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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang limin Wang Haoqin li Jiaxin Zhang Yang Ding Pan Pan li Bo Peng Hua Bai lin li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng li Meifeng Cai Shengjun Miao Yuan li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

Reversible li2C2O4 product regulation in li–CO2 batteries using single-atom alloy engineering

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Science China Chemistry 2025年

作者： Xinxin Zhang Yu Wang Yafei li Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University

The efficiency of lithium-carbon dioxide （li–CO2） batteries is limited by the sluggish generation/decomposition kinetics of the discharge products （i.e.,li2CO3and carbon） despite the use of state-of-the-art noble metal （NM） ***2C2O4has emerged as a promising alternative product;however,the thermodynamic instability of li2C2O4causes it to generally appear as an intermediate in li2CO3pathways rather than a product during ***,using comprehensive first-principles calculations,we report tailoring the discharge products of li–CO2batteries to li2C2O4via single-atom alloy （SAA） engineering,in which NM-doped copper SAAs （NM1Cu） are constructed for *** NM1Cu catalysts display a free-atom-like narrow d-band state and unique charge distribution over the solute NM1atom and the surrounding matrix Cu *** an optimized electronic structure is substantial in Ru1Cu and Ir1Cu,which is conducive to the co-activation and coupling of *** lithiation of*CO2intermediate that breaks the charge symmetry of the central C species can further reduce the kinetic barriers of the C–C *** advantages promote li2C2O4generation on Ru1Cu and Ir1Cu while suppress its subsequent ***,they exhibit low theoretical overpotentials and enable facile delithiation under normal charging *** work proposes a universal principle of manipulating electronic structures to achieve li2C2O4product,which provides practical guidance for the development of li–CO2batteries.

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Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Zinc alloys

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线上教学的虚拟仿真平台实践与应用

福建电脑 2020年第9期36卷 25-28页

作者：李基有张志龙张艳莉广东农工商职业技术学院广州510507

本文以广东农工商职业技术学院自主建设的“渥课(Vcooc)”虚拟仿真教学与实验平台为例,介绍了电子信息工程技术专业一种全新的线上教学与实验模式,构建一个融合虚拟仿真技术、电子电路技术等于一体,满足专业课程教学、项目仿真实训、考... 详细信息

本文以广东农工商职业技术学院自主建设的“渥课(Vcooc)”虚拟仿真教学与实验平台为例,介绍了电子信息工程技术专业一种全新的线上教学与实验模式,构建一个融合虚拟仿真技术、电子电路技术等于一体,满足专业课程教学、项目仿真实训、考试考核、资源库管理和课程管理与学生评价等功能为一体的学习与管理平台,帮助培养学生的自主学习、主动学习及主动获取知识的能力,达成线上教学目标。

关键词：资源共享线上教学虚拟仿真

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

甘肃西门塔尔牛甘州类群MSTN基因外显子多态性分析

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生物技术通报 2015年第6期31卷 165-169页

作者：李积友梁春花刘霞孙雪婧杜晓华甘肃省草食动物生物技术重点实验室兰州730070 甘肃省畜牧业产业管理局兰州730030 甘肃农业大学动物医学院兰州730070 甘肃农业大学生命科学技术学院兰州730070

采用PCR-SSCP方法检测50头甘肃西门塔尔牛甘州类群MSTN基因3个外显子的遗传多态性,并对群体内各等位基因进行测序,旨为探讨西门塔尔牛MSTN基因与肉质性状关联等方面的研究提供理论依据。结果显示,甘肃西门塔尔牛甘州类群MSTN基因3个外... 详细信息

采用PCR-SSCP方法检测50头甘肃西门塔尔牛甘州类群MSTN基因3个外显子的遗传多态性,并对群体内各等位基因进行测序,旨为探讨西门塔尔牛MSTN基因与肉质性状关联等方面的研究提供理论依据。结果显示,甘肃西门塔尔牛甘州类群MSTN基因3个外显子中,外显子2受B、C等位基因控制,形成BB、CC和BC 3种基因型,基因型频率分别为0.22(11/50)、0.64(32/50)、0.14(7/50);外显子1和外显子3分别受A等位基因与D等位基因控制,形成AA和DD基因型,基因型频率均为1(50/50)。序列分析表明,甘肃西门塔尔牛甘州类群MSTN基因3个外显子中,外显子2在第41 bp处发生了C→T的突变,但并没有导致氨基酸发生改变,属于同义突变;外显子1和3均无突变。统计结果表明,甘肃西门塔尔牛甘州类群MSTN基因3个外显子中,外显子2为中度多态,其余均无变化。

关键词： MSTN基因外显子遗传多态性西门塔尔牛

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铁路企业运维综合服务台的研究及实现

铁路计算机应用 2015年第3期24卷 22-25页

作者：李纪铀张锦超贺晓玲中国铁道科学研究院电子计算技术研究所北京100081

铁路企业需要摆脱传统的运维管理模式,推行基于综合服务台的运维管理模式势在必行。其中服务台作为用户和运维部门之间的信息交换反馈平台,为用户提供问题、事件、变更、发布等环节的统一接口,采用标准的运维管理流程对服务台的所有事... 详细信息

铁路企业需要摆脱传统的运维管理模式,推行基于综合服务台的运维管理模式势在必行。其中服务台作为用户和运维部门之间的信息交换反馈平台,为用户提供问题、事件、变更、发布等环节的统一接口,采用标准的运维管理流程对服务台的所有事件信息进行处理,为运维服务管理提供良好的支持平台。因此,服务台的设计和实现显得尤为重要。

关键词：运维服务综合服务台运维标准流程