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《哲对宁诺尔》载治疗协日乌素病方剂的特点

内蒙古民族大学学报（自然科学蒙古文版） 2024年第1期 36-39页

作者：白明雪吴玲玲韩九林不详

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蒙药材马钱子炮制法文献研究

内蒙古民族大学学报（蒙医药学版） 2024年第1期34卷 13-17页

作者：斯琴比力格吴青海韩九林不详

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南五味子果酒工艺优化及品质分析

农产品加工 2024年第8期 60-62页

作者：陈欣丁瑜瑜邱玉蓉黄九林安康学院化学化工学院陕西安康725000 安康学院秦巴中药资源研发中心陕西高校青年创新团队陕西安康725000

以酒精度为指标,采用单因素试验和正交试验确定南五味子果酒最佳发酵工艺,并进行品质分析。结果表明,南五味子果酒最佳发酵工艺为发酵温度32℃,发酵时间8 d,初始糖度26%,菌种接种量1.2%。在此条件下发酵出来的南五味子果酒酒精度为8°,... 详细信息

以酒精度为指标,采用单因素试验和正交试验确定南五味子果酒最佳发酵工艺,并进行品质分析。结果表明,南五味子果酒最佳发酵工艺为发酵温度32℃,发酵时间8 d,初始糖度26%,菌种接种量1.2%。在此条件下发酵出来的南五味子果酒酒精度为8°,还原糖质量浓度为23 mg/mL,感官评价良好。

关键词：南五味子果酒发酵工艺品质分析

An efficient Hauser-base electrolyte for rechargeable magnesium batteries

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Journal of Energy Chemistry 2023年第1期76卷 1-10,I0001页

作者： Mingxiang Cheng Yaru Wang Duo Zhang Shuxin Zhang Yang Yang Xuecheng Lv jiulin Wang Yanna NuLi School of Chemistry and Chemical Engineering Shanghai Electrochemical Energy Devices Research CenterShanghai Jiao Tong UniversityShanghai 200240China School of Energy and Power Engineering Dalian University of TechnologyDalian 116024LiaoningChina

Rechargeable magnesium batteries(RMBs)are considered the promising candidates for post lithium-ion batteries due to the abundant storage,high capacity,and dendrite-rare characteristic of Mg ***,the lack of practical electrolytes impedes the development and application of ***,through a one-step reaction of LiCl congenital-containing Knochel–Hauser base TMPL(2,2,6,6-tetrame thylpiperidinylmagnesium chloride lithium chloride complex)with Lewis acid AlCl_(3),we successfully synthesized an efficient amino-magnesium halide TMPLA *** and mass spectroscopy identified that the electrolyte comprises the typical di-nuclear copolymer[Mg_(2)Cl_(3)·6THF]+cation group and[(TMP)2AlCl_(2)]-anion group,further supported by the results of density functional theory calculations(DFT)and the Molecular dynamics(MD)*** TMPLA electrolyte exhibits promising electrochemical performance,including available anodic stability(>2.65 V ***),high ionic conductivity(6.05mS cm^(-1)),and low overpotential(<0.1 V)as well as appropriate Coulombic efficiency(97.3%)for Mg plating/*** the insertion Mo6S8cathode and conversion Cu S cathode delivered a desirable electrochemical performance with high capacity and good cycling stability based on the TMPLA *** particular,when compatible with low cost and easily synthesized Cu S,the Cu S||Mg cell displayed an extremely high discharge capacity of 458.8 mAh g^(-1)for the first cycle and stabilized at 170.2 mAh g^(-1)with high Coulombic efficiency(99.1%)after 50 cycles at 0.05 *** work proposes an efficient electrolyte with impressive compatibility with Mg anode and insertion/conversion cathode for practical RMBs and provides a more profound knowledge of the Lewis acid–base reaction mechanisms.

关键词： Rechargeable magnesium batteries Mg-Li dual-salt electrolyte Hauser-base In-situ synthesis Lewis acid–base reaction CuS cathode

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南北五味子油的成分分析及其生物活性研究

食品与发酵工业 2024年第13期50卷 263-269页

作者：黄九林刘文文韩柯妹王祯祯王叶陈莎莎韩胤伊安康学院化学化工学院陕西安康725000 秦巴中药资源开发与应用陕西高校青年创新团队陕西安康725000 秦巴中药资源开发与利用陕西省高校工程研究中心陕西安康725000

为了研究南北五味子油的成分及其生物活性,通过超临界CO_(2)萃取法提取南北五味子油,采用GC-MS和HPLC法分析其成分,利用HepG2细胞胰岛素抵抗模型测定其降糖活性,DPPH自由基清除实验测定其抗氧化活性。结果表明北五味子萃取物中五味子醇... 详细信息

为了研究南北五味子油的成分及其生物活性,通过超临界CO_(2)萃取法提取南北五味子油,采用GC-MS和HPLC法分析其成分,利用HepG2细胞胰岛素抵抗模型测定其降糖活性,DPPH自由基清除实验测定其抗氧化活性。结果表明北五味子萃取物中五味子醇甲、五味子乙素和脂肪酸含量明显高于南五味子,南五味子萃取物减轻胰岛素抵抗作用强于北五味子,北五味子萃取物DPPH自由基清除率高于南五味子。因此,南五味子降糖作用较好,北五味子抗氧化效果较好。

关键词：南北五味子油成分分析降糖活性抗氧化活性

基于网络药理学和分子对接探讨参枝苓口服液治疗阿尔茨海默病的作用机制

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中西医结合心脑血管病杂志 2024年第17期22卷 3104-3111页

作者：陈海阳温艺超郁志华陈久林刘特上海中医药大学上海市中医老年医学研究所上海200031

目的:基于网络药理学和分子对接技术探讨参枝苓口服液治疗阿尔茨海默病(AD)的作用机制。方法:利用中药系统药理学分析平台(TCMSP)和中药分子机制的生物信息学分析工具数据库(BATMAN-TCM)查找与参枝苓口服液中中药相关的化学成分及其作... 详细信息

目的:基于网络药理学和分子对接技术探讨参枝苓口服液治疗阿尔茨海默病(AD)的作用机制。方法:利用中药系统药理学分析平台(TCMSP)和中药分子机制的生物信息学分析工具数据库(BATMAN-TCM)查找与参枝苓口服液中中药相关的化学成分及其作用靶点;通过DisGeNET数据库获取与AD相关的靶标,并进一步筛选得到参枝苓口服液治疗AD的潜在作用靶点;利用Cytoscape软件构建成分-靶点相互作用网络,确认可能的关键靶点和关键通路;采用DAVID数据库对筛选出的潜在作用靶点进行基因本体(GO)功能分析及京都基因与基因组百科全书(KEGG)代谢通路富集分析;通过分子对接预测活性成分与靶蛋白的结合能力。结果:在参枝苓口服液中,共筛选出34个与AD相关的潜在活性成分和56个潜在作用靶点;GO生物功能分析共包含541条富集结果,主要涉及基因表达的正向调节、同源蛋白结合等;KEGG富集得到214条代谢通路,主要包括AD及自噬信号通路等。分子对接结果表示β-谷甾醇、山柰酚、木犀草素与半胱氨酸蛋白酶3(CASP3)、前列腺素内过氧化物合酶(PTGS2)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF)、B细胞淋巴瘤/白血病-2(Bcl-2)均可较好结合,可能是参枝苓口服液抗AD最有效的活性成分。结论:网络药理学及分子对接研究结果揭示了参枝苓口服液治疗AD的多成分、多靶点、多途径的作用特点,并预测了其可能的活性成分、作用通路和关键靶点,为其药效物质基础和作用机制提供了理论基础。

关键词：阿尔茨海默病参枝苓口服液网络药理学

Shen-Zhi-Ling oral solution improves learning and memory ability in Alzheimer’s disease mouse model

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Journal of Traditional Chinese Medicine 2019年第5期39卷 667-677页

作者： Chi Huiying Liu Te Pan Weidong Chen jiulin Wu Beiling Yu Zhihua Chen Chuan Shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200031China Department of Pathology Yale University School of MedicineConnecticut 06520USA Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200031China

OBJECTIVE: To investigate the effector mechanisms and effector targets of Shen-Zhi-Ling (SZL) oral solution in the treatment of Alzheimer's disease (AD). METHODS: In this study, we carried out gavage with SZL oral solution in an APP/PS-1 heterozygous double transgenic AD mouse model for 12 continuous weeks. Haematoxylin and eosin staining, Nissl staining and Annexin V/Propidium Iodide staining were used to detect the brain histopathology in AD mouse model. Immunofluorescence staining was used to detect the expression levels of autophagy's proteins. Morris water maze test was used to detect the learning and memory ability in AD mouse model. RESULTS: Pathological results showed that neuronal loss in the hippocampus of mice in the SZL intervention group was significantly alleviated and the number of apoptotic neurons was significantly decreased compared with the control group (physiological saline and non-intervention groups). Immunofluorescence staining results showed that the expression of autophagy activators, Beclin-1 and LC3B, was significantly increased in the hippocampal neurons of mice of the SZL intervention group, while the expression of the apoptotic factor, caspase- 3, was significantly decreased. At the same time, hippocampal accumulation of Aβ42 protein was significantly decreased. In addition, results of the water maze experiment showed that the latency period in mice from the SZL intervention group was significantly reduced. CONCLUSION: In summary, we believe that the SZL oral solution significantly activates autophagy in hippocampal neurons, effectively reducing the accumulation of Aβ42 peptides, alleviating neuronal injury and apoptosis, and ultimately improving the cognitive function in a mouse model of AD.

关键词： Alzheimer disease Autophagy Shen-Zhi-Ling oral solution

Research status and prospect of separators for magnesium-sulfur batteries

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Journal of Energy Chemistry 2023年第12期87卷 225-246,I0007页

作者： Shaopeng Chen Yaru Wang Yukun Sun Duo Zhang Shuxin Zhang Yazhen Zhao jiulin Wang Jun Yang Yanna NuLi School of Chemistry and Chemical Engineering Shanghai Electrochemical Energy Devices Research CenterShanghai Jiao Tong UniversityShanghai 200240China

Magnesium-sulfur(Mg-S)batteries have attracted wide research attention in recent years,and are considered as one of the major candidates to replace lithium-ion batteries due to the high theoretical energy density,low costs of active materials,and high ***,there are still significant challenges that need to be overcome before they can reach the large-scale practical *** key issue is the dissolution and shuttle effect of magnesium polysulfides(Mg-PSs),which leads to severe capacity degradation and shortens cycling life,greatly limiting the development of Mg-S *** order to overcome these challenges,great efforts have been made in cathode materials,electrolytes,and ***,we review the investigations on suppressing the shuttle effect of Mg-PSs via the modification of separators,including schemes such as coating the functional materials that can hold Mg-PSs on the surface of polyolefin-based or glass fiber(GF)separators,forming gel polymer separators via cross-linking polymerization reactions,and developing gel polymer electrolytes coupled with GF ***,an outlook is proposed for the future design on separator exploitation to accelerate the development of Mg-S battery technology.

关键词： Magnesium-sulfur batteries Polysulfides Shuttle effect Separator modification Gel polymer electrolytes

多抗广适高产小麦品种众岱100的栽培技术与推广应用

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中国种业 2024年第9期 125-126,129页

作者：刘庆伟陈钱权赵酒林董彦琪河南省新乡市农业科学院新乡453000 鹤壁麦大师农业科技有限公司鹤壁458000

众岱100是由鹤壁麦大师农业科技有限公司(以下简称麦大师种业)推广的矮秆、大穗、抗冻、抗倒、抗逆、高产、稳产小麦新品种。在育种过程中,众岱100凝聚了多种高产基因,因此具有突破性特征。众岱100于2022年同时通过黄淮冬麦区南片、北... 详细信息

众岱100是由鹤壁麦大师农业科技有限公司(以下简称麦大师种业)推广的矮秆、大穗、抗冻、抗倒、抗逆、高产、稳产小麦新品种。在育种过程中,众岱100凝聚了多种高产基因,因此具有突破性特征。众岱100于2022年同时通过黄淮冬麦区南片、北片麦区国家审定,2023年通过河北省审定。审定至今工作人员根据众岱100的品种特征和特性,不仅研究了切合实际的配套栽培技术,而且探索出可行的繁育推广模式,使众岱100累计推广面积达到300多万hm^(2),主要分布在黄淮南片、北片麦区,新增加小麦产量4.7亿kg,社会经济效益显著。

关键词：小麦众岱100 特征特性栽培技术推广应用

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