To evaluate the quality of Arnebiae Radix(AR)and Dictamni Cortex(DC)and study the efficacy of herbal extracts of these two herbs on the treatment of allergic contact dermatitis(ACD).Methods:Qualitative and quantitative analysis of effective components was performed using High Performance Thin Layer Chromatography(HPTLC),High Performance Liquid Chromatography(HPLC),and HPLC-Quadrupole Time of Flight-Mass Spectrometry(HPLC-QTOF-MS).In vitro allergic ACD 3D model was established by incubating 3D reconstructed human epidermis(RHE)with skin sensitizer,potassium dichromate.A total of 65 gene expression that were associated with ACD,which included 24 antioxidant responsive element(ARE)and 41 SENS-IS genes were quantified by q *** than or equal to 10 ARE genes and 18 SENN-IS genes were induced by 1.3-fold,demonstrating the successful establishment of in vitro ACD *** extracts of AR and DC were applied on the in vitro ACD model to study the ***:Batch 3 of AR and batch 2 of DC showed presence of all active ingredients with the highest *** ingredients of the herbs were extracted using a special oil and formulated into herbal oil *** herbal oil extracts were able to down regulate the induced genes in the in-vitro ACD skin model,bringing the tissue back to homeostatic ***:The oil extracts showed the potent efficacy of using AR and DC in ACD *** combination study will be done to optimize the formulation ratio which will be developed into a topical cream.

关键词： allergic contact dermatitis Arnebiae Radix Chinese medicine Dictamni Cortex 3D reconstructed epidermis quality control

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Feasibility of incorporating a bed-rest exercise program during a twin pregnancy: Case reports

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Open journal of Obstetrics and Gynecology 2012年第3期2卷 250-254页

作者： Chantale R. Brun jo-anne Hammond Michelle F. Mottola Samuel McLaughlin Foundation—Exercise & Pregnancy Laboratory London Canada School of Kinesiology and Recreation Université de Moncton Moncton Canada

Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.

关键词： Exercise Bed Rest Pregnancy Antepartum Muscle Conditioning Training

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Thermal conditioning of quail embryos has transgenerational and reversible long‑term effects

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journal of Animal Science and Biotechnology 2023年第6期14卷 2428-2438页

作者： Anais Vitorino Carvalho Christelle Hennequet‑Antier Romuald Rouger joel Delaveau Thierry Bordeau Sabine Crochet Nathalie Courousse Frederique Pitel anne Collin Vincent Coustham INRAE Universite de ToursBOA37380 ToursNouzillyFrance INRAE CNRSIFCEUniversite de ToursPRC37380 ToursNouzillyFrance Universite Paris-Saclay INRAEMaIAGE78350 Jouy‑en‑JosasFrance INRAE Bioinf OmicsUniversite Paris-SaclayMIGALE Bioinformatics Facility78350 Jouy‑en‑JosasFrance SYSAAF 37380 NouzillyFrance INRAE PEAT37380 NouzillyFrance INRAE INPTENVTUniversite de ToulouseGenPhySE31326 Castanet‑TolosanFrance INRAE Universite de Pau&Pays de L’AdourNuMeAE2S UPPAAquapole64310 Saint‑Pee‑Sur‑NivelleFrance

Background In the current context of global warming,thermal manipulation of avian embryos has received increasing attention as a strategy to promote heat tolerance in avian species by simply increasing the egg incubation ***,because of their likely epigenetic origin,thermal manipulation effects may last more than one generation with consequences for the poultry *** this work,a multigenerational and transgenerational analysis of thermal manipulation during embryogenesis was performed to uncover the long-term effects of such *** Thermal manipulation repeated during 4 generations had an effect on hatchability,body weight,and weight of eggs laid in Japanese quails,with some effects increasing in importance over ***,the effects on body weight and egg weight could be transmitted transgenerationally,suggesting non-genetic inheritance *** hypothesis is reinforced by the observed reversion of the effect on growth after five unexposed ***,a beneficial effect of thermal manipulation on heat tolerance was observed a few days after hatching,but this effect was not *** Our multigenerational study showed that thermal conditioning of quail embryos has a beneficial effect on post-hatch heat tolerance hampered by transgenerational but reversible defects on *** that no genetic variability underlies these changes,this study provides the first demonstration of epigenetic inheritance of traits induced by environmental temperature modification associated with long-term impacts in an avian species.

关键词： Avian Embryo Programming Temperature Transgenerational inheritance

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Imaging volumes during COVID-19:A Victorian health service experience

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World journal of Radiology 2022年第8期14卷 293-310页

作者： jo-anne Pinson My Linh Diep Vinay Krishnan Caroline Aird Cassie Cooper Christopher Leong Jeff Chen Nicholas Ardley Eldho Paul Mohamed Khaldoun Badawy Monash Health Imaging Monash HealthClaytonVictoria 3168Australia Department of Medical Imaging Peninsula HealthMelbourneVictoria 3099Australia Department of Medical Imaging and Radiation Sciences School of Allied Health CareFaculty of MedicineNursing and Health SciencesMonash UniversityClaytonVictoria 3800Australia Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourneVictoria 3800Australia

BACKGROUND The World Health Organisation declared the coronavirus disease 2019(COVID-19)a pandemic on March 11,*** globally,the relative caseload has been high,Australia’s has been relatively *** the pandemic,radiology services have seen significant changes in workflow across modalities and a reduction in imaging *** To investigate differences in modality imaging volumes during the COVID-19 pandemic across a large Victorian public health *** A retrospective analysis from January 2019 to December 2020 compared imaging volumes across two periods corresponding to the pandemic’s first and second *** volumes across patient class,modality and mobile imaging were summed for periods:wave 1(weeks 11 to 16 for 2019;weeks 63 to 68 for 2020)and wave 2(weeks 28 to 43 for 2019;weeks 80 to 95 for 2020).Microsoft Power Business Intelligence linked to the radiology information system was used to mine all completed *** Summed weekly data during the pandemic’s first wave showed the greatest decrease of 29.8%in adult outpatient imaging volumes and 46.3%in paediatric emergency department imaging *** nuclear medicine demonstrated the greatest decrease of 37.1%for the same *** nuclear medicine showed the greatest decrease of 47.8%,with angiography increasing by 50%.The pandemic’s second wave demonstrated the greatest decrease of 23.5%in adult outpatient imaging volumes,with an increase of 18.2%in inpatient imaging *** greatest decrease was 28.5%in paediatric emergency department imaging *** medicine showed the greatest decrease of 37.1%for the same *** nuclear medicine showed the greatest decrease of 36.7%.Mobile imaging utilisation increased between 57.8%and 135.1%during the first and second waves.A strong correlation was observed between mobile and nonmobile imaging in the emergency setting(Spearman’s correlation coefficient=-0.743,P=0.000).No correlation was observed in

关键词： COVID-19 Pandemic Radiology Imaging volume Modality Mobile imaging

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Risk Factors for Perinatal Asphyxia in Newborns Delivered at Term

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Open journal of Nursing 2016年第7期6卷 558-564页

作者： Anália Luana Sena de Souza Nilba Lima de Souza Débora Feitosa de França Samara Isabela Maia de Oliveira anne Karoline Candido Araújo Dândara Nayara Azevedo Dantas Federal University of Rio Grande do Norte/UFRN Natal Brazil Department of Nursing Health Science Center Federal University of Rio Grande do Norte (UFRN) Central Campus Natal Brazil Graduate Program in Nursing Federal University of Rio Grande do Norte/UFRN Natal Brazil

Perinatal asphyxia is defined as harm to the fetus or the newborn caused by hypoxia and/or ischemia of various organs with intensity to produce biochemical and/or functional changes. Understanding the risk factors for this clinical condition allows the identification of vulnerable groups, enabling an improvement in care planning in the perinatal period in neonatal intensive care units. In this sense, this research aimed to identify risk factors for perinatal asphyxia present in newborns term that showed record for this clinical condition. This was a cross-sectional, retrospective documentary, quantitative and descriptive, conducted from data from medical records of 55 infants admitted to a neonatal intensive care unit. As for maternal characteristics (78.0%) had between 16 and 35 years, only one child (53.0%) and (76.0%) had no prior history of miscarriage. As for pre-existing diseases or pregnancy (38.0%) developed by Hypertensive Pregnancy Specific disease (02.0%) were suffering from Hypertension and (02.0%) of Diabetes Mellitus. As for newborns, most infants had birth weight (43.6%) and correlation with gestational age (78.2%) compatible for good conditions of birth. Only (20.0%) of the infants had a difficult labor. It stood out although there was a slight predominance of severe asphyxia (50.9%) in the first minute and (45.5%) of the infants had record release intrauterine meconium. It was concluded that most mothers and newborns did not have risk factors for perinatal asphyxia, thus, this fact could be attributed to the structural conditions of service, especially in the care during labor, delivery and immediate assistance newborn.

关键词： Birth at Term Neonatal Asphyxia Neonatal Intensive Care Units Neonatal Nursing

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从ZT-1经验,看中国新药如何进入国际开发（英文）

从ZT-1经验,看中国新药如何进入国际开发（英文）

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2006第六届中国药学会学术年会

作者： jo-anne Lütjens Pietro Scalfaro Emmanuel Tamchès Debiopharm S.A. “Forum après-demain”Chemin Messidor 5-7CP 59111002 LausanneSwitzerland Debiopharm S.A. “Forum après-demain”Chemin Messidor 5-7CP 59111002 LausanneSwitzerland Debiopharm S.A. “Forum après-demain”Chemin Messidor 5-7CP 59111002 LausanneSwitzerland

＜正＞Chinese medicine has a wide range of chemical entities with interestingtherapeutic targets. However, until January 1993, date of signature of the MOU by China, only a few Chinese innovative NCEs were registered either in China or in other countries. Collaboration with foreign pharmaceutical companies appears to help speed-up the development of Chinese NCEs.

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Cardiovascular Risk Assessment in the Nursing Team of a Cardiology Hospital

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Open journal of Nursing 2016年第7期6卷 541-548页

作者： Marcela Paulino Moreira da Silva Claudinalle Farias Queiroz de Souza Kelly Cristina Torres Lemes Dândara Nayara Azevêdo Dantas anne Karoline Candido Araújo Tatiana Maria Nóbrega Elias Rejane Maria Paiva de Menezes Bertha Cruz Enders University Center of Rio Grande do Norte Natal Brazil University Center of Pernambuco Recife Brazil

Objective: Cardiovascular diseases are the most common causes of morbidity and the leading cause of mortality in the world scenario, accounting for about 20% of all deaths in individuals over 30 years. It has attributed this to the increase in the company’s exposure to risk factors. It identifies cardiovascular risk factors in the nursing team and compares the cardiovascular risk by Framingham score among professionals of middle and upper working in a referral hospital in cardiology. Method: Cross-sectional quantitative study was conducted in 2014, in a reference hospital in cardiology located in Recife/Pernambuco, Brazil. Data of cardiologic risk factors were collected from 82 nursing team members, comprised of technical, auxiliary nurses, and nurses between 30 and 74 years of age. The cardiovascular risk level was evaluated by the Framingham Score. Data were organized and analyzed by means of the SPSS, with descriptive statistics and Student-t test for the continuous variables. Results: Family history, stress and sedentary life style were the prevalent risk factors in more than half of the professionals. Only 5.23% of the technical and auxiliary nurses had a high risk score for cardiovascular event. Conclusion: The data indicates a low cardiovascular risk for these professionals and the presence of risk factors that can be modified. Health surveillance of these professionals is necessary in order to avoid a change to a risk of greater vulnerability.

关键词： Nursing Risk Factors Cardiovascular Disease

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Using electronic medical record data to assess chronic kidney disease,type 2 diabetes and cardiovascular disease testing,recognition and management as documented in Australian general practice:a cross-sectional analysis

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Family Medicine and Community Health 2022年第1期10卷 25-35页

作者： Julia L jones Natalie G Lumsden Koen Simons Anis Ta'eed Maximilian P de Courten Tissa Wijeratne Nicholas Cox Christopher J A Neil jo-anne Manski-Nankervis Peter Shane Hamblin Edward D Janus Craig L Nelson Nephrology Western HealthMelbourneVictoriaAustralia Medicine University of MelbourneMelbourneVictoriaAustralia Western Health Chronic Disease Alliance MelbourneVictoriaAustralia General Practice University of MelbourneMelbourneVictoriaAustralia Epidemiology and Biostatistics University of MelbourneMelbourneVictoriaAustralia Mitchell Institute for Education and Health Policy MelbourneVictoriaAustralia Chronic Disease Prevention and Management Victoria UniversityMelbourneVictoria3011 La Trobe University MelbourneVictoriaAustralia Neurology Western HealthMelbourneVictoriaAustralia Cardiology Western HealthMelbourneVictoriaAustralia Endocrinology and Diabetes Western HealthMelbourneVictoriaAustralia Medicine Western HealthMelbourneVictoriaAustralia

Objectives To evaluate the capacity of general practice(GP)electronic medical record(EMR)data to assess risk factor detection,disease diagnostic testing,diagnosis,monitoring and pharmacotherapy for the interrelated chronic vascular diseases-chronic kidney disease(CKD),type 2 diabetes(T2D)and cardiovascular *** Cross-sectional analysis of data extracted on a single date for each practice between 12 April 2017 and 18 April 2017 incorporating data from any time on or before data extraction,using baseline data from the Chronic Disease early detection and Improved Management in Primary Care *** data were extracted from GP EMRs using the Pen Computer Systems Clinical Audit Tool and descriptive statistics used to describe the study *** Eight GPs in Victoria,*** Patients were≥18 years and attended GP≥3 times within 24 months.37946 patients were *** Risk factor and disease testing/monitoring/treatment were assessed as per Australian guidelines(or US guidelines if none available),with guidelines simplified due to limitations in data availability where *** factor assessment in those requiring it:30%of patients had body mass index and 46%blood pressure within guideline recommended *** testing in at-risk population:17%had diagnostic testing as per recommendations for CKD and 37%for *** undiagnosed disease:Pathology tests indicating possible disease with no diagnosis already coded were present in 6.7%for CKD,1.6%for T2D and 0.33%familial *** prevalence:Coded diagnoses were recorded in 3.8%for CKD,6.6%for T2D,4.2%for ischaemic heart disease,1%for heart failure,1.7%for ischaemic stroke,0.46%for peripheral vascular disease,0.06%for familial hypercholesterolaemia and 2%for atrial *** prescriptions:the proportion of patients prescribed guideline-recommended medications ranged from 44%(beta blockers for patients for some condi

关键词： diagnosis testing record

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