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Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2022年第10期19卷 1073-1076页

作者： Junqiong huang Scot Leary jim Xiang Cancer Research Cluster Saskatchewan Cancer AgencySaskatoonSKCanada Department of Oncology College of MedicineUniversity of SaskatchewanSaskatoonSKCanada Department of Blood Transfusion Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhouChina Department of Biochemistry Microbiology and ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada

CD8^(+)effector T(T_(E))cells play a critical role in immunity against *** response to a pathogenic stimulus,antigenpresenting cells(APCs)deliver three signals[via T-cell receptor(TCR),costimulation,and cytokines]to naive CD8^(+)T cells,stimulating their entry into a developmental program characterized by T-cell expansion followed by a contraction *** the contraction phase,90-95%of IL-7R^(-)CD62L^(-)KLRG1^(+)T_(E)cells undergo cell apoptosis.

关键词： FOXO1 immunity stimulation

Author Correction:Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKa1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2023年第3期20卷 311-312页

作者： Junqiong huang Scot Leary jim Xiang Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Canada (GRID:grid.419525.e) (ISNI:0000 0001 0690 1414) University of Saskatchewan Department of Oncology College of Medicine Saskatoon Canada (GRID:grid.25152.31) (ISNI:0000 0001 2154 235X) Affiliated Hospital of Zunyi Medical University Department of Blood Transfusion Zunyi China (GRID:grid.413390.c) (ISNI:0000 0004 1757 6938) University of Saskatchewan Department of Biochemistry Microbiology and Immunology College of Medicine Saskatoon Canada (GRID:grid.25152.31) (ISNI:0000 0001 2154 235X) Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Canada (GRID:grid.419525.e) (ISNI:0000 0001 0690 1414) University of Saskatchewan Department of Oncology College of Medicine Saskatoon Canada (GRID:grid.25152.31) (ISNI:0000 0001 2154 235X)

In the version of this article initially published,unintended typographical errors in the original version of Fig.1B were made during manuscript *** revised Fig.1,including the correct Fig.1B,isshown below.

关键词： FOXO1 mTORC1 initially

Understanding China's Economic Growth from a Regional Policy Perspective

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China & World Economy 2023年第3期31卷 1-26页

作者： Jiashun huang jim huangnan Shen Zhiyan Sun School of Public Affairs and Institute of Intellectual Property University of Science and Technology of China Department of Applied Economics School of ManagementFudan UniversityChina Department of Development Strategy and Regional Economy Development Research Center of the State CouncilChina

There has been ongoing interest in China's economic *** were the drivers of China's economic growth in past years?What policies were used to promote China's economic growth?Although different lenses may be used to understand and explain China's economic growth,this paper draws on historical,theoretical,and empirical perspectives to discuss the nexus between China's regional policies and economic ***,we review the evolution of China's regional policy and the policy's changing emphasis in different development stages,from balanced,unbalanced,and coordinated development to synergistic *** we construct a theoretical model to illustrate the impact of regional policy on the local economy and conduct an empirical examination with a case study of regional policy using regression discontinuity *** paper analyzes the concept of regional policy and the underpinning logic of economic growth and presents practical approaches to formulate a better regional policyframework.

关键词： economic growth spatial distribution regional governance regional polic

Diagnosis of clinical and subclinical varicocele： how has it evolved？

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Asian Journal of Andrology 2016年第2期18卷 182-185,J0002,J0003页

作者： Ruth E Belay Gene Omar huang jim Ken-Chie Shen Edmund yuey Kun Ko Department of Urology Loma Linda University School of Medicine Loma Linda California USA.

In this review, we examine the evolution and application of various diagnostic modalities for varicoceles starting with venography, scintigraphy, and thermography and their role in the evaluation of a varicocele patient. Some of these methods have been supplanted by less invasive and more easily performed diagnostic modalities, especially ultrasound and Doppler examination of the scrotum. Advances in ultrasound and magnetic resonance imaging hold the potential to expand the role of imaging beyond that of visual confirmation and characterization of varicoceles. The ability to identify the early indicators of testicular dysfunction based on imaging findings may have implications for the management of varicoceles in the future.

关键词： scrotum testis varicocele

Controversies in varicocele repair - much ado about nothing？

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Asian Journal of Andrology 2016年第2期18卷 317-318页

作者： jim Ken-Chie Shen Gene Omar huang Edmund yuey Kun Ko Department of Urology Loma Linda University School of Medicine Loma LindaCalifornia USA.

Varicoceles have long been implicated in the pathogenesis of male factor infertility and recently, hypogonadism. Despite this, over the past half-century there has been widespread debate and disagreement among clinicians regarding the benefit of varicocele repair. In this commentary, we discuss recent data that has begun supporting the role ofvaricocele repair in treating male infertility and hypogonadism.

关键词： MALE-INFERTILITy MALE SUBFERTILITy

Evolving role of biomaterials in diagnostic and therapeutic radiation oncology

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Bioactive Materials 2020年第2期5卷 233-240页

作者： Siyu Shi Ravi Vissapragada Joseph Abi Jaoude Caroline huang Anmol Mittal Elisa Liu jim Zhong Vivek Kumar Department of Medicine Stanford School of MedicineStanfordCA94305USA College of Medicine and Public Health Flinders UniversityAdelaideSouth AustraliaAustralia Faculty of Medicine American University of BeirutBeirutLebanon Department of Medicine Rutgers New Jersey Medical SchoolNewarkNJ07102USA Department of Radiation Oncology Emory UniversityAtlantaGA30332USA Department of Restorative Dentistry Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemical and Materials Engineering New Jersey Institute of Technology07102USA Department of Biomedical Engineering New Jersey Institute of Technology07102USA

Radiation therapy to treat cancer has evolved significantly since the discovery of ***,radiation therapy still has room for improvement in reducing side effects and improving control of *** and more effective delivery of radiation has led us to novel techniques and use of *** in combination with radiation and chemotherapy have started to appear in pre-clinical explorations and clinical applications,with many more on the *** have revolutionized the field of diagnostic imaging,and now are being cultivated into the field of theranostics,combination therapy,and tissue *** review summarizes recent development of biomaterials in radiation therapy in several application areas.

关键词： Biomaterials Theranostics Nanoparticles Radiation therapy Self-assembly

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负极预嵌锂对锂离子电容器性能的影响

同济大学学报（自然科学版） 2017年第11期45卷 1701-1706页

作者：郑俊生章磊黄军 ZHENG jim P 同济大学新能源汽车工程中心上海201804 同济大学汽车学院上海201804 佛罗里达州立大学工学院塔拉哈希32310

采用SLMP(stabilized lithium metal powder)研究预嵌锂过程对锂离子电容器性能的影响.通过高倍率光学显微镜研究加入电解液后预嵌锂负极的变化;通过对比不同嵌锂含量对半电池与全电池性能的影响,分析得出含量对锂离子超级电容器的容量... 详细信息

采用SLMP(stabilized lithium metal powder)研究预嵌锂过程对锂离子电容器性能的影响.通过高倍率光学显微镜研究加入电解液后预嵌锂负极的变化;通过对比不同嵌锂含量对半电池与全电池性能的影响,分析得出含量对锂离子超级电容器的容量、能量密度和功率密度的影响,发现超稳态锂粉的质量分数在14%左右时,锂离子电容器可以获得较好的性能.

关键词：锂离子超级电容器预嵌锂能量密度

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Radial Variation in Sap Flux Density as a Function of Sapwood Thickness in Two Eucalyptus ( Eucalyptus urophylla ) Plantations

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Acta Botanica Sinica 2002年第12期44卷 1418-1424页

作者：周国逸黄志宏 jim MORRIS 李志安 John COLLOPy 张宁南白嘉雨中国科学院华南植物研究所广州510650 Centre for Forest Tree Technology Victoria3084Australia 中国林业科学院热带林业研究所广州510520

Radial variation in sap flux density (SFD) as a function of sapwood thickness is of importance in accurately estimating sap flux through sapwood area which, in turn, decides the precision of heat pulse application. However, until now, only a few studies have evaluated the magnitude and significance of sampling errors associated with radial gradients in SFD, which were based on the small monitoring measurement data from a few trees. Based on one year of heat pulse observation of two 3 - 4 years old Eucalyptus urophylla S. T.,P Blake plantations in Leizhou Peninsula, Guangdong Province, China, a way of data processing was developed to treat with the lots of SFD data measured from 39 trees. It was found that the radial variation in SFD as a function of sapwood thickness in the two eucalyptus plantation sites could be expressed as y = 3. 667 5x(3) - 7.295 5x(2) + 3.682 6x + 0. 567 4 (R-2 = 0. 939 1, n = 80, P = 0.01), where y is the ratio of SFD of a sensor to the average of four data in different depths, x is the ratio of a sensor depth to tire radial sapwood thickness. It was the same (as in the following equation) in Jijia site, y = 5.006 2x(3) - 9.116 1x(2) + 4. 454 4x + 0.463 4 (R-2 = 0. 806 9, n = 72, P = 0.01) in Hetou site. From cambium to heartwood, SFD showed some increases at first and then decreases continuously. However, because die trees were very young, the maximum SFD was only 0. 33 - 0. 36 times more than the minimum.

关键词： radial variation sap flux density sapwood thickness eucalyptus trees

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Gelatin encapsulation of chloropicrin and 1,3-dichloropropene as fumigants for soilborne diseases in the greenhouse cultivation of cucumber and tomato

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Journal of Integrative Agriculture 2017年第8期16卷 1758-1766页

作者： yAN Dong-dong WANG Qiu-xia LI yuan OUyANG Can-bin GUO Mei-xia jim Xinpei huang John Busacca Jong Neng Shieh Alisa ye yu Phil Howard Don Williams CAO Ao-cheng Key Laboratory of Integrated Pest Management in Crops Ministry of Agriculture/Institute of Plant Protection Chinese Academy of Agricultural Sciences Dow Agro Sciences R&D

Combined use of chloropicrin （Pic） and 1,3-dicloropropene （1,3-D） is as effective as methyl bromide （MB） at controlling soilborne diseases in many trials and commercial uses. However, Pic and 1,3-D are both highly volatile and may pose strong exposure risks to humans and the environment. A gelatin capsule formulation containing Pic and 1,3-D has been developed to reduce exposure risks to workers and bystanders and improved application safety. We conducted two experiments in tomato and cucumber greenhouses located in Beijing and Qingdao, China, to study the efficacy of Pic plus 1,3-D gelatin capsules applied at different dosages and soil depths. Results indicated that both injection and gelatin capsules of Pic plus 1,3-D provided good control of soil nematodes and reduced disease index of Fusarium wilt and root-knot nematode. Plant yield of tomato and cucumber treated with gelatin capsules was similar to MB treatment. Based on our results, gelatin capsules applied at a soil depth of 15 cm provided better control of soilborne diseases and led to higher fruit yield compared to an application depth of 5 cm. In conclusion, a gelatin capsule of Pic plus 1,3-D is a promising and novel formulation, which not only shows good efficacy in controlling soilborne diseases, but also reduces potential exposure risks of fumigants.

关键词： soil fumigation chloropicrin 1,3-dichloropropene gelatin capsule formulation efficacy application depth

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