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Nano Research 2017年第11期10卷 3885-3895页

作者： jin Sun yoo Gill Sang Han Seongha Lee Min Cheol Kim Mansoo Choi Hyun Suk Jung Jung-Kun Lee School of Advanced Materials Science amp Engineering Sungkyunkwan University Suwon 440-746 Republic of Korea Department of Mechanical Engineering and Materials Science University of Pittsburgh Pittsburgh Pennsylvania 15261 USA Department of Mechanical and Aerospace Engineering Seoul National University Seoul 08826 Republic of Korea

In spite of a continuous increase in their power conversion efficiency （PCE） and an economically viable fabrication process,organic-inorganic perovskite solar cells （PSCs） pose a significant problem when used in practical applications：They show fast degradation of the PCE when exposed to very humid *** this study,the stability of PSCs under very humid conditions is greatly enhanced by coating the surface of the PSC devices with a multi-layer film consisting of ultrahydrophobic and relatively hydrophilic layers.A hydrophobic composite of poly（methyl methacrylate）（PMMA）,polyurethane （PU）,and SiO2 nanoparticles successfully retards the water molecules from very humid ***,the hydrophilic layer with moderately PMMA captures the residual moisture within the perovskite layer;subsequently,the perovskite layer *** dual function of the coating film keeps the PCE of PSCs at 17.3% for 180 min when exposed to over 95% humidity.

关键词： perovskite solar cell stability surface coating ultrahydrophobic self-recovery

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 315-322页

作者： Eun-jin YANG Ji-Young MOON Min-jin KIM Dong Sam KIM Chan-Shick KIM wook Jae LEE Nam Ho LEE Chang-Gu HYUN Jeju Biodiversity Research Institute(JBRI) Jeju High-Tech Development Institute(HiDI) Jeju 699-943Korea Jeju Seaweed Industry Development Agency Cheju National UniversityJeju 690-756Korea Faculty of Biotechnology Cheju National UniversityJeju 690-756Korea Department of Chemistry Cheju National UniversityJeju 690-756Korea

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and *** the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of *** study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory *** results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response.

关键词： Nitric oxide Interleukin-6(IL-6) Prostaglandin E2(PGE2) Tumor necrosis factor-α(TNF-α) Seaweeds Pro-inflammatory mediators

Efficacy of Seprafilm~ graft with adhesiolysis in experimentally induced lid adhesion in rabbits

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 44-49页

作者： Sang wook jin Hee Bae Ahn Mi Sook Roh yoon Hyung Kwon Won Yeol Ryu Department of Ophthalmology College of MedicineDong-A University Department of Pathology College of MedicineDong-A University

AIM:To evaluate the efficacy of Seprafilm transplantation following adhesiolysis for preventing postoperative readhesion and improving surgical outcomes. METHODS:Primary blepharoplasty was carried out on both eyelids of 18 albino rabbits. After 2 weeks, a new skin incision was made, and adhesiolysis was performed on both eyelids. The rabbits were categorized into two groups, one with adhesiolysis alone in the left eyelid (control group), and the other with adhesiolysis with a Seprafilm graft in the right eyelid (Seprafilm group). The degrees of inflammation and fibrosis were examined with hematoxylin-eosin (HE) and Masson’s trichrome stains. Expression of α-smooth muscle actin (α-SMA) was also immunohistochemically examined. RESULTS:Eyelid examination immediately after the operation revealed mild swelling and hemorrhage in both groups, but these symptoms resolved after 1 week-2 weeks, and eyelid shape had recovered completely in both groups. Microscopic assessments demonstrated that the Seprafilm group showed less inflammation and fibrosis than the control group. The Seprafilm group also exhibited fewer α-SMA-positive cells than the control group. CONCLUSION:Based on these findings, we conclude that Seprafilm graft with adhesiolysis is an effective method for preventing postoperative readhesions after eyelid surgery.

关键词： Seprafilm adhesion adhesiolysis

Effect of esmolol and lidocaine on agitation in awake phase of anesthesia among children:a double-blind,randomized clinical study

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Chinese Medical Journal 2019年第7期132卷 757-764页

作者： Jae Young Ji jin Soo Park Ji Eun Kim Da Hyung Kim jin Hun Chung Hea Rim Chun Ho Soon Jung Sie Hyeon yoo Department of Anesthesiology and Pain Medicine Soonchunhyang University Hospital Cheonan31Soonchunhyang 6-gilDongnam-guCheonan-siChungcheongnam-do 330-721Korea

Background:Sevoflurane is widely used to anesthetize children because of its rapid action with minimal irritation of the ***,there is a high risk of agitation after emergence from *** surgery,in particular,can trigger agitation because patients have their eyes covered in the postoperative *** aim of this study was to determine whether or not esmolol and lidocaine could decrease emergence agitation in ***:Eighty-four patients aged 3 to 9 years undergoing strabismus surgery were randomly assigned to a control group(saline only),a group that received intravenous lidocaine 1.5 mg/kg,and a group that received intravenous esmolol 0.5 mg/kg and lidocaine 1.5 mg/*** was measured using the objective pain score,Cole 5-point score,and Richmond Agitation Sedation Scale score at the end of surgery,on arrival in the recovery room,and 10 and 30 min after ***:The group that received the combination of esmolol and lidocaine showed lower OPS and RASS scores than the other two groups when patients awoke from anesthesia(OPS=0(0-4),RASS=-4[(-5)-1])and were transferred to the recovery room(OPS=0(0-8),RASS=-1[(-5)-3])(P0.05).Conclusions:When pediatric strabismus surgery is accompanied by sevoflurane anesthesia,an intravenous injection of esmolol and lidocaine could alleviate agitation until arrival in the recovery room.

关键词： Agitation Esmolol Lidocaine Sevoflurane

Injection molding of micro patterned PMMA plate

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 148-152页

作者： Yeong-Eun yoo Tae-Hoon KIM Tae-jin JE Doo-Sun CHOI Chang-Wan KIM Sun-Kyung KIM Department of Nanomanufacturing Technology KIMM 171 Jang-dong Yusung-gu Daejeon 305-343 Korea Department of Product Design and Manufacturing Seoul National University of Technology

A plastic plate with surface micro features was injection molded to investigate the effect of pressure rise of melt on the replication of the micro structures. Prism pattern, which is used in many optical applications, was selected as a model pattern. The prism pattern is 50 μm in pitch and 108° in the vertical angle. The overall size of the plate was 335 mm×213 mm and the thickness of the plate varied linearly from 2.6 mm to 0.7 mm. The prism pattern was firstly machined on the nickel plated core block using micro diamond tool and this machined pattern core was installed in a mold for injection molding of prism patterned plate. Polymethyl methacrylate (PMMA) was used as a molding material. The pressure and temperature of the melt in the cavity were measured at different positions in the cavity and the replication of the pattern was also measured at the same positions. The results show that the pressure or temperature profile through the process depends on the shape and the size of the plate. The replication is affected by the temperature and pressure profiles at the early stage of filling, which is right after the melt reaches the position to be measured.

关键词： PMMA 注塑成型塑料板图案聚甲基丙烯酸甲酯压力上升加工模式位置测量

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： Young Ju Lee jin-Woo Jung Sangchul Lee Sang wook Lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun Lee Seong jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

The effect of diet-induced insulin resistance on DNA methylation of the androgen receptor promoter in the penile cavernosal smooth muscle of mice

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Asian Journal of Andrology 2013年第4期15卷 487-491,I0007页

作者： jin-wook Kim Mi-Mi Oh Cheol-Yong yoon Jae-Hyun Bae Je-Jong Kim Du-Geon Moon Department of Urology Korea University Medical Center Guro Hospital Seou1152-703 Korea and Department of Urology Korea University College of Medicine Seou1152 703 Korea

Population studies have suggested an association between diabetes and the symptoms of testosterone deficiency. Recently, the expression of the androgen receptor （AR） has been shown to be decreased in diabetic patients. Furthermore, diabetes has been shown to induce global methylation. In this study, we used an animal model to investigate whether diabetes results in increased methylation of the AR promoter and whether these changes are associated with the decreased expression of AR in penile cavernosal smooth muscle tissue. Twenty C57BL/6J mice were divided into two groups, receiving either high- （mature diabetic） or low- （mature control） caloric meals for 14 weeks. Another 10 mice were killed at 1 week （young control）. Animals in the mature diabetic group showed decreased testosterone levels, although this was not statistically significant. In both control groups, no significant methylation was observed in the AR promoter region CpG island （-85 to ＋339）. In the mature diabetic group, significant methylation was observed at ＋ 185 and ＋200 of the AR promoter. These changes were associated with increased homeostatic model assessment for insulin resistance （HOMA-IR） and decreased corpus cavernosal tissue mass and expression of AR mRNA and protein. We conclude that in these animals, insulin resistance increased the methylation of the GC-rich regions of the AR promoter, leading to decreased AR expression.

关键词： androgen receptor (AR) diabetes DNA methylation

Potential risk factors for nonalcoholic steatohepatitis related to pancreatic secretions following pancreaticoduodenectomy

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World Journal of Gastroenterology 2011年第32期17卷 3716-3723页

作者： Sun Choon Song Seong Ho Choi Dong wook Choi jin Seok Heo Woo Seok Kim Min Jung Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To identify risk factors for nonalcoholic steatohepatitis following pancreaticoduodenectomy, with a focus on factors related to pancreatic secretions. METHODS: The medical records of 228 patients who had a pancreaticoduodenectomy over a 16-mo period were reviewed retrospectively. The 193 patients who did not have fatty liver disease preoperatively were included in the final analysis. Hepatic steatosis was diagnosed using the differences between splenic and hepatic attenuation and liver-to-spleen attenuation as measured by non-enhanced computed tomography. RESULTS: Fifteen patients (7.8%) who showed postoperative hepatic fatty changes were assigned to Group A, and the remaining patients were assigned to Group B. Patient demographics, preoperative laboratory findings (including levels of C-peptide, glucagon, insulin and glucose tolerance test results), operation types, and final pathological findings did not differ significantly between the two groups; however, the frequency of pancreatic fistula (P = 0.020) and the method of pancreatic duct stenting (P = 0.005) showed significant differences between the groups. A multivari- ate analysis identified pancreatic fistula (HR = 3.332, P = 0.037) and external pancreatic duct stenting (HR = 4.530, P = 0.017) as independent risk factors for the development of postoperative steatohepatitis. CONCLUSION: Pancreatic fistula and external pancreatic duct stenting were identified as independent risk factors for the development of steatohepatitis following pancreaticoduodenectomy.

关键词：危险因素十二指肠脂肪肝切除术酒精性分泌物肝炎胰腺

Effects of obesity on lower urinary tract symptoms in Korean BPH patients

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Asian Journal of Andrology 2009年第6期11卷 663-668页

作者： Seung Hwan Lee Joon Chul Kim Ji-Youl Lee Jang Hwan Kim Cheol Young Oh Seung wook Lee Se Jeong yoo Byung Ha Chung Department of Urology Yonsei University Health System Seoul 135-720 Korea Department of Urology The Catholic University of Korea Seoul 137-701 Korea Department of Urology Hallym University Chuncheon 200-704 Korea Department of Urology Eulji Medical Center Eulji University Seoul 139-230 Korea

We analyzed the effects of obesity on lower urinary tract symptoms （LUTSs） in Korean benign prostatic hyperplasia （BPH） patients. This is a multicenter, cross-sectional, prospective study conducted in four centers in Korea. A total of 602 men with LUTSs secondary to BPH were included. BPH/LUTSs cases were men aged ≥ 40 years with intemational prostate symptom scores （IPSS） ≥ 8 points. Height, weight and waist circumference were measured. Among the 602 patients, 156 patients had a waist circumference above 90 cm, representing central obesity, and 215 patients had a body mass index above 25 kg m2. Waist circumference was positively correlated with prostate volume （P = 0.034）. Men with waist circumference 〉 90 cm experienced a 1.36-fold increased risk of severe LUTSs （95% CI 0.82-2.41） compared with men with waist circumference ≤ 90 cm. Prostate volume was positively correlated with urgency and nocturia in men with central obesity. In this population of Korean men diagnosed with BPH, central obesity rather than overall obesity seems to be the more important predictor of LUTSs correlated with BPH.

关键词： benign prostatic hyperplasia central obesity lower urinary tract symptom prostate

Ventricular fibrillation and sudden cardiac arrest in apical hypertrophic cardiomyopathy:Two case reports

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World Journal of Clinical Cases 2021年第35期9卷 11102-11107页

作者： Yae Min Park Albert Youngwoo Jang wook-jin Chung Seung Hwan Han Christopher Semsarian In Suck Choi Department ofCardiology Gachon University Gil Medical CenterIncheon 21556South Korea Agnes Ginges Centre for Molecular Cardiology Centenary Institute The University of SydneySydney 21556Australia

BACKGROUND Apical hypertrophic cardiomyopathy(HCM)is considered to have a benign prognosis in terms of cardiovascular *** serial case report aimed to raise awareness of ventricular fibrillation(VF)and sudden cardiac death(SCD)in apical *** SUMMARY Here we describe two rare cases of apical HCM that presented with documented VF and sudden cardiac *** patients were previously not recommended for primary prevention using implantable cardioverter-defibrillator(ICD)therapy based on current ***,both received ICD therapy for the secondary prevention of *** These cases illustrate serious complications including VF and aborted sudden cardiac arrest in apical HCM patients who are initially not candidates for primary prevention using ICD implantation based on current guidelines.

关键词： Apical hypertrophic cardiomyopathy Ventricular fibrillation Implantable cardioverter-defibrillator Case report