Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals
作者机构：State Key Laboratory for Animal Disease Control and PreventionSouth China Agricultural UniversityGuangzhou510642China National Avian Influenza Para-Reference LaboratoryGuangzhou510642China Key Laboratory of ZoonosesMinistry of Agriculture and Rural AffairsGuangzhou510642China National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and ControlGuangzhou510642China Key Laboratory of Zoonoses Prevention and Control of Guangdong ProvinceGuangzhou510642China State Key Laboratory of Agricultural MicrobiologyCollege of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China College of Animal Science and TechnologyZhongkai University of Agriculture and EngineeringGuangzhou510550China
出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)
年 卷 期：2024年第39卷第4期
页 面：546-555页
核心收录：
基 金：supported by the National Natural Science Foundation of China(32330104,32302956) the China Postdoctoral Science Foundation(2023T160252,Jiahao Zhang) the Guangzhou Science and Technology Plan Project(SL2022B03J01423) the Changjiang Distinguished Professor Program(2023,Wenbao Qi)
主 题：Avian influenza virus(AIV) H10N3 Evolution Pathogenicity
摘 要：The H10 subtype avian influenza virus(AIV)poses an ongoing threat to both birds and ***,fatal human cases of H10N3 and H10N8 infections have drawn public *** 2022,we isolated two H10N3 viruses(A/chicken/Shandong/0101/2022 and A/chicken/Shandong/0603/2022)from diseased chickens in *** analysis revealed that these viruses were genetically associated with human-origin H10N3 virus,with internal genes originating from local H9N2 *** to the H10N8 virus(A/chicken/Jiangxi/102/2013),the H10N3 viruses exhibited enhanced thermostability,increased viral release from erythrocytes,and accumulation of hemagglutinin(HA)***,we evaluated the pathogenicity of both H10N3 and H10N8 viruses in *** found that viral titers could be detected in the lungs and nasal turbinates of mice infected with the two H10N3 viruses,whereas H10N8 virus titers were detectable in the lungs and brains of ***,the proportion of double HA Q222R and G228S mutations in H10N3 viruses has increased since ***,the functional roles of the Q222R and G228S double mutations in the HA gene of H10N3 viruses remain unknown and warrant further *** study highlights the potential public health risk posed by the H10N3 virus.A spillover event of AIV to humans could be a foretaste of a looming ***,it is imperative to continuously monitor the evolution of the H10N3 influenza virus to ensure targeted prevention and control measures against influenza outbreaks.
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