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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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World Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： jing Yang hui Peng Sheng-Ke Tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRI)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRI reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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除草剂扑草净和阿特拉津对海草与大型藻类的毒性比较

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水生生物学报 2017年第4期41卷 930-934页

作者：高亚平蒋增杰杜美荣房景辉姜娓娓方建光中国科学院海洋研究所青岛266071 中国水产科学研究院黄海水产研究所农业部可持续发展重点开放实验室青岛266071 中国科学院大学北京100049

陆地径流等可引起海域中除草剂浓度升高,从而威胁海洋大型植物——海草和大型藻类的生长。以叶绿素荧光为主要指标测定除草剂阿特拉津和扑草净的低、中、高(1、5和25μg/L)浓度对4种常见海草:大叶藻(Zostera marina L.)、丛生大叶藻(***... 详细信息

陆地径流等可引起海域中除草剂浓度升高,从而威胁海洋大型植物——海草和大型藻类的生长。以叶绿素荧光为主要指标测定除草剂阿特拉津和扑草净的低、中、高(1、5和25μg/L)浓度对4种常见海草:大叶藻(Zostera marina L.)、丛生大叶藻(*** M.)、矮大叶藻(*** Aschers.&Graebn.)、红须根虾形藻(Phyllospadix iwatensis M.)和2种常见大型藻类:孔石莼Ulva lactuca L.和海索面Nemalion helminthoides的光合抑制。结果显示,低浓度1μg/L的扑草净和5μg/L的阿特拉津即对矮大叶藻、孔石莼和海索面产生了显著的光合抑制,抑制率约而7.54%—12.97%;大叶藻、丛生大叶藻和红须根虾形藻的扑草净和阿特拉津的显著作用浓度为5μg/L,在相同浓度下,扑草净的光合抑制较阿特拉津更强,同时,矮大叶藻及两种大型藻类较其他3种海草成体对除草剂作用更为敏感。

关键词：扑草净阿特拉津海草大型藻类叶绿素荧光毒性作用

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高级轿车轮胎气压监视系统

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齐齐哈尔大学学报（自然科学版） 2003年第4期19卷 35-38页

作者：姜立标王京春姜辉哈尔滨工业大学汽车工程学院威海264209 吉林大学生物与农业工程学院长春130025 威海市环翠技校威海264200

行车安全是汽车业界一个永恒的话题,而轮胎气压是影响行车安全的重要因素,所以在当代的许多新车型中都把轮胎气压监视系统作为标准配置。本文介绍了几种间接式和直接式轮胎气压监视系统的构成和工作原理。

关键词：行车安全轮胎气压监视系统

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui jiang hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Zinc-based fiber-shaped rechargeable batteries:Insights into structures,electrodes,and electrolytes

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Nano Research 2025年第1期18卷 278-293页

作者： Xuan Zhang Hongcheng Zhang Mengxiang Chen jingqi Lu Evgeny Zhuravlev jing jiang Pin Liu Shengyang Dong Du Yuan Guoyin Zhu Lianbo Ma Yizhou Zhang Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid evolution of flexible wearable electronics has spurred a growing demand for energy storage devices,characterized by low-cost manufacturing processes,high safety standards,exceptional electrochemical performance and robust mechanical *** novel flexible devices,fiber-shaped batteries(FSBs)have emerged as prominent solutions exceptionally suited to future applications,owing to their unique one-dimensional(1D)architecture,remarkable flexibility,potential for miniaturization,adaptability to deformation and compatibility with the conventional textile *** the forefront research on fiber-shaped batteries,zincbased FSBs(ZFSBs)have garnered significant attentions,featured by the promising electrochemical properties of metallic *** enthusiasm is driven by the impressive capacity of Zn(820 mAh·g^(-1))and its low redox potential(Zn/Zn^(2+):-0.76 V *** hydrogen electrode).This review aims to consolidate recent achievements in the structural design,fabrication processes and electrode materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted type and coaxial *** also place special emphasis on electrode modifications and electrolyte ***,we delve into the promising development opportunities and anticipate future challenges associated with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based batteries fiber-shape parallel type twisted type coaxial type

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金顶侧耳多糖—松仁复合饮料的研制

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食品科技 2011年第9期36卷 92-96页

作者：徐晶夏光辉姜瑞平金方平蒋秀芳通化师范学院制药与食品科学系通化134002

以金顶侧耳菌丝多糖和松仁为原料,通过正交试验对金顶侧耳多糖提取工艺和复合饮料的风味调配进行了优化,对增稠剂和乳化剂的种类和用量进行选择,确定复合饮料最佳生产工艺为6%金顶侧耳多糖提取液以6mL/g(干松仁)比率加入松仁乳中,以5.0... 详细信息

以金顶侧耳菌丝多糖和松仁为原料,通过正交试验对金顶侧耳多糖提取工艺和复合饮料的风味调配进行了优化,对增稠剂和乳化剂的种类和用量进行选择,确定复合饮料最佳生产工艺为6%金顶侧耳多糖提取液以6mL/g(干松仁)比率加入松仁乳中,以5.0%白砂糖、0.08%柠檬酸、0.02%乙基麦芽酚为风味调节剂,以0.06%的黄原胶、羧甲基纤维素钠和海藻酸钠为复合增稠剂,以0.20%的吐温80和蔗糖脂肪酸酯为复合乳化剂,在80℃、23MPa下均质2次,121℃杀菌15min。制得的金顶侧耳-松仁复合饮料具有金顶侧耳多糖和松仁蛋白双重保健功效,而且组织状态均匀,口感柔和,具有明显的松仁香味,是一种新型功能饮料。

关键词：复合饮料金顶侧耳多糖松仁

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Whole-brain Optical Imaging:A Powerful Tool for Precise Brain Mapping at the Mesoscopic Level

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Neuroscience Bulletin 2023年第12期39卷 1840-1858页

作者： Tao jiang hui Gong jing Yuan Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics Jiangsu Industrial Technology Research InstituteSuzhou215123China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074China

The mammalian brain is a highly complex network that consists of millions to billions of densely-interconnected *** dissection of neural circuits at the mesoscopic level can provide important structural information for understanding the *** approaches can achieve submicron lateral resolution and achieve“optical sectioning”by a variety of means,which has the natural advantage of allowing the observation of neural circuits at the mesoscopic *** whole-brain optical imaging methods based on tissue clearing or histological sectioning surpass the limitation of optical imaging depth in biological tissues and can provide delicate structural information in a large volume of *** with various fluorescent labeling techniques,whole-brain optical imaging methods have shown great potential in the brain-wide quantitative profiling of cells,circuits,and blood *** this review,we summarize the principles and implementations of various whole-brain optical imaging methods and provide some concepts regarding their future development.

关键词： Whole-brain optical imaging Optical sectioning Micrometer resolution Brain connectome Neural circuits Neuron

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Superradiance-Driven Phonon Laser

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Chinese Physics Letters 2018年第4期35卷 49-52页

作者： Ya-jing jiang Hao Lu hui jing Department of Physics Henan Normal University Xinxiang 453007 Key Laboratory for Quantum Optics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 Key Laboratow of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic hmovation Center for Quantum Effects and Applications Hunan Normal University Changsha 410081

We propose to enhance the generation of a phonon laser by exploiting optical superradiance. In our scheme, the optomechanical cavity contains a movable membrane, which supports a mechanical mode, and the superradiance cavity can generate the coherent collective light emissions by applying a transverse pump to an ultracold intracavity atomic gas. The superradiant emission turns out to be capable of enhancing the phonon laser *** indicates a new way to operate a phonon laser with the assistance of coherent atomic gases trapped in a cavity or lattice potentials.

关键词： Superradiance-Driven Phonon Laser

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