Synthesis and anti-tumor activity of all-trans retinoic acid derivatives
Synthesis and anti-tumor activity of all-trans retinoic acid derivatives作者机构：School of Pharmacy Anhui Medical University Hefei 230032 China Key Laboratory of Gene Resource Utilization for Severe Disease Antiinflammatory and lmmunopharmacology Ministry of Education and Anhui Province Anhui Medical University Hefei 230032 China
出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)
年 卷 期：2009年第20卷第7期
页 面：809-811页
核心收录：
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 10[医学]
主 题：All-trans retinoic acid Synthesis Cell differentiation NB4 cell lines
摘 要：A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays （FCM）. All compounds showed cytotoxicity, especially compounds la and ld exhibited a higher cytotoxicity than other derivatives and all-trans rethaoic acid （ATRA）. Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently. O 2009 Fei Hu Chert. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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