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Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals

Virologica Sinica 2024年第4期39卷 546-555页

作者： Shiping Ding Jiangtao Zhou Junlong Xiong Xiaowen Du Wenzhuo Yang jinyu huang Yi Liu Lihong huang Ming Liao Jiahao Zhang Wenbao Qi State Key Laboratory for Animal Disease Control and Prevention South China Agricultural UniversityGuangzhou510642China National Avian Influenza Para-Reference Laboratory Guangzhou510642China Key Laboratory of Zoonoses Ministry of Agriculture and Rural AffairsGuangzhou510642China National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control Guangzhou510642China Key Laboratory of Zoonoses Prevention and Control of Guangdong Province Guangzhou510642China State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China College of Animal Science and Technology Zhongkai University of Agriculture and EngineeringGuangzhou510550China

The H10 subtype avian influenza virus(AIV)poses an ongoing threat to both birds and ***,fatal human cases of H10N3 and H10N8 infections have drawn public *** 2022,we isolated two H10N3 viruses(A/chicken/Shandong/0101/2022 and A/chicken/Shandong/0603/2022)from diseased chickens in *** analysis revealed that these viruses were genetically associated with human-origin H10N3 virus,with internal genes originating from local H9N2 *** to the H10N8 virus(A/chicken/Jiangxi/102/2013),the H10N3 viruses exhibited enhanced thermostability,increased viral release from erythrocytes,and accumulation of hemagglutinin(HA)***,we evaluated the pathogenicity of both H10N3 and H10N8 viruses in *** found that viral titers could be detected in the lungs and nasal turbinates of mice infected with the two H10N3 viruses,whereas H10N8 virus titers were detectable in the lungs and brains of ***,the proportion of double HA Q222R and G228S mutations in H10N3 viruses has increased since ***,the functional roles of the Q222R and G228S double mutations in the HA gene of H10N3 viruses remain unknown and warrant further *** study highlights the potential public health risk posed by the H10N3 virus.A spillover event of AIV to humans could be a foretaste of a looming ***,it is imperative to continuously monitor the evolution of the H10N3 influenza virus to ensure targeted prevention and control measures against influenza outbreaks.

关键词： Avian influenza virus(AIV) H10N3 Evolution Pathogenicity

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基于OAM复用信号高效调制解调的声学超表面

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南京大学学报（自然科学版） 2024年第2期60卷 339-344页

作者：刘智黄保霖林玮赵瑾瑜南京航空航天大学物理学院南京211106 安徽建筑大学数理学院合肥230601

轨道角动量(Orbital Angular Momentum,OAM)复用是提高声学通信系统数据容量的一种潜在解决方案,提出一种利用声学超表面对OAM复用信号进行调制和解调的方法,利用该方法对独立声轨道角动量(Acoustic Orbital Angular Momentum,AOAM)信... 详细信息

轨道角动量(Orbital Angular Momentum,OAM)复用是提高声学通信系统数据容量的一种潜在解决方案,提出一种利用声学超表面对OAM复用信号进行调制和解调的方法,利用该方法对独立声轨道角动量(Acoustic Orbital Angular Momentum,AOAM)信号的幅度和相位进行分析,并通过仿真实现对AOAM信号的调制和解调.AOAM信号的相位和幅度提供正交自由度,通过设计合适的声学超表面并将其与二进制差分相位编码技术相结合,证明其可以实现AOAM复用信号的有效调制和解调.正交声学螺旋模态可防止模式耦合和串扰,从而增强声学多路复用.基于谐振的结构提供信号频率选择性,提高了交互效率,简化了终端设备,便于实现大容量声学通信系统的创建.

关键词：声学超表面声轨道角动量声信号复用

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PREVENTING RUMOR SPREADING ON SMALL-WORLD NETWORKS

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Journal of Systems Science & Complexity 2011年第3期24卷 449-456页

作者： jinyu huang Xiaogang JIN AI Institute School of Computer Science Zhejiang University Hangzhou 310027 China Ningbo Institute of Technology Zhejiang University Ningbo 315100 China

Since the spreading of harmful rumors can deeply endanger a society, it is valuable to investigate strategies that can efficiently prevent hazardous rumor propagation. To conduct this investigation, the authors modify the SIR model to describe rumor propagation on networks, and apply two major immunization strategies, namely, the random immunization and the targeted immunization to the rumor model on a small-world network. The authors find that when the average degree of the network is small, both two strategies are effective and when the average degree is large, neither strategy is efficient in preventing rumor propagation. In the latter case, the authors propose a new strategy by decreasing the credibility of the rumor and applying either the random or the targeted immunization at the same time. Numerical simulations indicate that this strategy is effective in preventing rumor spreading on the small-world network with large average degree.

关键词： Complex networks credibility immunization strategy rumor propagation

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Cognition and expansion of nursing science:A response to the discussion paper entitled“At the intersection of science and theory:How the Nurse Role Integration Model reconciles the conflict”

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International Journal of Nursing Sciences 2021年第1期8卷 141-142页

作者： Lei Lei jinyu huang Yu Luo School of Nursing Army Medical UniversityChongqingChina Department of Microbiology and Immunology McGill UniversityMontrealQuebecCanada

“Should research using animal models be included in the field of nursing science study?”When asked by colleagues during her ***,Sharon ***,a student at the University of Connecticut School of Nursing,realized she was not prepared to *** question inspired her to embark on a self-reflection journey regarding nursing roles and subsequently create the Nurses’Role Integration Model adapted from the Neuman Systems *** this model,Casavant identifies research such as investigation using animal models,collecting human clinical biomarkers,and clinical data analysis as primary prevention under the heading Science of Nursing,reflecting the nurse’s work.

关键词： nurse prevention Integration

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Dietary supplemental coated essential oils and organic acids mixture improves growth performance and gut health along with reduces Salmonella load of broiler chickens infected with Salmonella Enteritidis

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2554-2577页

作者： Zeqiong Hu Lin Liu Fangshen Guo Jia huang Jianing Qiao Ruichen Bi jinyu huang Kaichen Zhang Yuming Guo Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijingChina. Shanghai Meinong Biotechnology Co. Ltd.ShanghaiChina. Shandong Heyi Food Co. Ltd.Zaozhuang CityShandong ProvinceChina.

Background Reducing Salmonella infection in broiler chickens by using effective and safe alternatives to antibiotics is vital to provide safer poultry meat and minimize the emergence of drug-resistant Salmonella and the spread of salmonellosis to *** study was to first evaluate the protective efficacy of feeding coated essential oils and organic acids mixture(EOA)on broiler chickens infected with Salmonella Enteritidis(***,SE),and then its action mechanism was further *** A total of 4801-day-old Arbor Acres male chickens were randomly assigned into five treatments with six replicates,including non-challenged control fed with basal diet(A),SE-challenged control(B),and SE-infected birds fed a basal diet with 300 mg/kg of EOA(BL),500 mg/kg of EOA(BM)and 800 mg/kg of EOA(BH),*** birds on challenged groups were infected with Salmonella Enteritidis on d *** Feeding EOA showed a reversed ability on negative effects caused by SE infection,as evidenced by decreasing the feed conversion rate(FCR)and the ratio of villus height to crypt depth(VH/CD)(P<0.05),obviously decreasing intestinal and internal organs Salmonella load along with increasing cecal butyric acid-producing bacteria abundance(P<0.05).Moreover,supplemental different levels of EOA notably up-regulated claudin-1(CLDN-1),occludin(OCLN),zonula occludens-1(ZO-1),mucin-2(MUC-2),fatty acid binding protein-2(FABP-2),nuclear factor kappa-light-chainenhancer of activated B cells(NF-κB),myeloid differential protein-88(MyD88)and interleukin-6(IL-6)mRNA levels in the ileum of the infected chickens after challenge,whereas down-regulated toll-like receptor-4(TLR-4)mRNA levels(P<0.05).Linear discriminant analysis combined effect size measurements analysis(LEfSe)showed that the relative abundance of g_Butyricicoccus,g_Anaerotruncus and g_unclassified_f_Bacillaceae significantly was enriched in infected birds given ***,phylogenetic investigation of communities by reconstruct

关键词： Broiler chickens Essential oils and organic acids mixture Gut health Salmonella Enteritidis

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重症脓毒症患者临床预后影响因素及相关指标对预后的预测效能分析

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中国医药 2024年第1期19卷 84-88页

作者：林文佳黄瑾瑜甘日志杨春兰广东医科大学附属医院急诊医学中心湛江524023

目的探讨重症脓毒症患者临床预后影响因素及相关指标对预后的预测效能,以期为预后不良高危人群筛选及临床治疗方案制定提供更多参考。方法收集2018年1月至2022年12月于广东医科大学附属医院就诊的266例重症脓毒症患者的临床资料行回顾... 详细信息

目的探讨重症脓毒症患者临床预后影响因素及相关指标对预后的预测效能,以期为预后不良高危人群筛选及临床治疗方案制定提供更多参考。方法收集2018年1月至2022年12月于广东医科大学附属医院就诊的266例重症脓毒症患者的临床资料行回顾性分析。根据进入重症监护病房(ICU)后28 d是否死亡分为存活组(180例)和死亡组(86例)。比较存活组和死亡组基线临床特征资料,采用多因素Logistic回归方法评估重症脓毒症患者进入ICU后28 d死亡的影响因素;分析相关指标对重症脓毒症患者进入ICU后28 d死亡的预测效能。结果死亡组序贯器官衰竭估计评分、简化急性生理学评分Ⅱ(SAPSⅡ)评分、降钙素原水平、C反应蛋白水平、进入ICU后24 h及48 h血小板计数下降值高于/大于存活组,差异均有统计学意义(均P<0.001)。多因素Logistic回归分析结果显示,SAPSⅡ评分、进入ICU后24 h及48 h血小板计数下降值均是重症脓毒症患者进入ICU后28 d死亡的独立危险因素(比值比=1.197、1.082、1.057,95%置信区间:1.125~1.275、1.053~1.112、1.034~1.080,均P<0.001)。受试者工作特征曲线分析结果显示SAPSⅡ评分、进入ICU后24 h及48 h血小板计数下降值、三者联合的约登指数分别为0.394、0.382、0.376、0.626,其中三者联合预测效果最优。结论重症脓毒症患者进入ICU后28 d死亡与SAPSⅡ评分、进入ICU后24 h及48 h血小板计数下降值有关,以上指标联合用于重症脓毒症患者进入ICU后28 d死亡风险预测效能更优。

关键词：脓毒症预后简化急性生理学评分Ⅱ 血小板计数

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Dietary encapsulated essential oils and organic acids mixture improves gut health in broiler chickens challenged with necrotic enteritis

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Journal of Animal Science and Biotechnology 2020年第3期11卷 866-883页

作者： Van Hieu Pham Liugang Kan jinyu huang Yanqiang Geng Wenrui Zhen Yuming Guo Waseem Abbas Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Faculty of Animal Science and Veterinary Medicine Thai Nguyen University Agriculture and ForestryThai NguyenVietnam Menon Animal Nutrition Technology Co.Ltd. ShanghaiChina

Background:The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis(NE)due to Clostridium *** the present study,we investigated the effects of dietary supplementation with a blend of encapsulated essential oils and organic acids(BLJ)on growth performance and gut health using a coinfection model of NE in broiler ***:Two hundred and eighty-eight one-day-old male Arbor Acres broiler chicks were randomly assigned using a 2×2 factorial design into two groups fed either 0 or 500 mg/kg dietary BLJ and co-challenged(or not challenged for the control)with Eimeria spp./***:Infected birds fed the BLJ-supplemented diet exhibited an improved feed conversion ratio throughout the trial(P<0.01),a higher villus height and villus height/crypt depth ratio,and reduced intestinal *** counts,liver *** carriage,gut lesion scores and serum fluorescein isothiocyanate dextran(FITC-D)concentrations at 7 d postinfection compared with those of birds without BLJ supplementation(P<0.05).NE-infected birds fed BLJ exhibited significantly upregulated claudin-1 and IGF-2 mRNA levels(P<0.05),increased A20 mRNA expression and significantly downregulated TRAF-6,TNFSF15 and TOLLIP mRNA levels in the jejunum at 7 d post-infection compared with those in birds without BLJ supplementation(P<0.05).Compared with the uninfected and untreated birds,the uninfected birds fed BLJ displayed increased relative abundances of Lactobacillus and Coprococcus but reduced Rikenellaceae *** with the unsupplemented NE-challenged birds,infected birds fed BLJ showed an increased relative abundance of Unclassified_Lachnospiraceae and a significantly decreased relative abundance of ***:BLJ supplementation improved growth performance and gut health in NE-infected broiler chickens by strengthening the intestinal barrier function,positively modulating the gut microbiota community

关键词： Broiler chickens Clostridium perfringens Essential oils and organic acids Gut health

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广西地区幽门螺杆菌感染与帕金森

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科技与健康 2024年第17期3卷 1-4页

作者：韦彬黄进瑜韦欢全凤莲吴嘉琦广西科技大学第一附属医院广西柳州545000

分析广西地区幽门螺杆菌感染与帕金森病患者运动症状严重程度的相关性。将广西科技大学第一附属医院2022年1月—2023年12月收治的70例帕金森病患者纳入试验组,将广西科技大学第一附属医院同期的70例健康人员纳入参照组。对组间人员基本... 详细信息

分析广西地区幽门螺杆菌感染与帕金森病患者运动症状严重程度的相关性。将广西科技大学第一附属医院2022年1月—2023年12月收治的70例帕金森病患者纳入试验组,将广西科技大学第一附属医院同期的70例健康人员纳入参照组。对组间人员基本资料进行收集,实施碳-14尿素呼气试验,进行UPDRS PartⅢ评分,研究幽门螺杆菌感染与帕金森病患者血清维生素B12、帕金森病评定量表评分之间的相关性。结果显示,试验组的碳-14尿素呼气试验中幽门螺杆菌阳性率高于参照组(P0.05);试验组中幽门螺杆菌阳性组和阴性组的血清维生素B12水平比较,无统计学差异(P>0.05);幽门螺杆菌阳性组的UPDRS PartⅢ评分高于阴性组,组间数据差异具有统计学意义(P<0.05)。研究发现,感染幽门螺杆菌易加重帕金森病患者的运动症状,两者之间关系密切,值得探讨。

关键词：幽门螺杆菌感染帕金森血清维生素B12 运动症状

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On Designs of Decentralized Reputation Management for Permissioned Blockchain Networks

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1755-1773页

作者： jinyu Chen Long Shi Qisheng huang Taotao Wang Daojing He School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing210094China School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen518055China College of Electronics and Information Engineering Shenzhen UniversityShenzhen518060China School of Computer Science and Technology Harbin Institute of TechnologyShenzhen518055China

In permissioned blockchain networks,the Proof of Authority(PoA)consensus,which uses the election of authorized nodes to validate transactions and blocks,has beenwidely advocated thanks to its high transaction throughput and fault ***,PoA suffers from the drawback of centralization dominated by a limited number of authorized nodes and the lack of anonymity due to the round-robin block proposal *** a result,traditional PoA is vulnerable to a single point of failure that compromises the security of the blockchain *** address these issues,we propose a novel decentralized reputation management mechanism for permissioned blockchain networks to enhance security,promote liveness,and mitigate centralization while retaining the same throughput as traditional *** paper aims to design an off-chain reputation evaluation and an on-chain reputation-aided ***,we evaluate the nodes’reputation in the context of the blockchain networks and make the reputation globally verifiable through smart ***,building upon traditional PoA,we propose a reputation-aided PoA(rPoA)consensus to enhance securitywithout sacrificing *** particular,rPoA can incentivize nodes to autonomously form committees based on reputation authority,which prevents block generation from being tracked through the randomness of reputation ***,we develop a reputation-aided fork-choice rule for rPoA to promote the network’s ***,experimental results show that the proposed rPoA achieves higher security performance while retaining transaction throughput compared to traditional PoA.

关键词： Blockchain reputation management PoA throughput security decentralization

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Dietary coated essential oil and organic acid mixture supplementation improves health of broilers infected with avian pathogenic Escherichia coli

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Animal Nutrition 2023年第1期12卷 245-262页

作者： Van Hieu Pham Waseem Abbas jinyu huang Fangshen Guo Kaichen Zhang Linhua Kong Wenrui Zhen Yuming Guo Zhong Wang State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing100193China Faculty of Animal Science and Veterinary Medicine Thai Nguyen University Agriculture and ForestryThai NguyenViet Nam Menon Animal Nutrition Technology Co.Ltd. Shanghai201807China Tengzhou Heyi Food Co.Ltd. Zaozhuang277000China

Colibacillosis caused by avian pathogenic Escherichia coli(APEC)is a very prevalent disease in poultry farms in *** exploration of effective non-antibiotic substances is of great significance for the control of APEC *** experiment evaluated the efficacy of coated essential oil and organic acid(EOA)supplementation to prevent *** O78 infection in broiler chickens.A total of 288 one-day-old male broiler chicks were randomly distributed into 4 groups with 6 replicates per *** were fed a diet either supplemented with EOA(500 mg/kg feed)or not,and either uninfected or infected with *** O78 *** showed that *** O78 infection reduced body weight gain,increased mortality and the ratio of feed to gain along with cecal and liver *** load,damaged gut mucosa,induced local and systemic inflammation,and altered cecal microbial composition,diversity and function(P<0.05).Supplemental EOA improved feed conversion efficiency,lowered gross lesion scores and cecal *** population,enhanced intestinal goblet cells and serum IgG concentration,and tended to decrease serum IL-12 production(P<0.05).Essential oil and organic acid addition downregulated IFN-γmRNA,tended to decrease mucin-2 mRNA levels while upregulating IL-10 mRNA,and tended to increase ZO-1 gene expression in the jejuna of infected birds at 7 d after *** O78 challenge(P<0.05).The 16S rRNA gene sequencing indicated that both EOA addition and *** O78 challenge altered the diversity and composition of the cecal microbiota ***,infected birds fed EOA showed decreased Bacteroidetes and genus Lactobacillus abundance compared with the infected *** analysis showed that Firmicutes,Ruminococcaceae,Clostridiales,Clostridia,Lactobacillus,Lactobacilaceae,and cc-115 were enriched in the non-infected but EOA-treated group(P<0.05).Collectively,dietary EOA supplementation could mildly alleviate ***-induced gut injury and inflammation.

关键词： Encapsulated essential oil and organic acid mixture Avian pathogenic Escherichia coli Health Broiler chicken

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