检索结果-南通市图书馆

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Hanming jiang jing Zhai Department of Biochemistry School of Basic Medicine Taishan Medical University

Prostate cancer(PCa) is the most common non-skin cancer in old men and the incidenceof prostate cancer, especially for advanced or metastatic PCa, represents an obviouslyrising trend in China in recent years. Androgen deprivation is a standard treatment approachfor most prostate cancer patients. Unfortunately, the development of hormone-refractory prostate cancer(HRPC) has been observed to occur shortly after hormonaldeprivation therapy and few efficacious treatment options are available for curing, oreven improving the quality of life in patients with HRPC. Docetaxel, a natural product derivative,is approved to offer some extent of symptomatic and survival benefits for HRPCpatients. However, some of the patients are insensitive or even experience significant toxicityto docetaxel chemotherapy. Thus, identification of less toxic but effective novel agentsfor the treatment of HRPC is highly desirable. Acetyl shikonin is a derivatives of shikonin, anaphthoquinone compound and one of the active components of Lithospermum erythrorhizonSieb. et Zucc, a well known traditional herb in China. Its anti-tumor effect and theunderlying mechanism is still not known *** groups extracted and separated theacetyl shikonin from Lithospermum erythrorhizon Sieb. et Zucc by supercritical fluid extraction(SFE) and high-speed counter- current chromatography(HSCCC). Our preliminarydata showed that acetyl shikonin not only inhibits topoisomerase, induces prostate cancercell cycle S arrest, DNA damage and apoptosis, but also triggers autophagy, evidenced asincreased LC3 B,a marker of autophagy,expression and conversion. Confocal imaging andGFP–LC3B transfection further demonstrated the ability of acetyl shikonin-mediated autophagyin prostate cancer. Incubating the prostate cancer cells with acetyl shikonin triggersintracellular ROS generation, increases phosphorylation level of JNK and inhibitsAkt/mTOR axis. Moreover, blockade of the ROS-mediated-autophagy by antioxidant Nacetyl-cysteine

关键词： Prostate cancer autophagy Reactive Oxygen species

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Two New Schiff Bases Based on 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde: Syntheses, Crystal Structures and Properties

引用

Chinese Journal of Structural Chemistry 2019年第3期38卷 408-415页

作者： SUN Feng-Mei HAN Qiong jiang Zheng-jing ZHAO Pan-Xiang WANG Jia RUI Jia-Yi XU Ji-Ming School of Chemistry and Chemical Engineering Huaiyin Normal University

Two new Schiff bases based on 5-chloro-3-methyl-1-phenyl-1 H-pyrazole-4-carbaldehyde, namely, N-((5-chloro-3-methyl-1-phenyl-1 H-pyrazol-4-yl)methylene)-4-morpholinoaniline(Ⅲa) and N-((5-chloro-3-methyl-1-phenyl-1 H-pyrazol-4-yl)methylene)-3-fluoro-4-morpholinoaniline(Ⅲb), were synthesized and characterized by IR, LC-MS, 1 H NMR and 13 C NMR spectroscopy. Meanwhile, the three-dimensional configurations of the two title compounds were further characterized by single-crystal X-ray diffraction analyses. Both the compounds are thermodynamically stable trans-isomers. Moreover, the fluorescence properties and antioxidant activities against DPPH of the two target compounds have been investigated, and the results showed that the title compounds both have fluorescence performance and certain antioxidant activities against DPPH radical.

关键词： Schiff base 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde synthesis crystal structure property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Improvement of Rice Resistance to Sheath Blight by Pyramiding QTLs Conditioning Disease Resistance and Tiller Angle

引用

Rice science 2014年第6期21卷 318-326页

作者： ZUO Shi-min ZHANG Ya-fang CHEN Zong-xiang jiang Wei FENG Ming-hui PAN Xue-biao Key Laboratory of Crop Genetics and Physiology of jiangsu Province College of Agriculture Yangzhou University/Key Laboratory of Plant Functional Genomics of the Ministry of Education

Rice resistance to sheath blight （SB） is controlled by polygenes or quantitative trait loci （QTLs） and affected by plant morphological traits, qSB-9^TQ and TAG1^TQ, which control SB resistance and tiller angle （TA）, respectively, were employed to test whether the combination of the two genes will further improve rice SB resistance and reduce yield loss rather than only one of them or neither. Using two pairs of near isogenic lines （NILs）, TAC1^TQ was confirmed to contribute to SB resistance. However, its effect was less considerable than that of qSB-9^TQ. Subsequently, the two genes were introduced into two commercial rice varieties to develop a series of NILs. The NILs carrying both TAG1^TQ and qSB-9^TQ showed more resistance than the NILs containing only one of them. Comparing the grain yield per plant （GYP） under the three different SB disease conditions, namely slight, moderate and severe conditions, NILs carrying both genes apparently lost lower GYP than the NILs without the two genes and the NILs carrying only TAC1^TQ. Under slight disease condition, no significant differences were found on morphology, development and GYP associated traits except for TA between the NILs carrying both genes and either of them, indicating that the two genes have no inferior effect on rice agronomic traits. Results indicated that mAC1^TQ and qSB-9^TQ have high breeding potential, and pyramiding SB resistance QTL and morphological trait QTL is a potential approach in improving rice SB resistance.

关键词： breeding potential QTL pyramiding rice sheath blight yield

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydroiodic Acid Additive Enhanced the Performance and Stability of PbS-QDs Solar Cells via Suppressing Hydroxyl Ligand

引用

Nano-Micro Letters 2020年第3期12卷 117-128页

作者： Xiaokun Yang Ji Yang Jahangeer Khan hui Deng Shengjie Yuan Jian Zhang Yong Xia Feng Deng Xue Zhou Farooq Umar Zhixin Jin Haisheng Song Chun Cheng Mohamed Sabry jiang Tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyLuoyu Road 1037Wuhan 430074People’s Republic of China Department of Materials Science and Engineering and Shenzhen Key Laboratory of Nanoimprint Technology South University of Science and TechnologyShenzhen 518055People’s Republic of China Shenzhen R&D Center of Huazhong University of Science and Technology Shenzhen 518000People’s Republic of China School of Optical and Electronic Information Huazhong University of Science and Technology1037 Luoyu RoadWuhan 430074People’s Republic of China National Center for Magnetic Resonance in Wuhan State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071People’s Republic of China Physics Department College of Applied ScienceUmm Al-Qura UniversityMeccaKingdom of Saudi Arabia Solar Physics Lab National Research Institute of Astronomy and GeophysicsCairoEgypt

The recent emerging progress of quantum dot ink(QD-ink)has overcome the complexity of multiple-step colloidal QD(CQD)film preparation and pronouncedly promoted the device ***,the detrimental hydroxyl(OH)ligands induced from synthesis procedure have not been completely ***,a halide ligand additive strategy was devised to optimize QD-ink *** simultaneously reduced sub-bandgap states and converted them into iodide-passivated surface,which increase carrier mobility of the QDs films and achieve thicker absorber with improved *** corresponding power conversion efficiency of this optimized device reached 10.78%.(The control device was 9.56%.)Therefore,this stratege can support as a candidate strategy to solve the QD original limitation caused by hydroxyl ligands,which is also compatible with other CQD-based optoelectronic devices.

关键词： Hydroxyl ligand HI additive Surface passivation Quantum dots ink Solar cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

氟化钠对成骨细胞MC3T3-E1分化及Wnt信号转导通路的影响

引用

中国临床药理学杂志 2019年第4期35卷 355-357页

作者：何欢平静姜晨辉南昌大学抚州医学院药学教研室江西抚州344000

目的探究氟化钠(NaF)对成骨细胞MC3T3-E1分化及Wnt信号转导通路的影响。方法小鼠成骨细胞MC3T3-E1细胞分为实验组和对照组,实验组细胞以终浓度为0. 05,0. 10,0. 50,1. 00,2. 00,3. 00,5. 00 mmol·L^(-1)NaF处理,对照组细胞则以等量生... 详细信息

目的探究氟化钠(NaF)对成骨细胞MC3T3-E1分化及Wnt信号转导通路的影响。方法小鼠成骨细胞MC3T3-E1细胞分为实验组和对照组,实验组细胞以终浓度为0. 05,0. 10,0. 50,1. 00,2. 00,3. 00,5. 00 mmol·L^(-1)NaF处理,对照组细胞则以等量生理盐水处理。用细胞计数试剂盒(CCK-8)法检测MC3T3-E1细胞增殖情况;用碱性磷酸酶(ALP)试剂盒检测MC3T3-E1细胞内ALP含量;蛋白免疫印迹法检测MC3T3-E1细胞Wnt信号转导通路蛋白的表达。结果 0. 05,0. 10,0. 50,1. 00,2. 00,3. 00,5. 00 mmol·L^(-1)NaF处理48 h后,MC3T3-E1细胞生存率分别为(99. 18±2. 15)%,(92. 64±3. 15)%,(83. 69±2. 04)%,(70. 16±2. 49)%,(56. 15±3. 57)%,(42. 36±3. 58)%,(29. 56±1. 36)%。干预24 h后,对照组和低、中、高剂量实验组(0. 50,2. 00,5. 00 mmol·L^(-1)NaF) MC3T3-E1细胞ALP含量分别为(10. 98±3. 52),(13. 26±2. 96),(8. 63±2. 05),(7. 12±1. 24) U·g-1prot,β-catenin蛋白相对表达量分别为0. 88±0. 02,1. 23±0. 06,0. 68±0. 05,0. 35±0. 05,Lrp5蛋白相对表达量分别为0. 96±0. 04,1. 32±0. 02,0. 65±0. 06,0. 33±0. 06,差异均有统计学意义(均P <0. 05)。结论高浓度NaF可抑制MC3T3-E1细胞增殖、分化,但低浓度的NaF却可促进MC3T3-E1细胞分化,其作用机制与调控Wnt信号转导通路蛋白表达相关。

关键词：氟化钠成骨细胞增殖分化 Wnt信号转导通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An improved subspace weighting method using random matrix theory

引用

Frontiers of Information Technology & Electronic Engineering 2020年第9期21卷 1302-1307页

作者： Yu-meng GAO jiang-hui LI Ye-chao BAI Qiong WANG Xing-gan ZHANG School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China Institute of Sound and Vibration Research University of SouthamptonSouthampton SO171BJUK

The weighting subspace fitting(WSF)algorithm performs better than the multi-signal classification(MUSIC)algorithm in the case of low signal-to-noise ratio(SNR)and when signals are *** this study,we use the random matrix theory(RMT)to improve *** focuses on the asymptotic behavior of eigenvalues and eigenvectors of random matrices with dimensions of matrices increasing at the same *** approximative first-order perturbation is applied in WSF when calculating statistics of the eigenvectors of sample *** the asymptotic results of the norm of the projection from the sample covariance matrix signal subspace onto the real signal in the random matrix theory,the method of calculating WSF is *** results are shown to prove the superiority of RMT in scenarios with few snapshots and a low SNR.

关键词： Direction of arrival Signal subspace Random matrix theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remote sensing image segmentation based on region-split and graph cut

Remote sensing image segmentation based on region-split and ...

引用

2011 International Conference on Advanced Materials and Computer Science(ICAMCS 2011)

作者： jiang Hua WEN jing Computer school Guilin uniersity of electronic technology

According to the features of HVS,the algorithm uses region-split method to segment the remote sensing image into a large number of small regionsBy integrating gray feature and spatial location of each region,NC is used to segment the image among regions from global view,by which the final segmented image can be generatedExperimental results show that comparing with the traditional NC,operating speed is significantly improved as getting close segmentation quality,and this is a kind of effective method of image segmentation

关键词： remote sensing image segmentation region-split graph cut Normalized Cut

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study

引用

Cancer Biology & Medicine 2021年第3期18卷 841-848页

作者： Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song huilai Zhang jing Shen Hongmei jing Shuye Wang Xinan Cen hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He jingwen Wang O.A.O’Connor Daobin Zhou Department of Hematology Peking Union Medical College HospitalBeijing 100730China Department of Hematology Shanxi Provincial Cancer HospitalTaiyuan 030013China Department of Hematology Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Hematology Chinese PLA General HospitalBeijing 100039China Department of Lymphoma the 307 Hospital of PLABeijing 100071China Department of Lymphoma Peking University Cancer Hospital and InstituteBeijing 100142China Department of Lymphoma Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Hematology Beijing Friendship HospitalBeijing 100050China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Hematology the First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Hematology Peking University First HospitalBeijing 100034China Department of Hematology Beijing HospitalBeijing 100730China Department of Lymphoma Harbin Medical University Cancer HospitalHarbin 150081China Lymphoma Diagnosis and Treatment Center Institute of Hematology and Blood Diseases HospitalTianjin 300052China Department of Hematology Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Hematology Shanxi Provincial People’s HospitalTaiyuan 030012China Department of Hematology Beijing Tongren HospitalBeijing 100730China Columbia University Medical Center New York 10032-3784NYUSA

Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP *** the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,*** Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the *** unexpected adverse events(AEs)were reported and the observed AEs were ***:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients.

关键词： Peripheral T-cell lymphoma chidamide histone deacetylase inhibitor epigenetic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of a Positive Cis-Element Upstream of Human NKX3.1 Gene

引用

Acta Biochimica et Biophysica Sinica 2005年第11期37卷 773-778页

作者： An-Li jiang Peng-Ju ZHANG Xiao-Yan HU Wei-Wen CHEN Feng KONG Zhi-Fang LIU hui-Qing YUAN Jian-Ye ZHANG Department of Biochemistry,Medical School of Shandong University,Jinan 250012,China Department of Biochemistry Medical School of Shandong UniversityJinan 250012 China

NKX3.1 is a prostate-specific homeobox gene related to prostate development and *** this work,we aimed to identify precisely the functional cis-element in the 197 bp region(from-1032 to -836 bp)of the NKX3.1 promoter(from -1032 to +8bp),which was previously identified topresent positive regulatory activity on NKX3.1 expression,by deletion mutagenesis analysis and electro-phoretic mobility shift assay(EMSA).A 16 bp positive cis-element located between -920 and -905 bpupstream of the NKX3.1 gene was identified by deletion mutation analysis and proved to be a functionalpositive cis-element by *** will be important to further study the functions and regulatory mechanismsof this positive cis-element in NKX3.1 gene expression.

关键词： human NKX3.1 cis-acting element positive regulation mutagenesis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

引用

Protein & Cell 2020年第7期11卷 518-524页

作者： Bingbing He Wenbo Peng Jia Huang Hang Zhang Yingsi Zhou Xiali Yang jing Liu Zhijle Li Chunlong Xu Mingxing Xue hui Yang Pengyu Huang Instute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Itelligence Technology.Shanghai Research Center for Brain Science and Brain-Inspired ItelligenceShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of Life Science and Technology.ShanghaiTech University Shanghai 201210China College of Life Sciences University of Chinese Academy of SciencesBeljing 100049China Center for Animal Genomics Agricultural Genome Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China CAS Center for Excellence in Molecular Cell Science Chinese Academy ot ScencesShanghal 200031China

Dear Editor,RNA knockdown in vivo carries significant potential for dis-ease modeling and *** the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes,strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate,and RNA virus infection diseases when pathogenic DNA is not available(such as SARS-Cov-2 and MERS infections).

关键词： CRISPR/Cas9 mediated diseases

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：