Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors

作     者：Terence Moyana Jim Xiang 

作者机构：Department of Pathology and Laboratory MedicineUniversity of OttawaOttawaOntario K1H 8L6Canada Research UnitHealth Research DivisionSaskatchewan Cancer AgencyDepartments of Oncology.Microbiology and Immunology.University of Saskatchewan20 Campus DriveSaskatoonSaskatchewan STN 4H4Canada 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2006年第16卷第3期

页      面：241-259页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

主　　题：gene therapy adenovirus dendritic cells vaccine cytotoxic T lymphocytes antitumor immunity 

摘      要：Recent developments in tumor immunology and biotechnology have made cancer gene therapy and *** current efforts for cancer gene therapy mainly focus on using immunogenes,chemogenes and tumor sup-pressor *** to all these therapies is the development of efficient vectors for gene *** far,adenovirus(AdV)-mediated gene therapy is one of the most promising approaches,as has confirmed by studies relating to animaltumor models and clinical *** cells (DCs) are highly efficient,specialized antigen-presenting cells,and DC-based tumor vaccines are regarded as having much potential in cancer *** with DCs pulsedwith tumor peptides,Iysates,or RNA,or loaded with apoptotic/necrotic tumor cells,or engineered to express certaincytokines or chemokines could induce significant antitumor cytotoxic T lymphocyte (CTL) responses and *** both AdV-mediated gene therapy and DC vaccine can both stimulate antitumor immune responses,their therapeutic efficiency has been limited to generation of prophylactic antitumor immunity against re-challenge withthe parental tumor cells or to growth inhibition of small ***,this approach has been unsuccessful in com-bating welt-established tumors in animal ***,a major strategic goal of current cancer immunotherapy hasbecome the development of novel therapeutic strategies that can combat welt-established tumors,thus resembling realclinical practice since a good proportion of cancer patients generally present with significant *** this paper,wereview the recent progress in AdV-mediated cancer gene therapy and DC-based cancer vaccines,and discuss combinedimmunotherapy including gene therapy and DC *** underscore the fact that combined therapy may have someadvantages in combating well-established tumors vis-a-vis either modality administered as a monotherapy.