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Journal of Environmental Sciences 2007年第3期19卷 353-357页

作者： jin fen HU Jian-ying YANG Min State Key Lab of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China College of Environmental Science Peking University Beijing 100871 China

The vertical profiles of nonylphenol （NP） and nonylphenol ethoxylates （NPEOs） were investigated in a sediment core from the Beipaiming Channel, North China using high sensitive LC-MS and GC-MS metthods In this core, relatively high concentrations of NP and NPEOs occurred in the surface sediment （≤40 cm）, with the maximum value of NP and NPEOs reaching 3539 and 12735 mg/g, respectively, whereas, no NP or NPEOs were detected in deeper sediments （〉40 cm）. The high concentrations of NP and NPEOs in the surface layers suggested recent inputs in this area. NPEOs with short ethoxy chains （NPnEO, n=0-3） were dominant in the NPEO mixture with percentages from 54% to 78%, which were similar to the distribution of homolog NPEO in effluents from nearby sewage treatment plants （STPs）, indicating that the channel received the effluents from these STPs. The sewage treatment ratio was quite similar to that found in North America before the 1980s. Finally, the concentrations of NP and NPEOs were related to the total organic carbon （TOC）（p〈0.001）, suggesting that TOC was an important factor for vertical distribution of NPEOs and NP from the Beipaiming Channel.

关键词： nonylphenol nonylphenol ethoxylates sediment core Bohai Bay

Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study

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World Journal of Emergency Medicine 2021年第2期12卷 117-123页

作者： Wen Gao Yu-ping Zhang jing-fen jin Nursing Department School of MedicineZhejiang UniversityHangzhou 310058China Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND: Delirium in patients in intensive care units(ICUs) is an acute disturbance and fluctuation of cognition and consciousness. Though increasing age has been found to be related to ICU delirium, there is limited evidence of the effect of age on delirium outcomes. The aim of this study is to investigate the relationship between age categories and outcomes among ICU delirium ***: Data were extracted from the electronic ICU(e ICU) Collaborative Research Database with records from 3,931 patients with delirium. Patients were classified into non-aged(<65 years), youngold(65–74 years), middle-old(75–84 years), and very-old(≥85 years) groups. A Cox regression model was built to examine the role of age in death in ICU and in hospital after controlling covariates. RESULTS: The sample included 1,667(42.4%) non-aged, 891(22.7%) young-old, 848(21.6%) middle-old, and 525(13.3%) very-old patients. The ICU mortality rate was 8.3% and the hospital mortality rate was 15.4%. Compared with the non-aged group, the elderly patients(≥65 yeras) had higher mortality at ICU discharge(χ2=13.726, P=0.001) and hospital discharge(χ2=56.347, P<0.001). The Cox regression analysis showed that age was an independent risk factor for death at ICU discharge(hazard ratio [HR]=1.502, 1.675, 1.840, 95% confidence interval [CI] 1.138–1.983, 1.250–2.244, 1.260–2.687;P=0.004, 0.001, 0.002 for the young-, middle-and very-old group, respectively) as well as death at hospital discharge(HR=1.801, 2.036, 2.642, 95% CI 1.454–2.230, 1.638–2.530, 2.047–3.409;all P<0.001).CONCLUSIONS: The risks of death in the ICU and hospital increase with age among delirious patients.

关键词： Intensive care Delirium Aging Mortality

Inhibitory Effect of Isoflavones on Prostate Cancer Cells and PTEN Gene

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Biomedical and Environmental Sciences 2006年第1期19卷 35-41页

作者： fenG CAO TAI-YI jin YUAN-fen ZHOU Department of Occupational Health and Toxicology School of Public Health Fudan University Shanghai 200032 China

Objective To explore the mechanisms by which genistein and daidzein inhibit the growth of prostate cancer cells. Methods LNCaP and PC-3 cells were exposed to genistein and daldzein and cell viability was determined by MTF assay and cytotoxicity of the drugs by LDH test. Flow cytometry （FCM） was used to assess the cell cycle in LNCaP and PC-3 cells. Reverse transcription-polymerase chain reaction （RT-PCR） was applied to examine the expression of PTEN gene （a tumor suppressor gene）, estrogen receptor alpha gene （ERα）, estrogen receptor beta gene （ERβ）, androgen receptor gene （AR） and vascular endothelial growth factor gene （VEGF）. Results The viability of PC-3 and LNCaP cells decreased with increasing concentrations and exposure time of genistein and daidzein. Genistein increased G2/M phase cells in PC 3 cells while decreased S phase cells in LNCaP cells in a dose-dependent manner. Daidzein exerted no influence on the cell cycle of LNCaP and PC-3 cells, but the apoptosis percentage of LNCaP cells was elevated significantly by daidzein, Genistein induced the expression of PTEN gene in PC-3 and LNCaP cells. Daidzein induced the expression of PTEN gene in LNCaP but not in PC-3 cells. The expression of VEGF, ERα and ERβ genes decreased and AR gene was not expressed after incubation with genistein and daldzein in PC-3 cells. In LNCaP cells, the expression of VEGF and AR gene decreased but there was no change in the expression of ERα and ERβ gene after incubation with genistein and daidzein. Conclusion Genistein and daidzein exert a timeand dose-dependent inhibitory effect on PC-3 and LNCaP cells. The down-regulation of ER gene by daidzein influences the growth of PC-3 ceils directly, The inhibition of PC-3 cells by genistein and that of LNCaP cells by genistein and daidzein may be via Alct pathway that is repressed by PTEN gene, which subsequently down-regulates the expression of AR and VEGF genes. Our results suggest that the expression of PTEN gene plays a key role and s

关键词： Isoflavones Genistein Daidzein PC-3 LNCaP PTEN ERα ERβ VEGF

Metallothionein 1 Isoform Gene Expression Induced by Cadmium in Human Peripheral Blood Lymphocytes

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Biomedical and Environmental Sciences 2006年第2期19卷 104-109页

作者： XIU-LI CHANG TAI-YI jin YUAN-fen ZHOU Department of Occupational Medicine School of Public Health Fudan University Shanghai 200032 China

Objective To study the gene expression of metallothionein 1 （MT-1） isoforms in human peripheral blood lymphocytes （HPBLs）. Methods The expression of mRNA representing the seven active MT-I genes was determined in HPBLs by quantitative RT-PCR before and after exposure to cadmium. Results Basal expressions of MT-IX, and MT-1A in HPBLs were similar to expression of housekeeping gene. In contrast, the basal gene expressions of MT- 1 H, IF, 1E, and 1G were a little transcripts in human HPBLs. No signal was detected for MT-1B. There was a sex difference （P〈0.05）. in basal gene expression of MT-1E. The levels of gene expression of MT-1A, 1E, IF, 1G, 1H, and 1X increased, but the level of MT-1B did not increase after exposure to cadmium. Conclusions Gene expressions of MT-1 G, MT-1 H, MT-1 F, and MT-1X in HPBLs can be used as a potential biomarker of cadmium exposure.

关键词： Metallothionein 1 Gene Human peripheral blood lymphocytes Cadmium

Molecular Mechanisms and Genetic Basis of Heavy Metal Tolerance/ Hyperaccumulation in Plants

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Journal of Integrative Plant Biology 2005年第9期47卷 1025-1035页

作者： Xiao-EYANG Xiao-fen jin Ying fenG Ejazul ISLAM Key Laboratory of Environmental Remediation and Ecosystem Health of Ministry of Education College of Natural Resources and Environmental Sciences Zhejiang University Hangzhou 310029 China

Phytoremediation has gained increased attention as a cost-effective method for the remediation of heavy metal-contaminated sites. Because some plants possess a range of potential mechanisms that may be involved in the detoxification of heavy metals, they manage to survive under metal stresses. High tolerance to heavy metal toxicity could rely either on reduced uptake or increased plant internal sequestration, which is manifested by an interaction between a genotype and its environment. The growing application of molecular genetic technologies has led to increased understanding of mechanisms of heavy metal tolerance/accumulation in plants and, subsequently, many transgenic plants with increased heavy metal resistance, as well as increased uptake of heavy metals, have been developed for the purpose of phytoremediation. In the present review, our major objective is to concisely evaluate the progress made so far in understanding the molecular/cellular mechanisms and genetic basis that control the uptake and detoxification of metals by plants.

关键词： amino acids heat shock proteins metal-binding proteins metal transporters metallothioneins organic acids phytochelatins phytoremediation.

Insulin Expression in Rats Exposed to Cadmium

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Biomedical and Environmental Sciences 2007年第4期20卷 295-301页

作者： LI-JIAN LEI TAI-YI jin YUAN-fen ZHOU Department of Occupational Health School of Public Health Fudan University Shanghai 200032 China

To investigate the effects of cadmium exposure on insulin expression in rats. Methods Eighteen adult SD rats were administered cadmium subcutaneously （0.5, 1.0, and 2.0 mg/kg bw）. The effects on endocrine of pancreas were assessed. The levels of cadmium and zinc in pancreas, blood and urine glucose, serum insulin and urine NAG （N-acyetyl-β-glucosaminidase） were determined. The gene expressions of metallothionein （MT） and insulin were also measured, and the oral glucose tolerance tests （OGTT） were carried out. Results The contents of cadmium in pancreas in cadmium-treated rats were higher than that in the control group, which was associated with slight increase of zinc in pancreas. Cadmium-exposed rats （1.0 and 2.0 mg/kg bw） demonstrated a marked glucose intolerance. But the levels of serum insulin did not change significantly after cadmium administration, and the UNAG had no change in Cd-treated group. The gene expression of insulin decreased in 1.0 and 2.0 mg/kg bw cadmium-exposed groups, compared with the control group. The expression of MT-I was higher in the groups exposed to 1.0 and 2.0 mg/kg bw cadmium while the expression of MT-II was higher in the group exposed to 2.0 mg/kg bw cadmium. Conclusions Cadmium may be accumulated in the pancreas, resulting in the change of the expression of insulin, MT-I and MT-Ⅱ genes. Cadmium can influence the biosynthesis of insulin, but does not induce the release of insulin. The dysfunction of pancreas occurs earlier than that of kidney after administration of cadmium.

关键词： Cadmium Endocrine Insulin Metallothionein Oral glucose tolerance test

Orthogonal-triangular decomposition ghost imaging

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Chinese Physics B 2022年第8期31卷 399-404页

作者： jin-fen Liu Le Wang Sheng-Mei Zhao Institute of Signal Processing and Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China Nanjing Tech University Pujiang Institute Nanjing 211222China Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing 210003China

Ghost imaging(GI)offers great potential with respect to conventional imaging ***,there are still some obstacles for reconstructing images with high quality,especially in the case that the orthogonal measurement matrix is impossible to *** this paper,we propose a new scheme based on the orthogonal-triangular(QR)decomposition,named QR decomposition ghost imaging(QRGI)to reconstruct a better image with good *** the scheme,we can change the randomly non-orthogonal measurement matrix into orthonormal matrix by performing QR decomposition in two cases.(1)When the random measurement matrix is square,it can be firstly decomposed into an orthogonal matrix Q and an upper triangular matrix *** let the off-diagonal values of R equal to 0.0,the diagonal elements of R equal to a constant k,where k is the average of all values of the main diagonal,so the resulting measurement matrix can be obtained.(2)When the random measurement matrix is with full rank,we firstly compute its transpose,and followed with above QR ***,the image of the object can be reconstructed by correlating the new measurement matrix and corresponding bucket *** experimental and simulation results verify the feasibility of the proposed QRGI ***,the results also show that the proposed QRGI scheme could improve the imaging quality comparing to traditional GI(TGI)and differential GI(DGI).Besides,in comparison with the singular value decomposition ghost imaging(SVDGI),the imaging quality and the reconstruction time by using QRGI are similar to those by using SVDGI,while the computing time(the time consuming on the light patterns computation)is substantially shortened.

关键词： orthogonal-triangular(QR)decomposition ghost imaging correlated imaging

Consumption of soybean,soy foods,soy isoflavones and breast cancer incidence:Differences between Chinese women and women in Western countries and possible mechanisms

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Food Science and Human Wellness 2013年第3期2卷 146-161页

作者： fen-jin He jin-Qiang Chen Nature Soy Inc.PhiladelphiaPAUSA Science Writing Solutions USA Fox Chase Cancer Center PhiladelphiaPA 19111USA

Breast cancer is one of the most lethal diseases ***,there is a large difference in breast cancer incidence among Caucasian,Hispanic,African and Asian(***)women with Caucasian women being the highest and Asian women being the *** has been suggested that the dietary factors may account for approximately 50%of the breast *** of such dietary components which are typical to Asian but not Caucasian diet is soy foods.A number of epidemiological studies have suggested that increasing soy consumption could be related to the decreased risk of occurrence and/or mortality of breast *** this review,we first described briefly different types of soy products and their nutritional functions and ***,we described briefly soybean isoflavones,***(GEN),daidzein,glycitein,and presented several lines of evidence to demonstrate the possible association of soy flavone food consumption with incidence and prognosis of breast cancer;finally,we summarized several possible molecular mechanisms,including the effects of GEN as an agonist of ER,epigenetic and genome-wide effects,activation of peroxisome proliferator-activated receptors,induction of apoptosis and stimulation of autophagy,involved in the chemo-preventive effects of GEN on breast cancer.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Breast cancer incidence Genistein Soybean Soy foods Soy isoflavones

Biosensor Based on TTF@SiO_2 Nanoparticles as Electron Transfer Mediator for the Determination of Glucose

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Chemical Research in Chinese Universities 2006年第4期22卷 474-478页

作者： LI Xiao-hua XIAN Yue-zhong MIN Hong LI Chen-xin XIE Zong-hong ZHANG fen-fen jin Li-tong Department of Chemistry East China Normal University Shanghai 200062 P. R. China

Tetrathiafulvalene（TTF） was doped in an SiO2 network and the resulting nanocompesite was used as a mediator for the selective detection of glucose. The uniform TTF-doped silica（TIT@SiO2 ） nanoparticles were prepared by the water-in-oil（W/O） microemulsion method, and were characterized by transmission electron microscopy（TEM）. The core-shell structure TTF@ SiO2 could prevent TIT from leaching out into an aqueous solution. Combined with chitosan （CHIT）, which serves as a scaffold for glucose oxidase and nanocomposite immobilization, the GCE/TTF@ SiO2- CHIT-GOx biosensor was developed. Under optimal conditions, the biosensors exhibit a linear range of 1.0 × 10^-5 5 × 10^-3 mol/L with a detection limit down to 5.0 μmol/L（S/N = 3 ）. The excellent selectivity, sensitivity, and stability of the glucose biosensor show its potential for practical applications.

关键词： TTF@ SiO2 nanoparticle Chitosan Glucose Biosensor

Quality Prediction of Strip Steel Based on Windows-Mean MPLS

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Journal of Iron and Steel Research International 2010年第7期17卷 28-33页

作者： CHANG Yu-qing WANG jin-fen TAN Shuai WANG Fu-li CHEN Wei-dong School of Information Science and Engineering Northeastern University Shenyang 110819 Liaoning China Baosteel Industry Inspection Co Shanghai 201900 China

A windows-mean multi-way partial-least squares（MPLS）method was proposed to build the strip steel quality prediction model for continuous annealing *** proposed method can deal with the problem of large time lag in hardness measurement of the strip steel and the difficulties in building mechanism *** on the average trajectories of the process variable information,the proposed method was used to realize the strip steel quality *** with the traditional MPLS,the proposed method can eliminate the abundant and redundant process information and reduce the number of the model input ***,it can avoid the uneven-length modeling data problem of the traditional MPLS *** simulation result demonstrates the performance and advantages of the proposed method for predicting the strip steel hardness.

关键词： continuous annealing strip steel hardness quality prediction windows-mean MPLS