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济南大学学报（自然科学版） 2004年第1期18卷 80-82页

作者：孙志刚孙奕奇张玉璘刘灿济南大学信息科学与工程学院山东济南250022 北京科技大学信息工程学院北京100083

介绍了IP电话及其DSP技术相关问题 ,并针对于IP电话QOS不能得到保证的问题 ,提出了可以利用针对于IP电话的DSP语音处理系统来解决关键技术的方案 ,同时介绍了基于TMS32 0C6 2 11B的实时压缩语音处理系统方案。

关键词： IP电话 DSP 语音处理系统语音压缩

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济南市马鞍山路道路绿化景观模式分析研究

山东林业科技 2011年第6期41卷 34-36,23页

作者：尚红滕祺李伟光张杰山东建筑大学艺术学院山东济南250101

城市道路绿地是城市绿地系统的重要组成部分,是人们了解一个城市、感受城市景观特色与文化的重要窗口。作者通过对济南市马鞍山路道路绿化的实地调研,结合其道路性质及周边环境,分析现有绿化景观模式的优缺点,并给予相应的景观评价;针... 详细信息

城市道路绿地是城市绿地系统的重要组成部分,是人们了解一个城市、感受城市景观特色与文化的重要窗口。作者通过对济南市马鞍山路道路绿化的实地调研,结合其道路性质及周边环境,分析现有绿化景观模式的优缺点,并给予相应的景观评价;针对目前济南市老城区道路绿化改建过程中行道树的选择、保护与移植等问题,探求适合该类城市道路绿化建设的景观模式。

关键词：道路绿化景观模式景观评价

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一种用于浮筏功率流计算的新方法

山东大学学报（工学版） 2003年第3期33卷 241-244页

作者：张冰宋孔杰孙玲玲山东大学机械工程学院山东济南250061

针对振动控制中传递功率流的复杂矩阵运算,推导了一种用于复杂隔振系统功率流计算的新方法.本方法算法简捷,各子系统的动态传递方程采用了统一的形式,具有递推性和延拓性,适用于复杂多层耦合振动系统的动态特性分析.实例计算结果表明,... 详细信息

针对振动控制中传递功率流的复杂矩阵运算,推导了一种用于复杂隔振系统功率流计算的新方法.本方法算法简捷,各子系统的动态传递方程采用了统一的形式,具有递推性和延拓性,适用于复杂多层耦合振动系统的动态特性分析.实例计算结果表明,该方法能够预测各子系统联接界面或耦合点的功率流,清晰地描述不同频段下各界面能量传递及衰减特性,有利于分析复杂多层隔振系统的功率流传递特性.

关键词：浮筏功率流传递矩阵

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Keystone变换实现方法研究

电子学报 2022年第5期50卷 1218-1226页

作者：张亮张翔宇王国宏海军航空大学信息融合研究所山东烟台264001 中国人民解放军94326部队山东济南250000 海军航空大学航空电子与指挥系山东青岛266041 中北大学信息与通信工程学院山西太原030023

Keystone变换(Keystone Transform,KT)是一种经典的雷达目标距离走动校正工具,现有诸多实现方法中以基于线性调频Z变换(Chirp-Z Transform,CZT)和快速傅里叶逆变换(Inverse Fast Fourier Transform,IFFT)的“CZT+IFFT”方法计算量最低.本文针对“CZT+IFFT”方法存在的频谱混叠问题,提出修正的“CZT+IFFT”方法,同时运用时间尺度(Time-Scaling,TS)和尺度估计(Scale-Estimation,SE)概念,进一步提出2种梅林域的KT实现方法.仿真试验验证了分析结论的正确性和所提方法的有效性.

关键词：雷达 Keystone变换相参积累梅林变换线性调频Z变换时间尺度尺度估计

The Association Between Depression and All-Cause,Cause-Specific Mortality in the Chinese Population—China,2010-2022

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China CDC weekly 2024年第40期6卷 1022-1027页

作者： Jifei Wang Zhenping Zhao Jing Yang Limin Wang Mei zhang Maigeng Zhou Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan CityShandong ProvinceChina National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Depression is linked to higher all-cause and cardiovascular mortality rates,but its effects on specific subgroups and non-cardiovascular mortality in the Chinese population remain *** is added by this report?Both severe and mild to moderate depression were found to elevate mortality rates among the Chinese *** impact was particularly notable among males,urban residents,younger individuals,and those with higher education *** exhibited a stronger connection with fatalities related to suicide and non-suicidal *** are the implications for public health practice?Individuals experiencing mild depression require healthcare attention to avoid negative *** physical and psychological support is particularly crucial for high-risk subgroups.

关键词： mortality injuries cardiovascular

Correlation between single nucleotide polymorphisms of 17β-HSD-1 and endometrial adenocarcinoma

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现代妇产科进展 2011年第8期20卷 670-672页

作者： Qian Shao zhang Hong Han Wenfei Jian Yan Fu Weijiang Yang Xingsheng jinan Maternal and Infant Hospital Jinan 250001 Qilu Hospital of Shandong University

Objective: To investigate the correlation between 17-beta-hydroxysteroid dehydrogenase type1(17β-HSD-1) gene polymorphisms and risk of endometrial ***: Forty-one patients with endometrial adenocarcinoma were selected as experimen-tal group and twenty-seven healthy women were selected as control *** three common single nucleotide polymorphism of 17β-HSD-1 gene at sites + 1004,+ 1322 and + 1954 were detected by allele-specific PCR(ASA-PCR).The allele frequencies were analyzed by SPSS13.0 software between endometrial cancer cases and ***: We observed no significant difference in various frequency distribution between experimental group and control group.P1004= 0.994,P1322 = 0.974,and P1954 = ***: We found that three common SNPs with the 17β-HSD-1 gene were not associated with endometrial *** suggest that more research for 17β-HSD needs to explore.

关键词： 17-beta-hydroxysteroid dehydrogenase-type 1 Gene polymorphisms Endometrial neoplasms

Changes of Aroma Components in Hongdeng Sweet Cherry During Fruit Development

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Agricultural Sciences in China 2007年第11期6卷 1376-1382页

作者： zhang Xu JIANG Yuan-mao PENG Fu-tian HE Nai-bo LI Yan-ju ZHAO Deng-chao Yantai Academy of Agricultural Science and Technology Yantai 265500 P.R. China State Key Laboratory of Crop Biology College of Horticulture Science and Engineering Shandong Agricultural University Taian 271018 P.R. China Department of Science and Technology of Shandong Province Jinan 250011 P.R. China Shandong Academy of Forestry Sciences Jinan 250011 P.R. China

To study the changes of aroma components in sweet cherry during fruit development, the aroma components in sweet cherry fruit from the green stage, the color stage, the commercial stage, and the ripe stage were collected using head-space solid phase microextraction （HS-SPME）, and were analyzed using a gas chromatograph-mass spectrophotometer （GC- MS）. A total of 37 compounds were identified from the sample extracts. Aldehydes, alcohols, and esters were the major constituents. The aroma components behaved differently during the fruit developmental period. C6 aldehydes and aromatic aldehydes were the main aldehydes in the sweet cherry fruit. The contents of C6 aldehydes increased quickly to 84.16% in the color stage, then decreased as ripening proceeded, and then, the contents decreased to 59.20 and 55.58% at the commercial stage and the ripe stage, respectively. The aromatic aldehydes （benzaldehyde） increased as ripening proceeded, and the maximum was found at the ripe stage. Alcohols of sweet cherry fruit included C6 alcohols and aromatic alcohols. The content of （E）-2-hexen-l-ol increased as ripening proceeded. The maximum was found at the commercial stage; alcohol was only found at the ripe stage. Ester components included ethyl acetate, butanoic acid ethyl ester, hexanoic acid ethyl ester, which increased as the fruit ripened. Hexanal, （E）-2-hexenal, benzaldehyde, （E）-2-hexen-l-ol, ethyl acetate, and hexanoic acid ethyl ester were the characteristic aroma components of sweet cherry fruit. These aroma components started to form drastically at the color stage, and the main aroma was formed at the commercial stage, which then turned bad at the ripe stage because of the presence of alcohol. So the optimal harvest time of sweet cherry was at the commercial stage.

关键词： sweet cherry fruit development aroma components solid phase microextraction GC-MS

Tetramethylpyrazine nitrone improved mitochondrial dysfunction, downregulated α-synuclein, and reduced neurodegeneration in Parkinson disease models

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中国药理学与毒理学杂志 2019年第10期 843-844页

作者： GUO Bao-jian ZHENG Cheng-you QIU Xiao-ling zhang Zai-jun Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardiocerebrovascular Diseases Jinan University College of Pharmacy

OBJECTIVE The peroxisome proliferatoractivated receptor γ co-activator 1α(PGC-1α) and nuclear factor(erythroid-derived 2)-like 2(Nrf2) are key regulators controlling antioxidant defense, mitochondrial biogenesis and cellular proteostasis. Dysfunction of any of these processes has been implicated in the pathogenesis of Parkinson disease(PD). Activation of PGC-1α/Nrf2 might improve mitochondrial dysfunction, promote α-synuclein(α-syn) clearance, and attenuate degeneration of nigral dopaminergic neurons in PD. To test this, we used tetramethylpyrazine nitrone(TBN), a potent free radical scavenger, to activate PGC-1α/Nrf2 pathway. METHODS 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(MPTP)-induced mouse model, unilateral intrastriatal injection of 6-hydroxydopamine(6-OHDA)-induced rat model, and transgenic mice overexpression of human A53 T mutant α-synuclein were used to evaluate TBN's therapeutic efficacy and to explore its mechanisms of action. RESULTS TBN protected against 1-methyl-4-phenylpyridinium(MPP+) and 6-OHDA insult in cultured primary midbrain neurons. TBN promoted α-syn clearance by autophagy and proteasomal pathways in the cell models overexpressed human A53 T mutant α-syn. In MPTP-treated mouse and unilateral 6-OHDA-lesioned rat, as well as in α-syn transgenic mouse model, TBN improved motor impairment, increased survive of nigra dopaminergic neurons, and elevated striatal dopamine level, while decreased the products of oxidative ***, TBN down-regulated α-syn level in the brain and serum of α-syn transgenic mice. These improvements in vitro and in vivo were associated with activation of PGC-1α/Nrf2 signal pathway, resulting in reduced oxidative stress, enhanced mitochondrial function, and increased protein clearance. CONCLUSION Our work demonstrates that activation of PGC-1α/Nrf2 by TBN can maintain the survival of nigral dopaminergic neurons, and might be disease-modifying in PD models, providing the critical rationale for further devel

关键词： tetramethylpyrazine nitrone Parkinson disease peroxisome proliferator-activated receptor γ co-activator 1α nuclear factor(erythroid-derived 2)-like 2 α-synuclein

Correlations between alterations of T-helper 17 cells and treatment efficacy after concurrent radiochemotherapy in locally advanced cervical cancer (stage IIB-IIIB): a 3-year prospective study

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Chinese Medical Journal 2021年第8期134卷 954-962页

作者： Yi Liu Qiu-Fen Guo Jin-Long Chen Xi-Rui Li Fei Hou Xiao-Yan Liu Wen-Jing zhang Yan zhang Fu-Feng Gao You-Zhong zhang Bao-Xia Cui Nai-Fu Liu Department of Obstetrics and Gynecology Qilu HospitalShandong UniversityJi'nanShandong 250012China Medical Management Service Center of Health Commission of Shandong Health commission Ji'nanShandong 250014China Department of Gynecological Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJi'nanShandong 250117China Department of Medical Record Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJi'nanShandong 250117China Department of Gynecological Oncology Jinan Maternal and Child Care HospitalJi'nanShandong 250012China Department of Gynecological Oncology Taian Second Hospital of Traditional Chinese MedicineTaianShandong 271000China Department of Gynecology Weifang People's HospitalWeifangShandong 261000China

Background::Recently,T-helper 17(Th17)cells have been proved to play an important role in promoting cervical ***,till now,few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor *** study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer(LACC)patients before and after concurrent chemoradiotherapy(cCRT)and to analyze the correlations between the alterations in Th17 cells and treatment ***::A prospective study with 49 LACC(International federation of gynecology and obstetrics[FIGO]stage IIB-IIIB)patients and 23 controls was *** received the same cCRT schedule and were followed up for 3 *** Th17 cells(CD3+CD8-interleukin[IL]-17+T cells)and related cytokines IL-17,transforming growth factor-β(TGF-β),IL-10,IL-23,IL-6,and IL-22 were detected before and after *** between alterations of circulating Th17 cells and treatment efficacy were ***-Meier analysis was used for overall survival(OS)and progression-free survival(PFS).Results::We found that 40 patients finished the entire cCRT schedule and met the endpoint of this *** percentage of circulating Th17 cells in the LACC patients was higher than that in the controls,and it significantly decreased after cCRT(P<0.05).After cCRT,patients were divided into two groups based on the average of the Th17 cells *** subgroup of patients with a prominent decrease in circulating Th17 cells after cCRT had a higher treatment efficacy and longer PFS and OS *** with the control patients,LACC patients had higher IL-6,IL-10,IL-22,TGF-βlevels and a lower IL-23 level(P<0.05).After cCRT,IL-6,IL-10,IL-17,IL-23 level significantly increased and TGF-βlevel significantly decreased compared with the levels before cCRT(P<0.05).Conclusion::Circulating Th17 cells in the LACC patients(FIGO stage IIB-IIIB)were hi

关键词： Locally advanced cervical cancer Concurrent chemoradiotherapy Th17 cells Cytokines Treatment efficacy

Yield, Leaf Senescence, and Cry1Ac Expression in Response to Removal of Early Fruiting Branches in Transgenic Bt Cotton

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Agricultural Sciences in China 2008年第6期7卷 692-702页

作者： DONG He-zhong TANG Wei LI Wei-jiang LI Zhen-huai NIU Yue-hua zhang Dong-mei Cotton Research Center Shandong Academy of Agricultural Sciences/Shandong Provincial Key Lab for Cotton Culture and PhysiologyJinan 250100 P.R.China

Two-year field experiments were conducted at Linqing, Yellow River valley of China, to study the plant response to the removal of early fruiting branches in transgenic Bt （Bacillus thuringiensis） cotton （Gossypium hirsutum L.） from 2003 to 2004. Plants were undamaged and treated by removing two basal fruiting branches （FB） at squaring to form the control and the removal treatment, respectively. The plant height, leaf area （LA）, dry weight of fruiting forms （DWFF）, the number of fruiting nodes （NFN）, photosynthetic （Pn） rate, and levels of leaf chlorophyll （Chl）, N, P, K, and Cry lAc protein in main- stem leaves were measured at a 10- or 20-d interval after FB removal, and the sink/source ratio as indicated by NFN/LA and DWFF/LA was determined. FB removal significantly increased the plant height, LA, and plant biomass in both years. Lint yields were increased 7.5 and 5.2% by removal compared with their controls in 2003 and 2004, respectively. Significant increases in boll size （5.7 and 5.1%） were also observed in removal than in control for both years. Either NFN/LA or DWFF/LA was significantly reduced by removal before 40 d after removal; however, both NFN/LA and DWFF/LA were significantly enhanced by FB removal at 80 d after removal compared to the untreated control. There was no significant difference in fiber quality in the first two harvests between removal and control, but fiber strength and micronarie in the third harvest were significantly improved by FB removal. In terms of leaf Chl, Pn rate, levels of total N, P, and K in late season, leaf senescence was considerably delayed by FB removal. Levels of CrylAc protein in the fully expanded young leaves were considerably higher in FB-excised plants than in control, indicating FB removal enhanced CrylAc expression. It is suggested that the yield and quality improvement with FB removal may be attributed to the increased NFN/LA or DWFF/LA in late season and delayed leaf senescence, respectively. FB removal can be a

关键词： branch removal Bt cotton Cry lAc protein leaf senescence photosynthetic rate sink/source ratio