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Advancing drug safety and mitigating health concerns:High-resolution mass spectrometry in the levothyroxine case study

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Journal of Pharmaceutical Analysis 2024年第9期14卷 1361-1371页

作者： Hana Chmelařová maria Carmen Catapano Jean-Christophe Garrigues FrantišekŠvec Lucie Nováková Department of Analytical Chemistry Faculty of Pharmacy in Hradec KrálovéCharles UniversityAkademika Heyrovského 120350005Hradec KrálovéCzech Republic Laboratoire SOFTmAT(ImRCP) Universitéde ToulouseCNRS UMR 5623UniversitéPaul Sabatier118 route de Narbonne31062 Toulouse Cedex 9France

Levothyroxine is a drug with a narrow therapeutic *** the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability,which can result in major health ***,the increased adverse drug reactions have not been fully explained scientifically yet and a thorough investigation of the formulations is *** this study,we used a non-targeted analytical approach to examine the various levothyroxine formulations in detail and to reveal possible chemical ***-high-performance liquid chromatography coupled with a data-independent acquisition high-resolution mass spectrometry(UHPLC-DIA-HRmS)was ***-DIA-HRmS allowed not only the detection of levothyroxine degradation products,but also the presence of non-expected components in the *** these,we identified compounds resulting from reactions between mannitol and other excipients,such as citric acid,stearate,and palmitate,or from reactions between an excipient and an active pharmaceutical ingredient,such as levothyroxine-lactose *** addition to these compounds,undeclared phospholipids were also found in three *** non-targeted approach is not common in pharmaceutical quality control *** the presence of unexpected compounds in drug formulations proved that the current control mechanisms do not have to cover the full complexity of pharmaceutical formulations necessarily.

关键词： Levothyroxine Excipients Impurities UHPLC-DIA-HRmS Drug safety

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Analysis of shower particle pseudorapidity spectra in interactions of relativistic Au and Pb ions with emulsion nuclei

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Chinese Physics C 2011年第12期35卷 1095-1099页

作者： B.Z.Belashev m.K.Suleymanov S.Vokál J.Vrláková m.Ajaz Ali Zaman K.H.Khan Z.Wazir Institute of Geology Karelian Research Center Russian Academy of Sciences St. Petrozavodsk Russia COmSATS Institute of Information Technology Department of Physics Islamabad 44000 Pakistan Veksler and Baldin Laboratory of High Energy Physics JINR Dubna 141980 Russia P. J. afárik University Koice Slovakia

The pseudorapidity spectra of fast particles （with β 〉 0.7） produced in Au （at 11.6 A GeV） and Pb （at 158 A GeV） induced collisions with emulsion （Em） nuclei contain some visual plateaus and shoulders. The plateau is wider for Pb＋Em reactions compared with the Au＋Em ones. The existence of a plateau is expected for parton models. The Fourier transformation and maximum entropy methods were used to get additional information about the plateaus. The dependence of the plateaus on the centrality of the collisions was also studied using the number of g-particles to fix centrality. It shows that the maximum entropy method could confirm the existence of the plateau and the shoulder on distributions.

关键词： pseudorapidity spectra s-particles g-particles centrality Fourier transformation maximum entropy

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微弧氧化法制备钛基HA/CS涂层及其生物学特性

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稀有金属材料与工程 2013年第12期42卷 2586-2589页

作者：王国卿 Zver'kov D A 张乃生东北大学辽宁沈阳110004 莫斯科国立兽医与生物技术学院莫斯科109472 吉林大学吉林长春130062

采用微弧氧化法在医用钛表面制备羟基磷灰石(HA)/壳聚糖(CS)涂层。通过扫描电镜(SEm)、X射线衍射(XRD)仪、红外光谱(FTIR)仪分析涂层的形貌和物相,评价HA/CS涂层对成骨细胞的毒性及其在动物体内的生物活性,分析微弧氧化法制备钛基HA/CS... 详细信息

采用微弧氧化法在医用钛表面制备羟基磷灰石(HA)/壳聚糖(CS)涂层。通过扫描电镜(SEm)、X射线衍射(XRD)仪、红外光谱(FTIR)仪分析涂层的形貌和物相,评价HA/CS涂层对成骨细胞的毒性及其在动物体内的生物活性,分析微弧氧化法制备钛基HA/CS涂层的特征及其在骨修复中应用的可能性。结果表明:微弧氧化法可在钛表面生成HA/CS涂层,厚度40±2 m、粗糙度3.3±0.1 m、孔隙率(30±2)%,孔隙近圆形、直径几微米到20 m,结合强度20.5±1.1 mPa;涂层中HA与CS之间没有形成化学键,晶体HA占10%,平均粒径37 nm,非晶体HA占90%;钛基HA/CS涂层材料对成骨细胞增殖具有促进作用,无细胞毒性,在动物体内能够诱导骨小梁形成,具有高的生物活性。微弧氧化法制备的高生物活性钛基HA/CS涂层材料,在骨修复方面具有良好的应用前景。

关键词：微弧氧化羟基磷灰石壳聚糖复合涂层钛种植体生物活性

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Role of forests in headwater control with changing environment and society

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International Soil and Water Conservation Research 2021年第1期9卷 143-157页

作者： Josef Krecek Jana Nováková Ladislav Palán Eva Pazourková Evzen Stuchlík Department of Hydrology Czech Technical University in PragueThákurova 7CZ-16629Prague 6Czech Republic Independent Botanist Na Vrcholu 4CZ-13000PragueCzech Republic AON Impact Forecasting Václavskénáměstí19CZ-11000PragueCzech Republic Institute of Hydrobiology Biology CentreCzech Academy of SciencesNa Sádkách 7CZ-37005(C)eskéBudějoviceCzech Republic

Forest practices in headwater catchments are related to environmental and social *** aim of this study is to analyse the changing protective functions of forests in the upper plain of the Jizera mts.(North Bohemia,Czech Republic)since the second half of the 19th *** time,forests have gradually changed from native stands to spruce plantations(Picea abies),introducing exotic conifers(more resistant to air pollution),and,recently,back to more diverse mixed *** priority in pro-tective forest functions there shifted from flood protection to integrated control of water resources(quantity and quality).In the 1980s,forest-water interactions were degraded by consequences of extreme acid atmospheric deposition,forest die-back,and extensive *** the Jizerka catchment,first signs of recovery were observed in the early *** waters there are still affected by prolonged *** reconstruction of stream water chemistry at Jizerka follows the drop of the acid deposition in some 5 years,the revival of stream biota takes 10-15 *** 2071-2100,the pro-jected climate change shows rising annual air temperatures by 3.0-4.6℃,decreasing water yield by 65-123 mm,60%drop in'minimum residual discharge',and 20-30%rise in ***,these projected environmental changes cannot substantially decline the high potential in water resource recharge,or,start reverse processes in recent recovery from acidification and radically affect the exis-tence of planned mixed forests in the upper plain of the Jizera mts.

关键词： Headwater catchment Forest functions Water resource recharge Acid atmospheric deposition Climate change

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Stability case study of the ACROBOTER underactuated service robot

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Theoretical & Applied mechanics Letters 2012年第4期2卷 27-33页

作者： László L.kovács László Bencsik HAS-BmE Research Group on Dynamics of machines and Vehicles Budapest H-1521Hungary Department of Applied mechanics Budapest University of Technology and EconomicsBudapest H-1521Hungary

The dynamics of classical robotic systems are usually described by ordinary differential equations via selecting a minimum set of independent generalized coordinates. However, different parameterizations and the use of a nonminimum set of （dependent） generalized coordinates can be advantageous in such cases when the modeled device contains closed kinematic loops and/or it has a complex structure. On one hand, the use of dependent coordinates, like natural coordinates, leads to a different mathematical representation where the equations of motion are given in the form of differential algebraic equations. On the other hand, the control design of underactuated robots usually relies on partial feedback linearization based techniques which are exclusively developed for systems modeled by independent coordinates. In this paper we propose a different control algorithm formulated by using dependent coordinates. The applied computed torque controller is realized via introducing actuator constraints that complement the kinematic constraints which are used to describe the dynamics of the investigated service robotic system in relatively simple and compact form. The proposed controller is applied to the computed torque control of the planar model of the ACROBOTER service robot. The stability analysis of the digitally controlled underactuated service robot is provided as a real parameter case study for selecting the optimal control gains.

关键词： stability underactuation natural coordinates control constraints

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Clinical Study: Lotion Containing Propolis Special Extract GH 2002 0.5% vs. Placebo as On-Top Treatment of Herpes Zoster

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Health 2017年第10期9卷 1337-1347页

作者： Denisa Tomanova Simona Holcova m. Hladíková Dermatological Ambulatorium Consultancy of Dermatovenerology Brno Czech Republic Department of medical Informatics 2nd Faculty of Medicine Charles University of Prague Prague Czech Republic

Background: The aim of the clinical trial was to establish the contribution of propolis special extract GH 2002 as constituent of a lotion for the supportive treatment of Herpes zoster. methods: 60 patients with diagnosed Herpes zoster were either treated with a propolis containing (n = 33) or an identical, but propolis-free lotion (n = 27) for 28 days, as an add-on therapy to oral antiviral treatment with aciclovir. Study parameters were the assessment of pain on a visual analogue scale, the assessment of the formation of new vesicles, and the safety of application of the preparation. Results: Improvement of pain was significantly better and quicker in the propolis lotion group (p mparison showed 57.6% versus 25.9%. At least 50% of propolis-treated patients were lesion-free on day 14, versus day 28 in the control group (p = 0.013). The formation of new vesicles was also significantly suppressed. On day 3/4 the number of newly formed vesicles was 15 versus 25, on day seven the number of new vesicles was 4 versus 14 (p med through the global assessment of efficacy by the physician, with 75.8 versus 33.3% “good” to “excellent” ratings already on day 3/4, 90.9 vs. 44.4% on day 7, and 100 vs. 74.1% on day 28 (p m antiviral and anti-inflammatory effects of propolis special extract GH 2002 and at the same time demonstrate the benefits of the topical add-on to the syste

关键词： Herpes Zoster Propolis Controlled Clinical Trial

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Impact of welding equipment on power quality

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China Welding 2024年第3期33卷 44-51页

作者： kovács Attila molnár Judit Jármai Károly Institute of Physics and Electrical Engineering Department of Electrical and Electronic Engineering Institutional DepartmentUniversity of MiskolcMiskolc H3515Hungary Institute of Energy and Chemical Engineering University of MiskolcMiskolc H3515Hungary

In an industrial facility,many electrical consumers can affect the quality of ***,the freedom from interference sources of these devices and equipment can be crucial for quality and uninterrupted electricity *** welding equipment is also a possible source of *** electrical harmonic injections created by welding equipment into the electrical network can affect the operation of other consumers connected to the given distribution points and cause unjustified overheating and shutdowns of some network *** aim of the research is to analyse the current harmonic injection of welding equipment of different types and modes of operation connected to the internal distribution network of the industrial *** effectiveness of the active harmonic filter built into the welding equipment was also examined in the *** results showed that the built-in active harmonic filter of the DC045 laser welding equipment was ineffective because the total harmonic distortion(THD)was about three times the 8%allowed by IEEE 519−2022 *** current harmonic injection of mIG 320 and mm403 type welding equipment was more than five times the permissible value of 5%.The current harmonic distortion of the PLAS140 type plasma-jet cutter equipment was below the 5% value allowed in the standard,thus it complied with *** on the measurement results,it can be concluded that the use of protection against harmonics is also necessary for welding ***,proposals were made in the paper to reduce the effect of harmonics.

关键词： electrical transients harmonic distortion electrical network disturbances voltage breaks total harmonic distortion(THD)

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Hyperactive learning for data-driven interatomic potentials

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npj Computational materials 2023年第1期9卷 599-612页

作者： Cas van der Oord matthias Sachs Dávid Péter kovács Christoph Ortner Gábor Csányi University of Cambridge Cambridge CB21PZUK University of Birmingham Birmingham B152TTUK University of British Columbia VancouverBC V6T 1Z2Canada

Data-driven interatomic potentials have emerged as a powerful tool for approximating ab initio potential energy *** most time-consuming step in creating these interatomic potentials is typically the generation of a suitable training *** aid this process hyperactive learning(HAL),an accelerated active learning scheme,is presented as a method for rapid automated training database *** adds a biasing term to a physically motivated sampler(*** dynamics)driving atomic structures towards uncertainty in turn generating unseen or valuable training *** proposed HAL framework is used to develop atomic cluster expansion(ACE)interatomic potentials for the AlSi10 alloy and polyethylene glycol(PEG)polymer starting from roughly a dozen initial *** HAL generated ACE potentials are shown to be able to determine macroscopic properties,such as melting temperature and density,with close to experimental accuracy.

关键词： starting generating consuming

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Nonstationary laser-supported ionization wave in layer of porous substance with subcritical density

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matter and Radiation at Extremes 2024年第1期9卷 58-70页

作者： S.Yu Gus’kov R.A.Yakhin P.N.Lebedev Physical Institute of Russian Academy of Sciences Leninskii Prospect 53Moscow 119991Russia

A time-dependent analytical solution is found for the velocity of a plane ionization wave generated under nanosecond laser pulse action on the surface of a flat layer of low-Z porous substance with density less than the critical density of the produced *** corrections for the two-dimensional nature of the problem when a laser beam of finite radius interacts with a flat target,this solution is in quantitative agreement with measurements of ionization wave velocity in various *** solution compared with experimental data covering wide ranges of performance conditions,namely,(3-8)×10^(14)W cm^(−2)for laser pulse intensity,0.3-3 ns for pulse duration,0.35-0.53μm for laser wavelength,100-1000μm for laser beam radius,380-950μm for layer thickness,4.5-12 mg cm^(−3)for average density of porous substance,and 1-25μm for average pore *** parameters of the laser beam that ensure the generation of a plane ionization wave in a layer of subcritical porous matter are determined for the problem statements and are found to meet the requirements of practical applications.

关键词： laser pulse porous

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In vivo and in vitro study of resorbable magnesium wires for medical implants:mg purity,surface quality,Zn alloying and polymer coating

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Journal of magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar J.Luňácková m.Jex m.Žaloudková R.Vrbová m.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda m.Steinerová S.Habr K.Balík A.Singh Department of materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of mg-based *** low-alloyed mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure mg,commercially pure mg,mg-0.15Zn,mg-0.4Zn and mg-1Zn was ***,mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed mg-induced osteogenesis,polymer-coated mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： magnesium Resorbable mg wire mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation

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