Correlations between alterations of T-helper 17 cells and treatment efficacy after concurrent radiochemotherapy in locally advanced cervical cancer (stage IIB-IIIB): a 3-year prospective study

作     者：Yi Liu Qiu-Fen Guo Jin-Long Chen Xi-Rui Li Fei Hou Xiao-Yan Liu Wen-Jing Zhang Yan Zhang Fu-Feng Gao You-Zhong Zhang Bao-Xia Cui Nai-Fu Liu Liu Yi;Guo Qiu-Fen;Chen Jin-Long;Li Xi-Rui;Hou Fei;Liu Xiao-Yan;Zhang Wen-Jing;Zhang Yan;Gao Fu-Feng;Zhang You-Zhong;Cui Bao-Xia;Liu Nai-Fu

作者机构：Department of Obstetrics and GynecologyQilu HospitalShandong UniversityJi'nanShandong 250012China Medical Management Service Center of Health Commission of Shandong Health commissionJi'nanShandong 250014China Department of Gynecological OncologyShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJi'nanShandong 250117China Department of Medical RecordShandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJi'nanShandong 250117China Department of Gynecological OncologyJinan Maternal and Child Care HospitalJi'nanShandong 250012China Department of Gynecological OncologyTaian Second Hospital of Traditional Chinese MedicineTaianShandong 271000China Department of GynecologyWeifang People's HospitalWeifangShandong 261000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第8期

页      面：954-962页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Key Research and Development Program of China(No:2016YFC1302904) the National Natural Science Foundation of China(No:81572559) the Key Research Project of Shandong Province(No:2017CXGC1210) 

主　　题：Locally advanced cervical cancer Concurrent chemoradiotherapy Th17 cells Cytokines Treatment efficacy 

摘      要：Background::Recently,T-helper 17(Th17)cells have been proved to play an important role in promoting cervical ***,till now,few study has been carried out to understand the involvement of these cells in efficacy of anti-tumor *** study aimed to investigate the alterations in the percentage of circulating Th17 cells and related cytokines in locally advanced cervical cancer(LACC)patients before and after concurrent chemoradiotherapy(cCRT)and to analyze the correlations between the alterations in Th17 cells and treatment ***::A prospective study with 49 LACC(International federation of gynecology and obstetrics[FIGO]stage IIB-IIIB)patients and 23 controls was *** received the same cCRT schedule and were followed up for 3 *** Th17 cells(CD3+CD8-interleukin[IL]-17+T cells)and related cytokines IL-17,transforming growth factor-β(TGF-β),IL-10,IL-23,IL-6,and IL-22 were detected before and after *** between alterations of circulating Th17 cells and treatment efficacy were ***-Meier analysis was used for overall survival(OS)and progression-free survival(PFS).Results::We found that 40 patients finished the entire cCRT schedule and met the endpoint of this *** percentage of circulating Th17 cells in the LACC patients was higher than that in the controls,and it significantly decreased after cCRT(P0.05).After cCRT,patients were divided into two groups based on the average of the Th17 cells *** subgroup of patients with a prominent decrease in circulating Th17 cells after cCRT had a higher treatment efficacy and longer PFS and OS *** with the control patients,LACC patients had higher IL-6,IL-10,IL-22,TGF-βlevels and a lower IL-23 level(P0.05).After cCRT,IL-6,IL-10,IL-17,IL-23 level significantly increased and TGF-βlevel significantly decreased compared with the levels before cCRT(P0.05).Conclusion::Circulating Th17 cells in the LACC patients(FIGO stage IIB-IIIB)were hi