Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China):results from a prospective double-blind randomised clinical trial
作者机构：Department of Neurology and Stroke CenterThe First Affiliated HospitalJinan UniversityGuangzhouChina Department of NeurologyThe First Affiliated HospitalKunming Medical CollegeKunmingYunnanChina Department of NeurologyDongguan People HospitalDongguanGuangdongChina Department of Neurology and Stroke CenterFirst Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina
出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)
年 卷 期：2017年第2卷第3期
页 面：118-123页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported by the Science and Technology Program of Guangzhou(No.201508020004) received funding from the Medical Science and Technology Research of Guangdong Province(No.A2015461)
摘 要：Aim The role of clopidogrel in treating patients with acute ischaemic stroke is *** have conducted the clinical trial in order to evaluate the efficacy and safety of clopidogrel with a loading dose in treating patients with non-cardiogenic acute ischaemic *** Clopidogrel loading dose versus maintenance dose to treat patients with acute ischaemic stroke in China(CLASS-China)was a prospective,randomised,double-blind and placebo-controlled clinical trial in *** with acute ischaemic stroke of non-cardiogenic origin within 48 hours of onset were enrolled and those received thrombolysis were *** patients were divided into two treatment groups:loading dose and routine *** primary outcome was the incidence of stroke recurrence or progression within 7 *** safety outcome was measured by life-threatening *** intent-to-treat analysis was used for the statistical *** From March 2008 to March 2010,a total of 303 patients from 16 centres were recruited into this study;six were excluded because of lack of basic *** the enrolment was slow and the study drug expired in March 2010,this clinical trial was stopped earlier than *** significant baseline and demographic differences were seen between the two *** was no difference in primary outcome between the loading dosage group 16.1%(24/149)and control group 14.9%(22/148),respectively(p=0.782).The mortality and disability rate within 90 days in loading dose group(19.6%)was slightly lower than that in controlled group(23.4%),p=*** dose group had two(1.3%)cases of fatal haemorrhage and control group had four(2.7%)within 90 days,p=*** significant difference was detected in other adverse events between the *** In our study stopped early due to slow enrolment,loading dose of clopidogrel does not reduce the risk of recurrent *** trials with sufficient number of patients enrolled are needed to re-e
维普期刊数据库