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Research in Astronomy and Astrophysics 2017年第10期17卷 33-40页

作者： Ze-Xi Niu George Hobbs jing-bo Wang shi Dai Department of Astronomy Beijing Normal University Australia Telescope National Facility CSIRO Xinjiang Astronomical Observatory Chinese Academy of Sciences Key Laboratory of Radio Astronomy Chinese Academy of Sciences

The primary goal of pulsar timing array projects is to detect ultra-low-frequency gravitational waves. Pulsar data sets are affected by numerous noise processes including varying dispersive delays in the interstellar medium and from the solar wind. The solar wind can lead to rapidly changing variations that, with existing telescopes, can be hard to measure and then remove. In this paper we study the possibility of using a low frequency telescope to aid in such correction for the Parkes Pulsar Timing Array （PPTA） and also discuss whether the ultra-wide-bandwidth receiver for the FAST telescope is sufficient to model solar wind variations. Our key result is that a single wide-bandwidth receiver can be used to model and remove the effect of the solar wind. However, for pulsars that pass close to the Sun such as PSR J1022＋ 1022, the solar wind is so variable that observations at two telescopes separated by a day are insufficient to correct the solar wind effect.

关键词： stars: pulsars -- gravitational waves

Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo-[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides

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Chinese Chemical Letters 2009年第4期20卷 404-406页

作者： jing bo shi jing Gao Ya Ping Wang Qi Zheng Yao School of Pharmacy China Pharmaceutical University Nanjing 210009 China School of Pharmacy Anhui Medical University Hefei 230032 China School of Pharmaceutical Science Jiangsu University Zhenjiang 212013 China Zhaoke Pharmaceutical Company Limited Hefei 230088 China

A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed, synthesized and evaluated against vesicular stomatitis virus （VSV） in Wish cell. The antiviral activities of all compound... 详细信息

关键词： Oxadiazolo[3,4-d]pyrimidine nucleoside Antivirus Synthesis

Synthesis of new pyrimidine nucleoside derivatives with nitric oxide donors for antiviral activity

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Chinese Chemical Letters 2011年第8期22卷 899-902页

作者： jing bo shi Song Xu Ya Ping Wang jing jing Li Qi Zheng Yao School of Pharmacy China Pharmaceutical University Naniing 210009 China School of Pharmacy Anhui Medical University Hefei 230032 China Anhui Zhaoke Pharmaceutical Co. Ltd. Hefei 230088 China

New pyrimidine nucleoside derivatives with nitric oxide（NO） donor were systematically *** antivirus activities of these nucleoside analogues against vesicular stomatitis virus（VSV） in Wish cell were *** was demonstrated that most of compounds had stronger antiviral acitivity than acyclovir,while their toxicities were similar or lower to acyclovir.

关键词： Pyrimidine nucleoside NO-donor Antivirus Furoxans Oximes Synthesis

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基于医疗废物和沼气的零碳排放制氢系统研究

现代化工 2024年第5期44卷 233-238页

作者：周专边家瑜荆世博余金赵欣悦陈衡国网新疆电力有限公司新疆乌鲁木齐830000 国网新疆电力有限公司经济技术研究院新疆乌鲁木齐830000 华北电力大学北京102206

为了实现清洁高效的资源利用,提出了一种利用医疗废物和沼气的零碳排放制氢系统,该系统由等离子体汽化、固体氧化物燃料电池、蒸汽轮机循环和自热重整组成。混合系统被设计为一个能够生产氢气、热量和电力的多联产系统,以自身维持整个... 详细信息

为了实现清洁高效的资源利用,提出了一种利用医疗废物和沼气的零碳排放制氢系统,该系统由等离子体汽化、固体氧化物燃料电池、蒸汽轮机循环和自热重整组成。混合系统被设计为一个能够生产氢气、热量和电力的多联产系统,以自身维持整个计划生产氢气所需的能源消耗。对制氢系统的热力学和技术经济性进行了研究,结果表明,以医疗废物和沼气为原料的制氢工艺的能量效率和效率分别达到63.20%和59.15%,高于其他工艺;此外,该系统可以在3.25 a内收回初始成本,预计净现值将在25 a内达到80752.48万元。

关键词：医疗垃圾沼气制氢系统耦合参数分析

Synthesis and anti-tumor activity of all-trans retinoic acid derivatives

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Chinese Chemical Letters 2009年第7期20卷 809-811页

作者： Juan Shen jing bo shi Fei Hu Chen Yuan Wang jing jing Ruan Yan Huang School of Pharmacy Anhui Medical University Hefei 230032 China Key Laboratory of Gene Resource Utilization for Severe Disease Antiinflammatory and lmmunopharmacology Ministry of Education and Anhui Province Anhui Medical University Hefei 230032 China

A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays （FCM）. All compounds showed cytotoxicity, especially compounds la and ld exhibited a higher cytotoxicity than other derivatives and all-trans rethaoic acid （ATRA）. Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently. O 2009 Fei Hu Chert. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： All-trans retinoic acid Synthesis Cell differentiation NB4 cell lines

A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction

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Machine Intelligence Research 2024年第1期21卷 153-168页

作者： Zefa Hu Ziyi Ni jing shi Shuang Xu bo Xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative ***,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each *** paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above *** task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated *** this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status ***,our proposed special status"not mentioned"makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource *** experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings.

关键词： Medical dialogue understanding information extraction text generation knowledge-enhanced prompt low-resource setting dataaugmentation

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改进和声搜索算法的配电网智能规划研究

自动化技术与应用 2024年第7期43卷 79-83页

作者：曹茜于志勇荆世博李忠政王威国网新疆电力有限公司经济技术研究院新疆乌鲁木齐830002 山东科技大学智能装备学院山东泰安271019

为提高配电网运行的经济性、可靠性,提出基于改进和声搜索算法的配电网智能规划方法。采用线性潮流计算模式分析配电网当前负荷数据变化状态,以负荷数据作为配电网多目标规划基础,采用网损、开关动作次数最小化、电压平稳定最大化作为... 详细信息

为提高配电网运行的经济性、可靠性,提出基于改进和声搜索算法的配电网智能规划方法。采用线性潮流计算模式分析配电网当前负荷数据变化状态,以负荷数据作为配电网多目标规划基础,采用网损、开关动作次数最小化、电压平稳定最大化作为目标函数设计配电网多目标智能规划模型,使用改进和声算法以模型进行求解,得到最优配电网多目标智能规划方案。测试结果表明,所提方法可准确计算配电网当前电压幅值与电压相角数据,配电网无功优化容量补偿后,网损与开关动作次数均减小,电压平稳定得以保证。

关键词：和声搜索算法配电网智能规划线性潮流计算

Synthesis of novel methotrexate derivatives with inhibition activity of nitric oxide synthase

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Chinese Chemical Letters 2009年第2期20卷 178-180页

作者： Ming Sheng Feng Ping Guo Li Xun Jiang jing bo shi Yu Ping Cao Qi Zheng Yao Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China Nanjing Hicin Pharmaceutical Co. Ltd. Nanjing 210046 China

Seventeen 4-alkylamino/arylamino-substituted methotrexate （MTX） derivatives 6a-14a were designed and synthesized. Their inhibition activities against inducible nitric oxide synthase （iNOS） were evaluated in vitro. The pharmacological results showed that most of the prepared compounds displayed the potent inhibitory effects on iNOS.

关键词： Tetrahydrobiopterin Inhibitor of nitric oxide synthase Synthesis Methotrexate

An uncertainty investigation for liner impedance eduction methods

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Chinese Journal of Aeronautics 2024年第3期37卷 49-59页

作者： Weihao shi Xiaodong jing School of Energy and Power Engineering Beihang UniversityBeijing 100191China

Impedance eduction methods have been developed for decades to meet the increasing need for high-quality impedance data in the design and optimization of acoustic *** this end,it is important to fully investigate the uncertainty problem,to which only limited attention has been devoted so *** paper considers the possibility of acoustically-induced structural vibration as a nonnegligible uncertainty or error source in impedance eduction *** the frequency moves away from the resonant frequency,with the increase in the value of cavity reactance,the acoustic particle velocity inside liner orifices possibly decreases to the extent comparable to the vibration velocity of liner facing ***,the acoustically-induced vibration,although generally being weak except at the inherent structural frequencies,may considerably affect the impedance eduction results near the anti-resonant frequency where the liner has poor *** demonstrate the effect of structural vibration,the vibration velocity of liner facing sheet is estimated from the experimentally educed admittance of the liner samples whose orifices are sealed with ***,a three-dimensional numerical model is set up,in which normal particle velocity is introduced over the solid portion of liner facing sheet to imitate structural vibration,rather than directly solving the acoustic-structural coupling *** shown by the results,the vibration of liner facing sheet,whose velocity is as small as estimated by the experiment,can result in anomalous deviation of the educed impedance from the impedance model near the anti-resonant *** trend that the anomalous deviation varies with frequency is numerically captured.

关键词： Impedance eduction Uncertainty analysis Acoustically-induced structural vibration Anti-resonant frequency Perforated liner

Adverse effect of niobium and boron on hot deformation behavior of sulfur-containing steel

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Journal of Iron and Steel Research International 2024年第1期31卷 252-263页

作者： Guo-ning He shi-qi Wan bo Jiang Chao-lei Zhang Ya-zheng Liu Chun-jing Wu School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China

The hot deformation behaviors of sulfur-containing gear steel 20MnCr5 containing three different contents of Nb and B(0,0.021%Nb,and 0.024%Nb-0.0022%B)were *** compression and tenssion tests were carried out by Gleeble3800 at the austenite region from 850 to 1150℃and the adverse effects of Nb and B were analyzed by the fracture,microstructure and precipitate *** compression tests showed that the proportions of instable area in hot processing maps of 0.021%Nb and Nb-B steels were higher and the deformability of Nb free steel was *** tensile deformation experiments showed that the reduction areas of Nb free,0.021%Nb and Nb-B steels were 92%-99%,84%-98%and 67%-97%,*** addition of Nb or Nb and B inhibited the dynamic recrystallization during hot deformation,and consequently,more deformed grains were then formed in 0.021%Nb and Nb-B steels thus to obtain the microstructure with worse uniformity and then deteriorate the *** addition,the interaction between inclusions and microalloyed elements was also *** particles of 0.021%Nb and Nb-B steels dynamically precipitated during deformation and precipitated together with MnS thus to worsen the deformability,resulting in the decrease of reduction area.

关键词： Hot deformation Gear steel Processing map Dynamic recrystallization Microalloying