Transcriptional Regulation by HSV-1 Induced HTRP via Acetylation System

作     者：Jie CHEN Yan-mei LI Jian-feng LI Long-ding LIU Yun LIAO Rui-xiong NA Jing-jing WANG Li-chun WANG Qi-han LI 

作者机构：Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Kunming 650118 China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2010年第25卷第6期

页      面：417-424页

核心收录：

学科分类：0710[理学-生物学] 090701[农学-林木遗传育种] 0907[农学-林学] 07[理学] 09[农学] 071007[理学-遗传学] 

基　　金：The National Natural Science Foundation of China (30670094) the Ph.D. Programs Foundation of Ministry of Education of China (20060023008) 

主　　题：Herpes simplex virus type 1 (HSV-1) HTRP SAP30 Transcription regulation 

摘      要：The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 *** was found to interact with SAP30 (mSin3A Association Protein),one of the components of co-repressor complex mSin3A,which is part of the deacetylation transfer enzyme *** reveal the biological significance of the interaction between HTRP and SAP30,real-time PCR and a dual-luciferase detecting system was *** results indicate that HTRP could inhibit the transcription of a viral promoter,whose interaction with SAP30 synergistically affects transcriptional inhibition of the viral genes,and is related to HDAC enzyme *** experiments demonstrate that HTRP could promote HDAC activity by increasing the deacetylation level of lysine 14 and lysine 9 in histone H3.