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滇东南板仑磁铁矿集区矽卡岩矿物学、地球化学特征及其形成机制

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岩石学报 2024年第4期40卷 1205-1230页

作者：李睿昱覃小锋王宗起戴昱戴翔毕婧怡李东任赵钰磊桂林理工大学地球科学学院桂林541004 桂林理工大学广西隐伏金属矿产勘查重点实验室桂林541004 湖北省地质局水文地质工程地质大队荆州434020 自然资源部矿产勘查技术指导中心北京100083 广西区域地质调查研究院桂林541003

位于华夏、扬子和印支板块交接部位的滇东南板仑磁铁矿集区属于个旧-文山-德保矽卡岩型锡钨多金属成矿带的重要组成部分。前人对该区矽卡岩型磁铁矿床的地质特征和矿床成因等进行了少量的研究工作,但对矽卡岩的成因尚缺乏系统的研究,这... 详细信息

位于华夏、扬子和印支板块交接部位的滇东南板仑磁铁矿集区属于个旧-文山-德保矽卡岩型锡钨多金属成矿带的重要组成部分。前人对该区矽卡岩型磁铁矿床的地质特征和矿床成因等进行了少量的研究工作,但对矽卡岩的成因尚缺乏系统的研究,这严重制约了对该矿集区内矽卡岩成因的认识及磁铁矿找矿潜力的准确评价。本文以矿集区内最为典型的坤洪和洞哈磁铁矿床的矽卡岩为主要研究对象,在对矽卡岩及相关岩石的野外地质特征和岩相学等方面进行详细研究的基础上,借助LA-ICP-MS和EPMA等方法手段,重点对矽卡岩及相关岩石的地球化学和矿物化学特征进行系统研究。结果表明,矽卡岩的成岩成矿演化过程可划分为早期进变质矽卡岩阶段、晚期退变质矽卡岩阶段和硫化物-碳酸盐阶段等3个阶段;(岩浆)热液成因的硅质岩条带与晚二叠世OIB型基性杂岩体(即“半瓦型”岩体)在原始地幔标准化微量元素蜘蛛网图和球粒陨石标准化稀土元素配分模式图上均存在显著的差异,而与中三叠世岛弧型中-基性杂岩体(即“安定型”岩体)的模式曲线较为相似,均显示出Nb、Ta、P和Ti等元素明显亏损的特征;矽卡岩的模式曲线与硅质岩条带的模式曲线也较为相似,且含矿矽卡岩比无矿矽卡岩无论在微量元素和稀土元素含量还是模式曲线上均更加接近于硅质岩条带。矿物化学的研究结果表明,第一世代石榴石属于钙铁-铁铝-钙铝榴石系列(And80-83Alm9-11Gro5-7),含较多的钙铝榴石(Gro);而第二世代石榴石属于钙铁-铁铝榴石系列(And86-93Alm6-12),基本上不含或仅含极少量的钙铝榴石(Gro);由早期辉石→晚期辉石,辉石端员组分中钙铁辉石所占的比例相对减少,而透辉石的含量则具显著增加趋势。综合分析认为,形成矽卡岩的热液流体主要来源于中三叠世岛弧型中-基性杂岩体;矽卡岩型磁铁矿床的成岩成矿环境至少经历了从进变质矽卡岩阶段早期相对还原环境→进变质矽卡岩阶段晚期-退变质矽卡岩阶段相对氧化环境→后期硫化物-碳酸盐阶段相对还原环境的转变过程。

关键词：矽卡岩矿物学地球化学形成机制板仑磁铁矿集区滇东南

A review on the application,phytochemistry and pharmacology of Polygonatum odoratum,an edible medicinal plant

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未来食品学报(英文) 2023年第3期3卷 240-251页

作者： jingyi bi Huiyong Fang Jianyun Zhang Litao Lu Xian Gu Yuguang Zheng Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei ProvinceHebei University of Chinese MedicineShijiazhuang 050200China Hebei Chemical and Pharmaceutical College Shijiazhuang 050026China

Polygonatum odoratum is distributed in several countries around the world as a medicinal and dual-use plant,and its rhizomes are used in China as a traditional Chinese medicine,also as vegetables,foods,functional foods or tea,with a history of application for more than 2000 years,with precise efficacy and no toxic side ***,few reviews are published on its chemical composition and its pharmacological *** are many components of ***,including steroidal saponins,homoisoflavanones,isoflavones,flavonoids,alkaloids,lignin,volatile oil,polysaccharides and *** this review,recent advances of the history and consumption of ***,the types of chemical components,and the pharmacological effects manifested in antitumour and anticancer,antioxidant,slowing senescence,relieving fatigue and immune regulation are summarized and ***,the main active ingredients of the plant are homoisoflavanones,polysaccharides,saponins,and *** review provides a reference for its development and utilization in the field of functional food and medicine in the future.

关键词： Polygonatum odoratum Phytochemistry Pharmacology Edible medicinal plant

High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1772-1786页

作者： Yu Fan Jincai Wang jingyi Jian Yalei Wen Jiahao Li Hao Tian Jacques Crommen Wei bi Tingting Zhang Zhengjin Jiang Institute of Pharmaceutical Analysis/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China/College of Pharmacy Jinan UniversityGuangzhou 510632China KU Leuven-University of Leuven Pharmaceutical AnalysisDepartment of Pharmaceutical and Pharmacological SciencesLeuven 3000Belgium Laboratory of Analytical Pharmaceutical Chemistry Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium Department of Neurology the First Affiliated Hospital of Jinan University/Clinical Neuroscience Institutethe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's *** to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversible hMAO-B inhibitors with good blood-brain barrier *** this study,a high-throughput at-line nanofractionation screening platform was established with extracts from Chuanxiong Rhizoma,which resulted in the discovery of 75 active compounds,including phenolic acids,volatile oils,and phthalides,two of which were highly selective novel natural phthalide hMAO-B inhibitors that were potent,selective,reversible and had good blood‒brain *** docking and molecular dynamics simulations elucidated the inhibition ***(IC_(50)=103 nmol/L;SI=645)and neocnidilide(IC_(50)=131 nmol/L;SI=207)demonstrated their excellent potential as hMAO-B *** offset the limitations of deactivating enzymes associated with irreversible hMAO-B inhibitors such as *** SH-SY5Y cell assays,sedanolide(EC_(50)=0.962μmol/L)and neocnidilide(EC_(50)=1.161μmol/L)exhibited significant neuroprotective effects,comparable to the positive drugs rasagiline(EC_(50)=0.896μmol/L)and safinamide(EC_(50)=1.079μmol/L).These findings underscore the potential of sedanolide as a novel natural hMAO-B inhibitor that warrants further development as a promising drug candidate.

关键词： Human monoamine oxidase B inhibitors High-throughput screening At-linenanofractionation Parkinson's disease Cellular neuroprotection Traditional Chinese medicines(TCMs)

On the Proper Holomorphic Mappings between Equidimensional Hartogs Domains over Hermitian Symmetric Manifolds

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1215-1228页

作者： En Chao bi School of Mathematics and Statistics Qingdao UniversityQingdao 266071P.R.China

In this paper,we study a family of Hartogs domains fibred over Hermitian symmetric manifolds being a unit ball in C^(m).The aim of the present study is to establish the rigidity results about proper holomorphic mappings between two equidimensional Hartogs domains over Hermitian symmetric *** particular,we can fully determine its biholomorphic equivalence and automorphism group.

关键词： Proper holomorphic mapping Hartogs domains Hermitian symmetric manifolds

Advances in regional nodal management of early-stage breast cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： Zhao bi Yongsheng Wang Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group Z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

ORPA:a fast and efficient phylogenetic analysis method for constructing genome-wide alignments of organelle genomes

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Journal of Genetics and Genomics 2024年第3期51卷 352-358页

作者： Guiqi bi Xinxin Luan Jianbin Yan Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518124China Zhengzhou Research Base State Key Laboratory of Cotton BiologySchool of Agricultural SciencesZhengzhou UniversityZhengzhouHenan 450001China

Creating a multi-gene alignment matrix for phylogenetic analysis using organelle genomes involves aligning single-gene datasets manually,a process that can be time-consuming and prone to *** HomBlocks pipeline has been created to eliminate the inaccuracies arising from manual *** processing of a large number of sequences,however,remains a time-consuming *** conquer this challenge,we develop a speedy and efficient method called Organelle Genomes for Phylogenetic Analysis(ORPA).ORPA can quickly generate multiple sequence alignments for whole-genome comparisons by parsing the result files of NCbi BLAST,completing the task just in 1 *** increasing data volume,the efficiency of ORPA is even more pronounced,over 300 times faster than HomBlocks in aligning 60 high-plant chloroplast *** phylogenetic tree outputs from ORPA are equivalent to HomBlocks,indicating its outstanding *** to its speed and accuracy,ORPA can identify species-level evolutionary conflicts,providing valuable insights into evolutionary cognition.

关键词： Ultrafast alignment Organelle phylogenomics Phylogenomic conflict Efficient pipeline Multiple sequence alignment pipeline

bimetallic In2O3/bi2O3 Catalysts Enable Highly Selective CO2 Electroreduction to Formate within Ultra-Broad Potential Windows

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Energy & Environmental Materials 2024年第1期7卷 261-268页

作者： Zhongxue Yang Hongzhi Wang Xinze bi Xiaojie Tan Yuezhu Zhao Wenhang Wang Yecheng Zou Huaiping Wang Hui Ning Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemical Engineering College of New Energy China University of Petroleum (East China) Shandong Dongyue Future Hydrogen Energy Material Co. Ltd.

CO2electrochemical reduction reaction（CO2RR） to formate is a hopeful pathway for reducing CO2and producing high-value chemicals,which needs highly selective catalysts with ultra-broad potential windows to meet the industrial ***,the nanorod-like bimetallic In2O3/bi2O3catalysts were successfully synthesized by pyrolysis of bimetallic Inbi-MOF precursors.

关键词： bimetallic catalyst CO2 electrochemical reduction reaction formate oxygen vacancy wide potential window

Experimental and numerical study on dynamic mechanical behaviors of shale under true triaxial compression at high strain rate

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International Journal of Mining Science and Technology 2024年第2期34卷 149-165页

作者： Xiaoping Zhou Linyuan Han Jing bi Yundong Shou School of Civil Engineering Wuhan UniversityWuhan 430072China College of Civil Engineering Guizhou UniversityGuiyang 550025China

High-energy gas fracturing of shale is a novel,high efficacy and eco-friendly mining technique,which is a typical dynamic perturbing *** effectively extract shale gas,it is important to understand the dynamic mechanical properties of *** experiments on shale subjected to true triaxial compression at different strain rates are first conducted in this *** dynamic stress-strain curves,peak strain,peak stress and failure modes of shale are *** results of the study indicate that the intermediate principal stress and the minor principal stress have the significant influence on the dynamic mechanical behaviors,although this effect decreases as the strain rate *** characteristics of compression-shear failure primarily occur in shale subjected to triaxial compression at high strain rates,which distinguishes it from the fragmentation characteristics observed in shale under dynamic uniaxial ***,a numerical three-dimensional Split Hopkinson Pressure Bar(3D-SHPB),which is established by coupling PFC3D and FLAC3D methods,is validated to replicate the laboratory characteristics of *** dynamic mechanical characteristics of shale subjected to different confining stresses are systematically investigated by the coupling PFC3D and FLAC3D *** numerical results are in good agreement with the experimental data.

关键词： Dynamic behaviors True triaxial compression High strain rates Dynamic failure mechanism PFC3D-FLAC3D coupled method

Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu bi Zhang Jianfeng Liu College of Life Science and Technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in Science,Zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM