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Mechanisms of secondary damage to the thalamic nucleus and substantia nigra in an adult hypertensive rat model following middle cerebral artery occlusion

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Neural Regeneration Research 2010年第11期5卷 853-858页

作者： Li Xiong Jian Yu Songjie Liao Shihui Xing Zhan Zhao jinsheng zeng Stroke Center and Department of Neurology First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 Guangdong ProvinceChina

BACKGROUND： Following ischemia, apoptosis is observed at the ipsilateral ventropostenor thalamic nucleus and substantia nigra, which are distant from, but connected to, the ischemic cerebral cortex, in animals with normotension. However, secondary brain damage in hypertension has not been clearly investigated. OBJECTIVE： The present study determined whether neuronal apoptosis is associated with neuronal loss in the ipsilateral ventroposterior thalamic nucleus and substantia nigra following cortical ischemia in adult hypertensive rats. Results should provide options for determining a time window for anti-apoptotic therapy. DESIGN, TIME AND SETTING： All experimental procedures in this randomized, controlled trial were conducted at the Neurological Laboratory of the First Affiliated Hospital of Sun Yat-sen University of China between October 2006 and July 2008. MATERIALS： Monoclonal primary antibodies specific to mouse anti-rat microtubule-associated protein 2 and glial fibrillary acidic protein were respectively purchased from Sigma Chemical, USA and BD Pharmingen, USA. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling （TUNEL） detection kits were purchased from Roche Applied Science, Switzerland and Upstate, USA, respectively. METHODS： A total of 64 male, Sprague Dawiey rats, aged 60-90 days, were equally and randomly divided into middle cerebral artery occlusion and sham surgery groups. Renovascular hypertension was established in both groups by renal artery occlusion. Right distal middle cerebral artery occlusion was performed by electrocoagulation in the middle cerebral artery occlusion group. MAIN OUTCOME MEASURES： Microtubule-associated protein 2 and glial fibrillary acidic protein were detected by immunohistochemistry, and apoptotic cells were observed by TUNEL assay. The stainings were separately detected in the ipsilateral ventroposterior thalamic nucleus and substantia nigra. RESULTS： During the 4 weeks followin

关键词： ventroposterior thalamic nucleus substantia nigra apoptosis rats cerebral infarction neural regeneration

Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China):results from a prospective double-blind randomised clinical trial

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Stroke & Vascular Neurology 2017年第3期2卷 118-123页

作者： Ying Zhao Wanyong Yang Zefeng Tan Wenmin Wang Weimin Xiao jinsheng zeng Anding Xu Department of Neurology and Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouChina Department of Neurology The First Affiliated HospitalKunming Medical CollegeKunmingYunnanChina Department of Neurology Dongguan People HospitalDongguanGuangdongChina Department of Neurology and Stroke Center First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina

Aim The role of clopidogrel in treating patients with acute ischaemic stroke is *** have conducted the clinical trial in order to evaluate the efficacy and safety of clopidogrel with a loading dose in treating patients with non-cardiogenic acute ischaemic *** Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China)was a prospective,randomised,double-blind and placebo-controlled clinical trial in *** with acute ischaemic stroke of non-cardiogenic origin within 48 hours of onset were enrolled and those received thrombolysis were *** patients were divided into two treatment groups:loading dose and routine *** primary outcome was the incidence of stroke recurrence or progression within 7 *** safety outcome was measured by life-threatening *** intent-to-treat analysis was used for the statistical *** From March 2008 to March 2010,a total of 303 patients from 16 centres were recruited into this study;six were excluded because of lack of basic *** the enrolment was slow and the study drug expired in March 2010,this clinical trial was stopped earlier than *** significant baseline and demographic differences were seen between the two *** was no difference in primary outcome between the loading dosage group 16.1%(24/149)and control group 14.9%(22/148),respectively(p=0.782).The mortality and disability rate within 90 days in loading dose group(19.6%)was slightly lower than that in controlled group(23.4%),p=*** dose group had two(1.3%)cases of fatal haemorrhage and control group had four(2.7%)within 90 days,p=*** significant difference was detected in other adverse events between the *** In our study stopped early due to slow enrolment,loading dose of clopidogrel does not reduce the risk of recurrent *** trials with sufficient number of patients enrolled are needed to re-e

关键词： patients dosage routine

Hypoxia inducible factor-1alpha mediates protection of DL-3-n-butylphthalide in brain microvascular endothelial cells against oxygen glucose deprivation-induced injury

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Neural Regeneration Research 2012年第12期7卷 948-954页

作者： Weihong Yang Ling Li Ruxun Huang Zhong Pei Songjie Liao jinsheng zeng Department of Neurology First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina

Studies have demonstrated that DL-3-n-butylphthalide can significantly alleviate oxygen glucose deprivation-induced injury of human umbilical vein endothelial cells at least partly associated with its enhancement on oxygen glucose deprivation-induced hypoxia inducible factor-1α *** this study,we hypothesized that DL-3-n-butylphthalide can protect against oxygen glucose deprivation-induced injury of newborn rat brain microvascular endothelial cells by means of upregulating hypoxia inducible factor-1α *** assay and Hoechst staining results showed that DL-3-n-butylphthalide protected brain microvascular endothelial cells against oxygen glucose deprivation-induced injury in a dose-dependent *** blot and immunofluorescent staining results further confirmed that the protective effect was related to upregulation of hypoxia inducible factor-1α.Real-time RT-PCR reaction results showed that DL-3-n-butylphthalide reduced apoptosis by inhibiting downregulation of pro-apoptotic gene caspase-3 mRNA expression and upregulation of apoptosis-executive protease bcl-2 mRNA expression;however,DL-3-n-butylphthalide had no protective effects on brain microvascular endothelial cells after knockdown of hypoxia inducible factor-1α by small interfering *** findings suggest that DL-3-n-butylphthalide can protect brain microvascular endothelial cells against oxygen glucose deprivation-induced injury by upregulating bcl-2 expression and downregulating caspase-3 expression though hypoxia inducible factor-1α pathway.

关键词： DL-3-n-butylphthalide apoptosis brain microvascular endothelial cells hypoxia inducible factor-1α

Bilateral olfactory ensheathing cell transplantation promotes neurological function in a rat model of cerebral infarction

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Neural Regeneration Research 2011年第13期6卷 983-987页

作者： Zhihua Yang Wenli Sheng Huiyong Shen Qinghua Hou Rui Li jinsheng zeng Ruxun Huang Department of Neurology First Affiliated Hospital Jinan University Guangzhou 510120 Guangdong Province China Department of Neurology First Affiliated Hospital Sun Yat-sen University Guangzhou 510080 Guangdong Province China Department of Orthopedics Second Affifiated Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

In the present study, olfactory ensheathing cells were transplanted into the cortices of infarcted （infarct transplantation group）, normal （normal transplantation group）, and bilateral hemispheres （bilateral transplantation group）. Olfactory ensheathing cells migrated to the infarct focus. The number of growth associated protein 43-positive cells and nerve fibers was slightly increased in the infarct area. These changes were more evident in the bilateral cortical transplantation group. Results demonstrated that transplanted olfactory ensheathing cells can migrate in rats with cerebra infarction. The olfactory ensheathing cells on the normal side can also promote neurological function. Bilateral cortical transplantation exhibited superior effects over unilateral transplantation.

关键词： cerebral infarction cell transplantation olfactory ensheathing cells neural regeneration

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我国各类主要脑血管病诊断要点演变与更新

中华神经科杂志 2019年第9期52卷 681-683页

作者：曾进胜蒲传强中山大学附属第一医院神经内科广州510080 解放军总医院神经内科北京100853

自1978年以来,我国已更新并发表了4个版本的各类脑血管病诊断要点."中国各类主要脑血管病诊断要点2019"是在前3个版本的基础上,结合我国新版脑血管病分类和国际疾病分类-11,综合主要脑血管病类型的症状、体征和影像学检查结果,制定出的... 详细信息

自1978年以来,我国已更新并发表了4个版本的各类脑血管病诊断要点."中国各类主要脑血管病诊断要点2019"是在前3个版本的基础上,结合我国新版脑血管病分类和国际疾病分类-11,综合主要脑血管病类型的症状、体征和影像学检查结果,制定出的简明诊断要点.该诊断要点强调临床表现的重要性和影像学检查在确诊中的必要性,细化各种脑血管病的病因学诊断依据,是我国历年来最具体而全面的脑血管病诊断要点.

关键词：脑血管病诊断诊断,鉴别

Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis

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Stroke & Vascular Neurology 2020年第2期5卷 152-158页

作者： Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan jinsheng zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee Department of Neurology The First Affiliated HospitalSun Yat-sen UniversityGuangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological DiseasesNational Key Clinical Department and Key Discipline of NeurologyGuangzhouChina Department of Neurology and Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 不详

Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young *** incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all *** reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of *** PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July *** were synthesised by evidence *** recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow *** of evidence grading algorithm of Chinese Stroke Association was used to grade each *** This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of ***/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected *** therapy with low-molecular weight heparin should be initiated in patients with CVST *** the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic *** The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China.

关键词： prevention tables initiated

中国颅内静脉血栓形成诊断和治疗指南2019更新要点解读

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中华神经科杂志 2020年第9期53卷 641-643页

作者：曾进胜蒲传强中山大学附属第一医院神经科广东省重大神经疾病诊治研究重点实验室国家重点学科和国家临床重点专科广州510080 解放军总医院神经内科北京100853

在《中国颅内静脉系统血栓形成诊断和治疗指南2015》的基础上,结合近年国内外相关进展,修订的《中国颅内静脉血栓形成诊断和治疗指南2019》,主要将背景资料更新至2019年12月,推荐意见进行了细化和增补,内容涉及病因与危险因素、临床表... 详细信息

在《中国颅内静脉系统血栓形成诊断和治疗指南2015》的基础上,结合近年国内外相关进展,修订的《中国颅内静脉血栓形成诊断和治疗指南2019》,主要将背景资料更新至2019年12月,推荐意见进行了细化和增补,内容涉及病因与危险因素、临床表现、影像学诊断、治疗和预防各个方面,是指导我国诊断和治疗颅内静脉血栓形成的新依据。

关键词：颅内静脉血栓形成诊断治疗指南

A 4H-SiC trench IGBT with controllable hole-extracting path for low loss

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Chinese Physics B 2023年第4期32卷 714-718页

作者：吴丽娟刘恒宋宣廷陈星曾金胜邱滔张帮会 Hunan Provincial Key Laboratory of Flexible Electronic Materials Genome Engineering Changsha University of Science&TechnologyChangsha 410114China

A novel 4H-Si C trench insulated gate bipolar transistor(IGBT)with a controllable hole-extracting(CHE)path is proposed and investigated in this *** CHE path is controlled by metal semiconductor gate(MES gate)and metal oxide semiconductor gate(MOS gate)in the p-shield *** grounded p-shield region can significantly suppress the high electric field around gate oxide in Si C devices,but it weakens the conductivity modulation in the Si C trench IGBT by rapidly sweeping out *** effect can be eliminated by introducing the CHE *** CHE path is pinched off by the high gate bias voltage at on-state to maintain high conductivity modulation and obtain a comparatively low on-state voltage(VON).During the turn-off transient,the CHE path is formed,which contributes to a decreased turn-off loss(EOFF).Based on numerical simulation,the EOFFof the proposed IGBT is reduced by 89%compared with the conventional IGBT at the same VONand the VONof the proposed IGBT is reduced by 50%compared to the grounded p-shield IGBT at the same *** addition,the average power reduction for the proposed device can be 51.0%to 81.7%and 58.2%to 72.1%with its counterparts at a wide frequency range of 500 Hz to 10 k Hz,revealing a great improvement of frequency characteristics.

关键词： controllable hole-extracting path energy loss frequency characteristics Si C insulated gate bipolar transistor(IGBT)

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颅内静脉系统血栓形成的诊断和防治

中华神经科杂志 2020年第6期53卷 449-453页

作者：曾进胜范玉华中山大学附属第一医院神经科广东省重大神经疾病诊治研究重点实验室广州510080

颅内静脉系统血栓形成属于少见的脑血管病类型,其病因和危险因素与脑动脉闭塞性疾病不同,主要与各种原因导致的血栓前状态有关;临床症状复杂多样,缺乏特征性表现;影像学检查是确立诊断的主要依据,MRI/MRV是诊断本病和随访病情变化的最... 详细信息

颅内静脉系统血栓形成属于少见的脑血管病类型,其病因和危险因素与脑动脉闭塞性疾病不同,主要与各种原因导致的血栓前状态有关;临床症状复杂多样,缺乏特征性表现;影像学检查是确立诊断的主要依据,MRI/MRV是诊断本病和随访病情变化的最佳手段。目前主要针对病因治疗和血管再通治疗,其中抗凝治疗是最重要的手段,预防方面尚缺乏公认有效的措施。

关键词：颅内静脉系统血栓形成诊断治疗