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Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-Jun Zhang Zi-bing jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

r-Matrix Structure for a Restricted Flow with Bargmann Constraint

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Communications in Theoretical Physics 2005年第3X期44卷 393-395页

作者： CHEN jin-bing GENG Xian-Guo Department of Mathematics Zhengzhou University Zhengzhou 450052 China

This paper deals with the integrability of a finite-dimensional Hamiltonian system linked with the generalized coupled KdV hierarchy. For this purpose the associated Lax representation is presented after an elementary calculation. It is shown that the Lax representation enjoys a dynamical r-matrix formula instead of a classical one in the Poisson bracket on R2N. Consequently the resulting system is proved to be completely integrable in view of its r-matrix structure.

关键词： Poisson bracket Lax representation r-matrix Liouville integrability

A rational consideration of the genomic instability of human-induced pluripotent stem cells for clinical applications

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Science China(Life Sciences) 2023年第9期66卷 2198-2200页

作者： Hang Zhang Zi-bing jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730 China

Induced pluripotent stem cells (i PSCs) have gained popularity in regenerative medicine because of their ability to replicate and differentiate into multiple cell types, which has provided researchers with a powerful tool for modeling diseases and exploring treatments for human disorders. As i PSCs are obtained from the patient’s cells and possess the same potential as embryonic stem cells (ESCs).

关键词： pluripotent diseases rational

CARRIER PHOTOGENERATION IN POLY(N-VINYL-CARBAZOLE)-BASED PHOTOCONDUCTIVE THIN-FILM DEVICES

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Chinese Journal of Polymer Science 2006年第6期24卷 553-558页

作者： Hui jin Yan-bing Hou Xian-guo Meng Feng Teng Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronie Teehnology Beijing Jiaotong University Beijing 100044 China

In this paper, photoexcitation processes in the bilayer devices based on inorganic materials and poly（N-vinylcarbazole）（PVK） were investigated. In order to clarify the roles of inorganic materials in photoconductive properties of bilayer devices, TiO2 and ZnS were chosen to combine with PVK. A model for generation of photocurrent （Iph） in single layer device of PVK was obtained. It is deduced that the recombination rate constant （Pcomb） and the ionization rate constant （y） ofexcitons should be considered as the most important factors for Iph. For inorganic materials （TiO2 or ZnS）/PVK bilayer devices, in reverse bias of-4 V, the photocurrent of 115 mA/cm^2 in the TiO2/PVK device was observed, but the photocurrent in the ZnS/PVK device was only 10 mA/cma under the illumination light of 340 nm and the light intensity of 14.2 mW/cm^2. The weaker photocurrent is attributed to the absorption of ZnS within UV region and the energy offset at the interface between PVK and ZnS, which impedes the transport of charge carriers.

关键词： Polymer Inorganic semiconductor Photoconductive Photogeneration.

Theoretical Studies on the Hydrogen Bond Transfer and Proton Transfer between Anamorphoses of the Dihydrated Glycine Complex

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Chinese Journal of Structural Chemistry 2007年第5期26卷 580-586页

作者： WANG Ke-Cheng MENG Xiang-Jun SHI jin LI bing-Huan Department of Chemistry Tangshan Teacher＇s College Tangshan 063000 China

The conversion between anamorphoses of the dihydrated glycine complex was studied by means of B3LYP/6-31＋＋G^＊＊. It was found that proton transfer was accompanied by hydrogen bond transfer in the process of conversion between different kinds of anamorphoses. With proton transfer, the electrostatic action was notably increased and the hydrogen-bonding action was evidently strengthened when the dihydrated neutral glycine complex converts into dihydrated zwitterionic glycine complex. The activation energy required for hydrogen bond transfer between dihydrated neutral glycine complexes is very low （6.32 kJ·mol^-1）; however, the hydrogen bond transfer between dihydrated zwitterionic glycine complexes is rather difficult with the required activation energy of 13.52 kJ·mol^-1 due to the relatively strong electrostatic action. The activation energy required by proton transfer is at least 27.33 kJ·mol^-1, higher than that needed for hydrogen bond transfer. The activation energy for either hydrogen bond transfer or proton transfer is in the bond-energy scope of medium-strong hydrogen bond, so the four kinds of anamorphoses of the dihydrated glycine complex could convert mutually.

关键词： intermolecular interaction B3LYP glycine,hydrogen bond transfer proton transfer

Reductions to Korteweg-de Vries Soliton Hierarchy

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Communications in Theoretical Physics 2006年第2期45卷 231-235页

作者： CHEN jin-bing TAN Rui-Mei GENG Xian-Guo Department of Mathematics Southeast University Nanjing 210096 China Department of Mathematics Zhengzhou University Zhengzhou 450052 China Department of Information and Computational Science Zhengzhou University of Light industry Zhengzhou 450002China

Based on the nonlinearization of Lax pairs, the Korteweg-de Vries （KdV） soliton hierarchy is decomposed into a family of finite-dimensional Hamiltonian systems, whose Liouville integrability is proved by means of the elliptic coordinates. By applying the Abel-Jacobi coordinates on a Riemann surface of hyperelliptic curve, the resulting Hamiltonian flows as well as the KdV soliton hierarchy are ultimately reduced into linear superpositions, expressed by the Abel-Jacobi variables.

关键词： KdV soliton hierarchy Hamiltonian systems Riemann surface Abel-Jacobi coordinates

Boosting polyketides production in cell factories Shared target-pathway for pharmaceutical polyketides engineering

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Synthetic and Systems Biotechnology 2020年第1期5卷 35-36页

作者： Wen-bing jin Chun-Jun Guo Jill Roberts Institute for Research in Inflammatory Bowel Disease Dept of MedicineWeill Cornell MedicineNew YorkNY10021USA

Polyketides(PKSs)are secondary metabolites produced by microorganisms with important pharmaceutical applications[1].However,the production yield of these bioactive metabolites is often low in native hosts,largely because their biosynthetic gene clusters(BGCs)are mostly silent,or their starting substrates *** improve the production yield of PKSs,multiple strategies have been developed,including metabolic engineering the native hosts or heterologously overexpressing their BGCs in a different host[2,3].

关键词： starting mostly expressing

Composition of Ophiopogon Polysaccharide,Notoginseng Total Saponins and Rhizoma Coptid is Alkaloids Inhibits Myocardial Apoptosis in Diabetic Atherosclerosis Rabbits

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Chinese Journal of Integrative Medicine 2020年第5期26卷 353-360页

作者： jin Zhao-hui GAO Pu LIU Zheng-tang jin bing SONG Guang-yi XIANG Tian-yuan Geriatric Research Center Xiyuan HospitalChina Academy of Chinese Medicine SciencesBeijing(100091)China Liaoning Basic Medical Research Institute Shenyang(110005)China

Objective: To investigate the effects of Composition of Ophiopogon polysaccharide, Notoginseng total saponins and Rhizoma Coptidis alkaloids(CONR) on myocardial apoptosis of diabetic atherosclerosis(DA) rabbits Methods: Sixty male New Zealand white rabbits were randomly divided into 6 groups [control group, model group, CONR high-dose group(450 mg/kg), CONR medium-dose group(150 mg/kg), CONR low-dose group(50 mg/kg), and simvastatin group] by using a completely random method, 10 in each group. DA model was established by intravenously injected alloxan combined with high-fat diet and abdominal aortic balloon injury. After mediation for 10 weeks, fasting blood glucose(FBG), glycosylated hemoglobin(GHB), glycosylated serum protein(GSP), fructoseamine(FRA), aldose reductase(AR), advanced glycation end products(AGEs) in serum were measured by enzyme linked immunosorbent assay(ELISA) method;the expression of receptor of AGEs(RAGE) in myocardial tissue were observed by immunohistochemical method;and p-Jun N-terminal kinase(p-JNK), caspase-3, B-cell lymphoma-2(bcl-2) protein expression in myocardial tissue were measured by Western blotting. The myocardial apoptosis was detected by Td T-mediated d UTPnick-end labeling(TUNEL) method, and apoptosis index(AI) was calculated. Results: Compared with the control group, serum FBG, GHB, GSP, FRA, AR, AGEs and the expression of myocardium RAGE, p-JNK, caspase-3 proteins, as well as apoptosis index(AI) were significantly increased and bcl-2 protein was significantly decreased in the model group(P<0.01). Compared with the model group, the levels of serum FBG, GHB, GSP, FRA and AR showed a significant decline in CONR high-and medium-dose groups(P<0.01). FBG and GHB showed a significant decline in CONR low-dose group(P<0.01). Compared with the model group, the expression of serum AGEs and myocardium RAGE, p-JNK and caspase-3 protein as well as AI were significantly decreased and bcl-2 protein was significantly up-regulated in all treatme

关键词： ophiopogon polysaccharide notoginseng total saponins Rhizoma Coptidis alkaloids advanced glycation end products p-C-N-Jun teminal kinase diabetic atherosclerosis myocardial apoptosis

Functional microglia derived from human pluripotent stem cells empower retinal organs

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Science China(Life Sciences) 2022年第6期65卷 1057-1071页

作者： Mei-Ling Gao Xiao Zhang Fang Han Jia Xu Si-Jian Yu Kangxin jin Zi-bing jin Institute of Stem Cell Research The Eye HospitalWenzhou Medical UniversityWenzhou 325027China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China

Microglia are known to play essential roles in the development,progression and treatment of diverse neurodegenerative diseases in the central nervous system,including the retina,brain and spinal ***,brain-induced microglia-like cells(iMGs)have been generated from human pluripotent stem cells(hPSCs);however,retinal microglia have yet to be developed in *** this study,by mimicking in vivo microglial development,we established a simplified approach to differentiate hPSCs into high purity(>90%)*** iMGs express microglia-specific markers,release cytokines upon stimulation,and are capable of phagocytizing *** co-cultured with three-dimensional human retinal organoids(hROs),iMGs migrated into the hROs,tended to differentiate into resident retinal microglia,and simultaneously induced apoptosis in some neural ***,the resident i MGs in the hROs formed sparse web-like structures beneath the photoreceptor cell layer,resembling microglia's orientation in human *** conclusion,we developed a simplified and efficient method to generate microglia from human pluripotent stem cells,and we report the first derivation of retinaresident microglia in vitro,providing a new source of human retinal microglia for developmental and disease studies and regenerative therapeutics.

关键词： microglia retinal organoid pluripotent stem cells differentiation human induced reprogramming

Synthesis of Nitrogen Incorporated Carbon Nanotubes with Different Diameters by Catalytic Pyrolysis of Butylamine

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Chemical Research in Chinese Universities 2011年第6期27卷 903-905页

作者： jin Hai-ying bing Nai-ci WANG Ling-ling WANG Li-jun School of Urban Development and Environment Engineering Shanghai Second Polytechnic University Shanghai 201209 P. R. China

Bamboo-like nitrogen-doped carbon（CNx） nanotubes were synthesized by chemical vapor deposition （CVD） at a high reaction temperature of 600―900 °C. The butylamine and Fe/SBA-15 molecular sieve have been used as precursor and catalyst, respectively. Transmission electron microscopy（TEM） and high resolution transmission electron microscopy（HRTEM） observations show that the outer diameter and wall thickness as well as the inner diameter were increased with increasing reaction temperature in a temperature range of 600―800 °C. A synergism mechanism of the growth through bulk diffusion and the competitive growth through surface diffusion functions during the synthesis of CNx nanotubes was proposed.

关键词： Carbon nanotube Bamboo-like structure Nitrogen-doped carbon Multilayer structure