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Recent Progress on High-Z Metal-Based Nanomaterials for Cancer Radiosensitization

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Chinese Journal of Chemistry 2023年第19期41卷 2545-2556页

作者： Xiu Zhao Jun Li Qiongwei Wang Zhenzhong Zhang Junjie Liu Chaofeng Zhang jinjin shi School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhouHenan450001 China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases ZhengzhouHenan450001 China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhouHenan450001 China

Radiotherapy is a mainstay treatment for malignant tumors in clinical ***,enhancing radiation damage to tumor cells meanwhile sparing normal tissues is still a great challenge in *** with high atomic number(Z)values are promising radiosensitizers by promoting the radiation energy deposition in irradiated tumor cells,thus enhancing the therapeutic ratio of *** this review,we described the mechanisms of high-Z element based-radiosensitizers and systematically summarized the recent progress on high-Z metal-based nanomaterials,including high-Z metal-based nanoparticles,high-Z metal-based nanoscale metal-organic frameworks and high-Z metal-doping ***,further potential and challenges in this field were discussed.

关键词： Radiotherapy Nanoradiosensitizers High-Z metal Energy deposition Nanomaterial

Fe_(3)O_(4) nanoparticles encapsulated in graphitized and inplane porous carbon nanocages derived from emulsified asphalt for a high-performance lithium-ion battery anode

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Frontiers of Materials Science 2024年第2期18卷 89-100页

作者： Dandan Hu Linxiu Sui jinjin shi Dongfeng Li Yuxuan Zhang Yimeng Li Bingbing Hu Xiaoya Yuan School of Materials Science and Engineering Chongqing Jiaotong UniversityChongqing 400074China Institute of Advanced Functional Materials Chongqing Jiaotong UniversityChongqing 400074China Chongqing 2D Materials Institute Liangjiang New AreaChongqing 400044China

In this work,C@Fe_(3)O_(4) composites were prepared through a typical template method with emulsified asphalt as carbon source,ammonium ferric citrate as transition metal oxide precursor,and NaCl as *** an anode for lithium-ion batteries,the optimized C@Fe_(3)O_(4)-1:2 composite exhibits an excellent reversible capacity of 856.6 mA·h·g^(-1)after 100 cycles at 0.1A·g^(-1)and a high capacity of 531.1mA·h·g^(-1)after 300 cycles at 1 A·g^(-1),much better than those of bulk carbon/Fe_(3)O_(4) prepared without *** remarkable cycling performance mainly benefits from its well-designed structure:Fe_(3)O_(4) nanoparticles generated from ammonium ferric citrate during pyrolysis are homogenously encapsulated in graphitized and in-plane porous carbon nanocages derived from petroleum *** carbon nanocages not only improve the conductivity of Fe_(3)O_(4),but also suppress the volume expansion of FesO4 effectively during the charge discharge cycle,thus delivering a robust electrochemical *** work realizes the high value-added utilization of low-cost petroleum asphalt,and can be extended to application of other transition-metal oxides-based anodes.

关键词： emulsified asphalt Fe_(3)O_(4)nanoparticle in-plane pore lithium-ion battery anode

Boosting 5-ALA-based photodynamic therapy by a liposomal nanomedicine through intracellular iron ion regulation

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1329-1340页

作者： Airong Li Chenglin Liang Lihua Xu Yiyang Wang Wei Liu Kaixiang Zhang Junjie Liu jinjin shi Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

5-Aminolevulinic acid(5-ALA)has been approved for clinical photodynamic therapy(PDT)due to its negligible photosensitive ***,the curative effect of 5-ALA is restricted by intracellular biotransformation inactivation of 5-ALA and potential DNA repair of tumor *** by the crucial function of iron ions in 5-ALA transformation and DNA repair,a liposomal nanomedicine(MFLs@5-ALA/DFO)with intracellular iron ion regulation property was developed for boosting the PDT of 5-ALA,which was prepared by co-encapsulating 5-ALA and DFO(deferoxamine,a special iron chelator)into the membrane fusion liposomes(MFLs).MFLs@5-ALA/DFO showed an improved pharmaceutical behavior and rapidly fused with tumor cell membrane for 5-ALA and DFO ***@5-ALA/DFO could efficiently reduce iron ion,thus blocking the biotransformation of photosensitive protoporphyrin IX(Pp IX)to heme,realizing significant accumulation of ***,the activity of DNA repair enzyme was also inhibited with the reduction of iron ion,resulting in the aggravated DNA damage in tumor *** findings showed MFLs@5-ALA/DFO had potential to be applied for enhanced PDT of 5-ALA.

关键词： 5-Aminolevulinic acid Biotransformation interference Iron ion regulation DNA repair inhibition ALKBH2 Membrane fusion liposomes Photodynamic therapy Drug delivery

Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide

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Nano Research 2023年第1期16卷 735-745页

作者： Wenyan Yu Cuiping Xuan Bingbing Liu Lei Zhou Na Yin Enpeng Gong Zhenzhong Zhang Yinchao Li Kaixiang Zhang jinjin shi School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China

Antisense oligonucleotide(ASO)for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological ***,its therapeutic efficacy is seriously limited by a number of challenges including inefficient internalization,low blood-brain barrier(BBB)penetration,poor stability,and potential toxicity of the ***,a carrier-free programmed spherical nucleic acid nanostructure is developed for effective ischemic stroke therapy via integrating multifunctional modules into one DNA *** co-encoding caspase-3-ASO and transferrin receptor(TfR)aptamer into circle template,the spherical nucleic acid nanostructure(TD)was obtained via *** experimental results demonstrated that the developed TD displayed efficient BBB penetration capability(6.4 times)and satisfactory caspase-3 silence effect(2.3 times)due to the dense DNA packaging in *** together,our study demonstrated that the carrier-free programmed spherical nucleic acid nanostructure could significantly improve the therapeutic efficacy of ischemic stroke and was a promising therapeutic tool for various brain damage-related diseases.

关键词： antisense oligonucleotide caspase-3 blood-brain barrier(BBB)penetration anti-apoptosis ischemic stroke

Hydrogel-mediated drug delivery for treating stroke

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Chinese Chemical Letters 2023年第9期34卷 65-75页

作者： Wenyan Yu Enpeng Gong Bingbing Liu Lei Zhou Chengyuan Che Shu Hu Zhenzhong Zhang Junjie Liu jinjin shi School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou 450001China Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou 450001China

Stroke is a common disease and is the major cause of death and *** occurs and generates devastating neurological deficits when cerebral blood vessel is blocked(ischemic stroke,IS)or ruptured(hemorrhagic stroke,HS).Hydrogel,being biodegradable and biocompatible,have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure,owing to special ability to load different cargoes for multiple treatment strategies,such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells(MSCs)and neural progenitor cells(NPCs)for improving functional ***,a comprehensive review of the functional hydrogel for treatment of stroke is still ***,in this work,the main pathological mechanisms of stroke including IS and HS are comprehensively *** benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery ***,the application development of hydrogel for treatment of stroke is ***,the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future.

关键词： Drug delivery Functional hydrogel Stroke therapy Bioactive biomaterials Biological applications

Y-Shaped Circular Aptamer–DNAzyme Conjugates for Highly Efficient in Vivo Gene Silencing

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CCS Chemistry 2020年第6期2卷 631-641页

作者： Kaixiang Zhang Yanan Li Junjie Liu Xue Yang Yuanhong Xu jinjin shi Wei Liu Jinghong Li School of Pharmaceutical Sciences Key laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001 Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyBeijing Key Laboratory for Microanalytical Methods and InstrumentationTsinghua UniversityBeijing 100084 College of Life Sciences Qingdao UniversityQingdao 266071

Oligonucleotide drugs have been used widely as therapeutic agents for gene therapy,while their instability in biological media and inefficiency for intracellular delivery remain major hurdles for practical in vivo ***,we report a circular Y-shaped aptamer–DNAzyme conjugate(cYAD)for highly efficient in vivo gene silencing via RNA cleavage,which can been employed in various disease treatments,including cancer,inflammation,as well as viral *** studies revealed that cyclization of the DNA structure could improve the stability of oligonucleotide drugs in ***,the bivalent aptamer motifs provided a specific and enhanced tumor cell targeting ability for accumulation and retention of the oligonucleotide drugs at the tumor *** a proof of concept,a widely applicable Na+-dependent fluorescent sensor,NaA43 DNAzyme,was used to inhibit MET gene expression in mice tumor model tissues,which exhibited highly efficient gene silencing performance in vivo,which confirmed our findings with *** strategy provides a novel approach for the construction of oligonucleotide drugs for practical therapeutic applications.

关键词： in vivo gene silencing circular DNA structure aptamer DNAzyme

开挖的非正规填埋场重(类)金属污染及潜在生态环境风险分析——以嘉善县某填埋场为例

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环境卫生工程 2024年第3期32卷 78-83页

作者：施瑾瑾上海环境工程技术有限公司上海200000

为明确非正规垃圾填埋场开挖后土地资源是否可实现安全利用,以嘉善县某填埋场为例,对开挖范围基坑及侧壁多点采集样品,对其pH、有机质和重(类)金属浓度进行了检测。结果表明:基坑底部、侧壁土壤中均未检出汞,镉含量与背景点浓度接近,样... 详细信息

为明确非正规垃圾填埋场开挖后土地资源是否可实现安全利用,以嘉善县某填埋场为例,对开挖范围基坑及侧壁多点采集样品,对其pH、有机质和重(类)金属浓度进行了检测。结果表明:基坑底部、侧壁土壤中均未检出汞,镉含量与背景点浓度接近,样本含量均≤0.23 mg/kg;重金属总铬、总铜、总铅、总锌在所有样品中的浓度变化趋势相同,最大值分别为99.0、40.2、43.0、201.0 mg/kg,约为背景值的2.43倍、1.05倍、1.60倍和2.03倍,但均低于CJ/T 340—2016绿化种植土壤和GB 36600—2018土壤环境质量建设用地土壤污染风险管控标准(试行)的要求,可满足绿地用地要求。填埋场土壤中pH为6.77~8.26,基坑底部土壤有机质较低,均值约为7.96 g/kg,远小于绿化用地标准(12~80 g/kg),若要使得该土地符合绿化要求,则需增加有机质含量。根据Hakanson潜在生态风险指数法计算得到该填埋场土壤重(类)金属潜在生态风险RI值为8.85 (RI<150),表明该填埋场由汞、镉、砷、铅、铜、铬、锌、镍等8种重(类)金属造成的生态风险较低。

关键词：非正规填埋场开挖重(类)金属绿化用地生态风险评估

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Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

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Chinese Chemical Letters 2023年第2期34卷 65-88页

作者： Rui Liu Cong Luo Zhiqing Pang Jinming Zhang Shaobo Ruan Meiying Wu Lei Wang Tao Sun Nan Li Liang Han jinjin shi Yuanyu Huang Weisheng Guo Shaojun Peng Wenhu Zhou Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics School of PharmacyFudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 200433China State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China School of Pharmaceutical Sciences Zhengzhou UniversityKey Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou 450001China Tianjin Key Laboratory of Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Advanced Research Institute of Multidisciplinary Science School of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Radiology Center Key Laboratory of Molecular Target&Clinical PharmacologySchool of Pharmaceutical Sciences&The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Zhuhai Institute of Translational Medicine Zhuhai People's Hospital(Zhuhai hospital affiliated with Jinan University)Zhuhai 519000China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China

Decades have passed since the first nanoparticles-base medicine was approved for human cancer treatment, and the research and development of nanoparticles for drug delivery are always ***, the significant advances complicate nanoparticles’ branches, including liposomes, solid lipid nanoparticles, inorganic nanoparticles, micelles, nanovaccines and nano-antibodies, etc. These nanoparticles show numerous capabilities in treatment and diagnosis of stubborn diseases like cancer and neurodegenerative diseases, emerging as novel drug carriers or therapeutic agents in future. In this review, the complicated branches of nanoparticles are classified and summarized, with their property and functions concluded. Besides, there are also some delivery strategies that make nanoparticles smarter and more efficient in drug delivery, and frontiers in these strategies are also summarized in this review. Except these excellent works in newly-produced drug delivery nanoparticles, some points of view and future expectations are made in the end.

关键词： Nanoparticles Drug delivery Nanomaterials Delivery strategies Specific delivery Disease diagnosis Disease treatment

The Design of Elastic Network Control Software based on Data and Control Separation

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The Design of Elastic Network Control Software based on Data...