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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： li Zhong-hao PU Xiao-qi li Sha-sha DONG Xiao-ke zhang Guo-qiang WANG Yu liU jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(Plin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(Pling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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An ultrahigh energy storage efficiency and recoverable density in Bi_(0.5)Na_(0.5)TiO_(3)with the modification of Sr_(0.85)La_(0.1)TiO_(3)via viscous polymer process

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Journal of Materiomics 2024年第3期10卷 566-577页

作者： Fukang Chen lishun Yang Haoran Feng Qin li Xinyu Zeng Kun Yu Chunlin Song Yan Yan li jin Dou zhang School of Materials and Energy Southwest UniversityChongqing400715China Electronic Materials Research Laboratory Key Laboratory of the Ministry of EducationSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an710049China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Currently,the development of dielectric ceramic capacitors is restricted by the contradiction between high efficiency and high recoverable ***,a novel strategy was designed to achieve a su-perior balance between ***,introducing Sr_(0.85)La_(0.1)TiO_(3)can enhance the content of the weak polar phase(P4bm)to become the main component,which can optimize the relaxor behaviour and improve ***,the electric breakdown strength was effectively enhanced by grain refinement and viscous polymer ***,a high recoverable energy density of~5.3 J/cm^(3)and an excellent efficiency of~92.2%were attained in 0.9Bi_(0.5)Na_(0.5)TiO_(3)-0.1Na_(0.8)Sr_(0.1)NbO_(3)ceramic with the addition of 0.35Sr_(0.85)La_(0.1)TiO_(3)after viscous polymer *** piezoelectric force microscope had been applied to prove the high activity of the polar nanoregions and finite element analysis was adopted to explain the reasons for the enhancing electric breakdown *** addition,this ceramic exhibits good tem-perature and frequency stability,and a fast discharging rate of 0.11 ms,making it a potential candidate for the actual application.

关键词： Lead-free ceramics Energy storage BNT Landau-free energy

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Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation

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Asian Journal of Andrology 2024年第1期26卷 25-33页

作者： Kun zhang Xiu-Hua Xu Jian Wu Ning Wang Gang li Gui-Min Hao jin-Feng Cao Hebei Key Laboratory of Infertility and Genetics Department of Reproductive MedicineSecond Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Reproductive Medicine Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Neurology The 980th Hospital of the People's Liberation Army Joint Logistics Support Force(Bethune International Peace Hospital)Shijiazhuang 050000China.

The sperm DNA fragmentation index(DFI)is a metric used to assess DNA fragmentation within *** in vitro fertilizationembryo transfer(IVF-ET),high sperm DFI can lead to a low fertilization rate,poor embryo development,early miscarriage,etc.A kinase anchoring protein(AKAP)is a scaffold protein that can bind protein kinase A(PKA)to subcellular sites of specific substrates and protects the biophosphorylation *** protein antigen 17(SPA17)can also bind to *** study intends to explore the reason for the decreased fertilization rate observed in high sperm DFI(H-DFI)patients during *** addition,the study investigates the expression of AKAP,protein kinase A regulatory subunit(PKARIl),and SPA17 between H-DFI and low sperm DFI(L-DFI)***17 at the transcriptional level is abnormal,the translational level increases in H-DFI patients,and the expression of AKAP4/PKARIl protein decreases.H,O,has been used to simulate oxidative stress damage to spermatozoa during the formation of sperm *** indicates that H,O,increases the expression of sperm SPA17 protein and suppresses AKAP4/PKARIl protein *** processes inhibit sperm capacitation and reduce acrosomal *** culture data and IVF outcomes have been *** H-DFI group has a lower fertilization ***,the results indicate that the possible causes for the decreased fertilization rate in the H-DFI patients have included loss of sperm AKAP4/PKARIl proteins,blocked sperm capacitation,and reduced occurrence of acrosome reaction.

关键词： AKAP PKA SPA17 sperm capacitation sperm DNA fragmentation index

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Nanoscale Zero-Valent Iron(nZVI)for Heavy Metal Wastewater Treatment:A Perspective

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Engineering 2024年第5期36卷 16-20页

作者： Shaolin li Lei li Weixian zhang State Key Laboratory for Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Industries such as non-ferrous metal smelting discharge billions of gallons of highly toxic heavy metal wastewater(HMW)worldwide annually,posing a severe challenge to conventional wastewater treatment plants and harming the *** is traditionally treated via chemical precipitation using lime,caustic,or sulfide,but the effluents do not meet the increasingly stringent discharge *** issue has spurred an increase in research and the development of innovative treatment technologies,among which those using nanoparticles receive particular *** such initiatives,treatment using nanoscale zero-valent iron(nZVI)is one of the best *** nZVI is already well known for its site-remediation use,this perspective highlights its application in HMW treatment with metal *** demonstrate several advantages of nZVI in this wastewater application,including its multifunctionality in sequestrating a wide array of metal(loid)s(>30 species);its capability to capture and enrich metal(loid)s at low concentrations(with a removal capacity reaching 500 mg·g^(-1)nZVI);and its operational convenience due to its unique *** these advantages are attributable to nZVI’s diminutive nanoparticle size and/or its unique iron *** also present the first engineering practice of this application,which has treated millions of cubic meters of HMW and recovered tons of valuable metals(e.g.,Cu and Au).It is concluded that nZVI is a potent reagent for treating HMW and that nZVI technology provides an eco-solution to this toxic waste.

关键词： Nanoscale zero-valent iron Wastewater Heavy metal Resource recovery

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False Negative Sample Detection for Graph Contrastive Learning

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Tsinghua Science and Technology 2024年第2期29卷 529-542页

作者： Binbin zhang li Wang College of Data Science Taiyuan University of TechnologyJinzhong 030600China

Recently,self-supervised learning has shown great potential in Graph Neural Networks (GNNs) through contrastive learning,which aims to learn discriminative features for each node without label information. The key to graph contrastive learning is data augmentation. The anchor node regards its augmented samples as positive samples,and the rest of the samples are regarded as negative samples,some of which may be positive samples. We call these mislabeled samples as “false negative” samples,which will seriously affect the final learning effect. Since such semantically similar samples are ubiquitous in the graph,the problem of false negative samples is very significant. To address this issue,the paper proposes a novel model,False negative sample Detection for Graph Contrastive Learning (FD4GCL),which uses attribute and structure-aware to detect false negative samples. Experimental results on seven datasets show that FD4GCL outperforms the state-of-the-art baselines and even exceeds several supervised methods.

关键词： graph representation learning contrastive learning false negative sample detection

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Thermally modulated photoelectronic synaptic behavior in HfS_(2)/VO_(2) heterostructure

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Rare Metals 2024年第8期43卷 3798-3809页

作者： Le Wang lin Wang Xiao-Yun Ye Xiong-Hu Xu li-Yan Shang Ya-Wei li jin-Zhong zhang liang-Qing Zhu Zhi-Gao Hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(Shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Neuromorphic computing is known for its efficient computational speed,low latency,and reduced power consumption,which is considered a pivotal technology to overcome the von Neumann *** synapses are an indispensable component of neuromorphic computational artificial neural *** guarantee effective and precise processing of optical signals,it must have a high responsivity,detectivity,and the ability to adapt to various ***,a synaptic transistor based on the HfS_(2)/VO_(2) heterojunction with a responsivity of8.6×10^(3) A·W^(-1)and a detectivity of 1.26×10^(14)Jones at405 nm laser was ***,the typical synaptic behavior was successfully simulated,including postsynaptic currents(PSCs),the transition from shortterm plasticity(STP)to long-term plasticity(LTP).When VO_(2) converts from the semiconductor state to the metal state,the HfS_(2)/VO_(2) heterojunction transforms into a Schottky heterojunction from a TypeⅡheterojunction with ***'s important,the heterojunction still exhibits excellent responsivity and detectivity,as well as stability of synaptic *** addition,the classical Pavlovian conditioning experiment is simulated under different laser intensity to study the brain's associative learning *** results demonstrate that the HfS_(2)/VO_(2) heterojunction synapse exhibits significant responsivity and detectivity and is adaptable to high-temperature environments,showing great potential for neuromorphic computational applic ations.

关键词： HfS_(2) VO_(2) Phase transition Photoelectric synapse Heterojunction

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enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model

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Journal of Genetics and Genomics 2024年第2期51卷 256-259页

作者： Ming jin Jiajia lin Yu zhang Qingquan Xiao Xiangfeng Kong Xiumei zhang Zhurui Shao Yin Wang Yuyang Yu jinjing li Wan-jin Chen Guoling li Hui Yang Ning Wang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350004China HUIDAGENE Therapeutics Co. Ltd.Shanghai 200131China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which encodes the essential protein *** genetic condition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the second or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarcolemma,which predisposes individuals to myonecrosis and activation of inflammatory signaling ***,there is currently no effective cure for DMD,and glucocorticoid steroids are commonly used in clinical settings to delay symptom development(Merlini et al.,2003).

关键词： dystrophy Duchenne

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The APETALA2–MYBL2 module represses proanthocyanidin biosynthesis by affecting formation of the MBW complex in seeds of Arabidopsis thaliana

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Plant Communications 2024年第3期5卷 141-155页

作者： Wenbo Jiang Qinggang Yin jinyue liu Xiaojia Su Xiaoyan Han Qian li jin zhang Yongzhen Pang Institute of Animal Science Chinese Academy of Agricultural SciencesBeijing 100193China Key Laboratory of Plant Resources and Beijing Botanical Garden Institute of BotanyChinese Academy of SciencesBeijing 100093China

Proanthocyanidins(PAs)are the second most abundant plant phenolic natural *** biosynthesis is regulated by the well-documented MYB/bHLH/WD40(MBW)complex,but how this complex itself is regu-lated remains ill ***,in situ hybridization and b-glucuronidase staining show that APETALA2(AP2),a well-dened regulator offlower and seed development,is strongly expressed in the seed coat endothelium,where PAs ***2 negatively regulates PA content and expression levels of key PA pathway ***2 activates MYBL2 transcription and interacts with MYBL2,a key suppressor of the PA ***2 exerts its function by directly binding to the AT-rich motifs near the promoter region of *** and biochemical analyses revealed that AP2 forms AP2–MYBL2–TT8/EGL3 com-plexes,disrupting the MBW complex and thereby repressing expression of ANR,TT12,TT19,and *** analyses revealed that AP2 functions upstream of MYBL2,TT2,and TT8 in PA *** work reveals a new role of AP2 as a key regulator of PA biosynthesis in ***,this study sheds new light on the comprehensive regulation network of PA biosynthesis as well as the dual regulatory roles of AP2 in seed development and accumulation of major secondary metabolites in Arabidopsis.

关键词： Arabidopsis complex thereby

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Use of the Attain Select Ⅱ catheter delivery system to improve left ventricular lead implantation in cardiac resynchronization therapy

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Chinese Medical Journal 2011年第8期124卷 1209-1212页

作者： ZHOU Xian-hui TANG Bao-peng li jin-xin zhang Yu zhang Jiang-hua li Yao-dong Heart Center First Affiliated Hospital Xinjiang MedicalUniversity Urumqi Xinjiang 830000 China

Background Despite technical advances in tools used to facilitate implantation of cardiac resynchronization therapy （CRT） devices, there are many hurdles related mainly to the variation in the anatomy of the coronary veins. One such difficulty is the presence of a very sharply-angulated or tortuous of the lateral or posterolateral cardiac *** Totally 44 patients, 28 males and 16 females, with congestive heart failure and intraventricular conduction delay were studied retrospectively. There were 23 patients who had left ventricular （LV） lead implantation using standard techniques and equipment. For the other 21 patients with LV lead implantation we used the Attain Select Ⅱ catheter delivery system. The patients were seen every 3-6 months for 12 months and the efficacy of the primary procedure, LV lead implantation time, procedure and fluoroscopy time and the complications associated with the two techniques were *** There were no significant differences in the age, gender, New York Heart Association （NYHA） functional class,ischemic etiology, QRS duration, left ventricular ejection fraction, left ventricular end-diastolic diameter, left ventricular end-systolic diameter and LV dyssynchrony between the two groups. The LV lead implantation time, procedure time and fluoroscopy time were significantly shorter in the group using the Attain Select Ⅱ catheter delivery system; LV lead implantation time from （51-7） minutes to （40±7） minutes （P ＜0.001）, procedure time from （143±17） minutes to （124±18）minutes （P=0.001）, and fluoroscopy time from （45±7） minutes to （35±6） minutes （P＜0.001）. A successful procedure of LV lead implantation was significantly improved from 17/23 （74%） patients using the standard techniques and equipment, to 20/21 （95.3%） patients using the Attain Select Ⅱ catheter delivery system （P=0.06）Conclusion It is feasible and safe to implant LV leads through the coronary sinus using the Attain Select Ⅱ catheter delivery system.

关键词： cardiac resynchronization therapy congestive heart failure the Attain Select Ⅱ catheter delivery system left ventricular lead implantation

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Interface Engineering of Titanium Nitride Nanotube Composites for Excellent Microwave Absorption at Elevated Temperature

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Nano-Micro Letters 2024年第9期16卷 147-160页

作者： Cuiping li Dan li Shuai zhang Long Ma Lei zhang jingwei zhang Chunhong Gong College of Chemistry and Molecular Sciences Henan UniversityKaifeng 475004People’s Republic of China National and Local Joint Engineering Research Center for Applied Technology of Hybrid Nanomaterials Henan UniversityKaifeng 475004People’s Republic of China

Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction ***,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top ***,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening *** from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated ***,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 *** study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.

关键词： TiN nanotubes Interface engineering Polarization loss Impedance matching Electromagnetic wave absorption performance

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