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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu huang jinli huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Comparison of four techniques for estimating temporal change of seismic velocity with passive image interferometry

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Earthquake Science 2010年第5期23卷 511-518页

作者： Zhikun Liu jinli huang Jiaojiao Li Institute of Earthquake Science China Earthquake Administration Beijing 100036 China

Passive image interferometry （PII） is becoming a powerful tool for detecting the temporal variations in the Earth＇s structure, which applies coda wave interferometry to the waveforrns from the cross-correlation of seismic ambient noise. There are four techniques for estimating temporal change of seismic velocity with PII： moving-window cross-correlation technique （MWCCT）, moving-window cross-spectrum technique （MWCST）, stretching technique （ST） and moving-window stretching technique （MWST）. In this paper, we use the continuous seismic records from a typical station pair near the Wenchuan Ms8.0 earthquake fault zone and generate three sets of waveforms by stacking cross-correlation function of ambient noise with different numbers of days, and then apply four techniques to processing the three sets of waveforms and compare their results. Our results indicate that the techniques based on moving-window （MWCCT, MWCST and MWST） are superior in detecting the change of seismic velocity, and the MWCST can give a better estimate of velocity change than the other moving-window techniques due to measurement error. We also investigate the clock errors and their influences on measuring velocity change. We find that when the clock errors are not very large, they have limited impact on the estimate of the velocity change with the moving-window techniques.

关键词： passive image interferometry seismic ambient noise temporal variation moving-window cross-spectrum technique stretching technique

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Fine structure of Pn velocity beneath Sichuan-Yunnan region

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Science China Earth Sciences 2003年第z2期46卷 201-209页

作者： huang jinli (黄金莉) SONG Xiaodong (宋晓东) WANG Suyun (汪素云) Center for Analysis and Prediction China Seismological Bureau Beijing 100036 China Center for Analysis and Prediction China Seismological Bureau Beijing 100036 China Department of Geology University of Illinois Urbana IL 61801 USA Institute of Geophysics China Seismological Bureau Beijing 100081 China

We use 23298 Pn arrival-time data from Chinese national and provincial earthquake bulletins to invert fine structure of Pn velocity and anisotropy at the top of the mantle beneath the Sichuan-Yunnan and its adjacent region. The results suggest that the Pn velocity in this region shows significant lateral variation; the Pn velocity varies from 7.7 to 8.3 km/s. The Pn-velocity variation correlates well with the tectonic activity and heat flow of the region. Low Pn velocity is observed in southwest Yunnan , Tengchong volcano area, and the Panxi tectonic area. These areas have very active seismicity and tectonic activity with high surface heat flow. On the other hand, high Pn velocity is observed in some stable regions, such as the central region of the Yangtze Platform; the most pronounced high velocity area is located in the Sichuan Basin, south of Chengdu. Pn anisotropy shows a complex pattern of regional deformation. The Pn fast direction shows a prominent clockwise rotation pattern from east of the Tibetan block to the Sichuan-Yunnan diamond block to southwest Yunnan, which may be related to southeastward escape of the Tibetan Plateau material due to the collision of the Indian Plate to the Eurasia Plate. Thus there appears to be strong correlation between the crustal deformation and the upper mantle structure in the region. The delay times of events and stations show that the crust thickness decreases from the Tibetan Plateau to eastern China, which is consistent with the results from deep seismic sounding.

关键词： Sichuan-Yunnan region, Pn velocity, Seismic tomography.

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New ternary compound La_8Al_(13)Sn_3

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Rare Metals 2009年第5期28卷 491-493页

作者： HE Wei XIA Xiuwen ZHANG Jiliang huang jinli LIU Yixin Key Laboratory of Nonferrous Metal Materials and New Processing Technology （Ministry of Education） College of Materials Science and Engineering Guangxi University Nanning 530004 China Department of Physics and Electronic Information Science Guangxi Teachers Education University Nanning 530023 China

A new ternary compound La8Al13Sn3 was synthesized and studied by means of X-ray powder diffraction technique. The compound La8Al13Sn3 crystallizes in a hexagonal AlB2-type structure with space group P6/mmm （No. 191） and the lattice parameters a = 0.44919（1） nm and c = 0.43835（1） nm. The Smith and Snyder figure of merit for index, FN, is F30 = 197.3（30）. The Rietveld refinement for the crystal structure of the compound was carried out successfully. The liability R-factors of Rietveld refinement are Rp = 0.114 and Rwp = 0.148. The compound La8Al13Sn3 decomposes into LaAl2 with cubic structure and space group Fd 3m （227）, LaAl3 with hexagonal structure and space group P63/mmc （194）, and Sn at 720°C.

关键词： crystallography X-ray diffraction Reitveld method rare earth compounds

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Velocity Structure Beneath Active Faults and Seismic Tectonic Characteristics in the Beijing Area

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Earthquake Research in China 2011年第1期25卷 59-69页

作者： Gao Zhanwu Chen Qifu huang jinli Qi Cheng Li Le China Earthquake Disaster Prevention Center Beijing 100029China Institute of Earthquake Science China Earthquake AdministrationBeijing 100036China

Velocity structure beneath active faults in the Beijing area has been discussed,based on the digital crustal model of velocity from deep seismic sounding profiles and tomography imaging of P waves. We found that there exists nearly vertical deep faults beneath the Shunyi Depression and the Machiko Depression,which are very likely to be seismogenic faults in the future. In the superficial crust,the north segment of the Shunyi-QianmenLiangxiang fault,the north segment of the huangzhuang-Gaoliying fault and the Qinghe fault show a trend to converge but without intersecting with vertical deep faults. This kind of seismo-tectonic state has great potential to generate large earthquakes.

关键词： Active fault Velocity structure Beijing area

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Acute Toxicity Test of Abrus cantoniensis Hance Extract

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Medicinal Plant 2019年第6期10卷 32-34页

作者： Xuankai HU Haichun LONG Qiao WEI Yuxia WEI jinli huang Tingshu LI Zhidong LEI Suoyi huang Youjiang Medical University for Nationalities Baise 533000China Key Laboratory of Guangxi’s Colleges for the Study of Characteristic Ethnic Medicine in Youjiang River Basin Baise 533000China

[Objectives]To investigate the acute toxicity of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract to mice.[Methods]The medium lethal dose(LD50)in mice could not be determined,so the maximum dose method was used for *** were not fed but allowed to drink water for 16 h before the *** were 74 SPF Kunming Mice,half male and half female,and it was divided into extract group and blank control *** toxicity and death were recorded after intragastric administration and regular close *** any mice died,the dead mice were *** changes of heart,liver,spleen,lung,kidney,brain,stomach,small intestine and other organs were observed with the naked *** the end of the 14 d observation period,the surviving mice in each group were killed and *** gross pathological changes of the main organs were observed with the naked eye according to the same method mentioned above.[Results]There were no obvious toxic symptoms and no death in the mice.[Conclusions]The maximum doses of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract in mice were 1.61,1.71,1.65 and 1.79 g/L,*** it was found that the quarterly tests of petroleum ether extract,n-butanol extract,ethyl acetate extract and water extract suggested that the medicine was safe.

关键词： Abrus cantoniensis Hance Acute toxicity Maximum dosage

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中国东部及其邻区上地幔顶部Pn波速度结构及各向异性

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地球物理学报 2018年第7期61卷 2750-2759页

作者：王倩黄金莉刘志坤葛赟中国地质大学(北京)地球物理与信息技术学院北京100083

中国东部地处欧亚板块东南部,紧邻西太平洋板块俯冲带,有着复杂的地质构造和深部结构,是国内外学者研究的重点区域.本文采用Pn波层析成像方法反演得到了中国东部及其邻区上地幔顶部Pn波速度结构及各向异性.研究中应用的Pn到时数据主要... 详细信息

中国东部地处欧亚板块东南部,紧邻西太平洋板块俯冲带,有着复杂的地质构造和深部结构,是国内外学者研究的重点区域.本文采用Pn波层析成像方法反演得到了中国东部及其邻区上地幔顶部Pn波速度结构及各向异性.研究中应用的Pn到时数据主要来自多种地震观测报告,并特别补充了东北流动台阵、华北流动台阵以及区域地震台网记录的地震事件,拾取了大量高精度的Pn到时数据,最终挑选出2049个台站记录的24072次地震的240814条Pn波到时数据.结果显示,中国东部地区上地幔顶部平均速度为8.06km·s-1,速度变化范围为7.81~8.32km·s-1.东北地区东部表现为显著的低速异常,华北克拉通中、东部Pn呈现低速,而西部地区则表现为高速异常,华南地块主体表现为高速.反演结果还揭示江汉盆地、下辽河盆地、二连盆地及海拉尔盆地都显示出高速,而四川盆地和松辽盆地内部则呈现出不均匀的结构特征.四川盆地的高速异常显示出明显的分块现象,这可能是该盆地在沉积前具有不同的基底物质;松辽盆地的北部呈现为高速,而南部却表现为低速异常,这一特征与松辽盆地南、北部分别为高、低热流相对应,暗示盆地南部的岩石圈已经历了改造.研究进一步揭示Pn波低速区和高、低速过渡带的各向异性也较为强烈,而大部分强震都发生在这些区域之上的地壳内,说明这些部位容易发生变形而应力集中或产生应力差.

关键词：中国东部地区上地幔顶部 Pn波速度各向异性

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Laparoscopic Radical Cystectomy in The Elderly

Laparoscopic Radical Cystectomy in The Elderly

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第十五届全国泌尿外科学术会议

作者： huang Jian,Lin Tianxin, Xu Kewei, Jiang Chun, Han jinli, huang Hai Yin Xinbao 中山大学附属第二医院

INTRODUCTION: Muscle-invasive bladder cancer often occur in the elderly. Open radical cystectomy(ORC) is the standard treatment. Laparoscopic radical cystectomy (LRC) emerges as an minimally invasive alternative. Clinical outcomes of LRC in elderly patients haven’t been well confined and illustrated to date. In this study, we compared perioperative and surrogate oncological outcomes

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岩藻多糖对免疫低下小鼠模型免疫功能和肠道菌群的调节作用

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中国食品学报 2022年第5期22卷 92-102页

作者：黄娟黄金莉孙佳悦李瑶李华军大连医科大学微生态学教研室辽宁大连116044 大连海宝生物技术有限公司辽宁大连116044

目的:探究岩藻多糖(FUC)作为功能食品对免疫低下小鼠免疫功能及肠道菌群的调节作用。方法:40只雄性BABL/C小鼠随机分为4组,用环磷酰胺构建免疫低下小鼠模型,每天灌胃给予干预组高、低剂量的岩藻多糖,对照组、模型组每天给予等体积生理... 详细信息

目的:探究岩藻多糖(FUC)作为功能食品对免疫低下小鼠免疫功能及肠道菌群的调节作用。方法:40只雄性BABL/C小鼠随机分为4组,用环磷酰胺构建免疫低下小鼠模型,每天灌胃给予干预组高、低剂量的岩藻多糖,对照组、模型组每天给予等体积生理盐水。通过酶联免疫吸附试验、流式细胞术、16S rRNA基因高通量测序等方法,检测免疫低下小鼠的免疫功能和肠道菌群。结果:免疫低下模型小鼠机体免疫功能明显下降,小鼠脾脏组织和肠道组织损伤严重;经FUC干预后,小鼠脾脏组织、回肠组织形态破坏得到明显改善,脏器指数、血清中免疫球蛋白和细胞因子的质量浓度明显提高(P<0.05)。菌群分析表明,属水平上,与正常组比,模型组小鼠盲肠内容物中拟杆菌含量显著升高(P<0.05),乳酸杆菌、罗氏菌含量显著降低(P<0.05);经FUC干预后,免疫低下小鼠肠道中失调的菌群得到良好的恢复;FUC干预的各组小鼠,肠道中菌群结构与正常组趋近。结论:FUC可有效提高免疫低下小鼠的免疫功能,并能有效缓解环磷酰胺造成的肠黏膜损伤,其作用机制可能与FUC对肠道菌群的调节作用有关。

关键词：岩藻多糖免疫低下小鼠免疫功能肠道菌群

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新建本科院校大学生心理健康状况实证分析

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职业技术教育 2015年第5期36卷 50-54页

作者：石岩涛黄金利辽东学院经济学院统计系辽东学院财务处

选取新建本科院校辽东学院的学生进行心理测评问卷调查,运用均值向量比较和方差分析等方法,对1314份有效问卷的统计分析结果表明,样本的症状因子均值向量与常模向量间的差异性十分显著。另外,不同性别、学科、年级、生源地以及独生子女... 详细信息

选取新建本科院校辽东学院的学生进行心理测评问卷调查,运用均值向量比较和方差分析等方法,对1314份有效问卷的统计分析结果表明,样本的症状因子均值向量与常模向量间的差异性十分显著。另外,不同性别、学科、年级、生源地以及独生子女与非独生子女之间的心理健康水平也有十分显著的差异性,而不同家庭收入的大学生之间的心理健康水平却无显著性差异。

关键词：大学生心理健康 SCL-90 方差分析新建本科院校

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