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Chemical Research in Chinese Universities 2013年第6期29卷 1104-1109页

作者： SUN Chuan-wen WANG jing PANG chun-cheng li jing XIAO Di College of life and Environment Sciences Shanghai Normal University Shanghai 200234 P.R.China

A series of novel tetrahydro-4H-pyrano[3,2-c]pyridines（3a-3p） were synthesized and found to possess potent antiproliferative activity against leukemia K562 cells in vitro. Preliminary bioassay indicates that compounds 3a and 3e afford the best activity, the IC50 values of them were 6.93 and 7.51μg/mL, respectively, which were lower than that of the anticancer drug 5-FU（1C50=8.56μg/mL）. To reduce the toxicity of compounds 3a-3p to the prolife- ration of normal bematopoietic cells, a tumor targeted CD14 monoclonal antibody（McAb） was used in conjugation with compounds 3a--3p to get conjugates 4a--4p, respectively. The inhibitory activities of conjugates 4a--4p toward K562 cells were discovered to approach those of compounds 3a--3p. In the presence of CD14 McAb, tumor cells were found to be much more susceptible to conjugates 3a--3p than normal hematopoietic cells. Therefore, the toxicity of conjugates 4a--4p to normal hematopoietic cells declined obviously. For example, as for the toxicity of compound 3a compared with that of compound 4a, the value of ICs0 increased from 35.90 μmol/L to 39.52 μmol/L.

关键词： Tetrahydro-4H-pyrano[3,2-c]pyridine Leukemia K562 cell Anti-CDl4 monoclonal antibody(McAb) Conjugate Inhibitory Toxicity

Phylogeographic relationships of the southern green stink bug Nezara viridula （Hemiptera： Pentatomidae）

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Insect Science 2010年第5期17卷 448-458页

作者： Min li Zhong-Hua Fan Ji-Meng Hua chun-jing Niu chun-Xuan li Wen-Jun Bu Institute of Entomology College of Life Sciences Nankai University Tianjin China

The sequences of 16S rDNA, cytochrome oxidase subunit I （CO1） and cytochrome b （Cyt b） genes from nine field collections （seven provinces in China： Guangxi, Hubei, Guangdong, Guizhou, Zhejiang, Hunan, Jiangxi, and also southern and northern part oflran）, plus the sequences of Africa, Europe, Americas and Japan obtained form GenBank were used to re-analyse the genetic variation in the southern green stink bug Nezara viridula （linnaeus）. The phylogeographic re-analysis by using four algorithms （N J, MP, ML and Bayesian） showed three main lineages. The Iranian haplotypes fell into lineage II formed from Europe and America, rather than in lineage III from Asia; the Chinese haplotypes fell into the Asian clade. Our results suggested that African and non-African gene pools have been isolated since the Miocene era with the molecular clock calibrations for Heteroptera mtDNA, and not since the Pliocene as mentioned previously. The corresponding age of the separation of the eastern and western Asia clades is estimated to be 4.0-1.6 million years ago, coinciding with the Pliocene-Pleistocene epoch and with acute rising events in the Tibet Plateau locates in the western China, which may have formed the barriers observed today.

关键词： COI Cyt b 16S rDNA Nezara viridula phylogeographie

Bayesian empirical likelihood and variable selection for censored linear model with applications to acute myelogenous leukemia data

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International Journal of Biomathematics 2019年第5期12卷 43-61页

作者： chun-jing li Hong-Mei Zhao Xiao-Gang Dong School of Mathematics Jilin University Jilin Changchun 130012P.R.China School of Mathematics and Statistics Changchun University of Technology Jilin Changchun 130012 P.R.China

This paper develops the Bayesian empirical likelihood (BEL) method and the BEL vari-able selection for linear regression models with censored *** likelihood is a multivariate analysis tool that has been widely applietl to many fieltls such as biomed-ical and social *** introducing two special priors to the empirical likelihood function,we find two obvious superiorities of the BEL methods,that is (i) more precise coverage probabilities of the BEL credible region and (ii) higher accuracy and correct identification rate of the BEL model selection using an hierarchical Bayesian models *** current methods such as the LASSO,A LASSO and *** numerical simu-lations and empirical analysis of two data examples show strong competitiveness of the proposed method.

关键词： Bayesian empirical likeliliood censored linear regression coverage probabili-ties spike-and-slab prior

Neoclassical tearing mode stabilization by electron cyclotron current drive for HL-2M tokamak

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Chinese Physics B 2021年第7期30卷 355-361页

作者： jing-chun li Jia-Qi Dong Xiao-Quan Ji You-Jun Hu Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518000China University of California IrvineCalifornia 92697USA Southwestern Institute of Physics Chengdu 610041China Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China

Investigation of neoclassical tearing mode and its suppression by electron cyclotron current drive(ECCD)has been carried out in HL-2 M *** current driving capability of the electron cyclotron wave is *** is found that the deposition location can be effectively controlled by changing the poloidal *** validation of electron cyclotron wave heating and current driving has been demonstrated for the upper launcher *** show that 3.0 MW and2.5 MW modulated ECCD can completely stabilize(2,1)and(3,2)NTMs,*** non-modulated ECCD,radial misalignment as well as current profile broadening have deleterious effect on the NTM *** time required for suppression of(3,2)mode is shorter than that required for the suppression of(2,1)***,the time needed for complete stabilization at different initial island width has been quantitatively presented and analyzed.

关键词： neoclassical tearing mode magnetic island electron cyclotron current drive numerical modelling

Effects of Co-addition of DBS and PEG on Wetting Performance of TiO_2 Film

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Chemical Research in Chinese Universities 2011年第1期27卷 1-5页

作者： QU Yi-chun jing li-qiang WANG Wen-xin FU Hong-gang liU Yang Key Laboratory of Functional Inorganic Materials Chemistry Ministry of EducationSchool of Chemistry and Materials Science Heilongjiang University Harbin 150080 P. R. China

Nanocrystalline anatase TiO2 films with indium tin oxide（ITO） coated glass as the film substrate were fabricated through spin-coating technique. The TiO2 pastes were prepared with sodium dodecylbenzenesulfonate（DBS） modified TiO2 nanocrystals, synthesized by sol-hydrotherrnal processes in advance, together with different amounts of polyethylene glycol（PEG） macromolecules. The as-prepared films were mainly characterized by ultraviolet-visible （UV-Vis） spectroscopy, field emission scanning electron microscopy（FE-SEM） and water contact angle（WCA） measurement. Effects of the addition of DBS and PEG on the wetting performance of the resulting films and relevant mechanisms were principally investigated. The results show that the as-prepared film displays super-hydrophilic property after co-addition of DBS and PEG although it is not exposed to ultraviolet light prior to the WCA measure- ment. This appealing result is mainly attributed to the produced micro- and nanometer-scale hierarchical surface structure with uniformly dispersed micro papillae. Each papilla was made up of a great number of TiO2 nanoparticles. The possible formation mechanisms related to the DBS amphiphilic property of the characteristic surface were also suggested. Moreover, the resulting film also exhibits considerable durability in the superhydrophilicity, which is very useful for practical application in self-cleaning, anti-fogging, and bacteria-resistant fields.

关键词： Thin film Chemical synthesis Surface property

APPROACH TO THE REGIONAliZATION OF A GRICULTURAL-PASTURAliZATION AROUND CHANGSHAN ISLANDS IN NORTHERN YELLOW SEA

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Chinese Geographical Science 2002年第3期12卷 218-225页

作者： ZHANG Yao-guang,DONG li-jing,li chun-ping(Institute of Marine Resource,liaon ing Normal University,Dalian 116029,P.R.China) Institute of Marine Resource Liaoning Normal University Dalian P. R. China

Based on the data of resources,environment and foundation of productio n,applying principal compo-nents-clustering quantitative analysis,this article divides the maritime space of Changshan Islands into three regions of agricultural-pasturalization,pr oviding a scientific basis for the ra tional distribution of marine culti *** three re-gions are as follows:1)The region of an agricultural-pastu ralization in the northern part of ma ritime *** includes Da Wangjia and Shicheng *** ma in production is cultivation of praw n and molluscs in sea beach,float raft culture of mussel in shallow sea and scallop,and breeding of sea cucumber in subma rine.2)The region of agricultur-al-pasturalization in the middle we stern part of maritime *** includes Da Changshan and Guanglu island s,and west-ern part of Xiao Chengshan *** main production is float raft cultu re of mussel and scallop in shallow se a,and breed-ing of sea cucumber in submarine.3)The region of agricultural-pastura lization of the southeastern part of maritime *** includes the eastern part of Xiao ChangShan Island,Haiyang and Zhangzi *** main production is bre eding of abalone,sea cucumber,algaes and fish.

关键词： Changshan Islands agricultural-pasturalization of seash ore principal compo-nents-clustering analysis region alization

Non-Selective SiGe Graphic Epitaxial by MBE

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Journal of Electronic Science and Technology of China 2007年第4期5卷 325-327页

作者： Qian Zhou chun Han jing-chun li School of Microeleetronics and Solid-State Electronics Univ. of Electron. Science and Technology of China （UESTC） Chengdu 610054 China

To handle the thermal budget in SiGe BiCMOS process, a non-selective graphic epitaxial technology using molecular beam epitaxial （MBE） has been developed. SEM, AFM, XRD, and dislocation density measurements are carried out. The SiGe film＇s RMS roughness is 0.45nm, and dislocation density is 0.3×10^3cm^-2-1.2×10^3cm^-2. No dislocation accumulation exists on the boundary of the windows; this indicates the high quality of the SiGe film. The experiment results show that the technology presented in this paper meets the fabrication requirements of SiGe BiCMOS.

关键词： BiCMOS molecular beam epitaxial non-selective graphic epitaxial SiGe.

TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen li-Yong Zhu Zhi-Wei Cai Xiao Hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge Xiao-Yan Tang chun-jing li Yun-Long Pu Chong-Yi Jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

Complete Nucleotide Sequence of a Mumps Virus SP Strain Isolated in China

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Virologica Sinica 2009年第1期24卷 28-36页

作者： Shao-hui MA Jian-sheng liU Hai-jing SHI li-chun WANG jing-jing WANG Long-ding liU Qi-han li Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118 China

The complete nucleotide sequence of the mumps virus SP, which was isolated in China, was determined. As with other mumps viruses, its genome was 15 384 nucleotides (nts) in length and encoded seven proteins. The full-length nucleotide sequence of the SP isolate differed from other strains by 4% –6.8% at the nucleotide sequence level. Due to variations of amino acids over the full genome (including the HN and N genes), this isolate exhibited significant variations in the antigenic sites. This report is the first to describe the full-length genome of a genotype F strain and provide an overview of the diversity of genetic characteristics of a circulating mumps virus.

关键词： Complete nucleotide sequence Genotype F Mumps virus

Transcriptional Regulation by HSV-1 Induced HTRP via Acetylation System

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Virologica Sinica 2010年第6期25卷 417-424页

作者： Jie CHEN Yan-mei li Jian-feng li Long-ding liU Yun liAO Rui-xiong NA jing-jing WANG li-chun WANG Qi-han li Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Kunming 650118 China

The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 *** was found to interact with SAP30 (mSin3A Association Protein),one of the components of co-repressor complex mSin3A,which is part of the deacetylation transfer enzyme *** reveal the biological significance of the interaction between HTRP and SAP30,real-time PCR and a dual-luciferase detecting system was *** results indicate that HTRP could inhibit the transcription of a viral promoter,whose interaction with SAP30 synergistically affects transcriptional inhibition of the viral genes,and is related to HDAC enzyme *** experiments demonstrate that HTRP could promote HDAC activity by increasing the deacetylation level of lysine 14 and lysine 9 in histone H3.

关键词： Herpes simplex virus type 1 (HSV-1) HTRP SAP30 Transcription regulation