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Surface-modulated and thermoresponsive polyphosphoester nanoparticles for enhanced intracellular drug delivery

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Science China Chemistry 2014年第4期57卷 579-585页

作者： LI Yang WANG Feng SUN TianMeng du jinzhi YANG XianZhu WANG Jun Department of Polymer Science and Engineering University of Science and Technology of China Hefei National Laboratory for Physical Sciences at Microscale School of Life Sciences University of Science and Technology of China School of Medical Engineering Hefei University of Technology High Magnetic Field Laboratory of CAS University of Science and Technology of China

The chemical structure of end groups influenced the phase transition temperature of thermoresponsive polymers. We demonstrated a strategy for the preparation of the pH/thermo-responsive polymeric nanoparticles via subtle modification of end groups of thermoresponsive polymer segments with a carboxyl group and revealed its potential application for enhanced intracellular drug delivery. By developing a polymeric nanoparticle composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell, we showed that end groups of thermoresponsive polyphosphoester segments modified by carboxyl groups exhibited a pH/thermo-responsive behavior due to the hydrophilic to hydrophobic transitions of the end groups in response to the pH. Moreover, by encapsulating doxorubicin into the hydrophobic core of such pH/thermo-responsive polymer nanoparticles, their intracellular delivery and cytotoxicity to wild-type and drug-resistant tumor cells were significantly enhanced through the phase-transition-dependent drug release that was triggered by endosomal/lysosomal pH. This novel strategy and the multi-responsive polymer nanoparticles achieved by the subtle chain-terminal modification of thermoresponsive polymers provide a smart platform for biomedical applications.

关键词： thermoresponsive drug release polyphosphoester drug resistance

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磁流变减振技术研究与应用

汽车实用技术 2024年第17期49卷 83-87页

作者：张卫琴杜金枝胡群林刘海亮芜湖奇瑞科技有限公司安徽芜湖241000

磁流变减振技术作为一种先进的汽车悬架半主动控制技术,在过去几十年中受到了广泛关注。文章旨在探讨磁流变减振技术在汽车悬架系统中的应用,以提升车辆行驶中的稳定性与舒适性。通过分析磁流变液的工作原理及其在磁场作用下的快速响应... 详细信息

磁流变减振技术作为一种先进的汽车悬架半主动控制技术,在过去几十年中受到了广泛关注。文章旨在探讨磁流变减振技术在汽车悬架系统中的应用,以提升车辆行驶中的稳定性与舒适性。通过分析磁流变液的工作原理及其在磁场作用下的快速响应能力,设计一款基于磁流变减振技术的汽车减震器。按照汽车减震器性能测试标准对进行实验室测试和汽车操稳性能主观评价。结果表明,该磁流变减振器能够有效地快速调节阻尼力,实时适应路况变化,显著减少了车身振动和提高了驾驶舒适性,相对传统减震器有明显的性能优势。验证了磁流变减振技术在提升汽车性能方面的有效性,为进一步的产品开发与批量汽车应用提供了理论支持。

关键词：汽车悬架减震器磁流变液操稳性能

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Multiresponsive Polymer Assemblies Achieved by a Subtle Chain Terminal Modification

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Chinese Journal of Chemistry 2014年第1期32卷 51-56页

作者： Weiwei Liu Yucai Wang Yang Li Feng Wang Xianzhu Yang Tianmeng Sun jinzhi du Jun Wang Nano Science and Technology Institute University of Science and Technology of China Suzhou Jiangsu 215123 China Department of Polymer Science and Engineering University of Science and Technology of China Hefei Anhui 230026 China CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 China School of Medical Engineering Hefei University of Technology Hefei Anhui 230009 China Email: Xianzhu Yang (yangxz@***) Jun Wang (jwang699@***)[*]CAS Key Laboratory of Brain Function and Disease and School of Life Sciences University of Science and Technology of China Hefei Anhui 230027 China Tel.: 0086-0551-63600335 Fax: 0086-0551-63600402

Inspired by the influence of chemical structure of end groups on the phase transition temperature of thermoresponsive polymers,we demonstrated a strategy to control the multi-responsiveness of polymer assemblies via subtle modification of end groups of thermoresponsive polymer segments and revealed its potential application for drug *** developing polymer assemblies composed of poly(aliphatic ester) as the inner core and thermoresponsive polyphosphoester as the outer shell,we showed that end groups of thermoresponsive polyphosphoester segments controlled the surface property of assemblies and further determined the stimuli-responsive *** phase-transition temperatures of the unmodified polymer assemblies are tightly controlled by their surface properties due to the hydrophilic to hydrophobic transitions of end groups in response to an environmental stimulus (*** or light irradiation).External control over these surface properties can by asserted by adjusting the chemical structure and composition of the terminal groups of the thermoresponsive polyphosphoesters.

关键词： multi-responsive thermoresponsive phase-transition polyphosphoester

Electrode particulate materials for advanced rechargeable batteries:A review

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Particuology 2024年第3期86卷 160-181页

作者： Mingyang Ma Miao du Yan Liu Hongyan Lü Jialin Yang Zelin Hao jinzhi Guo Xinglong Wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Department of Chemistry Northeast Normal UniversityChangchunJilin130024China

The demand for large-scale energy storage is increasing due to the decreasing non-renewable resources and deteriorating environmental *** rechargeable batteries with high energy density and long cycle performance is an ideal choice to meet the demand of energy storage *** development of excellent electrode particles is of great significance in the commercialization of nextgeneration *** ideal electrode particles should balance raw material reserves,electrochemical performance,price and environmental *** them,the development of electrode particulate materials with excellent electrochemical properties is the top priority at *** this review,the typical researches of electrode materials are summarized in terms of crystal structure,morphology,pore structure,surface and interface ***,the structural characteristics and improvement methods of transition metal oxides,polyanionic compounds,Prussian blue and their analogues are ***,the different effects of particulate morphology,pore,surface and interface structure on the performance of electrode materials are *** designing high-performance electrode materials,preparation route should be set according to the particle properties of the materials and the synergistic effect of various optimization methods should be *** the same time,in addition to the electrode materials,other components of the rechargeable batteries,such as current collector,separator and electrolytes,should be optimized to improve the overall performance of the *** review would provide important guiding principle for designing high-performance electrode particulate materials.

关键词： Particulate properties Electrode materials Rechargeable batteries

Sprayable Immunotherapy Gel on Surgical Site Reduces Cancer Recurrence and Metastasis

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材料导报 2019年第9期33卷 1427-1428页

作者：张亚茹罗佳琪杜金志 Institutes for Life Sciences School of MedicineSouth China University of Technology School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of Technology

A large portion of cancer patients will undergo some types of surgery to treat their *** the continuous improvement in surgical techniques over the past decades,many patients still develop tumor recurrence,which leads to severe mortality[1-3].Immunotherapy provides a new promise to cure *** are major components of the innate immunity,and phagocytize foreign ***,cancer cells can escape macrophage recognition through displaying“don’t eat me”signal via up-regulation of CD47 protein on their surface[4-5].Several ongoing clinical trials are looking at ways to block CD47,but the side effects such as anemia and thrombocytopenia caused by systemic administration can not be ignored,since the red blood cells also express CD47 on their *** these severe side effects are essential to make CD47-blocking immunotherapies clinically applicable[6-7].In addition,the macrophages within tumor tissues are M2-like phenotype,and exert pro-tumourigenic activities.

关键词： Sprayable Immunotherapy Gel Cancer

A Molecular-Sieving Interphase Towards Low-Concentrated Aqueous Sodium-Ion Batteries

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Nano-Micro Letters 2024年第8期16卷 51-63页

作者： Tingting Liu Han Wu Hao Wang Yiran Jiao Xiaofan du jinzhi Wang Guangying Fu Yaojian Zhang Jingwen Zhao Guanglei Cui Qingdao Industrial Energy Storage Research Institute Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA 5005Australia Shandong Energy Institute Qingdao 266101People’s Republic of China Qingdao New Energy Shandong Laboratory Qingdao 266101People’s Republic of China

Aqueous sodium-ion batteries are known for poor rechargeability because of the competitive water decomposition reactions and the high electrode *** have been reported by saltconcentrated and organic-hybridized electrolyte designs,however,at the expense of cost and ***,we report the prolonged cycling of ASIBs in routine dilute electrolytes by employing artificial electrode coatings consisting of NaX zeolite and NaOH-neutralized perfluorinated sulfonic *** as-formed composite interphase exhibits a molecularsieving effect jointly played by zeolite channels and size-shrunken ionic domains in the polymer matrix,which enables high rejection of hydrated Na^(+)ions while allowing fast dehydrated Na^(+)*** this coating to electrode surfaces expands the electrochemical window of a practically feasible 2 mol kg^(-1) sodium trifluoromethanesulfonate aqueous electrolyte to 2.70 V and affords Na_(2)MnFe(CN)_(6)//NaTi_(2)(PO_(4))_(3) full cells with an unprecedented cycling stability of 94.9%capacity retention after 200 cycles at 1 *** with emerging electrolyte modifications,this molecular-sieving interphase brings amplified benefits in long-term operation of ASIBs.

关键词： Molecular sieving effect Electrode coatings Aqueous sodium ion batteries Dilute aqueous electrolytes

Oscillatory Dynamics of Heterogeneous Stem Cell Regeneration

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Communications on Applied Mathematics and Computation 2024年第1期6卷 431-453页

作者： Xiyin Liang jinzhi Lei School of Mathematical Sciences Center for Applied MathematicsTiangong UniversityTianjin300387China

Stem cell regeneration is an essential biological process in the maintenance of tissue homeostasis;dysregulation of stem cell regeneration may result in dynamic diseases that show oscillations in cell *** heterogeneity and plasticity are necessary for the dynamic equilibrium of tissue homeostasis;however,how these features may affect the oscillatory dynamics of the stem cell regeneration process remains poorly ***,based on a mathematical model of heterogeneous stem cell regeneration that includes cell heterogeneity and random transition of epigenetic states,we study the conditions to have oscillation solutions through bifurcation analysis and numerical *** results show various model system dynamics with changes in different parameters associated with kinetic rates,cellular heterogeneity,and *** show that introducing heterogeneity and plasticity to cells can result in oscillation dynamics,as we have seen in the homogeneous stem cell regeneration ***,increasing the cell heterogeneity and plasticity intends to maintain tissue homeostasis under certain *** current study is an initiatory investigation of how cell heterogeneity and plasticity may affect stem cell regeneration dynamics,and many questions remain to be further studied both biologically and mathematically.

关键词： Stem cell regeneration Heterogenous Hopf bifurcation Hematopoietic dynamical disease

Does the continuous wetting of the Tibetan Plateau contribute to the accelerated degradation of permafrost?

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Science China Earth Sciences 2024年第5期67卷 1714-1718页

作者： Yuyang WANG jinzhi DING Shilong PIAO Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Global warming is causing the Tibetan permafrost to degrade, as evidenced by rising ground temperatures, thicker active layer thickness, thinner permafrost layer, and melting underground ice, etc.(Ran et al., 2018;Wang et al., 2020).The degradation of permafrost not only profoundly alters the carbon cycling processes in high-altitude ecosystems,thereby influencing the regional climate system, but also affects landscape hydrological connectivity。

关键词： Tibetan landscape altitude

RNA interference in insects:the link between antiviral defense and pest control

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Insect Science 2024年第1期31卷 2-12页

作者： jinzhi Niu Ruoyu Chen Jin-Jun Wang Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqingChina

RNA interference(RNAi)is a form of gene silencing triggered by double-stranded RNA(dsRNA)that operates in all eukaryotic *** has been widely investigated in insects to determine the underlying molecular mechanism,to investigate its role in systemic antiviral defense,and to develop strategies for pest *** insect cells are infected by viruses,viral dsRNA signatures trigger a local RNAi response to block viral replication and generate virus-derived DNA that confers systemic ***-based insect pest control involves the application of exogenous dsRNA targeting genes essential for insect development or survival,but the efficacy of this approach has limited potency in many pests through a combination of rapid dsRNA degradation,inefficient dsRNA uptake/processing,and ineffective RNAi *** could be addressed by dsRNA screening and evaluation,focusing on dsRNA design and off-target management,as well as dsRNA production and *** review summarizes recent progress to determine the role of RNAi in antiviral defense and as a pest control strategy in insects,addressing gaps between our fundamental understanding of the RNAi mechanism and the exploitation of RNAi-based pest control strategies.

关键词： RNAi response systemic RNAi insecticidal dsRNA biological control off-targets