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Productivity Gap and Inward FDI Spillovers: Theory and Evidence from China

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China & world Economy 2021年第2期29卷 24-48页

作者： jim Huangnan Shen Hao wang Steve Chu-Chia Lin School of Management Fudan UniversityChina Center for International Development Harvard Kennedy SchoolUS School of Economics and Trade Guangdong University of Foreign StudiesChina School of Slavonic and East European Studies University College LondonUK Department of Economics National Chengchi UniversityTaiwanChina

This paper constructs a two-stage sequential game model to shed light on the spillover effect of inward FDI on the efficiency of domestic firms in host *** model shows that,given an optimal joint-venture policy made by foreign firms,the impact of the spillover effect of inward FDI is contingent upon the productivity gap between the domestic firms and foreign *** particular,we demonstrate that the spillover effect of inward FDI varies negatively with the productivity gap between domestic lowproductivity firms and foreign firms but works in the opposite way for high-productivity *** suggests that once the productivity gap widens,the entry of foreign firms will increase the efficiency of high-productivity firms but reduce the efficiency of lowproductivity *** support of our theoretical model,we provide robust empirical results by using the dataset of annual survey of Chinese industrial enterprises.

关键词： efficiency improvement inward FDI productivity gap spillover effect

Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1

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Cell Research 2005年第6期15卷 423-429页

作者： Deanna YANIw,jim HU Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development 24] Canada M5S 1A 8] Canada M5S 1A Hospital for Sick Children Toronto Canada M5G 1X8 Institute of Medical Science University of Toronto Toronto Programme in Lung Biology Research and the Canadian Institutes of Health Research Group in Lung Development Hospital for Sick Children Toronto Canada M5G 1X8 Institute of Medical Science University of Toronto Toronto Canada M5S 1A1 Departments of Paediatrics University of Toronto Toronto Canada M5S 1A1 Laboratory Medicine and Pathbiology University of Toronto Toronto

The role of Ese-2, an Ets family transcription factor, in gene regulation is not known. In this study, the interactionbetween Ese-2 and cytokeratin 18 (K18) intron 1 was characterized in lung epithelial cells. Reporter gene assays showedEse-2 was able to upregulate K18 intron 1 enhanced reporter gene expression by approximately 2-fold. we found thatfull length Ese-2 did not bind DNA strongly, therefore truncated versions of the protein, containing the ETS domain orPointed domain, were created and tested in electrophoresis mobility shift assays. Multiple interactions between the ETSdomain and putative DNA binding sites within K18 intron 1 were observed, which led to the determination of a possibleEse-2 DNA binding consensus sequence. These experiments suggest that Ese-2 could play a role in the regulation ofK18 expression in lung epithelial cells.

关键词： transcription factor epithelial cells cytokeratin 18 airway gene regulation.

小鼠SKA1蛋白的多克隆抗体制备、鉴定与初步应用

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细胞与分子免疫学杂志 2009年第3期25卷 239-241页

作者：姜飞刘小林李喜莲 jim w Xuan 西北农林科技大学动物科技学院陕西杨凌712100 加拿大西安大略大学生理与药学系安大略加拿大N6A5C1

目的:制备兔抗鼠SKA1(Spindle and Kinetochore Associated1)多克隆抗体。方法:利用PCR的方法得到小鼠SKA1基因并克隆至pGEX-2T原核表达载体中,转化入大肠杆菌BL21表达,经IPTG诱导表达GST-SKA1融合蛋白,经亲和层析纯化浓缩后免疫新西兰... 详细信息

目的:制备兔抗鼠SKA1(Spindle and Kinetochore Associated1)多克隆抗体。方法:利用PCR的方法得到小鼠SKA1基因并克隆至pGEX-2T原核表达载体中,转化入大肠杆菌BL21表达,经IPTG诱导表达GST-SKA1融合蛋白,经亲和层析纯化浓缩后免疫新西兰大耳白兔制备多克隆抗体,通过ELISA测定抗鼠SKA1多克隆抗体效价,用western blot测定其特异性。结果:构建了pGEX-2T-SKA1原核表达重组质粒,并诱导表达出GST-SKA1融合蛋白,免疫新西兰大耳白兔5周后获得多克隆抗体。ELISA测定表明SKA1多克隆抗体效价为1∶25600,western blot分析表明SKA1多克隆抗体具有良好的特异性。通过免疫组织化学方法发现,SKA1表达于高分化前列腺癌细胞中。结论:成功地制备了效价及特异性良好的兔抗鼠SKA1多克隆抗体,为SKA1基因功能的研究奠定基础。

关键词： SKA1基因纺锤体检测点多克隆抗体肿瘤小鼠

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Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors

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Cell Research 2006年第3期16卷 241-259页

作者： Terence Moyana jim Xiang Department of Pathology and Laboratory Medicine University of OttawaOttawaOntario K1H 8L6Canada Research Unit Health Research DivisionSaskatchewan Cancer AgencyDepartments of Oncology.Microbiology and Immunology.University of Saskatchewan20 Campus DriveSaskatoonSaskatchewan STN 4H4Canada

Recent developments in tumor immunology and biotechnology have made cancer gene therapy and *** current efforts for cancer gene therapy mainly focus on using immunogenes,chemogenes and tumor sup-pressor *** to all these therapies is the development of efficient vectors for gene *** far,adenovirus(AdV)-mediated gene therapy is one of the most promising approaches,as has confirmed by studies relating to animaltumor models and clinical *** cells (DCs) are highly efficient,specialized antigen-presenting cells,and DC-based tumor vaccines are regarded as having much potential in cancer *** with DCs pulsedwith tumor peptides,Iysates,or RNA,or loaded with apoptotic/necrotic tumor cells,or engineered to express certaincytokines or chemokines could induce significant antitumor cytotoxic T lymphocyte (CTL) responses and *** both AdV-mediated gene therapy and DC vaccine can both stimulate antitumor immune responses,their therapeutic efficiency has been limited to generation of prophylactic antitumor immunity against re-challenge withthe parental tumor cells or to growth inhibition of small ***,this approach has been unsuccessful in com-bating welt-established tumors in animal ***,a major strategic goal of current cancer immunotherapy hasbecome the development of novel therapeutic strategies that can combat welt-established tumors,thus resembling realclinical practice since a good proportion of cancer patients generally present with significant *** this paper,wereview the recent progress in AdV-mediated cancer gene therapy and DC-based cancer vaccines,and discuss combinedimmunotherapy including gene therapy and DC *** underscore the fact that combined therapy may have someadvantages in combating well-established tumors vis-a-vis either modality administered as a monotherapy.

关键词： gene therapy adenovirus dendritic cells vaccine cytotoxic T lymphocytes antitumor immunity

Evaluation of Terra/MODIS atmospheric profiles product(MOD07)over the Iberian Peninsula:a comparison with radiosonde stations

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International Journal of Digital Earth 2015年第10期8卷 771-783页

作者： JoséA.Sobrino Juan C.jiménez-Muñoz Cristian Mattar Guillem Sòria Global Change Unit–Image Processing Laboratory University of ValenciaValenciaSpain Laboratory for Analysis of the Biosphere Universidad de ChileSantiagoChile

Remote sensing techniques are a useful tool for continuous observation of the Earth at global ***,products derived from remote sensing data require a rigorous validation using in situ *** Resolution Imaging Spectroradiometer(MODIS)is not really a sounding instrument,but it does have 16 infrared bands(bands 20-36 covering the spectral range from 3μm to 14μm)that allow the retrieval of temperature and moisture profiles as well as total column integrated *** this paper we show the results obtained in the evaluation of MOD07 daytime and nighttime products over the Iberian Peninsula during the decade from 2000 to 2010 using nine radiosonde *** MODIS limitations in comparison with other sounding instruments,the validation provided satisfactory results,with bias(MOD07 minus radiosonde)water vapor,and bias around 1 K on average with standard deviations between 2 K and 3 K for air temperature at different pressure *** average,bias was positive and below 2 K with standard deviations around 5 K for the dew point temperature *** errors were found in this case for pressure levels higher than 50 hPa.

关键词： MODIS MOD07 atmospheric profiles water vapor air temperature dew point temperature

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视频传输差错掩盖技术研究现状与发展趋势

西南交通大学学报 2009年第4期44卷 473-483页

作者：彭强张蕾 Chen jim X. 西南交通大学信息科学与技术学院四川成都610031 乔治梅森大学计算机科学系

讨论了视频差错掩盖研究的发展过程和现状.介绍了常见的空域和时域差错掩盖算法,特别是基于边缘检测的空域自适应差错掩盖算法、基于运动向量外插的时域差错掩盖算法、多步多权值块变形差错掩盖算法以及基于失真度估计的SVC质量分级自... 详细信息

讨论了视频差错掩盖研究的发展过程和现状.介绍了常见的空域和时域差错掩盖算法,特别是基于边缘检测的空域自适应差错掩盖算法、基于运动向量外插的时域差错掩盖算法、多步多权值块变形差错掩盖算法以及基于失真度估计的SVC质量分级自适应差错掩盖算法.分析了这些算法在不同有损传输环境下的差错掩盖性能和适用环境.预测了差错掩盖技术可能的发展趋势.

关键词：视频编码视频传输差错控制差错掩盖

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Every man a hero

Every man a hero

Natural compounds and extracts from Mexican medicinal plants with anti-leishmaniasis activity: An update

作者： Ray Lambert and jim DeFelice.

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1105-1110页

作者： Gabriel Alfonso Gutiérrez-Rebolledo Susan Drier-Jonas María Adelina jiménez-Arellanes Unidad de Investigación Médica en Farmacología Hospital de EspecialidadesCentro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialAv. Cuauhtémoc 330Col. DoctoresDelg. Cuauhtémoc06720 Ciudad de MéxicoMexico

Leishmaniasis is considered as an emerging, uncontrolled disease and is endemic in 98 countries. Annually, about 2 million cases of cutaneous and 500000 cases of visceraltype leishmaniasis are recorded and 60000 persons died from the disease. In Mexico,cutaneous leishmaniasis is known as chiclero's ulcer and is reported in 22 states, it is considered as a health problem. For its treatment, pentavalent antimonial drugs are administered. These drugs cause severe side effects, are costly. Drug-resistant cases have been reported and have been developing for over 70 years. One alternative to the drugs that are currently available is to find active molecules in medicinal plants. Dihydrocorynantheine, corynantheine and corynantheidine are active against Leishmania major,while harmane, pleiocarpin, buchtienin, luteolin and quercetin are active against Leishmania donovani. In Mexico, about 20 medicinal plants have been evaluated against Leishmania mexicana, among which the most active are Tridax procumbens, Lonchocarpus xuul and Pentalinon andrieuxii. From these plants, active compounds with IC_(50)≤30 mg/mL or m M have been isolated, such as 3(S)-16,17-didehydrofalcarinol or Oxylipin, cholestra-4,20,24-trien-3-one or pentalinosterol, 24-methylcholest-4-24(28)-dien-3-one, cholest-4-en-3-one, 6,7-dihydroneridie-none, neridienone, cholest-5,20,24-trien-3β-ol, and isocordoin. Today, only pentalinonsterol has been synthesized and assayed in the visceral leishmaniasis experimental model using BALB/c mice infected with Leishmania donovani. Liposome formulation of this compound administered by intravenous route at 2.5 mg/kg showed a significant reduction of parasite load in mouse liver and spleen.

关键词： Active extracts Leishmaniasis Antileishmanicidal activity Natural compounds Mexican medicinal plants

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American spirit

American spirit