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Clinical and genetic analysis of Ser341Pro MYOC variant in a Korean family with primary open angle glaucoma

International Journal of Ophthalmology(English edition) 2020年第11期13卷 1689-1696页

作者： Sangwoo Moon Namhee Kim jiwoong lee Department of Ophthalmology Pusan National University College of MedicineBusan 49241Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan 49241Republic of Korea Department of Laboratory Medicine Dong A University College of MedicineBusan 49201Republic of Korea

AIM:To report the first discovery of Ser341Pro myocilin(MYOC)variant in Korea and analyze its clinical characteristics and genetic ***:Ten family members from three generations participated in this study and received the thorough ophthalmologic *** exome sequencing on a proband was performed to confirm the target mutations(MYOC c.1021T>C)in the family members,and the direct sequencing was *** was analyzed according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology(ACMG/AMP)***:A nucleotide change from thymine to cytosine at c.1021T>C was found in eight family *** members diagnosed with primary open angle glaucoma(POAG)were characterized by severe clinical presentations,high intraocular pressure,and poor response to medical treatment(100%of the patient required filtering surgery).On variant analysis by ACMG/AMP guidelines,Ser341Pro is not found in normal *** computational predictive programs support a deleterious effect of Ser341Pro variant(PoIyPhen 2,SIFT,Mutation Taster).Ser341Pro could be involved in moderate(PM)and supporting(PP)criteria(PM1,PM2,PP2,PP3).Combiningthe criteria,Ser341Pro has a combination of 2 moderate(PM1+PM2)and 2 supporting(PP2+PP3)criteria,which is interpreted to"likely pathogenic".CONCLUSION:The Ser341Pro variant is correlated with severe phenotype of *** are similar clinical aspects to previous studies:autosomal dominant inheritance,incomplete penetrance(62.50%and 66.67%),and proportion of patients requiring trabeculectomy(100%in both study).According to ACMG/AMP guidelines and the previous basic researches,the Ser341Pro variant had a"strong evidence of pathogenicity(PS3)"and then it could be interpreted to“pathogenic(PS3,PM1,PM2,PP2,PP3)”.Additionally,Ser341Pro variant can be reported as"c.1021T>C(***341Pro)",likely pathogenic,POAG,autosomal dominant”according to guideline.

关键词： Ser341Pro variant primary open angle glaucoma Korean

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Red cell distribution width/albumin ratio and 90-day mortality after burn surgery

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Burns & Trauma 2022年第1期10卷 768-777页

作者： Young Joo Seo Jihion Yu Jun-Young Park Narea lee jiwoong lee Ji Hyun Park Hee Yeong Kim Yu-Gyeong Kong Young-Kug Kim Department of Anesthesiology and Pain Medicine Hangang Sacred Heart HospitalHallym University College of MedicineSeoul 07247Republic of Korea Department of Anesthesiology and Pain Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Anesthesiology and Pain Medicine National Medical CenterSeoul 04564Republic of Korea Department of Anesthesiology and Pain Medicine CHA Gangnam Medical CenterCHA University School of MedicineSeoul 06135Republic of Korea

Background:Red cell distribution width(RDW)and serum albumin concentration are associated with postoperative ***,the usefulness of the RDW/albumin ratio in burn surgery remains ***,we evaluated the association between RDW/albumin ratio and 90-day mortality after burn ***:Between 2013 and 2020,a retrospective review of patients in a burn intensive care unit(ICU)was *** operating characteristic curve,multivariate Cox logistic regression,multivariate logistic regression and Kaplan-Meier analyses were conducted to evaluate the associ-ation between RDW/albumin ratio and 90-day mortality after burn ***,prolonged ICU stay rate(>60 days)and ICU stay were ***:Ninety-day mortality was 22.5%(210/934)in burn *** factors for 90-day mortality were RDW/albumin ratio at postoperative day 1,age,American Society of Anesthesiologists physical status,diabetes mellitus,inhalation injury,total body surface area burned,hypotensive event and red blood cell transfusion *** area under the curve of the RDW/albumin ratio at postoperative day 1 to predict 90-day mortality,after adjusting for age and total body surface area burned,was 0.875(cut-off value,6.8).The 90-day mortality was significantly higher in patients with RDW/albumin ratio>6.8 than in those with RDW/albumin ratio≤6.8(49.2%vs 12.3%,p6.8 than in those with RDW/albumin ratio≤6.8(34.5%vs 26.5%;21[11-38]vs 18[7-32]days).Conclusion:RDW/albumin ratio>6.8 on postoperative day 1 was associated with higher 90-day mortality,higher prolonged ICU stay rate and longer ICU stay after burn surgery.

关键词： Red cell distribution width Albumin ratio Mortality Mortality Burn Risk factor Surgery

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Recent Advances in Patterning Strategies for Full‑Color Perovskite Light‑Emitting Diodes

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Nano-Micro Letters 2024年第3期16卷 99-137页

作者： Gwang Heon lee Kiwook Kim Yunho Kim jiwoong Yang Moon Kee Choi Graduate School of Semiconductor Materials and Devices Engineering Center for Future Semiconductor Technology(FUST)Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea

Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution *** recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color *** integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous ***,we present state-of-the-art patterning technologies for the development of full-color ***,we highlight recent advances in the development of efficient ***,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated *** patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite *** review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.

关键词： Perovskite Light-emitting diode Full-color display High-resolution patterning Electroluminescence

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Spectroscopic Understanding of Structural and Electrical Property Variations in Dopant-Free ZnO Films

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Journal of Materials Science & Technology 2017年第6期33卷 523-526页

作者： Hyegyeong Kim jiwoong Kim Dooyong lee Won-Jae lee Jong-Seong Bae Jaekwang lee Sungkyun Park Department of Physics Pusan National University Department of Nano Engineering & Electronic Research Center Dong-Eui University Busan Center Korea Basic Science Institute

Physical property variation in dopant-free ZnO films was investigated. Film annealing under various environments（O_2, in-Air, N2 and vacuum） resulted in better crystallinity than in the as-grown film. In particular, the film annealed under the N_2 environment showed better crystallinity and electrical properties than films annealed in other environments. Based on spectroscopic analysis, we found a correlation between physical（structural, electrical） and chemical properties： The crystallinity of ZnO films is closely related to ZnO bonding, whereas carrier concentration is associated with VO（oxygen vacancy）.

关键词： ZnO films Annealing Oxygen vacancies Environmental stability

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Enhancing BiVO_(4)photoanode performance by insertion of an epitaxial BiFeO_(3)ferroelectric layer

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Journal of Energy Chemistry 2024年第2期89卷 71-78,I0003页

作者： Haejin Jang Yejoon Kim Hojoong Choi jiwoong Yang Yoonsung Jung Sungkyun Choi Donghyeon lee Ho Won Jang Sanghan lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

BiVO_(4)(BVO)is a promising material as the photoanode for use in photoelectrochemical ***,the high charge recombination and slow charge transfer of the BVO have been obstacles to achieving satisfactory photoelectrochemical *** address this,various modifications have been attempted,including the use of ferroelectric *** materials can form a permanent polarization within the layer,enhancing the separation and transport of photo-excited electron-hole *** this study,we propose a novel approach by depositing an epitaxial BiFeO_(3)(BFO)thin film underneath the BVO thin film(BVO/BFO)to harness the ferroelectric property of *** self-polarization of the inserted BFO thin film simultaneously functions as a buffer layer to enhance charge transport and a hole-blocking layer to reduce charge *** a result,the BVO/BFO photoanodes showed more than 3.5 times higher photocurrent density(0.65 mA cm^(-2))at 1.23 V_(RHE)under the illumination compared to the bare BVO photoanodes(0.18 m A cm^(-2)),which is consistent with the increase of the applied bias photon-to-current conversion efficiencies(ABPE)and the result of electrochemical impedance spectroscopy(EIS)*** results can be attributed to the self-polarization exhibited by the inserted BFO thin film,which promoted the charge separation and transfer efficiency of the BVO photoanodes.

关键词： Photoelectrochemical Photoanode BiVO_(4) Ferroelectric materials BiFeO_(3)

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Microsphere-assisted hyperspectral imaging:super-resolution,non-destructive metrology for semiconductor devices

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Light(Science & Applications) 2024年第6期13卷 1098-1111页

作者： Jangryul Park Youngsun Choi Soonyang Kwon Youngjun lee jiwoong Kim Jae-joon Kim Jihye lee Jeongho Ahn Hidong Kwak Yusin Yang Taeyong Jo Myungjun lee Kwangrak Kim Metrology and Inspection Equipment R&D Team Mechatronics ResearchSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department DRAM Process Development TeamSemiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department Semiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea

As semiconductor devices shrink and their manufacturing processes advance,accurately measuring in-cell critical dimensions(CD)becomes increasingly *** test element group(TEG)measurements are becoming inadequate for representing the fine,repetitive patterns in cell *** non-destructive metrology technologies like optical critical dimension(OCD)are limited due to their large spot diameter of approximately 25μm,which impedes their efficacy for detailed in-cell structural ***,there is a pressing need for small-spot and non-destructive metrology *** address this limitation,we demonstrate a microsphere-assisted hyperspectral imaging(MAHSI)system,specifically designed for small spot optical metrology with *** microsphere-assisted super-resolution imaging,this system achieves an optical resolution of 66 nm within a field of view of 5.6μm×5.6μ*** approach effectively breaks the diffraction limit,significantly enhancing the magnification of the *** MAHSI system incorporating hyperspectral imaging with a wavelength range of 400–790 nm,enables the capture of the reflection spectrum at each camera *** achieved pixel resolution,which is equivalent to the measuring spot size,is 14.4 nm/pixel and the magnification is *** MAHSI system enables measurement of local uniformity in critical areas like corners and edges of DRAM cell blocks,areas previously challenging to inspect with conventional OCD *** our knowledge,this approach represents the first global implementation of microsphere-assisted hyperspectral imaging to address the metrology challenges in complex 3D structures of semiconductor devices.

关键词： metrology resolution enable

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Defect engineering of ternary Cu-In-Se quantum dots for boosting photoelectrochemical hydrogen generation

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Carbon Energy 2023年第12期5卷 215-228页

作者： Shi Li Sung-Mok Jung Wookjin Chung Joo-Won Seo Hwapyong Kim Soo Ik Park Hyo Cheol lee Ji Su Han Seung Beom Ha In Young Kim Su-Il In Jae-Yup Kim jiwoong Yang Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical Engineering Dankook UniversityYonginRepublic of Korea Department of Chemistry and Nanoscience College of Natural ScienceEwha Womans UniversitySeoulRepublic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

Heavy-metal-free ternary Cu–In–Se quantum dots(CISe QDs)are promising for solar fuel production because of their low toxicity,tunable band gap,and high light absorption *** defects significantly affect the photophysical properties of QDs,the influence on photoelectrochemical hydrogen production is not well ***,we present the defect engineering of CISe QDs for efficient solar-energy *** acid–base reactions between metal halide–oleylamine complexes and oleylammonium selenocarbamate are modulated to achieve CISe QDs with the controlled amount of Cu vacancies without changing their *** them,CISe QDs with In/Cu=1.55 show the most outstanding photoelectrochemical hydrogen generation with excellent photocurrent density of up to 10.7 mA cm-2(at 0.6 VRHE),attributed to the suitable electronic band structures and enhanced carrier concentrations/lifetimes of the *** proposed method,which can effectively control the defects in heavy-metal-free ternary QDs,offers a deeper understanding of the effects of the defects and provides a practical approach to enhance photoelectrochemical hydrogen generation.

关键词： copper-indium-selenide defect engineering photoelectrochemical hydrogen generation quantum dots solar hydrogen

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2D MoS2 Helical Liquid Crystalline Fibers for Multifunctional Wearable Sensors

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Advanced Fiber Materials 2024年第6期6卷 1813-1824页

作者： Jun Hyun Park Jang Hwan Kim Su Eon lee Hyokyeong Kim Heo Yeon Lim Ji Sung Park Taeyeong Yun Jinyong lee Simon Kim Ho Jun Jin Kyeong Jun Park Heemin Kang Hoe Joon Kim Hyeong Min Jin jiwoong Kim Sang Ouk Kim Bong Hoon Kim Department of Robotics and Mechatronics Engineering DGISTDaegu 42988Republic of Korea Present Address:Platform Technology R&D Center LG ChemistrySeoul 07795Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Organic Materials and Fiber Engineering Soongsil UniversitySeoul 06978Republic of Korea Nano Convergence Technology Research Center Korea Electronics Technology Institute(KETI)Gyeonggi‑do 13509Republic of Korea Department of Green Chemistry and Materials Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering National Creative Research Initiative Center for Multi‑Dimensional Directed Nanoscale AssemblyKAIST Institute for NanocenturyKAISTDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak‑roYuseong‑guDaejeon 34134Republic of Korea

Fiber-based material systems are emerging as key elements for next-generation wearable devices due to their remarkable advantages,including large mechanical deformability,breathability,and high ***,greatly improved mechani-cal stability has been established in functional fiber systems by introducing atomic-thick two-dimensional(2D)*** development of intelligent fibers that can respond to various external stimuli is strongly needed for versatile *** this work,helical-shaped semiconductive fibers capable of multifunctional sensing are obtained by wet-spinning MoS2 liquid crystal(LC)*** mechanical properties of the MoS2 fibers were improved by exploiting high-purity LC dispersions consisting of uniformly-sized MoS2 ***,three-dimensional(3D)helical fibers with structural chirality were successfully constructed by controlling the wet-spinning process *** helical fibers exhibited multifunctional sensing characteristics,including(1)photodetection,(2)pH monitoring,(3)gas detection,and(4)3D strain sensing.2D materials with semiconducting properties as well as abundant surface reactive sites enable smart multifunctionalities in one-dimensional(1D)and helical fiber geometry,which is potentially useful for diverse applications such as wearable internet of things(IoT)devices and soft robotics.

关键词： Molybdenum disulfide(MoS2) Liquid crystal(LC) Two-dimensional(2D)material Sensor Fiber

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Correction:2D MoS2 Helical Liquid Crystalline Fibers for Multifunctional Wearable Sensors

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Advanced Fiber Materials 2024年第6期6卷 1997-1997页

作者： Park, Jun Hyun Kim, Jang Hwan lee, Su Eon Kim, Hyokyeong Lim, Heo Yeon Park, Ji Sung Yun, Taeyeong lee, Jinyong Kim, Simon Jin, Ho Jun Park, Kyeong Jun Kang, Heemin Kim, Hoe Joon Jin, Hyeong Min Kim, jiwoong Kim, Sang Ouk Kim, Bong Hoon Department of Robotics and Mechatronics Engineering DGIST Daegu Republic of Korea Platform Technology R&D Center LG Chemistry Seoul Republic of Korea Department of Materials Science and Engineering National Creative Research Initiative Center for Multi-Dimensional Directed Nanoscale Assembly KAIST Institute for Nanocentury KAIST Daejeon Republic of Korea Department of Materials Science and Engineering Soongsil University Seoul Republic of Korea Department of Organic Materials Engineering Chungnam National University Daejeon Republic of Korea Department of Materials Science and Engineering Chungnam National University Daejeon Republic of Korea Nano Convergence Technology Research Center Korea Electronics Technology Institute (KETI) Gyeonggi-do Republic of Korea Department of Green Chemistry and Materials Engineering Soongsil University Seoul Republic of Korea Department of Materials Science and Engineering Korea University Seoul Republic of Korea

In the Acknowledgements section, the following sentence was missing. "This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. RS-2024-00406240). " Th...

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